An extraordinarily beautiful, original, though-provoking, action-inciting creation." Thomas Berry - historian, priest and author of The Dream of the Earth, The Universe Story and the Great Work.
Most of the modeling performed in biology aims at achieving a quantitative description and understanding of the intracellular signaling pathways within a "typical cell". However, in many biologically important situations even genetically identical cell populations show a heterogeneous response. This means that individual members of the cell population behave differently. Such situations require the study of cell-to-cell variability and the development of models for heterogeneous cell populations. The main contribution of this thesis is the development of unifying modeling frameworks for signal transduction and proliferation processes in heterogeneous cell populations. These modeling frameworks allow for the detailed description of individual cells as well as differences between them. In contrast to many existing modeling approaches, the proposed frameworks allow for a direct comparison of model predictions with available data. Beyond this, the proposed population models can be simulated efficiently and, by exploiting the model structures, we are able to develop model-tailored Bayesian parameter estimation methods. These methods enable the calculation of the optimal parameter estimates, as well as the evaluation of the parameter and prediction uncertainties. The proposed tools allow for novel insights in population dynamics, in particular the model-based characterization of population heterogeneity and cellular subgroups. This is illustrated for two different application examples: pro- and anti-apoptotic signaling, which is interesting in the context of cancer therapy, and immune cell proliferation.
This volume, dealing with Nucleation, Aggregation and Crystallization, consists of a compilation of lectures offered at the international course held at Karolinska Institute and at the scientific meetings of the MARIE Network. The word “nucleation,” derived from “nuclear family,” refers to the concept of the progenitor, or the mother and the father of any family. Only in the last few centuries have physicists “borrowed” the word, and more recently, biologists for Theodor Schwann's cell theory. Most recently, the term has come into use in atomic theory, spectroscopy, and radioactivity, as well as in the fields of atomic bombs, fission, and fusion. Nucleation as a physicochemical process is followed by two poorly understood phenomenon — aggregation and crystallization, which underlie disorders like Alzheimer's and “mad-cow” disease (aggregation of amyloid plaque), cardiovascular diseases (deposition in coronary vessels of cholesterol and lipids), and the appearance of crystals under physiological conditions (gout, silicoses, and liver or kidney stones). Written by leading scientists in the field, including one Nobel Laureate, this book provides a unique perspective between the physical and chemical sciences on the one hand, and the biological and medical sciences on the other, and should be of considerable value to scientists, physicians, students, and the interested lay public.
Completely updated edition, written by a close-knit author team Presents a unique approach to stroke - integrated clinical management that weaves together causation, presentation, diagnosis, management and rehabilitation Includes increased coverage of the statins due to clearer evidence of their effectiveness in preventing stroke Features important new evidence on the preventive effect of lowering blood pressure Contains a completely revised section on imaging Covers new advances in interventional radiology
Indonesia is the home of the largest single Muslim community of the world. Its Christian community, about 10% of the population, has until now received no overall description in English. Through cooperation of 26 Indonesian and European scholars, Protestants and Catholics, a broad and balanced picture is given of its 24 million Christians. This book sketches the growth of Christianity during the Portuguese period (1511-1605), it presents a fair account of developments under the Dutch colonial administration (1605-1942) and is more elaborate for the period of the Indonesian Republic (since 1945). It emphasizes the regional differences in this huge country, because most Christians live outside the main island of Java. Muslim-Christian relations, as well as the tensions between foreign missionaries and local theology, receive special attention.
This text presents primary care information for the nurse-midwifery scope of practice, including management of primary care problems in essentially healthy women, and the management/coordination of primary care for pregnant women with significant, established medical conditions. The text covers prevention, including lifestyle changes and immunizations; screening; management of common health problems appropriate to nurse-midwifery practice; and the presentation and management of common health problems in pregnancy.
Primary Care of Women, Second Edition is an essential and easy-to use resource for healthcare providers who offer primary care to women. Ideal for new and experienced clinicians, it focuses on the need to address women’s health holistically. Each chapter begins by discussing common symptoms and how to evaluate them before moving on to diagnosis and management of the most common conditions seen in women. Topics include prevention, screening, management of common health problems, and the presentation and management of common health issues in pregnancy. Completely updated and revised, the Second Edition includes new chapters on sleep disorders, dental health, and complementary and alternative medicine. Also included is an increased focus on topics such as mental health and violence.
The second volume of the series Manuals in Biomedical Research, this book is aimed to be both a concise introduction to the diverse field of microscopy and a practical guide those who require the use of microscopic for methods in their research. It provides young as well as experienced scientists a state-of-the-art multidisciplinary overview of microscopic techniques, covering all the major microscopy fields in biomedical sciences and showing their application in evaluating samples ranging from molecules to cells and tissues.Microscopy has revolutionized our understanding of biological events. Within the last two decades, microscopic techniques have provided insights into the dynamics of biological processes that regulate such events. Biological discovery, to a large extent, depends on advances in imaging techniques and various microscopic techniques have emerged as central and indispensable tools in the biomedical sciences.The four authors bring with them extensive experiences spanning across disciplines such as Microbiology, Molecular and Cell Biology, Tissue Engineering, Biomedical and Regenerative Medicine and so forth, reinforcing the fact that microscopy has proven useful in countless investigations into the mysteries of life.
Jan Bakker vertelt over zijn leven, een leven waarin hij veel heeft meegemaakt. De Tweede Wereldoorlog in het hotel van zijn vader, het Victoria hotel in Groningen. De politionele acties in Indonesië waar hij als dienstplichtig militair bij de MP was ingedeeld. Het Odeon theater in Zwolle waar hij meer dan 20 jaar directeur van was. En niet te vergeten de vele reizen die hij samen met zijn vrouw maakte in Europa, Afrika het Midden-Oosten en Indonesië.
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