Der Wnt Signalweg stellt ein zentrales Regulationselement während der Embryonalentwicklung und in adulten Homöostaseprozessen dar, dessen Fehlregulierung eine wichtige Rolle in verschiedensten Krankheitsstadien spielt. LRP6 ist ein singelpass Transmembran-rezeptor, der zur Familie der Lipoproteinrezeptoren gehört und der innerhalb des Wnt/β-Catenin Signalweges als Korezeptor agiert. Die Bindung sekretierter Wnt Liganden an die extrazellulären Domänen von Frizzled und LRP6 an Empfängerzellen führt zur Aggregation von Rezeptor-Liganden Komplexen in Signalosome. Dies wird begleitet durch Serin/Threonin Phosphorylierung an Konservierten PPPSP und CK1 Motiven der intrazellulären Domäne (ICD) von LRP6, wodurch der intrazelluläre Signalweg aktiviert wird.
Although friction often frustrates civil-military relations, it is an inevitable and important part of the policymaking process. The system breaks down when there is too much friction or too little: when civilian and military leaders descend into open conflict or when one side acquiesces to the other and embraces groupthink. The system works best when both sides in the civil-military dialogue are able to speak candidly in an environment that fosters empathy and empowerment.
Memory has long been ignored by rhetoricians because the written word has made memorization virtually obsolete. Recently however, as part of a revival of interest in classical rhetoric, scholars have begun to realize that memory offers vast possibilities for today's writers. Synthesizing research from rhetoric, psychology, philosophy, and literary and composition studies, this volume brings together many historical and contemporary theories of memory. Yet its focus is clear: memory is a generator of knowledge and a creative force which deserves attention at the beginning of and throughout the writing process. This volume emphasizes the importance of recognizing memory's powers in an age in which mass media influence us all and electronic communication changes the way we think and write. It also addresses the importance of the individual memory and voice in an age which promotes conformity. Written in a strong, lively personal manner, the book covers a great deal of scholarly material. It is never overbearing, and the extensive bibliography offers rich vistas for further study.
This book illustrates how middle level English language arts teachers can draw upon young adult literature to facilitate students’ understanding of issues of oppression and allow them opportunities for social action. Each chapter centers on one novel that represents a contemporary topic including the refugee crisis, Indigenous rights, trauma, and bullying. In each, authors provide pre-, during-, and after reading strategies for teaching that connect the social issues in the texts to students’ lives and to the world around them. Research, writing, and digital literacies are emphasized throughout. Authors also include topics for teaching at the intersections of the focal topic with other areas of social justice. Finally, they provide a multitude of avenues for student action, emphasizing the need to move readers from understanding and awareness to asserting their own agency and capacities to effect change in their local, national, and global communities. Additional resources are also included as extensions, such as documentaries, young adult literature companions for study, connected music, and supplementary lesson plans.
This book shows the many facets of African engagements with the world. It starts from the premise that current global asymmetries ascribing Africa to a marginalized position are the effects of colonial and imperial pasts still lingering on. The decolonization process of the post-war structure which privileges the West in both political and economic terms. While new dependencies emerged, several old bonds were maintained and continue to influence African affairs quite strikingly. It is appropriate, then, to call these continued unequal relations between Africa and the West frankly 'neo-colonial'. This designation applies all the more as the post-colonial states of Africa inherited a complex legacy of foreign rule – colonial frontiers, colonial languages, colonial infrastructure and authoritarian institutions, as well as the social intricacies and imbalances so characteristic of the 'colonial situation'. The contributions to this volume look at various aspects of these complex processes from intellectual history perspectives. The topics dealt with are manifold. Contributions deliberately attack key themes, ideas and discourses of an intellectual history of Africa ('state', 'modernity', 'development', 'dependency', 'art', etc.), and introduce important engaged public intellectuals from Africa and the African diaspora. What is Africa, and how is she related to the rest of the world? How can she overcome her internal problems and her external dependencies? – These are perennial questions critically tackled by Africans throughout the 20th century. Dealing with various cases looked at from a variety of perspectives, the contributions to this book offer original insights into the intellectual history of Africa.
This little book really could change your life. It takes less than 30 minutes to read, but what you learn will impact the rest of your life; showing you how you can have so much more personal power.
This interdisciplinary book constitutes the first major and comparative study of resilience focused on victims-/survivors of conflict-related sexual violence (CRSV). Locating resilience in the relationships and interactions between individuals and their social ecologies (including family, community, non-governmental organisations and the natural environment), the book develops its own conceptual framework based on the idea of connectivity. It applies the framework to its analysis of rich empirical data from Bosnia-Herzegovina, Colombia and Uganda, and it tells a set of stories about resilience through the contextual, dynamic and storied connectivities between individuals and their social ecologies. Ultimately, it utilises the three elements of the framework – namely, broken and ruptured connectivities, supportive and sustaining connectivities and new connectivities – to argue the case for developing the field of transitional justice in new social-ecological directions, and to explore what this might conceptually and practically entail. The book will particularly appeal to anyone with an interest in, or curiosity about, resilience, and to scholars, researchers and policy makers working on CRSV and/or transitional justice. The fact that resilience has received surprisingly little attention within existing literature on either CRSV or transitional justice accentuates the significance of this research and the originality of its conceptual and empirical contributions. The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.
Literary form presents an important opportunity for understanding the relationship between literature and science. Through a series of close readings of poetry and prose, Unified Fields demonstrates that formal structures in literature can relate to scientific concepts through their essential interpretive functions. Janine Rogers engages with a wide range of writing from Canadian, British, and American authors, including the poetry of Elizabeth Bishop and Robyn Sarah as well as prose by Margaret Atwood, Ian McEwan, and Stephen Hawking. She employs an interdisciplinary approach combining formalist, historical, and theoretical literary practice, informed by interpretive frameworks developed in the philosophy of science. Although dedicated to contemporary texts, Rogers's analysis is frequently rooted in historical contexts of form, including Euclidean geometry and medieval romance, developed when the distinction between literature and science was not so drastic. These historical connections demonstrate that continuities of form resonate in both contemporary literature and science. Through critical analysis and engaging prose, Unified Fields bridges an important disciplinary gap by revealing how literary practice informs scientific understanding.
This introduction to peace education and yogic science provides a good toolkit to help bring contemplative peacebuilding (efforts to stop harm) practices to the classroom and community center. The latest research is presented alongside personal reflections of teachers and facilitators who have used these methods for instructing students or participants on facing the hectic realities of life with self-regulation and nonviolence. Exercises and practices are included, along with creative activities for emotional grounding and stress management.
A sympathetic history that focuses on the experiences of women and girls during the Holocaust and draws on new archival sources. Beginning in late 1940, over three thousand Jewish girls and young women were forced from their family homes in Sosnowiec, Poland, and its surrounding towns to worksites in Germany. Believing that they were helping their families to survive, these young people were thrust into a world where they labored at textile work for twelve hours a day, lived in barracks with little food, and received only periodic news of events back home. By late 1943, their barracks had been transformed into concentration camps, where they were held until liberation in 1945. Using a fresh approach to testimony collections, Janine P. Holc reconstructs the forced labor experiences of young Jewish females, as told by the women who survived and shared their testimony. Incorporating new source material, the book carefully constructs survivors’ stories while also taking a theoretical approach, one alert to socially constructed, intersectional systems of exploitation and harm. The Weavers of Trautenau elucidates the limits and possibilities of social relations inside camps and the challenges of moral and emotional repair in the face of indescribable loss during the Holocaust.
Diverse elements have created New Zealand’s distinctive political and social culture. First is New Zealand’s journey as a colony, and the various impacts this had on settler and Maori society. The second theme is the quest for what one prominent historian has labelled ‘national obsessions’ – equality and security, both individual and collective. The third, and more recent, theme is New Zealand’s emergence as a nation with a unique identity. New Zealand’s small geographic size and relative isolation from other societies, the dominant influence of British culture, the resurgence of Maori language and culture, the endemic instability of an economy based on a narrow range of pastoral products, and the dominance of the state in the lives of its people, all help to explain much of the present-day New Zealand psyche. This third edition of Historical Dictionary of New Zealand contains a chronology, an introduction, appendix, and an extensive bibliography. The dictionary section has over 800 cross-referenced entries on important personalities, politics, economy, foreign relations, religion, and culture. This book is an excellent access point for students, researchers, and anyone wanting to know more about New Zealand.
Squares and rectangles are not just for beginners! Fabric-lovers—you’ll agree with Amy Walsh and Janine Burke that sewing basic patterns with straight lines is just about the quickest and most satisfying way to get yourself to a finished quilt. Ten quilt projects include yardage and cutting requirements for multiple-sizes. Enjoy stress-free piecing, easy construction, and learn how to alter patterns for completely different looks by resizing the blocks, trying a different setting, or changing the color palette. With fun, no-fuss patterns like these, you’re free to explore all kinds of exciting possibilities with different colors, fabrics, and layouts!
A symbol of power, divinity, war, and justice, the eagle has been one of the most dominant birds in the human imagination for millennia. Exploring the rich history of this bird and its portrayal in art, film, literature, and poetry, this book examines how eagles became an emblematic creature that also embodies the paradoxes of our existence. Janine Rogers reveals that while humans associate eagles with light and learning, they also connect the birds to death and corruption. Eagles adorn flags, crests, and other emblems, but as she shows, they have also been relentlessly persecuted and perceived as predatory threats to livestock. While considering these contradictions, Rogers argues that eagles have suffered from the effects of human activities for years, from pesticide use to habitat destruction and global warming. She demonstrates the dangers of not saving eagles from destruction, as they are key to controlling pest populations and clearing carcasses. Featuring many illustrations of eagles in the wild, art, and popular culture, Eagle shines new light on our complex relationship with these birds, their international significance, and the dire implications of losing them to contemporary ecological threats.
The Endangered Self focuses on how the discovery of an HIV positive status affects the individual's sense of identity, on the experience of living with HIV and its effects on the individual's social relationships.
Media are incorporated into our physical environments more dramatically than ever before - literally opening up new spaces of interactivity and connection that transform the experience of being in the city. Public gatherings and movement, even the capabilities of democratic ideology, have been redefined. Urban Screens, mobile media, new digital mappings, and ambient and pervasive media have all created new ecologies in cities. How do we analyze these new spaces? Recognition of the mutual histories and research programs of urban and media studies is only the beginning. Cartographies of Place develops new vocabularies and methodologies for engaging with the distinctive situations and experiences created by media technologies which are reshaping, augmenting, and expanding urban spaces. The book builds upon the rich traditions and insights of a post-war generation of humanist scholars, media theorists, and urban planners. Authors engage with different historical and contemporary currents in urban studies which share a common concern for media forms, either as research tools or as the means for discerning the expressive nature of city spaces around the world. All of the media considered here are not simply "free floating," but are deeply embedded in the geopolitical, economic, and material contexts in which they are used. Cartographies of Place is exemplary of a new direction in interdisciplinary media scholarship, opening up new ways of studying the complexities of cities and urban media in a global context.
Shows how the design process can be successfully applied to satisfy market needs and trends Fashion design seems to be a glamorous mystery for which only the fortunate few have sufficient talent to succeed. In reality, commercially successful results can be achieved if the right processes are followed in the early design process. Fashion Design sets out basic principles and exercises in order to make fashion design a logical process, providing a framework from which they can expand your skills steadily. Fashion Design, 2nd Edition: Shows how the design process can be successfully applied to satisfy market needs and trends Has a problem solving approach, with practical design projects and portfolio exercises to encourage readers to develop their innovation, experimentation and versatility Pays special attention to computer-aided design (CAD) and employment opportunities, including an overview of what is involved in studying and becoming a designer in the contemporary fashion industry.
In recent years collaborative working has moved from being an optional extra of public service practice to being a core competency for individuals and teams. Has this led to better outcomes for those who use services? How to understand and to measure these outcomes and demonstrate these to a variety of different audiences remains a significant challenge for many. This revised edition of this bestselling textbook includes the latest research findings and contains more tools, frameworks and international examples of best practice to aid practitioners to more effectively evaluate partnerships. Up-to-date research evidence is presented in a practical and helpful way, making this an essential resource for students.
Robbie Savage could have been just another Manchester United reject. Instead, he used the Old Trafford scrapheap as a springboard to become one of the most instantly recognisable footballers in the Premier League, despite being told by Sir Alex Ferguson he was not good enough to stay in the class of '92 alongside David Beckham, Paul Scholes, Ryan Giggs, Nicky Butt and Gary Neville. For the last 16 years, Savage has carved out a reputation as a hard man and wind-up merchant with an unerring ability to grab a headline. From deliberately getting Tottenham's Justin Edinburgh sent off in a Wembley Cup final to the 'Jobbiegate' row with referee Graham Poll and the bust-ups with John Toshack, Rio Ferdinand, Graeme Souness and Paul Jewell, the list is endless. Yet numerous footballing legends will testify to the skill of the midfielder, who has starred for Crewe, Leicester, Birmingham, Blackburn and Derby and won 39 international caps for Wales. Behind the long blond hair, the Armani tattoo and the flamboyant cars, Savage has always been the heartbeat of his team. Savage! provides a unique insight into the extraordinary life of an elite sportsman, a colourful character and loving family man. Love him or loathe him, Robbie Savage's story is a remarkable one.
Single Subject Designs in Biomedicine draws upon the rich history of single case research within the educational and behavioral research settings and extends the application to the field of biomedicine. Biomedical illustrations are used to demonstrate the processes of designing, implementing, and evaluating a single subject design. Strengths and limitations of various methodologies are presented, along with specific clinical areas of application in which these applications would be appropriate. Statistical and visual techniques for data analysis are also discussed. The breadth and depth of information provided is suitable for medical students in research oriented courses, primary care practitioners and medical specialists seeking to apply methods of evidence practice to improve patient care, and medical researchers who are expanding their methodological expertise to include single subject designs. Increasing awareness of the utility in the single subject design could enhance treatment approach and evaluation both in biomedical research and medical care settings.
By examining Social Credit's anti-Semitic propaganda and the reaction of the Canadian Jewish Congress, Stingel details their mutual antagonism and explores why Congress was unable to stop Social Credit's blatant defamation. She argues that Congress's ineffective response was part of a broader problem in which passivity and a belief in "quiet diplomacy" undermined many of its efforts to combat intolerance. Stingel shows that both Social Credit and Congress changed considerably in the post-war period, as Social Credit abandoned its anti-Semitic trappings and Congress gradually adopted an assertive and pugnacious public relations philosophy that made it a champion of human rights in Canada. Social Discredit offers a fresh perspective on both the Social Credit movement and the Canadian Jewish Congress, substantively revising Social Credit historiography and providing a valuable addition to Canadian Jewish studies.
Janine Romero Valenzuela analyses the Bolivian lithium program in the largest empirical study to date with a focus on local perspectives and governance, identifying grievances and conflict dimensions. The case study shows that it is particularly an altered governance approach, the local trust in government and the high expectations that the Morales administration could create around lithium that influence local viewpoints. By applying the meaningful grievance concept on the local level, the book supports a further refinement of theories on a resource-governance-conflict-link.
How well does technology assessment (TA) relate to women's lives? If women are underrepresented in the long-term research and development process that leads to scientific advancements, how can TA understand technology aimed at women? It can't, claims the author of Technology Assessment: A Feminist Perspective. A relative new field, TA examines the social aspect of technology and provides information critical to decision making, policy development, safety standards, and avoiding litigation. Until gender analysis is introduced into all assessments of new technologies, Janine Marie Morgall argues, TA can't evaluate technology's impact upon women. Morgall investigates two areas of technology that affect women's lives: productive (clerical work) and reproductive (health care). Case studies of clerical workers and health care recipients illustrate gender-specify effects of technology ranging from word processors to treatments for infertility. These studies convincingly demonstrate that TA encourages innovations without questioning their effects on women. Issues of dominance, control, and conflicting values emerge from Morgall's feminist perspective and support her call for gender analysis of new technologies. In the series Labor and Social Change, edited by Paula Rayman and Carmen Sirianni.
A visual feast of the Midwest's homegrown bounty In this splendidly illustrated book, food writer and self-described farm groupie Janine MacLachlan embarks on a tour of seasonal markets and farmstands throughout the Midwest, sampling local flavors from Michigan, Ohio, Indiana, Illinois, Missouri, Iowa, Minnesota, and Wisconsin. She conducts delicious research as she meets farmers, tastes their food, and explores how their businesses thrive in the face of an industrial food supply. She tells the stories of a pair of farmers growing specialty crops on a few acres of northern Michigan for just a few months out of the year, an Ohio cattle farm that has raised heritage beef since 1820, and a Minnesota farmer who tirelessly champions the Jimmy Nardello sweet Italian frying pepper. Along the way, she savors vibrant red carrots, slurpy peaches, vast quantities of specialty cheeses, and some of the tastiest pie to cross anyone's lips. Informed by debates about eating local, seasonal crops, organic farming, sanitation, and biodiversity, Farmers' Markets of the Heartland tantalizes with special recipes from farm-friendly chefs and dozens of luscious color photographs that will inspire you to harvest the homegrown flavors in your own neighborhood.
Why did Yugoslavia fall apart? Was its violent demise inevitable? Did its population simply fall victim to the lure of nationalism? How did this multinational state survive for so long, and where do we situate the short life of Yugoslavia in the long history of Europe in the twentieth century? A History of Yugoslavia provides a concise, accessible, comprehensive synthesis of the political, cultural, social, and economic life of Yugoslavia—from its nineteenth-century South Slavic origins to the bloody demise of the multinational state of Yugoslavia in the 1990s. Calic takes a fresh and innovative look at the colorful, multifaceted, and complex history of Yugoslavia, emphasizing major social, economic, and intellectual changes from the turn of the twentieth century and the transition to modern industrialized mass society. She traces the origins of ethnic, religious, and cultural divisions, applying the latest social science approaches, and drawing on the breadth of recent state-of-the-art literature, to present a balanced interpretation of events that takes into account the differing perceptions and interests of the actors involved. Uniquely, Calic frames the history of Yugoslavia for readers as an essentially open-ended process, undertaken from a variety of different regional perspectives with varied composite agenda. She shuns traditional, deterministic explanations that notorious Balkan hatreds or any other kind of exceptionalism are to blame for Yugoslavia’s demise, and along the way she highlights the agency of twentieth-century modern mass society in the politicization of differences. While analyzing nuanced political and social-economic processes, Calic describes the experiences and emotions of ordinary people in a vivid way. As a result, her groundbreaking work provides scholars and learned readers alike with an accessible, trenchant, and authoritative introduction to Yugoslavia's complex history.
Chordates comprise lampreys, hagfishes, jawed fishes, and tetrapods, plus a variety of more unfamiliar and crucially important non-vertebrate animal lineages, such as lancelets and sea squirts. This will be the first book to synthesize, summarize, and provide high-quality illustrations to show what is known of the configuration, development, homology, and evolution of the muscles of all major extant chordate groups. Muscles as different as those used to open the siphons of sea squirts and for human facial communication will be compared, and their evolutionary links will be explained. Another unique feature of the book is that it covers, illustrates, and provides detailed evolutionary tables for each and every muscle of the head, neck and of all paired and median appendages of extant vertebrates. Key Selling Features: Has more than 200 high-quality anatomical illustrations, including evolutionary trees that summarize the origin and evolution of all major muscle groups of chordates Includes data on the muscles of the head and neck and on the pectoral, pelvic, anal, dorsal, and caudal appendages of all extant vertebrate taxa Examines experimental observations from evolutionary developmental biology studies of chordate muscle development, allowing to evolutionarily link the muscles of vertebrates with those of other chordates Discusses broader developmental and evolutionary issues and their implications for macroevolution, such as the links between phylogeny and ontogeny, homology and serial homology, normal and abnormal development, the evolution, variations, and birth defects of humans, and medicine.
In September 2002, a second workshop on the theme of the social context of technological change was held at the McDonald Institute for Archaeological Research, University of Cambridge. Discussion has been the core of these meetings so far, with the aim being to relate the results of the specialist investigator to broad historical questions concerning the nature and development of ancient societies. The papers presented here address a wider context: geographically, with the inclusion of the Aegean and thematically, with papers on natural products and raw materials. The time frame remains the same in covering the Late Bronze Age/New Kingdom. The majority of the papers draw on Egyptian evidence, and illustrate a multiplicity of approaches to the problems set by ancient technologies: modelling, methodology of art history and archaeology applied to a problematic group of artefacts, integration of archaeological and textual sources, and the application of the results of scientific analysis to illuminate ancient technology.
It is estimated that 20,000 people were subjected to rape and other forms of sexual violence during the 1992–1995 Bosnian war. Today, these men and women have been largely forgotten. Where are they now? To what extent do their experiences continue to affect and influence their lives, and the lives of those around them? What are the principal problems that these individuals face? Such questions remain largely unanswered. More broadly, the long-term consequences of conflict-related rape and sexual violence are often overlooked. Based on extensive interviews with male and female survivors from all ethnic groups in Bosnia-Herzegovina (BiH), this interdisciplinary book addresses a critical gap in the current literature on rape and sexual violence in conflict situations. In so doing, it uniquely situates and explores the legacy of these crimes within a transitional justice framework. Demonstrating that transitional justice processes in BiH have neglected the long-term effects of rape and sexual violence, it develops and operationalizes a new holistic approach to transitional justice that is based on an expanded conception of ‘legacy’ and has a wider application beyond BiH.
Generations of adults who were adopted as children have been kept in the dark about their original identities. The law sealing birth records, passed in 1935 in California during the Great Depression, swept adoptions emotional complexities under the rug and made it possible to keep adoption itself a secret. Reflecting extensive archival research and written for general audiences as well as professionals, Growing in the Dark: Adoption Secrecy and Its Consequences takes you through Californias early adoption laws, the sealing of records in the era of baby seller Georgia Tann, and the various consequences of this policy as they unfolded throughout the 20th century. WHAT REVIEWERS HAVE SAID: "...articulate, easy to read, and filled with real facts concerning sealed records." - Jean Brown, adoptee "If you work or live with adoption, you cannot afford to skip this book. Everyone seeking to reverse outdated sealed records laws should also provide a copy of the slim paperback to their legislatures." - Mirah Riben, author "...full of fascinating information...you wont be able to put it down." - Anita Field, Bastard Nation "Janine Baer, who was adopted in California, focuses on the California law enacted in 1935 sealing original birth certificates. Contrary to the popular perception, the intent of this law was not to protect the privacy of birthmothers. Rather, these records were sealed to protect children from the stigma of illegitimacy, to protect adoptive parents from intrusions by birthparents, to allow adoptive parents to keep the childs adoptive status a secret, to create the illusion that the birthparents did not exist, and to prevent adoptees from finding their birthfamilies. ...This is an excellent book for birthparents, adoptees, and adoptive parents who want to know how we got to where we are." - Jane Edwards, Portland, Oregon "Growing in the Dark, by virtue of its modest length and accessibility, can be used to educate people both within and outside of the adoption reform movement about the effects of sealed records and the faulty premises used to support them." - Barbara Busharis, American Adoption Congress "Decree" "Extensive notes and bibliographic information make it an excellent resource for those arguing for open records." - Sandra Falconer Pace, Canadian Council of Natural Mothers Note on price: Nonprofit organizations and resellers get 40% off. Call Xlibris for these orders: 1-888-795-4274.
In Suspect Saints and Holy Heretics Janine Larmon Peterson investigates regional saints whose holiness was contested. She scrutinizes the papacy's toleration of unofficial saints' cults and its response when their devotees challenged church authority about a cult's merits or the saint's orthodoxy. As she demonstrates, communities that venerated saints increasingly clashed with popes and inquisitors determined to erode any local claims of religious authority. Local and unsanctioned saints were spiritual and social fixtures in the towns of northern and central Italy in the thirteenth and fourteenth centuries. In some cases, popes allowed these saints' cults; in others, church officials condemned the saint and/or their followers as heretics. Using a wide range of secular and clerical sources—including vitae, inquisitorial and canonization records, chronicles, and civic statutes—Peterson explores who these unofficial saints were, how the phenomenon of disputed sanctity arose, and why communities would be willing to risk punishment by continuing to venerate a local holy man or woman. She argues that the Church increasingly restricted sanctification in the later Middle Ages, which precipitated new debates over who had the authority to recognize sainthood and what evidence should be used to identify holiness and heterodoxy. The case studies she presents detail how the political climate of the Italian peninsula allowed Italian communities to use saints' cults as a tool to negotiate religious and political autonomy in opposition to growing papal bureaucratization. Open Access edition funded by the National Endowment for the Humanities
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