This comprehensive book is a compilation of Professor Lubomir S. Hnilica's twenty years of research experimentally addressing the chemistry and the biological functions of chromosomal proteins. The histones and other nuclear proteins found associated with DNA in a number of tissues and cell types are featured. Lubomir Hnilica played a major role in establishing the extent to which these basic chromosomal polypeptides are conserved and the manner in which they interact with DNA to modify chromatin structure. In addition, non-histone chromosomal protein research is explained, and his technique of applying several biochemical and immunological approaches to the characterization of this complex and heterogeneous class of chromosomal polypeptides is discussed. Highlighted is the use of chemical crosslinking for studying protein/DNA interactions in intact cells. The proteins as well as the structure, organization, and regulation of the genes are also presented.
While the suburbs of most metropolitan areas are wealthier than their urban counterparts, rapid regional growth can improve the welfare of both city and suburb, according to a new book from Janet Rothenberg Pack. In Growth and Convergence in Metropolitan America, Pack identifies growth trends that have contributed to the convergence of welfare among regions. Pack analyzes demographic, social, and economic data from 277 metropolitan areas in the northeastern, midwestern, southern, and western United States between 1960 and 1990. Her analysis reveals a strong connection between regional growth and improved socioeconomic vitality. She finds little connection between population growth—the focus of many previous studies—and well-being, but a strong connection between per capita income growth and well-being. Moreover, there has been a major change in the factors associated with economic growth between the 1970s and 1980s. In the latter decade, the importance of an educated labor force and major universities have assumed major importance. This appears likely to have continued to be true in the 1990s. While current urban policy has focused on intra-metropolitan cooperation as the key to improving conditions in declining or slow-growing urban areas, Pack's analysis emphasizes the major differences among the larger regions of the country—both their cities and suburbs. From this perspective, national policies, both macro-economic policy and the progressive income tax, appear to be the most effective influences promoting regional convergence and improving the socio-economic well-being of both city and suburban residents.
In recent decades, global healthcare professionals and organisations have formed a wide, evidence-based consensus that breastfeeding is usually the best option for both mother and baby. However, women and professionals alike often face a sea of shifting attitudes and values, and complex social, cultural, political and economic factors that may influence women's feeding decisions. This book examines the global evidence, and the factors that affect women's decisions around initiating breastfeeding and maintaining it through the first year of their children's lives. It outlines potential areas for development and policy change at practitioner and strategic levels, and shows how health professionals can effectively communicate and provide information to help women make unpressured but informed decisions. Breastfeeding - Contemporary Issues in Practice and Policy is essential reading for healthcare professionals, policy movers and shapers, and all those with an interest in breastfeeding who wish to influence the development of related policies, practices and healthcare services.
Nucleosides, Nucleotides, and Their Biological Applications contains the proceedings of the Fifth International Round Table on Nucleosides, Nucleotides, and Their Biological Applications held at Research Triangle Park, North Carolina on October 20-22, 1982. Contributors focus on the biological applications of nucleosides and nucleotides, along with advances in synthetic chemistry. Topic range from fast-moving biochemical subjects such as the 2',5'-oligoadenylates and their relationship to interferons; adenosine and adenine nucleotide receptors; and nucleosides with selective antiviral action. This volume is organized into 11 chapters and begins with an overview of nucleosides that are used as antiviral agents and their mechanism of action, including idoxuridine, vidarabine, and trifluridine. The discussion then shifts to the chemical and biological properties of nucleosides of purines and ring analogs; 2'-fluoroarabinosyl pyrimidines and purine-like C-nucleosides; and the potential of 2',5'-oligoadenylates as chemotherapeutic agents. The reader is also introduced to receptors for adenosine and adenine nucleotides; the function of pyrrolo[2,3-d]pyrimidine nucleosides in polynucleotides; and unusual nucleoside synthons and oligonucleotide synthesis. A chapter on the synthesis of versatile C-nucleoside precursors and certain C-nucleosides concludes the book. This book will be of value to chemists, biologists, and those with an interest in nucleosides and nucleotides.
How can we make sense of the ongoing technological changes affecting journalism and journalists today? Will the new digital generation break down barriers for journalism, or will things just stay the same? These and other pertinent questions will be asked and explored throughout this exciting new book that looks at the changing dynamics of journalism in a digital era. Examining issues and debates through cultural, social, political and economic frameworks, the book gets to grip with today′s new journalism by understanding its historical threats and remembering its continuing resilience and ability to change with the times. In considering new forms of journalistic practice the book covers important topics such as: • truth in the new journalism • the changing identity of the journalist • the economic implications for the industry • the impact on the relationship between the journalist and their audience • the legal framework of doing journalism online. Vibrant in style and accessible to all, Digital Journalism is a captivating read for anyone looking to understand the advent of a new journalism that has been altered by the latest digital technologies.
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