An invaluable tool in Bioinformatics, this unique volume provides both theoretical and experimental results, and describes basic principles of computational intelligence and pattern analysis while deepening the reader's understanding of the ways in which these principles can be used for analyzing biological data in an efficient manner. This book synthesizes current research in the integration of computational intelligence and pattern analysis techniques, either individually or in a hybridized manner. The purpose is to analyze biological data and enable extraction of more meaningful information and insight from it. Biological data for analysis include sequence data, secondary and tertiary structure data, and microarray data. These data types are complex and advanced methods are required, including the use of domain-specific knowledge for reducing search space, dealing with uncertainty, partial truth and imprecision, efficient linear and/or sub-linear scalability, incremental approaches to knowledge discovery, and increased level and intelligence of interactivity with human experts and decision makers Chapters authored by leading researchers in CI in biology informatics. Covers highly relevant topics: rational drug design; analysis of microRNAs and their involvement in human diseases. Supplementary material included: program code and relevant data sets correspond to chapters.
This thesis studies the properties of the Higgs particle, discovered at the Large Hadron Collider (LHC) in 2012, in order to elucidate its role in electroweak symmetry breaking and cosmological phase transition in the early universe. It shows that a generic spin-2 Higgs impostor is excluded by the precision measurements of electroweak observables and perturbative unitarity considerations. It obtains LHC constraints on anomalous CP-violating Higgs-Top Yukawa couplings and examines the prospects of their measurement in future experiments. Lastly, it discusses in detail the electroweak phase transition and generation of cosmological matter–antimatter asymmetry in the universe with anomalous Higgs couplings.
Sustainable commercial fishing, species conservation, and bycatch are contentious topics. Great emphasis has been placed on the sustainable sourcing of particular species that we buy at the store and order in restaurants, but how can we trust that the fish on our plates, from a system-wide perspective, have been appropriately sourced? Even in what are commonly considered to be the best-managed fisheries in the world (i.e., Alaskan fisheries), thousands of tons of fish are wasted each year in the interest of providing certain species in certain ways to certain people, at certain prices. Are the management practices and regulations that we think are helping actually having the desired outcomes in terms of the effective use of natural resources? This book presents a framework that can enhance our understanding, research, and regulation of frontline organizing processes in commercial fisheries, which may be generalized to other resource extraction industries. It enables readers to better grasp and respond to the need to develop practices and regulations that involve effective use of all natural resources, rather than just a chosen few. The book is especially important to researchers and practitioners active in the fishing industry, and natural resource managers and regulators interested in understanding and improving their management systems. It is also highly relevant to organization and management researchers interested in coupled human and natural systems, ecological sensemaking, the role of quantum mechanics in organizational phenomena, sociomateriality, and sustainability. The book uses the real-world case of an Alaskan fishing fleet to explore how the commercial fishing industry (which includes businesses, management agencies, regulatory bodies, and markets, among others) entangles itself with natural phenomena in order to extract resources from them. After gaining a better understanding of these processes can we see how they can be improved, especially through changes to regulatory management systems, in order to foster not only more sustainable, but also less wasteful (these two goals are not necessarily interdependent in today's regulatory management systems), natural resource extraction and use. Such an understanding requires exploring how regulations, natural phenomena, human sensemaking processes, and market forces entangle at sea to materialize the fish that make their way to our plates - as well as those that, importantly, do not.
By 2010, 260 million citizens were living outside of their permanent hukou location, a major challenge to the constrictive Mao-era system of migration and settlement planning. Jason Young shows how these new forces have been received by the state and documents the process of change and the importance of China's hukou system.
Liquid Acquisition Devices for Advanced In-Space Cryogenic Propulsion Systems discusses the importance of reliable cryogenic systems, a pivotal part of everything from engine propulsion to fuel deposits. As some of the most efficient systems involve advanced cryogenic fluid management systems that present challenging issues, the book tackles issues such as the difficulty in obtaining data, the lack of quality data and models, and the complexity in trying to model these systems. The book presents models and experimental data based on rare and hard-to-obtain cryogenic data. Through clear descriptions of practical data and models, readers will explore the development of robust and flexible liquid acquisition devices (LAD) through component-level and full-scale ground experiments, as well as analytical tools. This book presents new and rare experimental data, as well as analytical models, in a fundamental area to the aerospace and space-flight communities. With this data, the reader can consider new and improved ways to design, analyze, and build expensive flight systems. - Presents a definitive reference for design ideas, analysis tools, and performance data on cryogenic liquid acquisition devices - Provides historical perspectives to present fundamental design models and performance data, which are applied to two practical examples throughout the book - Describes a series of models to optimize liquid acquisition device performance, which are confirmed through a variety of parametric component level tests - Includes video clips of experiments on a companion website
K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry Adopting his didactically skillful approach, K.C. Nicolaou compiles in this textbook the important synthetic methods that lead to a complex molecule with valuable properties. He explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections and contrasting these to other synthetic methods. A wonderful tool for learning and teaching and a must-have for all future and present organic and biochemists.
This book focuses on ubiquitous indoor localization services, specifically addressing the issue of floor plans. It combines computer vision algorithms and mobile techniques to reconstruct complete and accurate floor plans to provide better location-based services for both humans and vehicles via commodity smartphones in indoor environments (e.g., a multi-layer shopping mall with underground parking structures). After a comprehensive review of scene reconstruction methods, it offers accurate geometric information for each landmark from images and acoustics, and derives the spatial relationships of the landmarks and rough sketches of accessible areas with inertial and WiFi data to reduce computing overheads. It then presents the authors’ recent findings in detail, including the optimization and probabilistic formulations for more solid foundations and better robustness to combat errors, several new approaches to promote the current sporadic availability of indoor location-based services, and a holistic solution for floor plan reconstruction, indoor localization, tracking, and navigation. The novel approaches presented are designed for different types of indoor environments (e.g., shopping malls, office buildings and labs) and different users. A valuable resource for researchers and those in start-ups working in the field, it also provides supplementary material for students with mobile computing and networking backgrounds.
Modern biological databases comprise not only data, but also sophisticated query facilities and bioinformatics data analysis tools. This book provides an exploration through the world of Bioinformatics Database Systems. The book summarizes the popular and innovative bioinformatics repositories currently available, including popular primary genetic and protein sequence databases, phylogenetic databases, structure and pathway databases, microarray databases and boutique databases. It also explores the data quality and information integration issues currently involved with managing bioinformatics databases, including data quality issues that have been observed, and efforts in the data cleaning field. Biological data integration issues are also covered in-depth, and the book demonstrates how data integration can create new repositories to address the needs of the biological communities. It also presents typical data integration architectures employed in current bioinformatics databases. The latter part of the book covers biological data mining and biological data processing approaches using cloud-based technologies. General data mining approaches are discussed, as well as specific data mining methodologies that have been successfully deployed in biological data mining applications. Two biological data mining case studies are also included to illustrate how data, query, and analysis methods are integrated into user-friendly systems. Aimed at researchers and developers of bioinformatics database systems, the book is also useful as a supplementary textbook for a one-semester upper-level undergraduate course, or an introductory graduate bioinformatics course. About the Authors Kevin Byron is a PhD candidate in the Department of Computer Science at the New Jersey Institute of Technology. Katherine G. Herbert is Associate Professor of Computer Science at Montclair State University. Jason T.L. Wang is Professor of Bioinformatics and Computer Science at the New Jersey Institute of Technology.
Part of the in-depth and practical Pattern Recognition series, Practical Surgical Soft Tissue Pathology, 2nd Edition, helps you arrive at an accurate diagnosis by using a proven pattern-based approach. Leading diagnosticians guide you through the most common patterns seen in soft tissue pathology, applying appropriate immunohistochemistry and molecular testing, avoiding pitfalls, and making the best diagnosis. High-quality illustrations capture key morphologic patterns for a full range of common and rare tumor types, and a "visual index" at the beginning of the book directs you to the exact location of in-depth diagnostic guidance. - A consistent chapter organization by histologic pattern considers soft tissue tumors the way you approach them in daily practice, helping you arrive at a quick and accurate diagnosis. - A user-friendly design color-codes patterns to specific entities, and key points are summarized in tables and text boxes, so you can quickly and easily find what you are looking for. - Sweeping content updates keep you at the forefront of recent findings regarding all major neoplastic and non-neoplastic diseases of the soft tissues. - Improved pattern call-outs are now linked directly within the chapter, reinforcing the patterns for more efficient and complete understanding. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Sternberg's Diagnostic Surgical Pathology is a flagship book in pathology. This classic 2-volume reference presents advanced diagnostic techniques and the latest information on all currently known diseases. The book emphasizes the practical differential diagnosis of the surgical specimen while keeping to a minimum discussion of the natural history of the disease, treatment and autopsy findings. Contributors are asked to provide their expert advice on the diagnostic evaluation of every type of specimen from every anatomic site. This approach distinguishes it and provides a style of a personal consultation.
Since the end of Dennard scaling in the early 2000s, improving the energy efficiency of computation has been the main concern of the research community and industry. The large energy efficiency gap between general-purpose processors and application-specific integrated circuits (ASICs) motivates the exploration of customizable architectures, where one can adapt the architecture to the workload. In this Synthesis lecture, we present an overview and introduction of the recent developments on energy-efficient customizable architectures, including customizable cores and accelerators, on-chip memory customization, and interconnect optimization. In addition to a discussion of the general techniques and classification of different approaches used in each area, we also highlight and illustrate some of the most successful design examples in each category and discuss their impact on performance and energy efficiency. We hope that this work captures the state-of-the-art research and development on customizable architectures and serves as a useful reference basis for further research, design, and implementation for large-scale deployment in future computing systems.
The great expansion of economic activity since the end of World War II has caused an unprecedented rise in living standards, but it has also caused rapid changes in earth systems. Nearly all types of natural capital—the world’s stock of resources and services provided by nature—are in decline. Clean air, abundant and clean water, fertile soils, productive fisheries, dense forests, and healthy oceans are critical for healthy lives and healthy economies. Mounting pressures, however, suggest that the trend of declining natural capital may cast a long shadow into the future. Nature’s Frontiers: Achieving Sustainability, Efficiency, and Prosperity with Natural Capital presents a novel approach to address these foundational challenges of sustainability. A methodology combining innovative science, new data sources, and cutting-edge biophysical and economic models builds sustainable resource efficiency frontiers to assess how countries can sustainably use their natural capital more efficiently. The analysis provides recommendations on how countries can better use their natural capital to achieve their economic and environ mental goals. The report indicates that significant efficiency gaps exist in nearly every country. Closing these gaps can address many of the world’s pressing economic and environmental problems—economic productivity, health, food and water security, and climate change. Although the approach outlined in this report will entail demanding policy reforms, the costs of inaction will be far higher.
This reference, written by leading authorities in the field, gives basic theory, implementation details, advanced research, and applications of RF and microwave in healthcare and biosensing. It first provides a solid understanding of the fundamentals with coverage of the basics of microwave engineering and the interaction between electromagnetic waves and biomaterials. It then presents the state-of-the-art development in microwave biosensing, implantable devices -including applications of microwave technology for sensing biological tissues – and medical diagnosis, along with applications involving remote patient monitoring. this book is an ideal reference for RF and microwave engineer working on, or thinking of working on, the applications of RF and Microwave technology in medicine and biology. Learn: - The fundamentals of RF and microwave engineering in healthcare and biosensing - How to combine biological and medical aspects of the field with underlying engineering concepts - How to implement microwave biosensing for material characterization and cancer diagnosis - Applications and functioning of wireless implantable biomedical devices and microwave non-contact biomedical radars - How to combine devices, systems, and methods for new practical applications - The first book to review the fundamentals, latest developments, and future trends in this important emerging field with emphasis on engineering aspects of sensing, monitoring, and diagnosis using RF and Microwave - Extensive coverage of biosensing applications are included - Written by leaders in the field, including members of the Technical Coordinating Committee of the Biological Effects and Medical Applications of the IEEE Microwave Theory and Techniques Society
Available online: https://pub.norden.org/temanord2023-550/ To reduce emissions of hazardous combustion gases to air, ship owners can switch to cleaner fuels or install so called “scrubbers”, onboard the ship. In a scrubber, combustions gases are sprayed with water and the dirty wash water, the scrubber water, is discharged to the sea. The number of ships with scrubbers and the volumes of discharged scrubber water have increased dramatically the past decade. When allowing the use of scrubbers, the focus was on improving the air quality, while the impact on the marine environment was not considered. We have here analysed polycyclic aromatic compounds (PACs), the most toxic fraction of oil, in scrubber water from ships, and reviewed recent ecotoxicological scientific literature on PAC toxicity to marine organisms. Our conclusion is that in areas with intense shipping there is a serious risk for negative effects on marine organisms.
Since the end of Dennard scaling in the early 2000s, improving the energy efficiency of computation has been the main concern of the research community and industry. The large energy efficiency gap between general-purpose processors and application-specific integrated circuits (ASICs) motivates the exploration of customizable architectures, where one can adapt the architecture to the workload. In this Synthesis lecture, we present an overview and introduction of the recent developments on energy-efficient customizable architectures, including customizable cores and accelerators, on-chip memory customization, and interconnect optimization. In addition to a discussion of the general techniques and classification of different approaches used in each area, we also highlight and illustrate some of the most successful design examples in each category and discuss their impact on performance and energy efficiency. We hope that this work captures the state-of-the-art research and development on customizable architectures and serves as a useful reference basis for further research, design, and implementation for large-scale deployment in future computing systems.
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