Loss-of-function mutations in the steroid 5α-reductase 2 gene (SRD5A2) cause a disorder of male sexual differentiation in which the prostate does not form and external genitalia develop along female lines. Failure to synthesize dihydrotestosterone in fetal tissues that give rise to the male urogenital tract underlies the phenotype that characterizes this disorder. Studies of the SRD5A2 gene and its encoded enzyme at the molecular, biochemical, and endocrinological levels established the crucial role of dihydrotestosterone in formation of the male phenotype and in many other androgen actions and led to the development of drugs for the treatment of prostatic disease.
Learn how to effectively plan and deliver activities for the growing number of older people with developmental disabilities. Activities With Developmentally Disabled Elderly and Older Adults is an innovative new book that aims to stimulate interest and continued support for recreation program development and implementation among developmental disability and aging service systems. Particularly useful for human service professionals working in the areas of developmental disabilities and aging, this practical volume will also be of interest to researchers, educators, and students interested in recreation services with older adults who are developmentally disabled. The older adult population with developmental disabilities (DD) continues to grow rapidly, yet little is known about their needs and interests. In this book a wide variety of authors share innovative and creative strategies for programming activities with older adults with DD. They focus on diverse issues, services, and programs from researchers, educators, and practitioners, represented varied disciplines. Each chapter demonstrates the diversity that makes serving a growing number of older individuals with DD both challenging and rewarding. Among the wealth of information you will find in Activities With Developmentally Disabled Elderly and Older Adults are discussions on the characteristics of this population and challenge activity professionals to seek innovative program strategies to appropriately serve individuals with DD companionship/friendship, physical functioning, and retirement adjustment issues that confront older adults who have lived with lifelong disabling conditions how a continuum of recreational activities is needed to provide meaningful experiences to elders with developmental disabilities how to design therapeutic recreation programs survey instruments that can be used to gain information about the needs of elderly persons with DD how to find specific programs and services that are age appropriate and foster creative expression and positive self-esteem a rationale for the development of integrated recreation programs
The Art and Archaeology of the Aegean Bronze Age offers a comprehensive chronological and geographical overview of one of the most important civilizations in human history. Jean-Claude Poursat's volume provides a clear path through the rich and varied art and archaeology of Aegean prehistory, from the Neolithic period down to the end of the Bronze Age. Charting the regional differences within the Aegean world, his study covers the full range of material evidence, including architecture, pottery, frescoes, metalwork, stone, and ivory, all lucidly arranged by chapter. With nearly 300 illustrations, this volume is one of the most lavishly illustrated treatments of the subject yet published. Suggestions for further reading provide an up-to-date entry point to the full richness of the subject. Originally published in French, and translated by the author's collaborator Carl Knappett, this edition makes Poursat's deep knowledge of the Aegean Bronze Age available to an English-language audience for the first time.
Hydrocarbons and their derivatives (oxygenated and chlorinated, in particular), both natural and xenobiotic, represent a very large class of compounds whose conversions and degradation by microorganisms cover an extremely rich field, whose concepts are detailed in this book. The fascinating evolution of these concepts over the last twenty years has revealed the extent of the processes implemented in the environment and has multiplied their industrial applications. The resulting achievements and the current developments are described in this book.The English edition of this reference manual is an entirely revised and updated version of the French edition. It is intended for professionals, microbiologists and chemists, as well as scientists, engineers, teachers and post-doctoral researchers, who are interested by the conversions of hydrocarbons and by microbial ecology.The French edition of this book was awarded a special mention for engineering education text book by the Roberval Prize committee in 2007.
This book places grapes in the context of their family, the Vitaceae. It begins by focusing on the relationship of the family to other angiosperms and the interrelationships and characteristics of its genera. Two chapters emphasize the structure and development of its major vegetative and reproductive characteristics. Keys and illustrated descriptions for 19 North American species including 10 Vitis are provided. The three chapters on Vitis begin with a brief history of grape growing, with emphasis on North America. There is an illustrated life history of grape, following the two-year cycle from bud initiation to fruit maturity. The final chapter discusses the history of grapevine identification in North America, concluding with descriptions and illustrations of 30 important North American cold climate cultivars. The book is a general resource for understanding the growth, development, life history, and identification of grapes and the Vitaceae.
- NEW! Refocused and streamlined content eliminates "content saturation" by drastically reducing the amount of advanced practice and examination procedures, techniques, and content that are applicable to nurse practitioner levels; thus keeping readers focused on the most common and important learnings and procedures. - NEW! Student laboratory manual (sold separately) provides an invaluable resource for mastering physical examination. - NEW! Improved page layout features a less cluttered and more reader-friendly look thanks to the removal of extraneous tables and illustrations. - NEW! Improved text design includes updated fonts, photos, and illustrations to make the material more readable and the concepts easier-to-understand. - NEW! Two new concept overviews incorporate the physiological principles of metabolism and nutrition into text material. - NEW! Updated electronic documentation content ensures accuracy and congruency with the most current technology and best practices. - NEW! Updated ethnic/cultural/spiritual variations content reflects the latest trends currently being seen in practice today.
Offering multidisciplinary guidance to all health care practitioners who provide clinical care for children and adolescents, the 7th Edition of Emans, Laufer, Goldstein’s Pediatric & Adolescent Gynecology has been extensively revised to keep you up to date in this complex field. You’ll find comprehensive coverage of the full spectrum of medical and surgical approaches to common and uncommon problems – everything from infants with vulvar rashes, to the child with early or late onset of puberty, to adolescents and young adults with ovarian cysts or STDs. More than 40 experts in the field, led by editors from Boston Children’s Hospital and Harvard Medical School, have contributed to ensure this classic text remains relevant and useful in daily practice.
Scripture says "be anxious for nothing," yet most of us find ourselves increasingly worried and anxious--about our families, our jobs, our finances, our security, and so much more. We're even worried about our level of anxiety! Integrating both the psychological and spiritual aspects of anxiety, therapist Jean Holthaus offers this research-driven and faith-informed approach to understanding why we experience anxiety and shows us how to effectively manage it by developing three essential skills: - living in the present moment - suspending judgment - believing yourself to be competent and equipped by God Our world is never going to be a completely safe and understandable place. But with Holthaus's help, our hearts and minds can experience greater and lasting peace.
Do the objects that we perceive though our senses exist autonomously, independent of the mind that perceives them? Three and a half centuries have gone by without a universally acceptable solution. Jean-Ren? Vernes shows that this failure results from the fundamental error in classical thinking, which identifies reason with determinant reason alone
The Skills of Document Use: From Text Comprehension to Web-Based Learning examines functional literacy from a psychological standpoint. It offers a comprehensive discussion of the cognitive skills involved in reading, comprehending, and making use of complex documents. Understanding such skills is important at times when printed and online informat
Drawing on family correspondence, Jean Barman offers a new interpretation of early settlement across Canada in the stories of two young sisters from Pictou County, Nova Scotia, who took the train west to British Columbia in 1886.
Uniting dozens of seemingly disparate results from different fields, this book combines concepts from mathematics and computer science to present the first integrated treatment of sequences generated by 'finite automata'. The authors apply the theory to the study of automatic sequences and their generalizations, such as Sturmian words and k-regular sequences. And further, they provide applications to number theory (particularly to formal power series and transcendence in finite characteristic), physics, computer graphics, and music. Starting from first principles wherever feasible, basic results from combinatorics on words, numeration systems, and models of computation are discussed. Thus this book is suitable for graduate students or advanced undergraduates, as well as for mature researchers wishing to know more about this fascinating subject. Results are presented from first principles wherever feasible, and the book is supplemented by a collection of 460 exercises, 85 open problems, and over 1600 citations to the literature.
In "The Invention of Cuneiform" Jean-Jacques Glassner offers a compelling introduction to a seminal era in human history. Returning to early Mesopotamian texts that have been little studied or poorly understood, he traces the development of writing from the earliest attempts to the sophisticated system of roughly 640 signs that constituted the Sumerian repertory by about 3200 B.C.
Style plays a major role in the translation of literary as well as non-literary texts, and Translation and Style offers an updated survey of this highly interdisciplinary area of translation studies. Jean Boase-Beier examines a variety of disciplines and theoretical approaches including stylistics, literary criticism, and narratology to investigate how we translate style. This revised and expanded edition of the 2006 book Stylistic Approaches to Translation offers new and accessible explanations on recent developments in the field, notably in the areas of Relevance Theory and cognitive stylistics. With many authentic examples to show how style affects translation, this book is an invaluable resource for both students and scholars working in translation studies and comparative literature.
Learn the core concepts of nursing care and apply them to the clinical setting! Concepts for Nursing Practice, 3rd Edition uses a simplified, intuitive approach to describe 57 important concepts relating to all areas of nursing practice. For easier understanding, this book also makes connections among related concepts and links you to other nursing textbooks. Exemplars for each concept provide useful examples and models, showing how concepts are successfully applied to practice. New to this edition are updated research evidence and a new Population Health concept. Written by conceptual learning expert Jean Giddens, this text will help you build clinical reasoning skills and prepare confidently for almost any clinical nursing situation. - Authoritative content written by expert contributors and meticulously edited by concept-based learning expert Jean Giddens sets the standard for the rapidly growing concept-based curriculum movement. - A total of 57 important nursing concepts are clearly defined and analyzed, spanning the areas of patient physiology, patient behavior, and the professional nursing environment. - Case studies in each chapter make it easier to apply knowledge of nursing concepts to real-world situations. - UNIQUE! Featured Exemplars sections describe selected exemplars related to each nursing concept, covering the entire lifespan and all clinical settings, and help you assimilate concepts into practice. - UNIQUE! Logical framework of concepts by units and themes helps you form immediate connections among related concepts --- a key to conceptual learning. - UNIQUE! Interrelated Concepts illustrations provide visual cues to understanding and help you make connections across concepts. - NEW! UPDATED content reflects the latest research evidence and national and international practice guidelines. - NEW! Population Health concept reflects the future of nursing, in which health care organizations learn to deliver care that is high in quality, patient-centered, cost-effective, and evidence-based. - NEW! Featured Exemplars sections provide a brief explanation of some of the most important exemplars. - NEW! Discussion questions in case studies reinforce your understanding of each concept. - NEW! UPDATED exemplar links connect you to concept exemplars in other RN- and LPN/LVN-level Elsevier nursing titles.
“Re-education” consists in training people injured either by illness or the vagaries of life to achieve the best functionality now possible for them. Strangely, the subject is not taught in the normal educational curricula of the relevant professions. It thus tends to be developed anew with each patient, without recourse to knowledge of what such training, or assistance in such training, might be. New paradigms of re-education are in fact possible today, thanks to advances in cognitive science, and new technologies such as virtual reality and robotics. They lead to the re-thinking of the procedures of physical medicine, as well as of re-education. The first part looks anew at re-education in the context of both international classifications of functionality, handicap and health, and the concept of normality. The second part highlights the function of implicit memory in re-education. And the last part shows the integration of new cognition technologies in the new paradigms of re-education.
Drawing from the latest brain research--morphological, physiological, chemical and genetic--and placing these findings in the context of psychology, philosophy, art and literature, a prominent microbiologist illuminates the evolution of the brain and translates what new developments in neuroscience may predict for the future of humanity.
Jean-Jacques Lecercle's remarkable Philosophy of Nonsense offers a sustained and important account of an area that is usually hastily dismissed. Using the resources of contemporary philosophy - notably Deleuze and Lyotard - he manages to bring out the importance of nonsense' - Andrew Benjamin, University of Warwick Why are we, and in particular why are philosophers and linguists, so fascinated with nonsense? Why do Lewis Carroll and Edward Lear appear in so many otherwise dull and dry academic books? This amusing, yet rigorous new book by Jean-Jacques Lecercle shows how the genre of nonsense was constructed and why it has proved so enduring and enlightening for linguistics and philosophy.
Introduced as a quantum extension of Maxwell's classical theory, quantum electrodynamics has been the first example of a Quantum Field Theory (QFT). Eventually, QFT has become the framework for the discussion of all fundamental interactions at the microscopic scale except, possibly, gravity. More surprisingly, it has also provided a framework for the understanding of second order phase transitions in statistical mechanics. As this work illustrates, QFT is the natural framework for the discussion of most systems involving an infinite number of degrees of freedom with local couplings. These systems range from cold Bose gases at the condensation temperature (about ten nanokelvin) to conventional phase transitions (from a few degrees to several hundred) and high energy particle physics up to a TeV, altogether more than twenty orders of magnitude in the energy scale. Therefore, this text sets out to present a work in which the strong formal relations between particle physics and the theory of critical phenomena are systematically emphasized. This option explains some of the choices made in the presentation. A formulation in terms of field integrals has been adopted to study the properties of QFT. The language of partition and correlation functions has been used throughout, even in applications of QFT to particle physics. Renormalization and renormalization group properties are systematically discussed. The notion of effective field theory and the emergence of renormalisable theories are described. The consequences for fine tuning and triviality issue are emphasized. This fifth edition has been updated and fully revised, e.g. in particle physics with progress in neutrino physics and the discovery of the Higgs boson. The presentation has been made more homogeneous througout the volume, and emphasis has been put on the notion of effective field theory and discussion of the emergence of renormalisable theories.
Thoroughly researched using experimentation and re-examination of all previously published evidence, Molecular and Physiological Mechanisms of Muscle Contraction is a carefully crafted treatise and revision of previous conceptions of muscle contraction. It presents detailed descriptions of new, previously unpublished data and hybrids recent finding
Therapy in Sleep Medicine, by Drs. Teri J. Barkoukis, Jean K. Matheson, Richard Ferber, and Karl Doghrami, provides the clinically focused coverage you need for rapid diagnosis and effective treatment of sleep disorders. A multidisciplinary team of leading authorities presents the latest on sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic disorders affecting sleep, sleep therapy for women, sleep therapy in geriatric patients, controversies, and future trends in therapy in a highly illustrated, easy-to-follow format. Diagnose and treat patients effectively with complete coverage of the full range of sleep disorders. Find diagnostic and treatment information quickly and easily thanks to a highly illustrated, easy-to-read format that highlights key details. Stay current on discussions of hot topics, including sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic disorders affecting sleep, sleep therapy for women, sleep therapy in geriatric patients, controversies, and future trends in therapy. Tap into the expertise of a multidisciplinary team of leading authorities for well-rounded, trusted guidance.
The work at hand is the only comprehensive history of Anson County, spanning over 225 years of the county's growth from a vast wilderness to a thriving industrial and agricultural community. The first third of the volume traces politics in the county. The middle portion covers Anson's social history, including education, religion, agriculture and industry, social and cultural life, etc. The final third of the book provides biographical sketches of scores of Anson "Men and Women of Note" and a number of source record collections of great import to genealogists.
Conventional thinking has brands trying to give customers what they want. But what if wanting is no longer enough? A customer may want a great mobile phone, for example, and there are many options. But a huge majority will choose the now iconic iPhone, even waiting long hours in lines to purchase the latest model. This is not simply about wanting. It’s about desire. The question for brand marketers is how to make that elusive magic happen. In Desire by Design, Jean-Pierre Lacroix unravels the irrational element of desire and explains how brands, designers, and marketers can tap into the emotional high that elicits such passion for certain brands. Jean-Pierre shapes high-level ideas and insights from neuroscience, cult fanaticism, and behavioral psychology into practical worksheets that explain the how-to in creating desire for a brand. Using design philosophies he has developed through his thirty years of experience, Jean-Pierre offers interesting history, insights from scientific research, and actionable advice to lead brands from a “want” category to the much-coveted “desire” space in the marketplace.
How do people come up with truly original ideas? The answer is to think outside the box—way outside. For the past decade, Cyril Bouquet, Jean-Louis Barsoux, and Michael Wade, professors of innovation and strategy at IMD Business School, have studied inventors, scientists, doctors, entrepreneurs, and artists. These people, or “aliens,” as the authors call them, are able to make leaps of creativity, and use five patterns of thinking that distinguish them from the rest of us. These five patterns—Attention, Levitation, Imagination, Experimentation, and Navigation—lead to a fresh and flexible approach to problem-solving. Alien thinkers know how to free the imagination so it can detect hard-to-observe patterns. They practice deliberate ways to retreat from the world in order to see the big picture underlying a problem. And they approach ideas in systematic ways that reflect the constraints of reality. Through surprising and compelling stories, the authors show how readers can use this method to develop out-of-this-world ideas. ALIEN Thinking can help any of us find innovative solutions to the most difficult problems.
Ireland in the Nineteenth Century: A Breviate of Official Publications offers information on the compilation of documents regarding Ireland from the 1-000 Act of Union until the 1970's, covering subjects such as education, agriculture, poverty, finance, health, and transport. The book first focuses on government documents, including the Act of Union, parliamentary privilege, peerage, public offices and public works, local government areas, and grand jury presentments. The text also looks at documents in finance, ownership and valuation of land, agriculture, and poverty and health measures. Topics include employment of the poor, emigration, drainage and reclamation of waste areas, fisheries, land legislation, and survey and valuation of Ireland. The manuscript touches on documents on health and living conditions and transport and communications. Areas covered include hospitals, charitable institutions, roads, railways, navigation, shipping, ports and harbors, and overseas communications. The book also ponders on documents on education and culture, ecclesiastical matters, trade industry and labor, legal administration, and civil commotion. The text is a dependable reference for readers interested in documents relating to education, agriculture, poverty, finance, health and transport, and government functions of Ireland.
Founded in 1781 by pioneers from what is today northern Mexico, El Pueblo de Los Angeles mirrors the history and heritage of the city to which it gave birth. When the pueblo was the capital of Mexico’s Alta California, the region’s rancheros came here to celebrate mass or to attend fiestas in the historic Plaza. Following California’s statehood in 1850, the pueblo for a time ranked among the most lawless towns of the American West. American speculators, wealthy rancheros, and Italian wine merchants crowded its dusty streets. The town’s first barrio and the vibrant precincts of Old Chinatown soon grew up nearby. As Los Angeles burgeoned into a modern metropolis, its historic heart fell into ruin, to be revitalized by the creation in 1930 of the romantic Mexican marketplace at Olvera Street. Here, two years later, David Alfaro Siqueiros painted the landmark mural América Tropical, whose story is a fascinating tale of art, politics, and censorship. In the decades since, the pueblo has remained one of Southern California’s most enduring and most complex cultural symbols. El Pueblo vividly recounts the story of the birthplace of Los Angeles. An engaging historical narrative is complemented by abundant illustrations and a tour of the pueblo’s historic buildings. The book also describes initiatives to preserve the pueblo’s rich heritage and considers the significance of its multicultural legacy for Los Angeles today
For many years, intensive care has focused on avoiding immediate death from acute, life-threatening conditions. However, there are increasing reports of a number of lingering consequences for those who do indeed survive intensive care. Examples include on-going high risk of death, neurocognitive defects, significant caregiver burden, and continued high healthcare costs. Surviving Intensive Care, written by the world's experts in this area, is dedicated to better understanding the consequences of surviving intensive care and is intended to provide a synopsis of the current knowledge and a stimulus for future research and improved care of the critically ill.
Will understanding our brains help us to know our minds? Or is there an unbridgeable distance between the work of neuroscience and the workings of human consciousness? In a remarkable exchange between neuroscientist Jean-Pierre Changeux and philosopher Paul Ricoeur, this book explores the vexed territory between these divergent approaches--and comes to a deeper, more complex perspective on human nature. Ranging across diverse traditions, from phrenology to PET scans and from Spinoza to Charles Taylor, What Makes Us Think? revolves around a central issue: the relation between the facts (or "what is") of science and the prescriptions (or "what ought to be") of ethics. Changeux and Ricoeur ask: Will neuroscientific knowledge influence our moral conduct? Is a naturally based ethics possible? Pursuing these questions, they attack key topics at the intersection of philosophy and neuroscience: What are the relations between brain states and psychological experience? Between language and truth? Memory and culture? Behavior and action? What is a mental representation? How does a sign relate to what it signifies? How might subjective experience be constructed rather than discovered? And can biological or cultural evolution be considered progressive? Throughout, Changeux and Ricoeur provide unprecedented insight into what neuroscience can--and cannot--tell us about the nature of human experience. Changeux and Ricoeur bring an unusual depth of engagement and breadth of knowledge to each other's subject. In doing so, they make two often hostile disciplines speak to one another in surprising and instructive ways--and speak with all the subtlety and passion of conversation at its very best.
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