Preclinical and Clinical Modulation of Anticancer Drugs focuses on the theoretical and practical approaches to designing and enacting modulation principles. Each class of anticancer drug and the different types of modulators used within each drug class are discussed within individual chapters. The molecular and biochemical rationale for the use of specific modulators is discussed in detail, and preclinical and clinical implications of the data are integrated into each chapter. Mechanisms of drug resistance and the reasons behind circumventing the resistant phenotype are covered. The book will interest cancer chemotherapists, pharmacologists, oncologists, biochemists, and experimental therapeutics researchers, in addition to students studying the principles of drug discovery and protocol design.
Houdini the caterpillar is a classroom pet who loves the spotlight. When his tricks stop being so amazing, Houdini needs to come up with a new act. Pedersen combines science and fiction in a fresh and entertaining way to explain the stage's of a monarch butterfly's metamorphosis. Full color.
A lively and intimate portrait of an unsung heroine in American dance Martha Hill (1900–1995) was one of the most influential figures of twentieth century American dance. Her vision and leadership helped to establish dance as a serious area of study at the university level and solidify its position as a legitimate art form. Setting Hill's story in the context of American postwar culture and women's changing status, this riveting biography shows us how Hill led her colleagues in the development of American contemporary dance from the Kellogg School of Physical Education to Bennington College and the American Dance Festival to the Juilliard School at Lincoln Center. She created pivotal opportunities for Martha Graham, Doris Humphrey, Charles Weidman, Hanya Holm, José Limón, Merce Cunningham, and many others. The book provides an intimate look at the struggles and achievements of a woman dedicated to taking dance out of the college gymnasium and into the theatre, drawing on primary sources that were previously unavailable. It is lavishly illustrated with period photographs.
John Payne Collier (1789–1883), one of the most controversial figures in the history of literary scholarship, pursued a double career. A prolific and highly influential writer on the drama, poetry, and popular prose of Shakespeare's age, Collier was at the same time the promulgator of a great body of forgeries and false evidence, seriously affecting the text and biography of Shakespeare and many others. This monumental two-volume work for the first time addresses the whole of Collier's activity, systematically sorting out his genuine achievements from his impostures. Arthur and Janet Freeman reassess the scholar-forger's long life, milieu, and relations with a large circle of associates and rivals while presenting a chronological bibliography of his extensive publications, all fully annotated with regard to their creditability. The authors also survey the broader history of literary forgery in Great Britain and consider why so talented a man not only yielded to its temptations but also persisted in it throughout his life.
In Inside Apartheid, South African-born Janet Levine recounts the horrors and struggles she faced against the minority white government’s brutal system of repression from a rare perspective—that of a white woman who worked within the system even as she fought to transform it. With candor and courage, Levine skillfully interweaves her personal story of a privileged white citizen’s growing awareness of the evils of apartheid with a moving account of the increasing violence in and radical polarization of South Africa. Inside Apartheid brings to life both the unsurpassed physical beauty and the institutionalized brutality of the country Levine loves so deeply. We accompany her on a daring trip to the devastated black township of Soweto immediately following the unrest in 1976. There she visits the home of a “colored” family with no way out of apartheid induced poverty. On a journey through the “black” homelands where Levine discovers firsthand the horrifying evidence of the long-term genocide of three million people. As a student activist, as a journalist, and as an elected member of the Johannesburg City Council, Levine openly attacked the government’s policies in hundreds of speeches and articles, led election campaigns for one of her mentors, member of Parliament Helen Suzman, and was associated with Steve Biko and other less internationally famous but equally important South African figures. Levine was a founding member of the first black taxi co-operative in South Africa, and instrumental in having hundreds of illegally fired black workers reinstated with back pay after the Johannesburg strikes of 1980. We feel Levine’s pain when she finally asks soul-searching questions about the effectiveness of being a white activist. Inside Apartheid, with such honest witness-bearing, may be her most important act of all.
The Summer Smarts series features activities and skills exercises that provide a substantive and fun bridge that covers all appropriate subjects between grades during the summer.
This practical, step-by-step guide examines the stages of contemplating, planning, and implementing curriculum mapping initiatives that can improve student learning and create sustainable change.
Compared to nice Ms. Simpson, Mr. Garrett, Ellie's substitute teacher, seems mean and unfair, until his handling of several class crises changes Ellie's feelings towards him.
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