Janet Lau's thesis describes her studies into the use of phthalocyanine-based photosensitizers in combined chemo- and photodynamic therapy (PDT) and targeted PDT. In order to carry out this study, Lau uses several approaches: conjugation with a chemotherapeutic oxaliplatin derivative, use of a polyamine ligand 2 with a view to targeting the polyamine transporters over-expressed in tumor cells, and employment of a quencher that can inhibit their photodynamic activity but can still be removed under a tumor-associated environment such as low pH and high thiol concentration. This thesis reports dual activatable photosensitizers for the first time. Overall the studies included are original and the effects have been well demonstrated at the cellular level. The work in this thesis is of much current interest and importance, and can pave foundation for further developments. Accordingly, part of the results has been published in prestigious scientific journals.
If questions of subjectivity and identification are at stake in all biographical writing, they are particularly trenchant for contemporary women biographers of women. Often, their efforts to exhume buried lives in hope of finding spiritual foremothers awaken maternal phantoms that must be embraced or confronted. Do women writing in fact have any greater access to their own mothers' lives than to the lives of other women whose stories have been swept away like dust in the debris of the past? In Thinking through the Mothers, Janet Beizer surveys modern women's biographies and contemplates alternatives to an approach based in lineage and the form of thought that emphasizes the line, the path, hierarchy, unity, resemblance, reflection, and the aesthetic-mimesis-that depends on these ideas. Through close readings of memoirs and fictions about mothers, Beizer explores how biographers of the women who came before rehearse and rewrite relationships to their own mothers biographically as they seek to appropriate the past in a hybrid genre she calls "bio-autography." Thinking through the Mothers features the work of George Sand and Colette and spans such varied figures as Gustave Flaubert, Julian Barnes, Louise Colet, Eunice Lipton, Vladimir Nabokov, Huguette Bouchardeau, and Christa Wolf. Beizer seeks an alternative to women's "salvation biography" or "resurrection biography" that might resist nostalgia, be attentive to silence, and reinvent the means to represent the lives of precursors without appropriating traditional models of genealogy.
This book represents a classic compilation of current knowledge about mouse development and its correlates to research in cell biology, molecular biology, genetics, and neuroscience. Emphasis is placed on the research strategy, experimental design, and critical analysis of the data, disguishing this from other books that only focus on protocols for mouse developmental research. Selected chapters are indexed to electronic databases such as GeneBank, GenBank, Electronic Mouse Atlas, and Transgenic/Knockout, further increasing the utility of this book as a reference.*Broad-based overview of mouse development from fundamental to specialist levels*Extensive coverage of a wide range of developmental mutations of the mouse*Excellent benchmark illustrations of brain, craniofacial, gut and heart development*In-depth experiment-based assessment of concepts in mammalian development*Focus on models of specific relevance to human development*Comprehensive reference to key literature and electronic databases related to mouse development*High-quality full-color production
This book introduces readers to basic concepts of sociolinguistics with a focus on Spanish in the US. The coverage goes beyond linguistics to examine the history and politics of Spanish in the US, the relationship of language to Latinx identities, and how language ideologies and policies reflect and shape societal views of Spanish and its speakers. Accessible to those with no linguistic background, this book provides students with a foundation in the study of language and society, and the opportunity to relate theoretical concepts to Spanish in the US in a range of contexts, including everyday speech, contemporary culture, media, education and policy. The book is a substantially revised and expanded 2nd edition of Spanish Speakers in the USA, including new chapters on the history of Spanish in the US, the demographics of Spanish in the US, and language policy; and expanded chapters on language ideologies, race, identity, media, and education. A Spanish-language edition of this book is also available: https://www.multilingual-matters.com/page/detail/?K=9781800413931.
Food Safety: Emerging Issues, Technologies and Systems offers a systems approach to learning how to understand and address some of the major complex issues that have emerged in the food industry. The book is broad in coverage and provides a foundation for a practical understanding in food safety initiatives and safety rules, how to deal with whole-chain traceability issues, handling complex computer systems and data, foodborne pathogen detection, production and processing compliance issues, safety education, and more. Recent scientific industry developments are written by experts in the field and explained in a manner to improve awareness, education and communication of these issues. - Examines effective control measures and molecular techniques for understanding specific pathogens - Presents GFSI implementation concepts and issues to aid in implementation - Demonstrates how operation processes can achieve a specific level of microbial reduction in food - Offers tools for validating microbial data collected during processing to reduce or eliminate microorganisms in foods
Pasta? Pancakes? Pizza? It's time to say "hello" to forbidden foods and "see you later" to fad diets! The Food Lover's Healthy Habits Cookbook by nutrition expert Janet Helm, MS, RD and the editors at Cooking Light proves that, with the right tools, delicious and healthy can happily coexist in any lifestyle. This unique collection of more than 250 road-tested recipes, tips and solutions has done all of the thinking for you. Each section dishes up brand-new secrets to living a healthier life, straight from more than 50 nutrition and fitness experts, bloggers, chefs and Cooking Light readers.
Therapists' Guide to Overcoming Grief and Loss after Brain Injury is written as a neurobehavioral and cognitive intervention manual for clinicians who counsel persons with brain injury. The Therapist's Guide provides step-by-step protocols, using the content of the patient workbook Overcoming Grief and Loss after Brain Injury. Each of the 9 Lessons can be used as a basis for therapy appointments with consumers. Most mental health clinicians do not fully understand the special learning needs of this client population or how to modify the usual psychotherapy or counseling process to accommodate their unique impairments and allow them to benefit. The Therapists' Guide provides the structure, grounded in the current brain injury literature that allows the clinician to teach and guide the client effectively.
Prenatal and Postnatal Care: A Woman-Centered Approach is a comprehensive resource for the care of the pregnant woman before and after birth. Ideal as a graduate text for newly-qualified adult nurses, family and women’s health practitioners, and midwives, the book can also be used as an in-depth reference for antenatal and postpartum care for those already in practice. Beginning by outlining the physiological foundations of prenatal and postnatal care, and then presenting these at an advanced practice level, the book moves on to discuss preconception and prenatal care, the management of common health problems during pregnancy, and postnatal care. Each chapter includes quick-reference definitions of relevant terminology and statistics on current trends in prenatal and postnatal care, together with cultural considerations to offer comprehensive management of individual patient needs. Written by experts in the field, Prenatal and Postnatal Care: AWoman-Centered Approach, deftly combines the physiological foundation of prenatal and postnatal care with practical application for a comprehensive, holistic approach applicable to a variety of clinical settings.
Preclinical and Clinical Modulation of Anticancer Drugs focuses on the theoretical and practical approaches to designing and enacting modulation principles. Each class of anticancer drug and the different types of modulators used within each drug class are discussed within individual chapters. The molecular and biochemical rationale for the use of specific modulators is discussed in detail, and preclinical and clinical implications of the data are integrated into each chapter. Mechanisms of drug resistance and the reasons behind circumventing the resistant phenotype are covered. The book will interest cancer chemotherapists, pharmacologists, oncologists, biochemists, and experimental therapeutics researchers, in addition to students studying the principles of drug discovery and protocol design.
A completely revised and updated edition of the leading mammalogy textbook, featuring color photographs throughout and a new streamlined structure for enhanced use in courses. There are more than 6,400 species in the class Mammalia, including the blue whale—the largest animal that has ever lived—and the pygmy shrew, which weighs little more than a dime. Such diversity among mammals has allowed them to play critical roles in every ecosystem, whether marine, freshwater, alpine, tundra, forest, or desert. Reflecting the expertise and perspective of five leading mammalogists, the fifth edition of Mammalogy: Adaptation, Diversity, Ecology significantly updates taxonomy, adds a new introductory chapter on the science of mammalogy, and highlights several recently described species. To enhance its appeal to students, textual material has been reduced, consolidated, and streamlined without sacrificing breadth or depth of coverage. The fifth edition includes • for the first time, stunning color photographs throughout • chapters rearranged and grouped to best reflect phylogenetic relationships, with updated numbers of genera and species for each family • updated mammalian structural and functional adaptations, as well as ordinal fossil histories • recent advances in mammalian phylogeny, biogeography, social behavior, and ecology, with 12 new or revised cladograms reflecting current research findings • new breakout boxes on novel or unique aspects of mammals • new work on female post-copulatory mate choice, cooperative behaviors, group defense, and the role of the vomeronasal system • discussions of the current implications of climate change and other anthropogenic factors for mammals Maintaining the accessible, readable style for which Feldhamer and his coauthors are well known, this new edition of Mammalogy is the authoritative textbook on this amazingly diverse class of vertebrates.
Your child deserves to get a good night's sleep, be in a good mood, and feel their best, like any other child.?Award-winning author, speaker, mom, and clinician Dr. Janet Lintala details how to help your constipated, irritable, sleep-deprived autistic child. You've known something was missing from your approach to support your autistic child, and now you have the protocols to help your child sleep better, feel better, behave better, and be ready to connect with the world and learn. In The Un-Prescription for Autism, Dr. Lintala explains how supporting overlooked conditions?appropriately?can bring transformative results in areas including: Constipation Diarrhea Acid reflux Irritability Aggression Night awakenings The Un-Prescription for Autism provides hundreds of research citations, clear explanations, detailed protocols, and stories from Dr. Lintala’s clinic to help parents act quickly to restore their child's health, self-control, and language--paving the way for reaching their full potential.
Design That Cares: Planning Health Facilities for Patients and Visitors, 3rd Edition is the award-winning, essential textbook and guide for understanding and achieving customer-focused, evidence-based health care design excellence. This updated third edition includes new information about how all aspects of health facility design – site planning, architecture, interiors, product design, graphic design, and others - can meet the needs and reflect the preferences of customers: patients, family and visitors, as well as staff. The book takes readers on a journey through a typical health facility and discusses, in detail, at each stop along the way, how design can demonstrate care both for and about patients and visitors. Design that Cares provides the definitive roadmap to improving customer experience by design.
Women's Health Principles and Clinical Practice is your practical guide and reference text to comprehensive women's health care. It provides a framework for approaching women at different stages of their lives including adolescence, menopause, and older womanhood. It addresses common conditions not traditionally addressed in specialty training and places a strong emphasis on preventive health. The text examines the care of women who have traditionally been invisible or ignored in clinical training, including lesbians and women with developmental disabilities. Newer areas such as the care of women at genetic risk for cancer are also examined. Also included are lists of organizations and web sites that provide up-to-date evidence-based information on the topics presented in the text.
Written and edited by the most respected authorities in forensic nursing and forensic sciences, this new edition provides the tools and concepts you need to collect evidence that is admissible in court, determine the significance of that evidence, and provide accurate, reliable testimony while administering high-quality patient care. Now in full color throughout, it remains the most comprehensive, highly illustrated text of its kind. - Provides a comprehensive, updated guide to forensic nursing science, paying special attention to the International Association of Forensic Nurses's (IAFN) goals for forensic nursing. - Retains a focus on assessment skills and the collection and preservation of evidence, following the established guidelines of the forensic sciences. Prepares you to provide testimony as a fact witness or a forensic nursing expert. Includes an illustrated case study in almost every chapter, helping you relate the information to clinical practice. - Highlights important recommendations for interventions in Best Practice boxes, including the evidence base for each. - Summarizes important points in Key Point boxes, so you can quickly review the most important concepts in each chapter. - Explores the evolving role of forensic nurses in today's health care facilities and the community. - Edited by Virginia Lynch, founding member and first President of the International Association of Forensic Nurses and Janet Barber Duval, both well-respected pioneers and educators in the field. - Contains 300 full-color illustrations integrated throughout the text, so you can view evidence quickly and easily, as it is likely to appear in practice. - Presents information on courtroom testimony and depositions in one reorganized, streamlined chapter, giving you a full, organized treatment of this extremely important topic. - Includes twelve new chapters: Digital Evidence, Medical Evidence Recovery at the Death Scene, Asphyxia, Electrical and Thermal Injury, Intrafamilial Homicide and Unexplained Childhood Death, Human Trafficking, Credential Development for Forensic Nurses, Gangs and Hate Crimes, Ethics Issues in Forensic Nursing, Forensic Physics and Fracture Analysis, Sexual Deviant Behaviors and Crime and Forensic Epidemiology. - Contains heavily revised information on Prehospital Evidence, Forensic Investigation in the Hospital, and Human Abuse and Deaths in Custody. - Features critical thinking questions with every case study, so you can thoroughly consider the implications of each clinical scenario.
An eye-opening game-changer of a book that sheds new light on how horses learn, think, perceive, and perform, and explains how to work with the horse’s brain instead of against it. In this illuminating book, brain scientist and horsewoman Janet Jones describes human and equine brains working together. Using plain language, she explores the differences and similarities between equine and human ways of negotiating the world. Mental abilities—like seeing, learning, fearing, trusting, and focusing—are discussed from both human and horse perspectives. Throughout, true stories of horses and handlers attempting to understand each other—sometimes successfully, sometimes not—help to illustrate the principles. Horsemanship of every kind depends on mutual interaction between equine and human brains. When we understand the function of both, we can learn to communicate with horses on their terms instead of ours. By meeting horses halfway, we achieve many goals. We improve performance. We save valuable training time. We develop much deeper bonds with our horses. We handle them with insight and kindness instead of force or command. We comprehend their misbehavior in ways that allow solutions. We reduce the human mistakes we often make while working with them. Instead of working against the horse’s brain, expecting him to function in unnatural and counterproductive ways, this book provides the information needed to ride with the horse’s brain. Each principle is applied to real everyday issues in the arena or on the trail, often illustrated with true stories from the author’s horse training experience. Horse Brain, Human Brain offers revolutionary ideas that should be considered by anyone who works with horses.
Thoroughly revised and updated, the New Edition of this definitive text explains how to care for neonates using the very latest methods. Of diagnosis and treatment.Rennie & Roberton's Textbook of Neonatology, 5th Edition represents the state-of-the-art on neonatal care, providing not only detailed pathophysiology and clinical chapters on every condition of the neonate but also comprehensive chapters on the psychosocial aspects of neonatology, such as handling perinatal death and ethical and legal aspects of neonatal care. Contributions from Fetal Medicine experts and Obstetricians provide valuable peripheral information essential to the practice of neonatology.Rennie & Roberton's Textbook of Neonatology, 5th Edition is the gold standard for neonatal care and will be an invaluable tool for everyone involved in the care of the neonate. It serves as an authoritative reference for practitioners, a valuable preparation tool for neonatal certification exams, and a useful resource for the entire neonatal care team Improved illustration program throughout –color figures, line drawings. Will facilitate quick review and enhance comprehension. Major changes have been made to the chapters on genomics, screening,and a range of neurologic, respiratory and cardiovascular disorders including: resuscitation and ventilation, chronic lung disease, periventricular leucomalcia.This book continues to provide the user with the latest clinically relevant applications in diagnosis and management to enable user to derive appropriate differential diagnosis and management plans. Latest advances in imaging techniques included (CT, cranial ultrasonography, MRI. There has been tremendous growth in the pace of development and refinement of imaging techniques. This book will ensure that the user if fully aware of their clinical applications. Incorporates the latest guidelines on clinical governance (as recommended by RCPCH).Helps ensure implementation of appropriate management plans. Selected “key references now included at end of each chapter. Experts carefully select the most important articles for further reading to facilitate further understanding/research
Features three new chapters on exercise and cognitive function, energy and fatigue, and pain; thoroughly revised chapters on the correlates of exercise, neuroscience, stress, depression, and sleep. Includes a glossary.
A clinically-focused handbook that provides an overview of the different types of insulin, delivery methods, emerging treatments, and cutting-age devices. The aim of the handbook is to discuss insulin treatment strategies that can improve glucose control, enhance patient adherence, and minimize adverse effects and disease-related complications. Concise scope and size is ideal for busy healthcare professionals that regularly encounter patients with diabetes and require an up-to-date snapshot of advances in diabetes care.
Education is one of the most fundamental prerequisites to economic growth and social stability in the world. It is also one of the most inadequately realised goals of development, with the average education of global adults remaining essentially at primary levels. Advancing Global Education is the second in a series of volumes that explores prospects for human development-how development appears to be unfolding globally and locally, how we would like it to evolve, and how better to assure that we move it in desired directions. The first volume addressed the reduction of global poverty. The third will turn to the enhancement of global health. Advancing Global Education presents the most extensive set of forecasts of global education participation and attainment levels to date-providing and exploring a massive, multi-issue database and proposing a scenario for accelerating educational attainment throughout major world regions and 183 countries.
This practical and informative text lays out the product of a number of years of clinical research into suicide behaviour and its prevention. While the focus is on non-affective psychosis and the schizophrenia-spectrum disorders, the mechanisms underlying suicide behaviour in this group may well underlie or at least influence suicide behaviour in other disorders. The authors describe methods of assessment through individual formulation, and a cognitive behavioural intervention through case studies, to reduce the risk of suicide. This book argues that: · Suicide behaviour lies on a cognitive-behavioural continuum from ideation, through intention to action. · Mechanisms based on biased information processing systems, the development of suicide schema, and appraisal styles are likely to be fruitful in explaining suicidal thoughts and behaviours. · A psychological theory of suicide behaviour is needed in order to develop a mechanism of suicide and to understand the components of suicidal thoughts and behaviours. · Suicide risk can be reduced through the use of the intervention methods described within the text Cognitive Behavioural Prevention of Suicide in Psychosis evaluates practical applications of contemporary research on this topic, and will therefore be of interest to practitioners, post-graduates in training, and researchers studying suicide and/or psychosis.
Diabetes is a chronic disease involving self-management by the patients. This book teaches providers the skills to translate and transfer complex medical information to empower patients to participate in making well-informed decisions about their own care on a daily basis, as directed by the American Diabetes Association. It provides the basic knowledge around the pathophysiology of diabetes, different management options including insulin management and calculations, information on how foods affect blood sugars and how to address cardiovascular risk factors. This book aims to change clinical outcomes through its unique presentation of information and its approach to awareness. Key Features Follows a unique approach in imparting techniques that bring long-term patient behaviour changes, making the provision of chronic disease management more efficient and satisfying Serves to help professionals in their day-to-day patient management to achieve better outcomes Addresses the area of need for primary care and helps to make well-informed decisions by understanding the essential cost of care
Take control of your cholesterol with this 10-point plan from nutrition and fitness expert Dr. Janet Brill—without using drugs. If you are one of the nearly 100 million Americans struggling with high cholesterol, then Dr. Janet Brill offers you a revolutionary new plan for taking control of your health—without the risks of statin drugs. With Dr. Brill’s breakthrough Cholesterol Down Plan, you simply add nine “miracle foods” to your regular diet and thirty minutes of walking to your daily routine. That’s all. This straightforward and easy-to-follow program can lower your LDL (“bad”) cholesterol by as much as 47 percent in just four weeks. Cholesterol Down explains Dr. Brill’s ten-point plan as well as the science behind it. You’ll learn how each miracle food affects LDL cholesterol and how the foods work together for maximum effect, as well as: • How eating whole grains helps reduce LDL cholesterol in your bloodstream • Why antioxidants keep plaque from building up in your arteries • How certain steps change the structure of LDL cholesterol particles (and why it’s best for them to be large and fluffy) • Why walking just thirty minutes a day lowers “bad” cholesterol and cuts dangerous belly fat With everything you need to stay focused on the plan, including a daily checklist, a six-month chart for racking LDL cholesterol changes, tools for assessing your risk level for cardiovascular disease, sample weekly menus, and even heart-healthy recipes, Cholesterol Down is the safe and effective alternative or complement to statin drugs.
New immigrants_those arriving since the Immigration Reform Act of 1965_have forever altered American culture and have been profoundly altered in turn. Although the religious congregations they form are often a nexus of their negotiation between the old and new, they have received little scholarly attention. Religion and the New Immigrants fills this gap. Growing out of the carefully designed Religion, Ethnicity and the New Immigration Research project, Religion and the New Immigrants combines in-depth studies of thirteen congregations in the Houston area with seven thematic essays looking across their diversity. The congregations range from Vietnamese Buddhist to Greek Orthodox, a Zoroastrian center to a multi-ethnic Assembly of God, presenting an astonishing array of ethnicity and religious practice. Common research questions and the common location of the congregations give the volume a unique comparative focus. Religion and the New Immigrants is an essential reference for scholars of immigration, ethnicity, and American religion.
This book is a practical and easily readable guide for neurologists, obstetricians, and primary care doctors treating female patients with neurological illness in their reproductive years. Offers wide ranging coverage, including family planning and lactation Presents information in approachable tables and summaries, focusing on high yield information useful for clinical consultation Is written by a team of experts and edited by recognized leaders in the field
A detailed scientific and conservation record of a group of ivory and bone furniture overlays excavated at Begram, stolen from the National Museum of Afghanistan, privately acquired on behalf of Kabul, analysed and conserved at the British Museum and returned to the National Museum in 2012
A detailed scientific and conservation record of a group of ivory and bone furniture overlays excavated at Begram, stolen from the National Museum of Afghanistan, privately acquired on behalf of Kabul, analysed and conserved at the British Museum and returned to the National Museum in 2012
A detailed scientific and conservation record of a group of ivory and bone furniture overlays excavated at Begram, stolen from the National Museum of Afghanistan, privately acquired on behalf of Kabul, analysed and conserved at the British Museum and returned to the National Museum of Afghanistan in 2012.
Profiling the best places to eat and stay on any budget, this handbook includes a language guide with useful words and phrases in seven languages. Travelers will find all the transportation options from the Channel Tunnel to Rhine cruises. of color photos. 192 maps.
Sequels, the most popular and long-lasting guide to novels in series, returns with greatly expanded series listings. Mysteries continue to be a mainstay, with fantasy, science fiction, and romance listings, plus non-genre fiction selections from authors such as Edward Abbey and Lawrence Durrell. The authors have carefully sifted through a growing group of series to select those most likely to be available in a medium-sized public library, weeding out esoteric, obscure, and less popular series. This classic reference includes hundreds of annotated series, title and subject indexes, and suggestions for reading order. Library professionals will find Answers to the perennial question, "What should I read next?" Guidance on the chronology of a series Easy-to-use tools to identify novels by character, setting, and author The definitive resource for novels in series Including series started since 1989 and updated through 2007, Sequels will be the most complete resource for general readers and library patrons as well as readers' advisors; public, university, and high school reference librarians; acquisition and collection management librarians; and even bookstore staff and book reviewers. The expanded Sequels, 4th edition, will become the RA and reference librarian's resource of choice
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