Paul and Me tells of the effect of not one but two devastating, life-changing diseases of Parkinson's and dementia. It follows their progression on his life and his sister's life, and his sister who was forever changed too. It takes us from the beginning diagnosis to the many trials and tribulations of a ten-year journey to the very, very silent end--though, at times, an amusing but always a loving journey. Going from living alone in a two-story house to an unexpected diagnosis, to a rehabilitation facility, to an assisted-living facility, to a nursing home, and, finally, to hospice care was a long journey for Paul. Other family members and the author were forever changed by what seemed at times a never-ending journey.
Yoga is an extremely beneficial therapy for ameliorating physical symptoms of both Parkinson's disease (PD) and multiple sclerosis (MS), and improving emotional wellbeing through breathing, asana, relaxation and meditation. Outlining each condition, its pathology, treatment and its impact on the lives of those affected, the book describes how yoga practice can be tailored to meet the specific needs of those with PD and MS, by improving mobility, balance, strength and wellbeing. Postures are categorised by their useful application, such as joint mobilising, balance and stability, stretching, alongside guidance on how to identify what is needed. Descriptions of yoga movements are accompanied by illustrations throughout, along with sample lesson plans and the personal testimonies of those who have experienced the benefits first hand. Ideal for yoga therapists and yoga teachers working with people with PD or MS, as well as students of the practice, it will also be of interest to practitioners working with beginner client groups and those with limited mobility.
Understanding the molecular pathogenesis of Parkinson’s disease (PD) is a priority in biomedical research and a pre-requisite to improve early disease diagnosis and ultimately to developing disease-modifying strategies. In the past decade and a half, geneticists have identified several genes that are involved in the molecular pathogenesis of PD. They not only identified gene variants segregating with familial forms of PD but also genetic risk factors of sporadic PD via genome-wide association studies (GWAS). Understanding how PD genes and their gene products function holds the promise of unraveling key PD pathogenic processes. Therefore the precise cellular role of PD proteins is currently the subject of intense investigation. Interestingly, a number of PD proteins have enzymatic functions, including kinase, GTPase or ATPase functions. In the context of understanding disease pathogenesis or developing disease-modifying therapies, enzymes possess several useful features. Firstly, enzymes are often key elements of cellular signaling networks, acting as on-off switches to determine signaling intensity. For instance, kinases mediate phosphorylation events, which activate or inactivate their substrates, while GTPases modulate activity of their effector proteins via direct interaction in a GDP/GTP dependent manner. ATPases also control cellular processes through their involvement in cellular energy production and/or in transmembrane transport. Secondly, enzymes are attractive targets for therapeutics development. This is exemplified by the growing number of kinase inhibitors approved for clinical use, while compounds modulating GTPases or ATPases have also been proposed as potential therapeutics. Finally, as elements in cellular signaling networks, enzymes are not generally constitutively active but subject to further regulation through additional signaling components. Knowledge of how PD kinases, GTPases and ATPases are activated or inactivated can aid in understanding how PD signaling networks are deregulated in disease and point to new possibilities in targeting pathological signaling processes. The objective of this research topic is to provide an overview of current knowledge on the regulation of cellular signaling networks of PD kinases, GTPases and ATPases. Both upstream and downstream signaling events will be covered, with a focus on molecular events that can readily be monitored (relevance as disease biomarkers) and have a potential to be modulated (relevance as potential therapeutic target).
Yoga is an extremely beneficial therapy for ameliorating physical symptoms of both Parkinson's disease (PD) and multiple sclerosis (MS), and improving emotional wellbeing through breathing, asana, relaxation and meditation. Outlining each condition, its pathology, treatment and its impact on the lives of those affected, the book describes how yoga practice can be tailored to meet the specific needs of those with PD and MS, by improving mobility, balance, strength and wellbeing. Postures are categorised by their useful application, such as joint mobilising, balance and stability, stretching, alongside guidance on how to identify what is needed. Descriptions of yoga movements are accompanied by illustrations throughout, along with sample lesson plans and the personal testimonies of those who have experienced the benefits first hand. Ideal for yoga therapists and yoga teachers working with people with PD or MS, as well as students of the practice, it will also be of interest to practitioners working with beginner client groups and those with limited mobility.
Parkinson's disease (PD) is the second most common neurodegenerative disorder, affecting approximately 1-2% of people 65 years of age and older1,2 and 3-5% of people over the age of 85.2 Parkinson's has long been characterized by its motor symptoms; however, non-motor symptoms are increasingly recognized and have a greater significance when assessed by health-related quality of life, health economics, and institutionalization rates.3 Of particular interest are impairments of the visual, vestibular, and oculomotor systems as well as impairments in the integration of these systems. There remains a lack of available evidence regarding these deficits in people with Parkinson's disease. Clinically, visual, vestibular, oculomotor, and system integration deficits are often not recognized or assessed, despite the importance of these deficits to postural stability.4,5 These deficits also have the potential to have a significant influence on overall function and general quality of life.4,5 Additional research is needed to better understand the presence of visual, vestibular, and oculomotor impairments in Parkinson's disease including patient perceptions, the relative prevalence of these deficits, their effect on function, their potential association with Parkinsonian fatigue, and other potential associations to determine how these deficits affect individuals and who these deficits most affect. In Aim 1, we performed a qualitative analysis to understand patient perceptions with regard to the presence of visual, vestibular, and oculomotor deficits in patients with Parkinson's disease and their effect on function. In Aim 2 we performed a large-scale quantitative study to determine the presence of various measures of visual, vestibular, oculomotor, and system integration deficits. We also examined a measure of visual functioning in this group using the National Eye Institute 25-item Visual Functioning Questionnaire. Aim 3 examined the relationship between our measures of visual, vestibular, oculomotor, and system integration function to fatigue in people with Parkinson's disease. We also performed a secondary analysis to determine if functional balance was a mediator in this relationship. Finally, in Aim 4 we performed exploratory analyses from our data to determine potential associations with our measures of visual, vestibular, oculomotor, and system integration dysfunction to measures of visual functioning, health-related quality of life, and patient dependent factors including age, sex, disease duration and PD classification. Overall, these studies recognize that people with Parkinson's disease perceive deficits in the visual, vestibular, and oculomotor systems and relate these deficits to functional limitations. Our results confirm the presence of these deficits in individuals with PD and support evidence suggesting they impact function. We did not find any associations between our explanatory variables or functional balance to fatigue. We also did not find any associations between our explanatory visual, vestibular, and oculomotor variables and sex, disease duration, or PD classification supporting the idea that these deficits occur early in the disease process and are present in all types of PD. Finally, our results support the need for future investigations of deficits of visual, vestibular, and oculomotor function to further understand their underlying pathophysiology as well as guide potential interventions to treat these deficits.
Therapy in Sleep Medicine, by Drs. Teri J. Barkoukis, Jean K. Matheson, Richard Ferber, and Karl Doghrami, provides the clinically focused coverage you need for rapid diagnosis and effective treatment of sleep disorders. A multidisciplinary team of leading authorities presents the latest on sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic disorders affecting sleep, sleep therapy for women, sleep therapy in geriatric patients, controversies, and future trends in therapy in a highly illustrated, easy-to-follow format. Diagnose and treat patients effectively with complete coverage of the full range of sleep disorders. Find diagnostic and treatment information quickly and easily thanks to a highly illustrated, easy-to-read format that highlights key details. Stay current on discussions of hot topics, including sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic disorders affecting sleep, sleep therapy for women, sleep therapy in geriatric patients, controversies, and future trends in therapy. Tap into the expertise of a multidisciplinary team of leading authorities for well-rounded, trusted guidance.
Praise for the new edition: In this 7th edition of Physical Change and Aging: A Guide for the Helping Professions the authors, Drs. Saxon, Etten and Perkins, bring to all health care professionals and those interacting with older adults a multidisciplinary foundational reference with state of the art and science approaches to caring for aging persons in our society. This comprehensive book provides geriatric care principles for the expert care provider as well as the novice learner in one book through a compelling reading style that transforms complex principles into simple to comprehend and apply principles. --- Marion Newton, PhD, RN, BSN, MN, PMHCNS-BC, PMHNP-BC, ANEF The seventh edition of this classic multidisciplinary text for students of gerontology continues to offer practical, user-friendly, and comprehensive information about the physical changes and common pathologies associated with the aging process. Fully updated with current information regarding diagnosis, risk factors, prevention recommendations, treatment approaches, and medications along with new statistics on prevalence and evidence-based clinical guidelines, this textbook focuses on physical changes and common pathologies of aging, while also considering the psychological and social implications with which they are inextricably linked. Through a systems-based approach, positive aspects of aging are emphasized, showing the reader how older adults can gain greater personal control through lifestyle changes and preventive health strategies. Included is important content related to teaching, health, and well-being, such as nutrition, medications, aging with lifelong disabilities, complementary and alternative therapies, and death and dying. The seventh edition features a new chapter on gerontechnology, with new content on the influence of pandemics, including COVID-19, on death, dying, grieving, and funeral rituals. This multifaceted text also delivers new and updated information on diagnosis and treatment, along with stressed behaviors and interventions to promote more personal control over the individual aging process. Helpful appendices include practical suggestions for improving safety for older adults and websites of relevant organizations, along with a glossary of medical terms used in the text. Purchase includes digital access for use on most mobile devices or computers. New to the Seventh Edition: A brand-new chapter on gerontechnology Updated information on diagnosis and treatment, risk factors, and prevention recommendations New statistics for prevalence and clinical guidelines/recommendations Focus on behaviors and interventions providing personal control over aging process Practical suggestions for improving older adult safety Influence of COVID-19 on death, dying, grieving, and funeral rituals Test bank and PowerPoint slides Key Features: A unique systems-based approach covering the anatomy and physiology of each organ system Focuses on common health problems within each body system Addresses psychological and social implications of aging Provides evidence-based treatment strategies Describes practical applications of aging data - how to use the data to so adults can gain greater personal freedom Useful as textbook, practitioner's guide and family caregiver resource
[This book] has been honed into an elegant compendium. This outstanding work should be widely read ñ it is perhaps the best example of an integrative approach to gerontology." Score: 94, 4 stars ñ Doody's "Phyisical Change & Aging has been a well-respected resource for caregivers ever since it was published in 1978. This updated version carries on the tradition of providing valuable information on the aging process and age-related health issues." ñ Former First Lady Mrs. Rosalynn Carter This sixth edition of a classic multidisciplinary text for students of gerontology continues to offer practical, reader-friendly information about the physical changes and common pathologies associated with the aging process. It places special emphasis on the psychological and social implications of these changes in the lives of older adults. The book is distinguished by its thorough focus on anatomy and physiology and common health problems pertaining to each body system. It emphasizes the positive aspects of aging and demonstrates how the elderly population can gain greater personal control, through lifestyle changes and preventive health strategies, toward the goal of optimal aging. This sixth edition has been thoroughly updated to present new research findings that differentiate "normal" aging from actual pathology and includes substantially updated information on diagnosis and treatment. It incorporates new data from healthy older adults demonstrating that the aging process is not necessarily as devastating as earlier research had indicated. The book provides new data and guidelines on risk factors, nutrition, preventive measures, interventions, and commonly prescribed medications, and includes expanded treatment of complementary and alternative therapies. Also included is an updated discussion of grief, ethical issues, and funeral options. The book reinforces information with practical applications of aging data. Written for students of gerontology, social work, human services, nursing, medicine, occupational and physical therapy, counseling, and elder law, it presents information that is clearly understandable for those without an extensive background in biology or medicine. Additionally, the book is a useful practitioner's guide and an easily understandable book for family caregivers. THIS SIXTH EDITION INCLUDES NEW INFORMATION ON: Diagnosis and treatment Behaviors and interventions that promote more control over an individual's aging process Genetic/DNA theories Dementia and Parkinson's disease Immunotherapy Lifelong health disparities Animal-assisted therapy Prayer and meditation Pharmacogenetics Geragogy (self-directed learning) Caregiver health as a public health issue Natural funerals (biodegradable caskets, burial urns, dying at home)
Movement Disorders in Children brings the combined expertise and experience of two world-known authorities to the systematic and practical study of movement disorders in infancy and childhood. Aimed at the clinicians and professionals who manage children with these disorders, Emilio Fernandez-Alvarez and Jean Aicardi cover not only the well-known diseases, but also the less well-known conditions, such as ‘transient’ and ‘paroxysmal’ movement disorders. It is the first time all the available information, currently spread throughout journals and individual chapters in other books, has been brought together in one volume and specifically directed towards the care of children with movement disorders. With its clinical emphasis, full coverage and extensive but selective references, this book will be essential reading for child neurologists, pediatricians and physiotherapists.
This new edition presents an integrated approach to neurotoxicology, the study of organisms' responses to changes in their environment and how interruption of the flow of information by chemical exposure causes a wide range of effects - from learning deficits, sensory disturbances in the extremities, and muscle weakness to seizures and signs simila
Provides a thorough overview of the role of fluorine in pharmaceutical science and development Includes chapters on fluorinated analogues of natural products, fluorinated amino acids and peptides, and derivatives of sugars Classifies marketed and in-development fluorinated pharmaceuticals according to their therapeutic classes
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