Jean Chothia's Books

André Antoine

By: Jean Chothia

Write a review Read reviews Take a Quiz Solve Book Puzzle

This book investigates Antoine's exploration of the possibilities and limitations of stage realism, his concept of a workshop theatre for new writing and acting, his experiments and achievements in the mise en scene at the Théâtre Libre and Théâtre Antoine, in the classics at the Odéon and in the early silent film.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

231

Publisher

Cambridge University Press

Published Date

ISBN 10

0521252199

ISBN 13

9780521252195

English Drama of the Early Modern Period 1890-1940

By: Jean Chothia

Write a review Read reviews Take a Quiz Solve Book Puzzle

English Drama of the Early Modern Period 1890-1940

By: Jean Chothia

The period 1890-1940 was a particularly rich and influential phase in the development of modern English theatre: the age of Wilde and Shaw and a generation of influential actors and managers from Irving and Terry to Guilgud and Olivier. Jean Chothia's study is in two parts beginning with a portrait of the period, setting the narrative context and considering the dramatic social and cultural changes at work during this time. It then focuses on some of the main themes in the theatre, from Shaw and comedy, to the rise of political and radio drama, providing an interpretative framework for the period. This volume will be of great benefit to students and academics of English literature and drama, as it covers the work of the major dramatists of the period as well as considering the dramatic output of literary figures, such as James, Eliot and Lawrence.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

351

Publisher

Routledge

Published Date

ISBN 10

1315504200

ISBN 13

9781315504209

Lipocalins

By: Bo Akerstrom,Niels Borregaard,Darren R. Flower,Jean-Philippe Salier

Write a review Read reviews Take a Quiz Solve Book Puzzle

Lipocalins

By: Bo Akerstrom,Niels Borregaard,Darren R. Flower,Jean-Philippe Salier

Less than a decade has elapsed since the publication in 2000 of the first anthology devoted to lipocalins (Biochim Biophys Acta 1482, 2000), and only a few years since the first Lipocalin International Symposium in Copenhagen in 2003 (Benzon Symposium no. 50The Lipocalin Protein Superfamily, Copenhagen, 2003) and the introduction of a public lip

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

221

Publisher

CRC Press

Published Date

ISBN 10

1498712738

ISBN 13

9781498712736

The Brain as a Chemical Machine

Nicotinic receptors and neuronal communication

By: Jean-Pierre Changeux,Stuart J. Edelstein

Write a review Read reviews Take a Quiz Solve Book Puzzle

The Brain as a Chemical Machine

Nicotinic receptors and neuronal communication

By: Jean-Pierre Changeux,Stuart J. Edelstein

The purpose of this book is to give a clear and straightforward account of the remarkable properties of the nicotinic receptor for acetylcholine, a membrane protein involved in chemical transduction in the nervous system that is also the target of a widely used drug, nicotine. This molecule also happens to be the first pharmacological receptor and ion channel ever to have been identified. Jean-Pierre Changeux has played a leading role with Stuart J. Edelstein in the investigation of nicotinic acetylcholine receptors and allosteric proteins. The aim of this book is not only to review the most recent experimental and theoretical breakthroughs in the study of the nicotinic receptor, but also to give the reader a sense of the intellectual excitement and adventure that accompanied the various stages of discovery. This richly illustrated volume furnishes an exceptional opportunity for scientists and students to follow the course of a major advance in our understanding of the molecular basis of brain functions. Jean-Pierre Changeux is honorary professor at the Collège de France and at the Institut Pasteur, a member of the French Academy of Sciences. In addition to L’Homme neuronal [Neuronal Man] he is the author of Raison et Plaisir and L’Homme de vérité. He is also co-author, with Alain Connes, of Matière à penser [Conversations on Mind, Matter, and Mathematics] and, with Paul Ricœur, of La Nature et la Règle [What Makes Us Think?]. All thought-provoking works. Stuart J. Edelstein is Professor of Biochemistry at the University of Geneva and a foreign associate member of the Academy of Sciences. "The nicotinic acetylcholine receptor has served for many decades as the prototype for neurotransmitter receptors. Acetylcholine was the first neurotransmitter shown to be involved in the fonction of the mammalian brain and its nicotinic receptor the first receptor to be characterized. Jean-Pierre Changeux is the indisputable pioneer in this field. This volume summarizes with great lucidity the history of a highly important topic in neuroscience." Paul Greengard, Nobel laureate in Medecine - The Rockefeller University "From the molecule to thought itself - an extraordinary journey! Changeux and Edelstein are uniquely qualified to relate this utterly fascinating story, whose philosophical implications are no less important than the scientific research underlying them." Jean-Marie Lehn, Nobel laureate in Chemistry - ISIS-Université Louis Pasteur, Strasbourg "The human brain is as much a chemical as an electrical network. Its intricacy and sophistication set it apart from any known technical device. The groundbreaking papers by Monod, Jacob, Wyman, and Changeux in the 1960s on chemical regulation and control were eye-opening for all us who were doing experimental research in ths field, and they have turned out to be crucial for understanding biological evolution and learning in a broad sense. Since then Changeux and Edelstein have achieved international fame for their work on nicotinic acetylcholine receptors, amply documented in this masterful account." Manfred Eigen, Nobel laureate in Chemistry - Max Planck Institute for Biophysical Chemistry, Göttingen "One hesitates to call this book a monograph, for despite its comprehensive treatment of a complex subject it is not meant solely for specialized readers. In concentrating on a single class of neuroreceptors, the nicotinic acetylcholine receptor, it seeks to draw out general principles which apply more widely. It will therefore be welcomed not only by serious workers and students in the field of neurobiology, but also by anyone interested in the broader field of neuroscience." Sir Aaron Klug OM FRS, Nobel laureate in Chemistry - University of Cambridge "Changeux and Edelstein have provided a concise yet highly comprehensive account of perhaps the prototypical neurotransmitter complex, the nicotinic acetylcholine receptor. The story of how the roles played by this signal transduction system in nicotine dependence, learning, memory, and the processes of cognition came to be unraveled is an exciting saga, both beautiful and profound. A lovely historico-scientific document." Floyd E. Bloom, Professor Emeritus - The Scripps Research Institute "Changeux and Edelstein describe a classically Cartesian process of scientific investigation that leads to a most non-Cartesian conclusion. Having elucidated the mechanisms of action and interaction by which the various elements that make up the nicotinic acetylcholine receptor operate throughout the nervous system, from neuromuscular junctions to the brain itself, the authors turn to the role of thse structures and mechanisms in supporting cognition and giving access to consciousness - thus parting ways with Descartes and the view that the mind is able somehow to exist independently of the body. A work of truly remarkable erudition and insight." Roger Guillemin, Nobel laureate in Medicine - Salk Institute for Biological Studies “This book is unlike any recent scientific book. It is more like a forty-year research meeting in one of the world’s most creative neurobiology laboratories—an intellectual tour de fortcheat surveys the developmental trends and achievements of twentieth-century neuroscience in molecular, structural, and functional terms. The book therefore becomes an extraordinary educational saga, moving from Sir Henry Dale’s pharmacology of nicotine to genetic diseases involving mutations of the cation channel function of nicotinic acetylcholine receptors. Research into these archetypal proteins has been carried out by pharmacologists, biochemists, molecular biologists, electrophysiologists, behavioral scientists, and geneticists, with Jean-Pierre Changeux and his coworkers participating in every aspect of this remarkable inquiry. Nicotinic acetylcholine receptors are the workhorse of the fast actions of the chemical signal acetylcholine, abundantly transmitted in both the peripheral and the central nervous system. Thanks to their variable sub- unit composition they come in many flavors, mediating control of voluntary muscles in the periphery and helping to regulate reward functions, cognition, and memory in the brain. This rich functionality leads the authors to describe models of neuromuscular junction development as well a global workspace model of cognitive function and its role in effortful learning. The nicotinic acetylcholine receptor was among the first ligand-gated ion channels to be sequenced and studied by patch-clamp methods. It has been the object of neurobiological research in England, France, Germany, Japan, and the United States, with contributions of equal weight being made by many teams of researchers over a number of decades, all carefully chronicled and explained by the authors. This book is to be highly recommended to young scientists who want to discover into how many fields a single protein molecule can take them—from snake venom action to myasthenia gravis, addiction, learning, and schiz- ophrenia—if they are willing patiently to learn new research techniques rather than specialize in a single method or instrument. To investigate the nicotinic acetylcholine receptor in all its aspects requires a Renaissance mind, and it is exactly this that Changeux and Edelstein have brought to bear on one of the most studied topics in neuroscience of the last century.” TAMAS BARTFAI, Chair and Professor, Department of Neuropharmacology The Scripps Research Institute

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

299

Publisher

Odile Jacob

Published Date

ISBN 10

2738179487

ISBN 13

9782738179487

Nicotinic Acetylcholine Receptors

From Molecular Biology to Cognition

By: Jean-Pierre Changeux,Stuart J. Edelstein

Write a review Read reviews Take a Quiz Solve Book Puzzle

Nicotinic Acetylcholine Receptors

From Molecular Biology to Cognition

By: Jean-Pierre Changeux,Stuart J. Edelstein

The acetylcholine nicotinic receptor is among the most studied receptors in neuroscience. Involved in muscle contraction and a wide variety of other neurological functions, including the processing of nicotine, it was the first receptor to be isolated and observed at the molecular level, providing a major research pathway for scientists working in neuroscience, biochemistry, pharmacology, and behavioral science. This book describes four decades of scientific research that inform our current understanding of this receptor. Jean-Pierre Changeux and Stuart J. Edelstein played important roles in pioneering research on the acetylcholine nicotinic receptor and on allosteric proteins, and here they reveal the complete scientific trajectory of that research. They begin with a historical perspective, describing how several fields converged around a single receptor and then explain the initial receptor purification and characterization. Subsequent chapters trace the investigations into various aspects of receptor structure and function, including the chemical structure of the binding site, the identity and properties of the ion channel, and the mechanism of signal transmission. In the final portion of the book, Changeux and Edelstein discuss recent studies on the three-dimensional structure of the receptor molecule and share their novel understanding of inherited diseases such as congenital myasthenia and epilepsy. They also address the integration of the receptor into its synaptic membrane environment and its distribution, physiology, and regulation in brain functions and cognition. Richly illustrated and lucidly written, this book provides an exceptional opportunity for scientists and students to follow a historic advance in our knowledge of molecular mechanisms and the workings of the brain.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

298

Publisher

ODILE JACOB PUBLISHING CORP

Published Date

ISBN 10

0976890801

ISBN 13

9780976890805

Cytokines and Cytokine Receptors

Physiology and Pathological Disorders

By: Constantin A. Bona,Jean-Pierre Revillard

Write a review Read reviews Take a Quiz Solve Book Puzzle

Cytokines and Cytokine Receptors

Physiology and Pathological Disorders

By: Constantin A. Bona,Jean-Pierre Revillard

The field of cytokine research is expanding at a rapid pace Contributions from the major leading groups in the world on the structure and biological properties of cytokine and cytokine receptors, as well as integrated reviews on cytokines in various physiological and pathological conditions were presented in three issues of International Reviews of Immunology This collection of articles provided a unique source of information However, important discoveries are emerging very rapidly and some of the reviews written in 1997 are already outdated In this book, the editors assemble reviews that have been updated by their authors to include all the recent publications and unpublished data from the authors' laboratories This volume should serve as an excellent reference source for all those concerned by the multiple faces of cytokines in basic research and in the clinic

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

864

Publisher

CRC Press

Published Date

ISBN 10

0203305132

ISBN 13

9780203305133

La génomique en biologie végétale

By: Jean-François Morot-Gaudry,Jean-François Briat

Write a review Read reviews Take a Quiz Solve Book Puzzle

La génomique en biologie végétale

By: Jean-François Morot-Gaudry,Jean-François Briat

Cet ouvrage illustre de façon claire et pédagogique les méthodes et les concepts qui sont à la base des progrès de la génomique en biologie végétale (grands programmes internationaux de séquençage, outils de la bio-informatique, méthodes d'analyse de l'expression des gènes incluant leurs produits métaboliques finaux et leur spécificité tissulaire et/ou cellulaire). Il rend compte des applications potentielles de la génomique dans les domaines de la génétique et de l'amélioration des plantes, de l'écophysiologie et de l'agronomie. Ce livre s'adresse aux étudiants de fin d'études universitaires ou agronomiques, aux professeurs de l'enseignement supérieur, aux techniciens, aux ingénieurs et scientifiques qui souhaitent acquérir des connaissances en génomique végétale.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

356

Publisher

Editions Quae

Published Date

ISBN 10

2738011675

ISBN 13

9782738011671

Abstraction in Artificial Intelligence and Complex Systems

By: Lorenza Saitta,Jean-Daniel Zucker

Write a review Read reviews Take a Quiz Solve Book Puzzle

Abstraction in Artificial Intelligence and Complex Systems

By: Lorenza Saitta,Jean-Daniel Zucker

Abstraction is a fundamental mechanism underlying both human and artificial perception, representation of knowledge, reasoning and learning. This mechanism plays a crucial role in many disciplines, notably Computer Programming, Natural and Artificial Vision, Complex Systems, Artificial Intelligence and Machine Learning, Art, and Cognitive Sciences. This book first provides the reader with an overview of the notions of abstraction proposed in various disciplines by comparing both commonalities and differences. After discussing the characterizing properties of abstraction, a formal model, the KRA model, is presented to capture them. This model makes the notion of abstraction easily applicable by means of the introduction of a set of abstraction operators and abstraction patterns, reusable across different domains and applications. It is the impact of abstraction in Artificial Intelligence, Complex Systems and Machine Learning which creates the core of the book. A general framework, based on the KRA model, is presented, and its pragmatic power is illustrated with three case studies: Model-based diagnosis, Cartographic Generalization, and learning Hierarchical Hidden Markov Models.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

488

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1461470528

ISBN 13

9781461470526

Computational Systems Biology

Chapter 14. Advances in Machine Learning for Processing and Comparison of Metagenomic Data

By: Jean-Luc Bouchot,William L. Trimble,Gregory Ditzler,Yemin Lan,Steve Essinger,Gail Rosen

Write a review Read reviews Take a Quiz Solve Book Puzzle

Computational Systems Biology

Chapter 14. Advances in Machine Learning for Processing and Comparison of Metagenomic Data

By: Jean-Luc Bouchot,William L. Trimble,Gregory Ditzler,Yemin Lan,Steve Essinger,Gail Rosen

Recent advances in next-generation sequencing have enabled high-throughput determination of biological sequences in microbial communities, also known as microbiomes. The large volume of data now presents the challenge of how to extract knowledge—recognize patterns, find similarities, and find relationships—from complex mixtures of nucleic acid sequences currently being examined. In this chapter we review basic concepts as well as state-of-the-art techniques to analyze hundreds of samples which each contain millions of DNA and RNA sequences. We describe the general character of sequence data and describe some of the processing steps that prepare raw sequence data for inference. We then describe the process of extracting features from the data, assigning taxonomic and gene labels to the sequences. Then we review methods for cross-sample comparisons: (1) using similarity measures and ordination techniques to visualize and measure differences between samples and (2) feature selection and classification to select the most relevant features for discriminating between samples. Finally, in conclusion, we outline some open research problems and challenges left for future research.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

Publisher

Elsevier Inc. Chapters

Published Date

ISBN 10

0128070153

ISBN 13

9780128070154

Computer-Aided Molecular Design

Theory and Applications

By: Jean-Pierre Doucet,Jacques Weber

Write a review Read reviews Take a Quiz Solve Book Puzzle

Computer-Aided Molecular Design

Theory and Applications

By: Jean-Pierre Doucet,Jacques Weber

The computer-aided design of novel molecular systems has undoubtedly reached the stage of a mature discipline offering a broad range of tools available to virtually any chemist. However, there are few books coveringmost of these techniques in a single volume and using a language which may generally be understood by students or chemists with a limited knowledge of theoretical chemistry. The purpose of this book is precisely to review, in such a language, both methodological aspects and important applications of computer-aided molecular design (CAMD), with a special emphasis on drug design and protein modeling.Using numerous examples ranging from molecular models to shapes, surfaces, and volumes, Computer-Aided Molecular Design provides coverage of the role molecular graphics play in CAMD. The text also treats the very notion of the structure of molecular systems by presenting both the various experimental techniques giving access to it and the most common model builders based on force fields. Separate chapters are devoted to other important topics in CAMD, such as Monte Carlo and molecular dynamics simulations; most common quantum chemical methods; derivation and visualization of molecular properties; and molecular similarity. Finally, strategies used in protein modeling and drug design, such as receptor mapping and the pharmacophore approach, are presented and illustrated by several examples.The book is addressed to students and researchers who wish to enter this new exciting field of molecular sciences, but also practitioners in CAMD as a comprehensive source of refreshing information in their field.Key Features* Presents a comprehensive introduction to computer-aided molecular design* Describes applications of CAMD through the use of numerous examples* Emphasizes strategies used in protein modeling and drug design* Includes separate chapters devoted to other important topics in CAMD, such as:* Monte Carlo and molecular dynamics simulations* Common quantum chemical methods* Derivation and visualization of molecular properties* Molecular similarity

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

517

Publisher

Elsevier

Published Date

ISBN 10

0080529747

ISBN 13

9780080529745

Bioinformatics For Dummies

By: Jean-Michel Claverie,Cedric Notredame

Write a review Read reviews Take a Quiz Solve Book Puzzle

Bioinformatics For Dummies

By: Jean-Michel Claverie,Cedric Notredame

Bioinformatics – the process of searching biological databases, comparing sequences, examining protein structures, and researching biological questions with a computer – is one of the marvels of modern technology that can save you months of lab work. And the most amazing part is that, if you know how, you can use highly sophisticated programs over the Internet without paying a dime and sometimes, without installing anything new on your own computer. All you need to know is how to use these technological miracles. That's where Bioinformatics For Dummies comes in. If you want to know what bioinformatics is all about and how to use it without wading through pages of computer gibberish or taking a course full of theory, this book has the answers in plain English. You'll find out how to Use Internet resources Understand bioinformatics jargon Research biological databases Locate the sequences you need Perform specific tasks, step by step Written by two experts who helped develop the science, Bioinformatics For Dummies is all about getting things done. If you're just getting your feet wet, start at the beginning with a quick review of those necessary parts of microbiology and an overview of the tools available. If you already know what you want to do, you can go directly to a chapter that shows you how. Get the lowdown on Researching and analyzing DNA and protein sequences Gathering information from all published sources Searching databases for similar sequences and acquiring information about gene functions through sequence comparisons Producing and editing multiple sequence comparisons for presentation Predicting protein structures and RNA structures Doing phylogenetic analysis With an Internet connection and Bioinformatics For Dummies, you'll discover how to peruse databases that contain virtually everything known about human biology. It's like having access to the world's largest lab, right from your desk. This book is your lab assistant – one that never takes a day off, never argues when you ask it for help, and won't demand a benefits package.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

484

Publisher

For Dummies

Published Date

ISBN 10

0764516965

ISBN 13

9780764516962

English Drama of the Early Modern Period 1890-1940

By: Jean Chothia

Write a review Read reviews Take a Quiz Solve Book Puzzle

English Drama of the Early Modern Period 1890-1940

By: Jean Chothia

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

239

Publisher

Routledge

Published Date

ISBN 10

1315504197

ISBN 13

9781315504193

André Antoine

By: Jean Chothia

Write a review Read reviews Take a Quiz Solve Book Puzzle

André Antoine

By: Jean Chothia

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

231

Publisher

Cambridge University Press

Published Date

ISBN 10

0521252199

ISBN 13

9780521252195

Selected Writings Of Jean Genet

By: Jean Genet

Write a review Read reviews Take a Quiz Solve Book Puzzle

Selected Writings Of Jean Genet

By: Jean Genet

Excerpts from the novels, plays, and poems of the French convict, prostitute, and literary artist join notes from his film, The Penal Colony, letters, essays, and a rare interview, all edited by a contemporary biographer.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

482

Publisher

Harper Collins

Published Date

ISBN 10

0880014202

ISBN 13

9780880014205

Jean le Bleu

By: Jean Giono

Write a review Read reviews Take a Quiz Solve Book Puzzle

Jean le Bleu

By: Jean Giono

Reprint of the 1932 ed. published by Grasset, Paris, which was issued in the author's series: Le passage du vent.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

275

Publisher

Le Livre de poche

Published Date

ISBN 10

2253000221

ISBN 13

9782253000228

Book's by Jean Chothia

André Antoine

André Antoine

English Drama of the Early Modern Period 1890-1940

English Drama of the Early Modern Period 1890-1940

Lipocalins

Lipocalins

The Brain as a Chemical Machine

The Brain as a Chemical Machine

Nicotinic Acetylcholine Receptors

Nicotinic Acetylcholine Receptors

Cytokines and Cytokine Receptors

Cytokines and Cytokine Receptors

La génomique en biologie végétale

La génomique en biologie végétale

Abstraction in Artificial Intelligence and Complex Systems

Abstraction in Artificial Intelligence and Complex Systems

Computational Systems Biology

Computational Systems Biology

Computer-Aided Molecular Design

Computer-Aided Molecular Design

Bioinformatics For Dummies

Bioinformatics For Dummies

English Drama of the Early Modern Period 1890-1940

English Drama of the Early Modern Period 1890-1940

André Antoine

André Antoine

Selected Writings Of Jean Genet

Selected Writings Of Jean Genet

Jean le Bleu

Jean le Bleu

Username

Password

Username

Password

Password again

Birthday

Email