Drafted against her will to serve the regime of Vladimir Putin as an intelligence seductress, Dominika Egorova engages in a charged effort of deception and tradecraft with first-tour CIA officer Nathaniel Nash before a forbidden attraction threatens their careers.
Red Sparrow is now a major motion picture starring Jennifer Lawrence and Joel Edgerton! Now available in a single collection, the complete electrifying New York Times bestselling trilogy—Red Sparrow, Palace of Treason, and The Kremlin’s Candidate—“a primer in twenty-first-century spying...terrifically good” (The New York Times Book Review) from veteran CIA officer Jason Matthews. In present-day Russia, ruled by President Vladimir Putin, Russian intelligence officer Dominika Egorov struggles to survive in the post-Soviet intelligence jungle. Forced to become a “Sparrow”—a spy trained in the art of seduction to elicit information from unsuspecting marks—she’s been assigned to Nathaniel Nash, a CIA officer who handles the organization’s most sensitive Russian intelligence. The action in The Red Sparrow Trilogy careens between Russia, France, Hong Kong, Turkey, Greece, Italy, and the United States as these two young intelligence officers, trained in their respective spy schools, collide in a charged atmosphere of deception and a forbidden spiral of carnal attraction that threatens both their careers and consumes intelligence agencies from Moscow to the highest offices in the US government. In each book they confront not only the shadows and intrigues of the Russian and American intelligence networks but highly trained, cold-blooded killers assigned to destroy them. With a plot ripped from tomorrow’s headlines, and written with sophisticated brio, The Red Sparrow Trilogy has been hailed as a monumental accomplishment “as suspenseful and cinematic as the best spy movies” (The Philadelphia Inquirer); “fans of the genre’s masters including John le Carré and Ian Fleming will happily embrace Matthews’s central spy” (USA TODAY). Collected together, the three novels form a stunning masterwork of suspense, intrigue, sex, and violence.
Slavoj Zizek is one of the most provocative and important thinkers writing in contemporary philosophy. This book is an engaged debate with Zizek. It contains a series of specially commissioned critical essays from an impressive collection of contributors covering the full extent of his oeuvre. Essays examine Zizek on cultural theory, film studies, ethics, political theory, social theory, Kant and Lacanian psychoanalysis. In the spirit of Zizek‘s own interventions, these essays critically interrogate his ideas, challenging him to respond directly which he does in an extended polemical reply that concludes the collection. This volume represents an exciting and important contribution to contemporary theoretical debate and adds significantly to the growing literature on Zizek.
AN INVESTIGATION OF EPIC FINANCIAL INTRIGUE, RENDER UNTO ROME EXPOSES THE SECRECY AND DECEIT THAT RUN COUNTER TO THE VALUES OF THE CATHOLIC CHURCH. The Sunday collection in every Catholic church throughout the world is as familiar a part of the Mass as the homily and even Communion. There is no doubt that historically the Catholic Church has been one of the great engines of charity in history. But once a dollar is dropped in that basket, where does it go? How are weekly cash contributions that can amount to tens of thousands of dollars accounted for? Where does the money go when a diocese sells a church property for tens of millions of dollars? And what happens when hundreds of millions of dollars are turned over to officials at the highest ranks, no questions asked, for their discretionary use? The Roman Catholic Church is the largest organization in the world. The Vatican has never revealed its net worth, but the value of its works of art, great churches, property in Rome, and stocks held through its bank easily run into the tens of billions. Yet the Holy See as a sovereign state covers a mere 108 acres and has a small annual budget of about $280 million. No major book has examined the church’s financial underpinnings and practices with such journalistic force. Today the church bears scrutiny by virtue of the vast amounts of money (nearly $2 billion in the United States alone) paid out to victims of clergy abuse. Amid mounting diocesan bankruptcies, bishops have been selling off whole pieces of the infrastructure—churches, schools, commercial properties—while the nephew of one of the Vatican’s most powerful cardinals engaged in a lucrative scheme to profiteer off the enormous downsizing of American church wealth.
Selected by Choice magazine as an Outstanding Academic Title During the eighteenth century, North American colonists began to display an increasing appetite for professional and amateur theatrical performances and a familiarity with the British dramatic canon ranging from the tragedies of Shakespeare, Addison, and Rowe to the comedies of Farquhar, Steele, and Gay. This interest sparked demand for both the latest hits of the London stage and a body of plays centered on patriotic (and often partisan) British themes. As relations between the crown and the colonies soured, the texts of these plays evolved into a common frame of reference for political arguments over colonial policy. Making the transition to print, these arguments deployed dramatic texts and theatrical metaphors for political advantage. Eventually, with the production of American propaganda plays during the Revolution, colonists began to develop a patriotic drama of their own, albeit one that still stressed the "British" character of American patriotism. Performing Patriotism examines the role of theatrical performance and printed drama in the development of early American political culture. Building on the eighteenth-century commonplace that the theater could be a school for public virtue, Jason Shaffer illustrates the connections between the popularity of theatrical performances in eighteenth-century British North America and the British and American national identities that colonial and Revolutionary Americans espoused. The result is a wide-ranging survey of eighteenth-century American theater history and print culture.
Workplace injuries happen every day and can profoundly affect workers, their families, and the communities in which they live. This textbook is for workers and students looking for an introduction to injury prevention on the job. Foster and Barnetson bring the field into the twenty-first century by including discussions of how precarious employment, gender, and ill-health can be better handled in Canadian OHS.
Two Appalachian authors record personal stories of local resistance against the coal industry in this “revelatory work . . . oral history at its best” (Studs Terkel). Developed as an alternative to strip mining, mountaintop removal mining consists of blasting away the tops of mountains, dumping waste into the valleys, and retrieving the exposed coal. This process buries streams, pollutes wells and waterways, and alters fragile ecologies—all of which has a devastating impact on local communities. Something's Rising gives a stirring voice to the lives, culture, and determination of the people fighting this destructive practice in the coalfields of central Appalachia. The people who live, work, and raise families here face not only the destruction of their land but also the loss of their culture and health. Each person's story, unique and unfiltered, is prefaced with a biographical essay that vividly establishes the interview settings and the subjects' connections to their region. Included here are oral histories from Jean Ritchie, "the mother of folk," who doesn't let her eighty-six years slow down her fighting spirit; Judy Bonds, a tough-talking coal-miner's daughter; Kathy Mattea, the beloved country singer who believes cooperation is the key to winning the battle; Jack Spadaro, the heroic whistle-blower who has risked everything to share his insider knowledge of federal mining agencies; Larry Bush, who doesn't back down even when speeding coal trucks are used to intimidate him; Denise Giardina, a celebrated writer who ran for governor to bring attention to the issue; and many more.
This second edition of Climate Change is an accessible and comprehensive guide to the science behind global warming. Exquisitely illustrated, the text is geared toward students at a variety of levels. Edmond A. Mathez and Jason E. Smerdon provide a broad, informative introduction to the science that underlies our understanding of the climate system and the effects of human activity on the warming of our planet. Mathez and Smerdon describe the roles that the atmosphere and ocean play in our climate, introduce the concept of radiation balance, and explain climate changes that occurred in the past. They also detail the human activities that influence the climate, such as greenhouse gas and aerosol emissions and deforestation, as well as the effects of natural phenomena. Climate Change concludes with a look toward the future, discussing climate model projections, exploring the economic and technological realities of energy production, and presenting a view of the global warming challenge through the lens of risk. Each chapter features profiles of scientists who advanced our understanding of the material discussed. This new edition expands on the first edition’s presentation of scientific concepts, making it ideal for classroom use for a wide swath of undergraduate and masters students with both science and nonscience backgrounds.
Orphaned at the age of 9 in Stockholm, Sweden, Jacob is taken by an ill-tempered uncle on a merchant ship bound for London. He survives a shipwreck en route that leaves him homeless and, once again, abandoned. This time on the streets of a Dickensian London. Unable to speak English, he struggles, often stealing to survive. In desperation, he lies about his age to sign up with the Hudson’s Bay Fur Company as an indentured laborer. Certainly, no place for a 12-year-old boy with limited skills in a brutal physical world where death is often. Wilderness of the Heart is based on the astonishing true story of Jacob Fahlstrom who finds himself alone in the vast, untamed wilderness of North America. A place splintered by Indian conflict and warring fur companies. Danger exists in all directions. Caught in this volatile world he must learn and adapt quickly if he is to survive. But impulsiveness finds him deep in the woods, lost and gravely injured. He is rescued by Ojibwe hunters who take this bizarre oddity back to the tribe. They have never seen blond hair and blue eyes, believing him to be something supernatural. Something to fear. Cruelty and beatings ensue until Thunder Bear, a respected warrior, reluctantly steps in to help. Wilderness of the Heart is the journey of a boy, not only fighting to survive but learning to become a man who can take care of himself, for he is truly alone in this place where death lurks in the shadow of towering pines.
The archaeological study of the ancient world has become increasingly popular in recent years. A Research Guide to the Ancient World: Print and Electronic Sources, is a partially annotated bibliography. The study of the ancient world is usually, although not exclusively, considered a branch of the humanities, including archaeology, art history, languages, literature, philosophy, and related cultural disciplines which consider the ancient cultures of the Mediterranean world, and adjacent Egypt and southwestern Asia. Chronologically the ancient world would extend from the beginning of the Bronze Age of ancient Greece (ca. 1000 BCE) to the fall of the Western Roman Empire (ca. 500 CE). This book will close the traditional subject gap between the humanities (Classical World; Egyptology) and the social sciences (anthropological archaeology; Near East) in the study of the ancient world. This book is uniquely the only bibliographic resource available for such holistic coverage. The volume consists of 17 chapters and seven appendixes, arranged according to the traditional types of library research materials (bibliographies, dictionaries, atlases, etc.). The appendixes are mostly subject specific, including graduate programs in ancient studies, reports from significant archaeological sites, numismatics, and paleography and writing systems. These extensive author and subject indexes help facilitate ease of use.
Over the past century or more, the genres of fantasy, horror, and supernatural fiction have increasingly expanded beyond literature and into an array of media—film, television, comic books, and art. Many of the leading figures in the field engage in multimedia enterprises that allow their work to reach a much wider public than the mere readers of books. In Disorders of Magnitude: A Survey of Dark Fantasy, Jason V Brock analyzes the intersection of literature, media, and genre fiction in essays, reviews, and pioneering interviews. Beginning with the pulp magazines of the 1920s, Brock studies such dynamic figures as H. P. Lovecraft, Forrest J Ackerman, Harlan Ellison, and the Southern California writers known collectively as “The Group”—Ray Bradbury, Charles Beaumont, Richard Matheson, Rod Serling, and William F. Nolan. This collection also includes filmmakers Roger Corman, George Romero, and Dan O’Bannon, and such fantasy artists as H. R. Giger. Graced with dozens of photographs from the author’s personal collection, this wide-ranging study offers a kaleidoscopic look at the multifarious ways in which fantasy, horror, and the supernatural have permeated our culture. Brock—himself a fiction writer, critic, and filmmaker—concludes the book with touching eulogies to the recently deceased Ray Bradbury and Ray Harryhausen. Highlighting so many figures essential to the understanding of fantasy and horror, Disorders of Magnitude will appeal to fans of these fiction genres around the world.
Hockey occupies a prominent place in the Canadian cultural lexicon, as evidenced by the wealth of hockey-centred stories and novels published within Canada. In this exciting new work, Jason Blake takes readers on a thematic journey through Canadian hockey literature, examining five common themes - nationhood, the hockey dream, violence, national identity, and family - as they appear in hockey fiction. Blake examines the work of such authors as Mordecai Richler, David Adams Richards, Paul Quarrington, and Richard B. Wright, arguing that a study of contemporary hockey fiction exposes a troubled relationship with the national sport. Rather than the storybook happy ending common in sports literature of previous generations, Blake finds that today's fiction portrays hockey as an often-glorified sport that in fact leads to broken lives and ironic outlooks. The first book to focus exclusively on hockey in print, Canadian Hockey Literature is an accessible work that challenges popular perceptions of a much-beloved national pastime.
In recent decades digital devices have reshaped daily life, while tech companies’ stock prices have thrust them to the forefront of the business world. In this rapid, global development, the promise of a new machine age has been accompanied by worries about accelerated joblessness thanks to new forms of automation. Jason E. Smith looks behind the techno-hype to lay out the realities of a period of economic slowdown and expanding debt: low growth rates and an increase of labor-intensive jobs at the bottom of the service sector. He shows how increasing inequality and poor working conditions have led to new forms of workers’ struggles. Ours is less an age of automation, Smith contends, than one in which stagnation is intertwined with class conflict.
The stranger-than-fiction story of the now-notorious Lowcountry clan, in all its Southern Gothic intensity—by an author with unparalleled access to and knowledge of the players, the history, and the place. The most famous man in South Carolina lives in prison. He stands convicted of a staggering amount of wrongdoing—more than 100 crimes and counting. Once a high-flying, smooth-talking, pedigreed Southern lawyer, Alex Murdaugh is now disbarred and disgraced. For more than a decade, prosecutors asserted that Alex was secretly a fraud, a thief, a drug trafficker, and an all-around phony. On the night of June 7, 2021, they claimed, he also became a killer, shooting dead his wife and son in a desperate bid to escape accountability. The many crimes of Alex Murdaugh, exposed piecemeal over the last two years, have appalled the general public. Yet his implosion—the spectacular manner in which he has turned his vaunted family name to mud—has also proved mesmerizing. With every revelation, Alex Murdaugh has been shown to be a man without bottom, though he insists he never harmed his family. Remarkably, all of his misdeeds have precedent. In Swamp Kings, Jason Ryan reveals Alex’s evil actions are only the tip of the iceberg. When it comes to the Murdaugh family of Hampton County, history has a way of repeating itself. For every alleged, headline-grabbing crime associated with Alex Murdaugh, mirror-image incidents have played out within his family’s past, including parallel instances of fraud, theft, illicit trafficking of babies and booze, calamitous boat crashes, and even alleged murder. There were some crimes committed by Alex’s kin that even he would not dare mimic. Covering a century of depravity in an impoverished and isolated stretch of the Deep South, Swamp Kings weaves together the jaw-dropping narratives of generations of Murdaughs before culminating in the telling of a murder trial for the ages. Page after page the family’s legacy is laid bare as a spotlight is finally trained on the Murdaugh men who have long lorded over the South Carolina Lowcountry.
From 2002 to 2008, the Bush administration argued that Iran was developing nuclear weapons, despite years of inconclusive International Atomic Energy Agency inspection reports. In the absence of substantive evidence, much of the debate was conducted via public forums with a heavy persuasive element to the discourse. This book offers an in-depth consideration of the rhetoric surrounding Irans controversial nuclear programme. It takes an interdisciplinary approach, examining speeches, interviews, news reports, online message boards and newspaper layouts during the Bush Presidency (2000-2008). Engaging with visual grammar and narrative, the book looks at layouts from the Associated Press, The New York Times and The Washington Post, amongst others. The book points out, using rhetorical theory and discourse analysis, the conditions that lent credibility to the Bush administrations position by examining the arguments Bush and his political surrogates put forward, and the discourse strategies that influenced which ideas gained salience and which were downplayed. Political communication and Foucaults theory of governmentality are brought in to articulate the implications regarding the influence, importance and expansion of executive power.
From his 1952 short story 'Roog' to the novels The Divine Invasion and VALIS, few authors have had as great of an impact in the latter half of the 20th century as Philip K. Dick. In The Postmodern Humanism of Philip K. Dick, Jason Vest explores the work of this prolific, subversive, and mordantly funny science-fiction writer. He examines how Dick adapted the conventions of science fiction and postmodernism to reflect humanist concerns about the difficulties of maintaining identity, agency, and autonomy in the latter half of the 20th century. In addition to an extensive analysis of the novel Now Wait for Last Year, Vest makes intellectually provocative comparisons between Dick and the works of Franz Kafka, Jorge Luis Borges, and Italo Calvino. He offers a detailed examination of Dick's literary relationship to all three authors, illuminating similarities between Dick and Kafka that have not previously been discussed, as well as similarities between Dick and Borges that scholars frequently note but fail to explore in detail. Like Kafka, Borges, and Calvino, Dick employs fantastic, unreal, and visionary fiction to reflect the disruptions, dislocations, and depressing realities of twentieth-century life. By comparing him to these other writers, Vest demonstrates that Dick's fiction is a fascinating barometer of postmodern American life even as it participates in an international tradition of visionary literature.
Throughout the Classical period, the Athenian hoplite demonstrated an unwavering willingness to close with and kill the enemies of Athens, whenever and wherever he was required to do so. Yet, despite his pugnacity, he was not a professional soldier; he was an untrained amateur who was neither forced into battle nor adequately remunerated for the risks he faced in combat. As such, when he took his place in the phalanx, when he met his enemy, when he fought, killed and died, he did so largely as an act of will. By applying modern theories of combat motivation, this book seeks to understand that will, to explore the psychology of the Athenian hoplite and to reveal how that impressive warrior repeatedly stifled his fears, mustered his courage and willingly plunged himself into the ferocious savagery of close-quarters battle.
Published in partnership with the Toronto Maple Leafs and officially licensed by the NHL, this is the one and only official Toronto Maple Leafs Centennial publication! The Toronto Maple Leafs are one of the most storied franchises in all of sport and without question -- the most recognized team in all of hockey. Through this journey of a hundred years of Maple Leaf hockey, fans will read of ups and downs, triumphs and tears, laughter and laments. This publication tells the Leafs' complete history and introduces fans to coaches, as well as such legends as: Apps and Armstrong, Kennedy and Keon, Broda and Bower, Salming and Sundin, but also players who wore the Blue and White and left far more modest legacies. It takes fans to Toronto's first game, the construction of Maple Leaf Gardens and subsequent move to the Air Canada Centre. It celebrates Toronto's Stanley Cups and Hall of Fame players and demonstrates that through each exciting season, the Toronto Maple Leafs have forever remained our team and enjoyed the incredibly loyal support of a nation of fans. Published in complete partnership with the Toronto Maple Leafs and scheduled to release as the Leafs enter their 100th season, this official centennial publication includes contributions from many of the biggest names in Leaf history. Author Kevin Shea gained unprecedented access to players -- past and present -- as well as team executives to offer this book the most compelling, informed, and accurate portrayal of Toronto's historic hockey team and their important place in both the world of hockey and the culture of Canada. Combined with incredible archival photographs and a truly incredible design, this is the definitive and must have book for fans of the Blue and White.
The primary focus of this book is to demonstrate how Hebrews represents, in view of its historical and religious context, human fidelity to God. Thus, the basic thesis is twofold. First, with regard to the divine-human relationship in the ancient Mediterranean world, the belief in the reciprocity rationale was one primary dynamic for establishing fidelity to a relationship and has been applied by some scholars, such as David deSilva, to Hebrews as the way to understand its strategy for creating perseverance. A major problem with the application of this dynamic is that a common optimistic anthropological assumption is associated with the various reciprocity systems in the ancient world, both Jewish and pagan. This assumption is required if reciprocity is to be effective for establishing ongoing fidelity. Second, there was, however, a middle Judaic stream that can be traced from the period of the exile which held to a pessimistic anthropology. This anthropological assumption crippled the perceived success of reciprocity to secure fidelity. Thus, the solution to God's people's inability to remain faithful was an act of God that transformed the human condition and enabled faithfulness to the relationship. The argument of this book is that Hebrews, with its emphasis upon the inauguration of the new covenant by Jesus' high priestly ministry, belongs to this latter stream of thought in understanding how fidelity is secured between God and his people. Hebrews, thus, implicitly rejects the rationale of reciprocity for fidelity. The implications of this offers a fresh perspective on the soteriology of Hebrews.
This atlas is a comprehensive review of spine surgery, discussing traditional and new techniques. Divided into sections, the first part introduces surgical anatomy. The following sections focus on procedures for different parts of the spine – cervical, thoracic and lumbosacral, to present expanded coverage of all aspects of spine surgery. Each section presents numerous disorders and different surgical techniques for their management. Highly illustrated, each chapter discusses indications for a surgical approach, the most common surgeries, pertinent anatomy, postoperative care and potential complications. Key points are summarised for each chapter. Written by recognised US authors, this atlas is enhanced by 800 full-colour illustrations, clinical pictures and radiographic images. Key points Comprehensive review of spine surgery covering new and traditional techniques Discusses disorders and surgeries in different spinal sections Key points summarised for each chapter Recognised US author team Includes 800 illustrations, clinical pictures and radiographic images
Embark on a journey that transcends the boundaries of art and technology in the groundbreaking realm of Creative Convergence: The AI Renaissance in Art and Design. This isn't just another book on art and technology- it's a journey that sparks curiosity, fuels innovation, and challenges traditional artistic boundaries. Discover the power of generative Artificial Intelligence (AI) as it melds with human expression, propelling artistry into uncharted territories and redefining traditional notions of both originality and creativity. The text is not just about art or AI; it is about the fusion of both, catalyzing a creative revolution that challenges previous assumptions about human-machine collaboration and how ideation, conceptualization, process and execution are radically rethought. Have you ever wondered how/will AI revolutionize training, education and execution in art and design? Delve into this captivating treatment that contextualizes the disruptions we are experiencing today in the technological innovations and artistic responses and integrations of the past five hundred years. Human creativity has always struggled against technological advance, but ultimately integrated and redefined what "art" is in each era. As such, you will see how AI can be incorporated in various artistic disciplines in this study. Explore real-world case studies that showcase AI's practical impact on 3D design, drawing, digital art, and even web design. The book also addresses the controversial question: Can AI be a co-creator in the creative and artistic process, even assisting in creating an original, signature style? Brace yourself for revelations that will challenge your perceptions of traditional artistry.
This book examines catalysts for Buddhist formation in ancient South Asia and expansion throughout and beyond the northwestern Indian subcontinent to Central Asia by investigating symbiotic relationships between networks of religious mobility and trade.
Black British musicians have been making jazz since around 1920 when the genre first arrived in Britain. This groundbreaking book reveals their hidden history and major contribution to the development of jazz in the UK. More than this, though, the chapters show the importance of black British jazz in terms of musical hybridity and the cultural significance of race. Decades before Steel Pulse, Soul II Soul, or Dizzee Rascal pushed their way into the mainstream, black British musicians were playing jazz in venues up and down the country from dance halls to tiny clubs. In an important sense, then, black British jazz demonstrates the crucial importance of musical migration in the musical history of the nation, and the links between popular and avant-garde forms. But the volume also provides a case study in how music of the African diaspora reverberates around the world, beyond the shores of the USA - the engine-house of global black music. As such it will engage scholars of music and cultural studies not only in Britain, but across the world.
This book is among the first to address the issues raised by the International Criminal Court (ICC) from an International Relations perspective. By clearly outlining a theoretical framework to interpret these issues, Ralph makes a significant contribution to the English School's study of international society. More specifically, he offers a concise definition of 'world society' and thus helps to resolve a longstanding problem in international theory. This groundbreaking conceptual work is supported by an in-depth empirical analysis of American opposition to the ICC. Ralph goes beyond the familiar arguments related to national interests and argues that the Court has exposed the extent to which American notions of accountability are tied to the nation-state. Where other democracies are willing to renegotiate their social contract because they see themselves as part of world society, the US protects its particular contract with 'the people' because it offers a means of distinguishing America and its democracy from the rest of the world. This 'sovereigntist', or more accurately 'Americanist', influence is further illustrated in chapters on the sources of law, universal jurisdiction, transatlantic relations and US policy on international humanitarian law in the war on terror. The book concludes by evoking E.H. Carr's criticism of those great powers who claim that a harmony exists between their particular interests and those of wider society. It also recalls his argument that great powers sometimes need to compromise and in this context, Ralph argues that support for the ICC is a more effective means of fulfilling America's purpose and a less costly sacrifice than that demanded by the 'Americanist' policy of nation-building.
The Guest Editors have compiled a comprehensive issue that addresses the current clinical diagnosis, treatment,and management of infections in children. Top authors in their field have written review articles on the following topics: Update on Varicella Zoster Virus in Children; Emerging Respiratory Viruses in Children; Bronchiolitis in Children; Antimicrobial resistance in pediatrics in Children; New updates in influenza vaccination in Children; Changing epidemiology of CAP in Children; Zika Virus in Children; Ebola Virus in Children; Infections in Children on biologics; New rapid diagnostics in Children; Infections in HSCT Children; Changing epidemiology of H. influenzae infections in Children; Norovirus in Children; PEP in children; Syphilis in Children; Encephalitis in Children; and Malaria in Children. Infectious disease physicians will have the most current and up-to-date best practice information in their field.
An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, pharmacology, and clinical applications. After heart disease, cancer is the number one killer worldwide, and the tumor microenvironment is forever changing, creating an ever-greater demand for safer, more effective anticancer agents. In response to that demand, the $100 billion cancer drug market continues to grow, with our increased understanding of cancer leading to new drugs being used clinically almost every year. Anticancer Therapeutics is divided into three sections. Section 1 is an introduction to cancer and therapeutics, and covers the etiology and cellular and molecular basis of cancer. In Section 2, the authors focus on the anticancer agents — their discovery, synthesis, mode of action, mechanisms of resistance, and adverse reactions. Section 3 focuses on specific cancers, explaining how and why the various agents discussed in Section 2 are used, both individually and in combination, to treat different cancers. Integrates aspects of basic science, including chemistry and pharmacology and clinical medicine in relation to cancer therapeutics Written by an author team comprising specialists in medicinal chemistry, pharmacology, and oncology Features full-color images throughout illustrating how drugs bind to cellular targets and exert their pharmacological effect Divided into three sections, covering the etiology and cellular and molecular basis of cancer, anticancer agents, and drug applications for different cancers. Providing the reader with an integrated understanding of all aspects of the science of anticancer agents, this is an ideal textbook for undergraduates studying medicine, nursing, medicinal chemistry, pharmacy, pharmacology and other allied heath / life sciences. It is also a valuable bench reference for pharmacists, medics, and pharmaceutical researchers working in both academia and industry.
The intelligence community's flawed assessment of Iraq's weapons systems—and the Bush administration's decision to go to war in part based on those assessments—illustrates the political and policy challenges of combating the proliferation of weapons of mass destruction. In this comprehensive assessment, defense policy specialists Jason Ellis and Geoffrey Kiefer find disturbing trends in both the collection and analysis of intelligence and in its use in the development and implementation of security policy. Analyzing a broad range of recent case studies—Pakistan's development of nuclear weapons, North Korea's defiance of U.N. watchdogs, Russia's transfer of nuclear and missile technology to Iran and China's to Pakistan, the Soviet biological warfare program, weapons inspections in Iraq, and others—the authors find that intelligence collection and analysis relating to WMD proliferation are becoming more difficult, that policy toward rogue states and regional allies requires difficult tradeoffs, and that using military action to fight nuclear proliferation presents intractable operational challenges. Ellis and Kiefer reveal that decisions to use—or overlook—intelligence are often made for starkly political reasons. They document the Bush administration's policy shift from nonproliferation, which emphasizes diplomatic tools such as sanctions and demarches, to counterproliferation, which at times employs interventionist and preemptive actions. They conclude with cogent recommendations for intelligence services and policy makers.
An argument for retaining the notion of personal property in the products we “buy” in the digital marketplace. If you buy a book at the bookstore, you own it. You can take it home, scribble in the margins, put in on the shelf, lend it to a friend, sell it at a garage sale. But is the same thing true for the ebooks or other digital goods you buy? Retailers and copyright holders argue that you don't own those purchases, you merely license them. That means your ebook vendor can delete the book from your device without warning or explanation—as Amazon deleted Orwell's 1984 from the Kindles of surprised readers several years ago. These readers thought they owned their copies of 1984. Until, it turned out, they didn't. In The End of Ownership, Aaron Perzanowski and Jason Schultz explore how notions of ownership have shifted in the digital marketplace, and make an argument for the benefits of personal property. Of course, ebooks, cloud storage, streaming, and other digital goods offer users convenience and flexibility. But, Perzanowski and Schultz warn, consumers should be aware of the tradeoffs involving user constraints, permanence, and privacy. The rights of private property are clear, but few people manage to read their end user agreements. Perzanowski and Schultz argue that introducing aspects of private property and ownership into the digital marketplace would offer both legal and economic benefits. But, most important, it would affirm our sense of self-direction and autonomy. If we own our purchases, we are free to make whatever lawful use of them we please. Technology need not constrain our freedom; it can also empower us.
Sternberg's Diagnostic Surgical Pathology is a flagship book in pathology. This classic 2-volume reference presents advanced diagnostic techniques and the latest information on all currently known diseases. The book emphasizes the practical differential diagnosis of the surgical specimen while keeping to a minimum discussion of the natural history of the disease, treatment and autopsy findings. Contributors are asked to provide their expert advice on the diagnostic evaluation of every type of specimen from every anatomic site. This approach distinguishes it and provides a style of a personal consultation.
Experiencing Life offers biblical examples of some of the harder situations teens might face and gives them the knowledge needed to persevere in the face of peer pressure and uncertainty. Useful as a discussion tool in small groups, this Bible study covers issues of loving, giving, and serving, which manifest in everyday life.
In “grassroots” campaigns, the grass isn’t always green—or natural. In today’s chaotic world, where the multiplication of information sources creates competing narratives, credibility is the key to winning the war of ideas. This is the reason why governments and corporations resort to astroturfing—creation of ostensibly grassroots movements set up to advance political agendas and commercial campaigns. The democratization of information and polarization of politics offer a perfect storm. Fake Politics tells the stories of how this practice has transformed political activism into a veiled lobbying effort by the rich and the powerful. Through a series of vignettes involving the tea party, oil industry, big tobacco, big data, and news media, this book will explore the similarities and differences between various campaigns that appeared as grassroots but, in reality, were lobbying efforts fueled by governments, corporations, major industries, and religious institutions. The process, named for the artificial grass fields at football stadiums and high schools across the country, became so prevalent in the last two decades that it now sits at a tipping point. In the era of “fake news” and “alternative facts,” with the truth well on its way to becoming indistinguishable from fabrication, what can the past of astroturfing tell us about the future of grassroots activism?
Sharpen your critical thinking skills and prepare for real-world practice with clinical cases Build and enhance your knowledge of orthopaedic physical therapy with this accessible, case-filled resource. Each case includes a discussion of the health condition, examination, evaluation, diagnosis, plan of care and interventions, evidence-based practice recommendations, and references. NPTE-style review questions accompanying each case reinforce your learning. Featuring more than three dozen cases and new content, this updated edition of Physical Therapy Case Files: Orthopaedics is an ideal resource for coursework, NPTE preparation, and in the clinic. New: Coverage of blood flow restriction, dry needling, thoracic spine manipulation, and exercise for chronic low back pain 37 orthopaedic cases with National Physical Therapy Examination-style review questions to help users learn best practices in the context of patient care Evidence-based cases written by leading clinicians, researchers, and academics Includes evidence-based ratings for treatment plans Perfect for coursework use and NPTE preparation
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