Were you always curious about biology but were afraid to sit through long hours of dense reading? Did you like the subject when you were in high school but had other plans after you graduated? Now you can explore the human genome and analyze DNA without ever leaving your desktop! Bioinformatics For Dummies is packed with valuable information that introduces you to this exciting new discipline. This easy-to-follow guide leads you step by step through every bioinformatics task that can be done over the Internet. Forget long equations, computer-geek gibberish, and installing bulky programs that slow down your computer. You’ll be amazed at all the things you can accomplish just by logging on and following these trusty directions. You get the tools you need to: Analyze all types of sequences Use all types of databases Work with DNA and protein sequences Conduct similarity searches Build a multiple sequence alignment Edit and publish alignments Visualize protein 3-D structures Construct phylogenetic trees This up-to-date second edition includes newly created and popular databases and Internet programs as well as multiple new genomes. It provides tips for using servers and places to seek resources to find out about what’s going on in the bioinformatics world. Bioinformatics For Dummies will show you how to get the most out of your PC and the right Web tools so you'll be searching databases and analyzing sequences like a pro!
This book gives a comprehensive and up-to-date treatment of the theory of "simple" liquids. The new second edition has been rearranged and considerably expanded to give a balanced account both of basic theory and of the advances of the past decade. It presents the main ideas of modern liquid state theory in a way that is both pedagogical and self-contained. The book should be accessible to graduate students and research workers, both experimentalists and theorists, who have a good background in elementary mechanics. - Compares theoretical deductions with experimental results - Molecular dynamics - Monte Carlo computations - Covers ionic, metallic, and molecular liquids
The second volume of the proceedings of the international seminar devoted to locali· zation and delocalization in quantum chemistry is divided into four parts. The first one is mainly concerned with the localizability of electrons in ionized and exited states. The second part shows how is it possible to take advantage of the localizability of electrons to compute molecular wave-functions. The third part of the book is an homogeneous analysis of the electronic collective excitation and of the motion of excitons in organic solids. The last section is devoted to the study of the role of electron localizability in the chemical reactivity of molecules. Concluding remarks are concerned with a careful analysis of the localizability concept itself in relation with a possible interpretation of the wave-mechanics. PART I ELECTRON LOCALIZATION IN IONIZED AND EXCITED STATES APPLICATIONS OF PAIR DENSITY ANALYSIS R. CONSTANCIEL and L. ESNAULT Centre de Mecanique Ondulatoire Appliquee, Paris, France Abstract. The method of pair density analysis is applied to various kinds of calculations. We examine the influence of the quality of the wavefunction and of the nuclear configuration; the problem of hybridization is discussed, as weIl as the relations between separability and excitation.
Spectroscopy and Modeling of Biomolecular Building Blocks presents an overview of recent advances in the intertwining of the following research fields: photon and electron spectroscopy, quantum chemistry, modelling and mass-spectrometry. The coupling of these disciplines offers a new point of view to the understanding of isolated elementary building blocks of biomolecules and their assemblies. It allows the unambiguous separation between intrinsic properties of biomolecular systems and those induced by the presence of their environment. The first chapters provide background in modelling (I), frequency-resolved spectroscopy using microwave, infrared and UV photons, time-resolved spectroscopy in the femtosecond domain and energy-resolved electron spectroscopy (II) and production of gas-phase neutral and ionic biomolecular species, mass-spectrometry, ion mobility and BIRD techniques (III). Chapter IV is devoted to case studies of gas-phase experimental investigations coupled to quantum or classical calculations. The topics are structural studies of nucleobases and oligonucleotides, peptides and proteins, sugars; neuromolecules; non-covalent complexes; chiral systems, interactions of low-energy electrons with biomolecules in the radiation chemistry context and very large gas-phase biomolecular systems. The fifth chapter concerns the link between gas-phase and liquid-phase. Different treatments of solvation are illustrated through examples pointing out the influence of progressive addition of water molecules upon properties of nucleobases, peptides, sugars and neuromolecules. - Offer a new perspective to the understanding of isolated elementary building blocks of bio molecules - Includes case studies of experimental investigations coupled to quantum or classical calculations
Can the mind really generate a physical disease? Conversely, can the body cause mental illness? What do we know today about their interaction? The relations between body and mind are the source of many problems that are currently treated separately by psychoanalysts and doctors because of the compartmentalisation between their disciplines. Despite differences in clinical practice, we all stand to benefit from a common understanding of the reciprocal influences of the mind and the body and the ways in which these are interrelated. It is time to stop treating the body in isolation from treatment of the mind and to understand that where the psychic apparatus fails in its key task of managing the excitations generated by the tensions and frustrations of everyday life, it is the body that takes over. With a wealth of clinical examples, the author proposes an innovative theoretical and clinical approach that seeks to break down the barriers between biology and psychoanalysis; he also demonstrates its benefits for the health and recovery of patients and its implications for disease prevention.
Here is a helpful guide, A-to-Z guide on the structures of chemicals implicated in contact dermatitis. It describes each molecule along with its principal name for classification. The dictionary also lists the most important synonyms, the Chemical Abstract Service (CAS) Registry Number that characterizes the substance and its chemical structure, and relevant literature references. This guide is a must-have for each physician involved with the diagnosis and treatment of patients with contact dermatitis and allergic skin disease.
This book provides a comprehensive overview of the history of ideas about the sun and the stars, from antiquity to modern times. Two theoretical astrophysicists who have been active in the field since the early 1960s tell the story in fluent prose. About half of the book covers most of the theoretical research done from 1940 to the close of the twentieth century, a large body of work that has to date been little explored by historians. The first chapter, which outlines the period from about 3000 B.C. to 1700 A.D., shows that at every stage in history human beings have had a particular understanding of the sun and stars, and that this has continually evolved over the centuries. Next the authors systematically address the immense mass of observations astronomy accumulated from the early seventeenth century to the early twentieth. The remaining four chapters examine the history of the field from the physicists perspective, the emphasis being on theoretical work from the mid-1840s to the late 1990s--from thermodynamics to quantum mechanics, from nuclear physics and magnetohydrodynamics to the remarkable advances through to the late 1960s, and finally, to more recent theoretical work. Intended mainly for students and teachers of astronomy, this book will also be a useful reference for practicing astronomers and scientifically curious general readers.
Whether it is to understand the networks of individuals, the physical makeup of a household or community, or to develop strategies for finding difficult-to-reach populations such as the homeless or drug-addicted, applied researchers increasingly need to understand spatial methods. In this brief volume, the techniques of network analysis, mapping, and finding hidden populations are explained in simple, practical language. The authors describe when and how to use these techniques and offer numerous examples of how the methods have worked in community psychology, drug research, risk assessment, and network analysis, among other settings.
Molecular Cytology, Volume 2: Cell Interactions deals with the morphology and biochemistry of the cell, with emphasis on the more dynamic aspects of cytology. It looks at gene transfer in somatic cells, nucleocytoplasmic interactions in oocytes and eggs, and cell differentiation, transformation, malignancy, aging, and death. Organized into four chapters, this volume begins with a discussion of nucleocytoplasmic interactions in somatic cells and unicellular organisms. The next chapter examines the experimental interventions at early stages in the egg cytoplasm with reference to Xenopus oocytes, as well as oogenesis, the structure and composition of the cytoplasm and the nucleus, fertilization of sea urchin eggs, and the nuclear determinants of early embryogenic development. Additionally, a chapter explains the mechanisms underlying cell senescence, arrest of cell growth, and cell death; the mechanisms of cell differentiation as the normal outcome of embryonic development; the morphological and biochemical changes that occur in cells when they become senescent; and the metastasis of cancer cells. The book concludes with a chapter that presents a few general ideas about biochemical cytology. This book is a valuable reference for cell biologists, biochemists, cytologists, advanced students, research workers, and laypersons interested in learning the fundamentals of descriptive cytology, biochemistry, embryology, genetics, and molecular biology.
The purpose of this book is to give a clear and straightforward account of the remarkable properties of the nicotinic receptor for acetylcholine, a membrane protein involved in chemical transduction in the nervous system that is also the target of a widely used drug, nicotine. This molecule also happens to be the first pharmacological receptor and ion channel ever to have been identified. Jean-Pierre Changeux has played a leading role with Stuart J. Edelstein in the investigation of nicotinic acetylcholine receptors and allosteric proteins. The aim of this book is not only to review the most recent experimental and theoretical breakthroughs in the study of the nicotinic receptor, but also to give the reader a sense of the intellectual excitement and adventure that accompanied the various stages of discovery. This richly illustrated volume furnishes an exceptional opportunity for scientists and students to follow the course of a major advance in our understanding of the molecular basis of brain functions. Jean-Pierre Changeux is honorary professor at the Collège de France and at the Institut Pasteur, a member of the French Academy of Sciences. In addition to L’Homme neuronal [Neuronal Man] he is the author of Raison et Plaisir and L’Homme de vérité. He is also co-author, with Alain Connes, of Matière à penser [Conversations on Mind, Matter, and Mathematics] and, with Paul Ricœur, of La Nature et la Règle [What Makes Us Think?]. All thought-provoking works. Stuart J. Edelstein is Professor of Biochemistry at the University of Geneva and a foreign associate member of the Academy of Sciences. "The nicotinic acetylcholine receptor has served for many decades as the prototype for neurotransmitter receptors. Acetylcholine was the first neurotransmitter shown to be involved in the fonction of the mammalian brain and its nicotinic receptor the first receptor to be characterized. Jean-Pierre Changeux is the indisputable pioneer in this field. This volume summarizes with great lucidity the history of a highly important topic in neuroscience." Paul Greengard, Nobel laureate in Medecine - The Rockefeller University "From the molecule to thought itself - an extraordinary journey! Changeux and Edelstein are uniquely qualified to relate this utterly fascinating story, whose philosophical implications are no less important than the scientific research underlying them." Jean-Marie Lehn, Nobel laureate in Chemistry - ISIS-Université Louis Pasteur, Strasbourg "The human brain is as much a chemical as an electrical network. Its intricacy and sophistication set it apart from any known technical device. The groundbreaking papers by Monod, Jacob, Wyman, and Changeux in the 1960s on chemical regulation and control were eye-opening for all us who were doing experimental research in ths field, and they have turned out to be crucial for understanding biological evolution and learning in a broad sense. Since then Changeux and Edelstein have achieved international fame for their work on nicotinic acetylcholine receptors, amply documented in this masterful account." Manfred Eigen, Nobel laureate in Chemistry - Max Planck Institute for Biophysical Chemistry, Göttingen "One hesitates to call this book a monograph, for despite its comprehensive treatment of a complex subject it is not meant solely for specialized readers. In concentrating on a single class of neuroreceptors, the nicotinic acetylcholine receptor, it seeks to draw out general principles which apply more widely. It will therefore be welcomed not only by serious workers and students in the field of neurobiology, but also by anyone interested in the broader field of neuroscience." Sir Aaron Klug OM FRS, Nobel laureate in Chemistry - University of Cambridge "Changeux and Edelstein have provided a concise yet highly comprehensive account of perhaps the prototypical neurotransmitter complex, the nicotinic acetylcholine receptor. The story of how the roles played by this signal transduction system in nicotine dependence, learning, memory, and the processes of cognition came to be unraveled is an exciting saga, both beautiful and profound. A lovely historico-scientific document." Floyd E. Bloom, Professor Emeritus - The Scripps Research Institute "Changeux and Edelstein describe a classically Cartesian process of scientific investigation that leads to a most non-Cartesian conclusion. Having elucidated the mechanisms of action and interaction by which the various elements that make up the nicotinic acetylcholine receptor operate throughout the nervous system, from neuromuscular junctions to the brain itself, the authors turn to the role of thse structures and mechanisms in supporting cognition and giving access to consciousness - thus parting ways with Descartes and the view that the mind is able somehow to exist independently of the body. A work of truly remarkable erudition and insight." Roger Guillemin, Nobel laureate in Medicine - Salk Institute for Biological Studies “This book is unlike any recent scientific book. It is more like a forty-year research meeting in one of the world’s most creative neurobiology laboratories—an intellectual tour de fortcheat surveys the developmental trends and achievements of twentieth-century neuroscience in molecular, structural, and functional terms. The book therefore becomes an extraordinary educational saga, moving from Sir Henry Dale’s pharmacology of nicotine to genetic diseases involving mutations of the cation channel function of nicotinic acetylcholine receptors. Research into these archetypal proteins has been carried out by pharmacologists, biochemists, molecular biologists, electrophysiologists, behavioral scientists, and geneticists, with Jean-Pierre Changeux and his coworkers participating in every aspect of this remarkable inquiry. Nicotinic acetylcholine receptors are the workhorse of the fast actions of the chemical signal acetylcholine, abundantly transmitted in both the peripheral and the central nervous system. Thanks to their variable sub- unit composition they come in many flavors, mediating control of voluntary muscles in the periphery and helping to regulate reward functions, cognition, and memory in the brain. This rich functionality leads the authors to describe models of neuromuscular junction development as well a global workspace model of cognitive function and its role in effortful learning. The nicotinic acetylcholine receptor was among the first ligand-gated ion channels to be sequenced and studied by patch-clamp methods. It has been the object of neurobiological research in England, France, Germany, Japan, and the United States, with contributions of equal weight being made by many teams of researchers over a number of decades, all carefully chronicled and explained by the authors. This book is to be highly recommended to young scientists who want to discover into how many fields a single protein molecule can take them—from snake venom action to myasthenia gravis, addiction, learning, and schiz- ophrenia—if they are willing patiently to learn new research techniques rather than specialize in a single method or instrument. To investigate the nicotinic acetylcholine receptor in all its aspects requires a Renaissance mind, and it is exactly this that Changeux and Edelstein have brought to bear on one of the most studied topics in neuroscience of the last century.” TAMAS BARTFAI, Chair and Professor, Department of Neuropharmacology The Scripps Research Institute
Evaluation, from connotations to complex judgements of value, is probably the most neglected dimension of meaning. Calling for a new understanding of truth and value, this book is a comprehensive study of evaluation in natural language, at lexical, syntactic and discursive levels. Jean Pierre Malrieu explores the cognitive foundations of evaluation and uses connectionist networks to model evaluative processes. He takes into account the social dimension of evaluation, showing that ideological contexts account for evaluative variability. A discussion of compositionality and opacity leads to the argument that a semantics of evaluation has some key advantages over truth-conditional semantics and as an example Malrieu applies his evaluative semantics to a complex Shakespeare text. His connectionist model yields a mathematical estimation of the consistency of text with ideology, and is particularly useful in the identification of subtle rhetorical devices such as irony.
The epoch of representation is as old as the West. Indeed, representation is the West, understood as what at once designates and expands its own limits. But what comes after the West? What comes after representation's disclosure of its own limit? The central problem posed in these essays, collected from over a decade of work, is how in the wake of Western ontologies to conceive the coming, the birth that characterizes being. We are now at the limit of representation, where objects as we experience them have been show to be merely objects of representation--or rather, of presentation, since there is nothing to (re)present. The first part of this book, "Existence," asks how, today, one can give sense of meaning to existence as such, arguing that existence itself, as it comes nude into the world, must now be our "sense." In examining what this birth to presence might be, we should not ask what presence "is"; rather we should conceive presence as presence to someone, including to presence itself. This birth is not the constitution of an identity, but the endless departure of an identity from, and from within, its other, or others. Its coming is not desire but jouissance, the joy of averring oneself to be continually in the state of being born--a rejoicing of birth, a birth of rejoicing. The second section, "Poetry," asks: What art exposes this? In writing, in the voice, in painting? And what if art is exposed to it? How does it inscribe (or rather, "exscribe," in a term the book develops) the coming existence as such? The author's trajectory in this book crosses those of Hegel, Schlegel, Baudelaire, Nietzsche, Freud, and Heidegger, in their comments on art and politics, existence and corporeality, everyday life and its modes of existence and ecstasy. An analysis that dares this crossing involves all the varied accounts of existence, political as well as philosophical, and all the realms of poverty.
Jean Vanier celebrates the gospel of John in his highly anticipated latest work, Drawn into the Mystery of Jesus through the Gospel of John. Thoroughly personal and inspiring, it challenges all Christians to encounter the fullness of life lived in close communion with God. Vanier writes: "These insights that I share in this book come from the life of Jesus in me ... They also flow from my life with people who are weak and who have taught me to welcome Jesus from the place of the poverty in me." Jean Vanier was a friend and influential mentor to the late Henri Nouwen. Toward the end of his life, Nouwen left Harvard to live and work at one of Jean Vanier's L'Arche communities. This was perhaps the most profound experience of Christianity Nouwen experienced. The thought and spiritual direction/discipleship of Jean Vanier is available to all in Drawn into the Mystery of Jesus through the Gospel of John.
Provides a thorough overview of the role of fluorine in pharmaceutical science and development Includes chapters on fluorinated analogues of natural products, fluorinated amino acids and peptides, and derivatives of sugars Classifies marketed and in-development fluorinated pharmaceuticals according to their therapeutic classes
Drawing from the latest brain research--morphological, physiological, chemical and genetic--and placing these findings in the context of psychology, philosophy, art and literature, a prominent microbiologist illuminates the evolution of the brain and translates what new developments in neuroscience may predict for the future of humanity.
My Father, I put myself in your hands", wrote Charles de Foucauld in his journal. "Whatever you make of me, I thank you, I am ready for everything, I accept everything, I thank you for everything." When he was killed by bandits in 1916, the French aristocrat-turned-monk was virtually unknown. Over the course of a century, however, the radiance of Foucauld's hidden life has spread more and more, and the Church now recognizes him as a saint. His youth and early adulthood read like a novel—the loss of his parents; his education in Paris, where he abandoned the faith of his childhood; his military career in French Algeria; and his exploration of Morocco. After a conversion at the age of twenty-eight, Foucauld was charged with a desire to surrender himself completely to God, leading him eventually to a life of prayer in the Algerian desert. There he devoted himself to adoration of the Blessed Sacrament and charity toward his Muslim neighbors—even to the point of death. Jean-Jacques Antier describes Foucauld's dramatic, inspiring life in a vivid narrative style. He based his biography on the man's writings and correspondence as well as interviews with numerous people who knew him. Illustrated with sixteen pages of photos, and indexed.
In this wide-ranging book, one of the boldest thinkers in modern neuroscience confronts an ancient philosophical problem: can we know the world as it really is? Drawing on provocative new findings about the psychophysiology of perception and judgment in both human and nonhuman primates, and also on the cultural history of science, Jean-Pierre Changeux makes a powerful case for the reality of scientific progress and argues that it forms the basis for a coherent and universal theory of human rights. On this view, belief in objective knowledge is not a mere ideological slogan or a naive confusion; it is a characteristic feature of human cognition throughout evolution, and the scientific method its most sophisticated embodiment. Seeking to reconcile science and humanism, Changeux holds that the capacity to recognize truths that are independent of subjective personal experience constitutes the foundation of a human civil society.
This book is the first to offer a global perspective on the unique contemporary media phenomenon of transnational television channels. It is also the first to compare their impact in different regions of the globe. Revealing great richness and diversity across some of the world's main geocultural regions (Europe, the Middle East, Africa, South Asia, Greater China and Latin America), international contributors with in-depth industry knowledge examine the place of these channels in the process of globalization, their impact on the nation-state and on regional culture and politics. The book also considers audiences and geocultural TV markets, providing new ways of thinking about the emerging transnational media order.
A prominent feature of the social revolution in France has been the decline of the great national institutions -- the Republic, the Army, the church, and the schools -- which are losing their symbolic value and are no longer the targets of ideological disputes. As a result, there is a growing basic consensus among the French people. At the same time, the French have developed a new interest in managing local problems -- due to the decentralization law -- which has led to the establishment of many voluntary associations. Changes in family life following the "revolution" of 1968 have led to greater instability among couples, but at the same time have strengthened the kinship system resulting in increased life expectancy. The customs of the French have also changed. The French education system, originally based on authority and regulations, is now making increasing use of experimentation and negotiation. As a result, the attitude of the French towards authority has totally changed and the French have learned to negotiate and cooperate among themselves. All these changes can be interpreted as progressive moves toward liberty, equality, and individualism. There is little danger of social instability, since French society remains in remarkably robust health.
En pleine congruence avec l’ambition du Groupe Européen pour l’Administration Publique d’encourager les échanges interculturels, ce livre constitue une entreprise originale, mi-anglophone mi-francophone. Cet ouvrage issu du Congrès du GEAP 2010 a pour objet de combler un déplorable fossé et de donner une visibilité internationale au « cas français ». Dès lors ce livre, en 18 chapitres rédigés en français par une équipe interdisciplinaire (politistes, sociologues, historiens, socio-historiens, juristes) avec plus de 150 pages en anglais et une vaste bibliographie unifiée, entend offrir à tous les spécialistes de l’administration publique de par le monde un point d’accès unique au plus récent état des savoirs sur l’administration en France – ce pays où le mot État s’écrit avec un E majuscule. ============================================ In full compliance with the ambition of the European Group for Public Administration to encourage cross-cultural exchanges, this book is a genuinely original undertaking. It is a hybrid Anglophone-Francophone product. This book from EGPA 2010 Conference purpose to bridge a regrettable gap and to give international visibility to the “French case”. Thus, this book, in 18 chapters written in French by an interdisciplinary team (political scientists, sociologists, historians, sociohistorians, jurists) with more than 150 pages in English and a vast unified bibliography, offers to all students of public administration in the world a unique entry gate to the latest state of the art of administrative studies in France – this country where the State is to be spelled with a capital S.
Continuing on to the electronic revolution, Martin's account takes in the changes wrought on writing by computers and electronic systems of storage and communication, and offers surprising insights into the influence these new technologies have had on children born into the computer age. The power of writing to influence and dominate is, indeed, a central theme in this history, as Martin explores the processes by which the written word has gradually imposed its logic on society over four thousand years. The summation of decades of study by one of the world's great scholars on the subject, this fascinating account of writing explains much about the world we inhabit, where we uneasily confer, accept, and resist the power of the written word.
This ambitious work aims to shed new light on the relations between Husserlian phenomenology and the present-day efforts toward a scientific theory of cognitionwith its complex structure of disciplines, levels of explanation, and conflicting hypotheses. The books primary goal is not to present a new exegesis of Husserls writings, although it does not dismiss the importance of such interpretive and critical work. Rather, the contributors assess the extent to which the kind of phenomenological investigation Husserl initiated favors the construction of a scientific theory of cognition, particularly in contributing to specific contemporary theories either by complementing or by questioning them. What clearly emerges is that Husserlian phenomenology cannot become instrumental in developing cognitive science without undergoing a substantial transformation. Therefore, the central concern of this book is not only the progress of contemporary theories of cognition but also the reorientation of Husserlian phenomenology. Because a single volume could never encompass the numerous facets of this dual aim, the contributors focus on the issue of naturalization. This perspective is far-reaching enough to allow for the coverage of a great variety of topics, ranging from general structures of intentionality, to the nature of the founding epistemological and ontological principles of cognitive science, to analyses of temporality and perception and the mathematical modeling of their phenomenological description. This book, then, is a collective reflection on the possibility of utilizing a naturalized Husserlian phenomenology to contribute to a scientific theory of cognition that fills the explanatory gap between the phenomenological mind and brain.
The acetylcholine nicotinic receptor is among the most studied receptors in neuroscience. Involved in muscle contraction and a wide variety of other neurological functions, including the processing of nicotine, it was the first receptor to be isolated and observed at the molecular level, providing a major research pathway for scientists working in neuroscience, biochemistry, pharmacology, and behavioral science. This book describes four decades of scientific research that inform our current understanding of this receptor. Jean-Pierre Changeux and Stuart J. Edelstein played important roles in pioneering research on the acetylcholine nicotinic receptor and on allosteric proteins, and here they reveal the complete scientific trajectory of that research. They begin with a historical perspective, describing how several fields converged around a single receptor and then explain the initial receptor purification and characterization. Subsequent chapters trace the investigations into various aspects of receptor structure and function, including the chemical structure of the binding site, the identity and properties of the ion channel, and the mechanism of signal transmission. In the final portion of the book, Changeux and Edelstein discuss recent studies on the three-dimensional structure of the receptor molecule and share their novel understanding of inherited diseases such as congenital myasthenia and epilepsy. They also address the integration of the receptor into its synaptic membrane environment and its distribution, physiology, and regulation in brain functions and cognition. Richly illustrated and lucidly written, this book provides an exceptional opportunity for scientists and students to follow a historic advance in our knowledge of molecular mechanisms and the workings of the brain.
This book provides the solid foundation of knowledge therapists need to safely and accurately treat musculoskeletal disorders of the spine. It presents a comprehensive view of applied functional anatomy and biomechanics of the whole spine, examining normal and abnormal function of the spine, the response of tissues to injury, and the effects of age-related changes. Thoroughly referenced and extensively illustrated with over 200 original, high-quality diagrams, it serves as an excellent resource for clinical decision making. The 2nd edition explores several areas in greater depth - including the sacroiliac joint, thoracic biomechanics, muscles - and reviews recent papers and the scientific evidence of functional anatomy. Accessory and physiological spinal movements are thoroughly described. Palpation is covered in detail. Numerous guidelines for safe practice are provided. A valuable, comprehensive chapter covers posture, lifting, and the prevention of injury. Coverage of applied anatomy and biomechanics is written by therapists for therapists. New theories on thoracic biomechanics are presented, rarely covered by other anatomy books. All topics have been updated to reflect recent scientific evidence, enabling the reader to more effectively formulate and manage treatment plans. New illustrations to complement the text and improve readers' understanding of the material. A one-of-a-kind chapter covering the sacroiliac joint has been comprehensively revised. Expanded material is provided on the autonomic nervous system, thoracic spine biomechanics, and the biomechanics of the lower limb as it relates to the spine. New sections address adverse neural tension, cervical discs, proprioception and muscle imbalance, and mechanics of the jaw and upper cervical spine. An update on vertebral artery and blood supply presents the latest knowledge on the subject.
The Lewis concept of acids and bases is discussed in every general, organic and inorganic chemistry textbook. This is usually just a descriptive treatment, as it is not possible to devise a single numerical scale suitable for all occasions. However quantitative Lewis acid-base chemistry can be developed by compiling reaction-specific basicity scales which can be used in specific branches of chemistry and biochemistry. Lewis Basicity and Affinity Scales: Data and Measurementbrings together for the first time a comprehensive range of Lewis basicity/affinity data in one volume. More than 2400 equilibrium constants of acid-base reactions, 1500 complexation enthalpies, and nearly 2000 infrared and ultraviolet shifts upon complexation are gathered together in 25 thermodynamic and spectroscopic scales of basicity and/or affinity. For each scale, the definition, the method of measurement, an exhaustive database, and a critical discussion are given. All the data have been critically examined; some have been re-measured; literature gaps have been filled by original measurements; and each scale has been made homogeneous. This collection of data will enable experimental chemists to better understand and predict the numerous chemical, physical and biological properties that depend upon Lewis basicity. Chemometricians will be able to apply their methods to the data matrices constructed from this book in order to identify the factors which influence basicity and basicity-dependent properties. In addition, measured experimental basicities and affinities are essential to computational chemists for the validation, calibration and establishment of reliable computational methods for quantifying and explaining intermolecular forces and the chemical bond. Lewis Basicity and Affinity Scales: Data and Measurement is an essential single-source desktop reference for research scientists, engineers, and students in academia, research institutes and industry, in all areas of chemistry from fundamental to applied research. "The book is a noteworthy piece of work and represents a timely and vast accumulation of knowledge regarding Lewis bases that brings together accurate thermodynamic and spectroscopic data on typical reference Lewis acids. As such, it should serve as a useful and general guide to basicity." J. AM. CHEM. SOC. 2011, 133, 642
Nephrology and Fluid/Electrolyte Physiology, a volume in Dr. Polin’s Neonatology: Questions and Controversies Series, offers expert authority on the toughest neonatal nephrology and fluid/electrolyte challenges you face in your practice. This medical reference book will help you provide better evidence-based care and improve patient outcomes with research on the latest advances. Reconsider how you handle difficult practice issues with coverage that addresses these topics head on and offers opinions from the leading experts in the field, supported by evidence whenever possible. Find information quickly and easily with a consistent chapter organization. Get the most authoritative advice available from world-class neonatologists who have the inside track on new trends and developments in neonatal care. Stay current in practice with coverage on lung fluid balance in developing lungs and its role in neonatal transition; acute problems of prematurity: balancing fluid volume and electrolyte replacement in very-low-birth-weight and extremely-low-birth-weight neonates; and much more.
Nephrology and Fluid/Electrolyte Physiology, a volume in Dr. Polin's Neonatology: Questions and Controversies Series, offers expert authority on the toughest neonatal nephrology and fluid/electrolyte challenges you face in your practice. This medical reference book will help you provide better evidence-based care and improve patient outcomes with research on the latest advances. Reconsider how you handle difficult practice issues with coverage that addresses these topics head on and offers opinions from the leading experts in the field, supported by evidence whenever possible. Find information quickly and easily with a consistent chapter organization. Get the most authoritative advice available from world-class neonatologists who have the inside track on new trends and developments in neonatal care. Purchase each volume individually, or get the entire 6-volume set, which includes online access that allows you to search across all titles! Stay current in practice with coverage on lung fluid balance in developing lungs and its role in neonatal transition; acute problems of prematurity: balancing fluid volume and electrolyte replacement in very-low-birth-weight and extremely-low-birth-weight neonates; and much more. Access the fully searchable text online at www.expertconsult.com.
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