This book explores the subjects of child sex abuse, flaws in the justice system, cultural support for vigilantism, prison violence, and the socio-legal philosophy of punishment. Child sex abuse leaves a scar that lasts a lifetime. Can any legal punishment balance the scales of justice? Can sex offenders ever repay their debt to society, or more importantly, to the victim? For some victims of this traumatic abuse, the debt remains unpaid, and it accrues interest. Vigilantes seek to avenge child victims by hunting down sex offenders in the community. Sometimes prisoners in correctional facilities conspire with rogue correctional officers to mete out their own form of “convict justice” on people who hurt children. While their motives and methods differ, these outraged citizens seek retribution through violence because they are disgusted with a justice system they believe shows extraordinary leniency toward child sex abusers. Whether this violence occurs in the community or in jail cells across the country, the message these vigilantes broadcast is the same: if the government won’t seek retribution, they will. The story is told through a series of case studies based on interviews with real-life vigilantes, most of whom are serving life sentences for their crimes. For the first time, vigilantes have been given a chance to tell their own stories. Patrick Drum, Steven Sandison, Joseph Druce, Jeremy Moody, Jon Watson, James Fairbanks, and others have shared their personal insights to help us get inside the vigilante mind. For some readers, these accounts will humanize people considered to be simply murderers. For others, it will demystify the popular portrayals of vigilantes in our society.
Genome-wide association (GWA) studies and tumor-specific epigenome, transcriptome and genome sequencing projects are generating an ever-growing list of susceptibility alleles, as well as putative gain- and loss-of-function gene mutations associated with cancer. These genetic changes ultimately need to be validated to determine their contribution to the initiation, progression and likelihood of treatment response for various cancers. The bottle-neck is no longer obtaining sequence data or completion of the GWA studies, but rather the ability efficiently to validate candidate genes identified by these projects. In vivo studies in animal models are the “gold standard” for validation of these candidate drivers and modifiers of cancer. Furthermore, once a gene product or molecular pathway has been validated as playing an important role in the development or progression of cancer, animal models provide the necessary preclinical data for evaluation of the efficacy and toxicity of new therapeutics targeting that gene or pathway. As such, animal models play an essential role in cancer research by facilitating the translation of genomic discoveries into preclinical studies that precede new targeted therapies for cancer. In this chapter, we will discuss vertebrate and invertebrate animal models as they apply to cancer genomics, as well as key technologies employed. In particular, we will focus on the use of murine and zebrafish human tumor xenografts and transgenic models.
Tomb Rider, Final Fantasy VII, Soul Blade, Jet Moto, and Wipeout XL are among the 30 top PlayStation games featured in this guide. The size and scope of the PlayStation's library make this book all the more attractive to gamers looking to select and succeed at the best titles available. Here they'll find the strategies, secrets, cheats, and solutions they need.
Over the past century or more, the genres of fantasy, horror, and supernatural fiction have increasingly expanded beyond literature and into an array of media—film, television, comic books, and art. Many of the leading figures in the field engage in multimedia enterprises that allow their work to reach a much wider public than the mere readers of books. In Disorders of Magnitude: A Survey of Dark Fantasy, Jason V Brock analyzes the intersection of literature, media, and genre fiction in essays, reviews, and pioneering interviews. Beginning with the pulp magazines of the 1920s, Brock studies such dynamic figures as H. P. Lovecraft, Forrest J Ackerman, Harlan Ellison, and the Southern California writers known collectively as “The Group”—Ray Bradbury, Charles Beaumont, Richard Matheson, Rod Serling, and William F. Nolan. This collection also includes filmmakers Roger Corman, George Romero, and Dan O’Bannon, and such fantasy artists as H. R. Giger. Graced with dozens of photographs from the author’s personal collection, this wide-ranging study offers a kaleidoscopic look at the multifarious ways in which fantasy, horror, and the supernatural have permeated our culture. Brock—himself a fiction writer, critic, and filmmaker—concludes the book with touching eulogies to the recently deceased Ray Bradbury and Ray Harryhausen. Highlighting so many figures essential to the understanding of fantasy and horror, Disorders of Magnitude will appeal to fans of these fiction genres around the world.
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