The long-awaited story of the science, the business, the politics, the intrigue behind the scenes of the most ferocious competition in the history of modern science—the race to map the human genome. On May 10, 1998, biologist Craig Venter, director of the Institute for Genomic Research, announced that he was forming a private company that within three years would unravel the complete genetic code of human life—seven years before the projected finish of the U.S. government’s Human Genome Project. Venter hoped that by decoding the genome ahead of schedule, he would speed up the pace of biomedical research and save the lives of thousands of people. He also hoped to become very famous and very rich. Calling his company Celera (from the Latin for “speed”), he assembled a small group of scientists in an empty building in Rockville, Maryland, and set to work. At the same time, the leaders of the government program, under the direction of Francis Collins, head of the National Human Genome Research Institute at the National Institutes of Health, began to mobilize an unexpectedly unified effort to beat Venter to the prize—knowledge that had the potential to revolutionize medicine and society. The stage was set for one of the most thrilling—and important—dramas in the history of science. The Genome War is the definitive account of that drama—the race for the greatest prize biology has had to offer, told by a writer with exclusive access to Venter’s operation from start to finish. It is also the story of how one man’s ambition created a scientific Camelot where, for a moment, it seemed that the competing interests of pure science and commercial profit might be gloriously reconciled—and the national repercussions that resulted when that dream went awry.
This volume is part of a two-volume set that contains over 1,000 local and national articles, from historical newspapers and other publications, relating to the pioneer history of the area of northeastern Kentucky known as the "Buffalo Trace," including the counties of Mason, Bracken, Fleming, Robertson and Lewis, and the adjacent Ohio counties of Adams and Brown.
A journey from Burning Man to the Akashic Field that suggest how 5-MeO-DMT triggers the human capacity for higher knowledge through direct contact with the zero-point field • Examines Bufo alvarius toad venom, which contains the potent natural psychedelic 5-MeO-DMT, and explores its entheogenic use • Proposes a new connection between the findings of modern physics and the knowledge held by shamans and religious sages for millennia The venom from Bufo alvarius, an unusual toad found in the Sonoran desert, contains 5-MeO-DMT, a potent natural chemical similar in effect to the more common entheogen DMT. The venom can be dried into a powder, which some researchers speculate was used ceremonially by Amerindian shamans. When smoked it prompts an instantaneous break with the physical world that causes out-of-body experiences completely removed from the conventional dimensions of reality. In Tryptamine Palace, James Oroc shares his personal experiences with 5-MeODMT, which led to a complete transformation of his understanding of himself and of the very fabric of reality. Driven to comprehend the transformational properties of this substance, Oroc combined extensive studies of physics and philosophy with the epiphanies he gained from his time at Burning Man. He discovered that ingesting tryptamines unlocked a fundamental human capacity for higher knowledge through direct contact with the zero-point field of modern physics, known to the ancients as the Akashic Field. In the quantum world of nonlocal interactions, the line between the physical and the mental dissolves. 5-MeO-DMT, Oroc argues, can act as a means to awaken the remarkable capacities of the human soul as well as restore experiential mystical spirituality to Western civilization.
This new edition of a well-established textbook covers the environmental and engineering aspects of the management of rainwater and wastewater in areas of human development. Urban Drainage deals comprehensively not only with the design of new systems, but also the analysis and upgrading of existing infrastructure. Keeping its balance of principles, practice and research, this new edition has significant new material on modelling, resilience, smart systems, and the global and local context. The two new authors bring further research and practice-based experience. This is an essential text for undergraduate and graduate students, lecturers and researchers in water engineering, environmental engineering, public health engineering, engineering hydrology, and related non-engineering disciplines. It also serves as a dependable reference for drainage engineers in water service providers, local authorities, and for consulting engineers. Extensive examples are used to support and demonstrate the key issues throughout the text.
The long-awaited story of the science, the business, the politics, the intrigue behind the scenes of the most ferocious competition in the history of modern science—the race to map the human genome. On May 10, 1998, biologist Craig Venter, director of the Institute for Genomic Research, announced that he was forming a private company that within three years would unravel the complete genetic code of human life—seven years before the projected finish of the U.S. government’s Human Genome Project. Venter hoped that by decoding the genome ahead of schedule, he would speed up the pace of biomedical research and save the lives of thousands of people. He also hoped to become very famous and very rich. Calling his company Celera (from the Latin for “speed”), he assembled a small group of scientists in an empty building in Rockville, Maryland, and set to work. At the same time, the leaders of the government program, under the direction of Francis Collins, head of the National Human Genome Research Institute at the National Institutes of Health, began to mobilize an unexpectedly unified effort to beat Venter to the prize—knowledge that had the potential to revolutionize medicine and society. The stage was set for one of the most thrilling—and important—dramas in the history of science. The Genome War is the definitive account of that drama—the race for the greatest prize biology has had to offer, told by a writer with exclusive access to Venter’s operation from start to finish. It is also the story of how one man’s ambition created a scientific Camelot where, for a moment, it seemed that the competing interests of pure science and commercial profit might be gloriously reconciled—and the national repercussions that resulted when that dream went awry.
Chemistry and Methods of Enzymes, Third Edition focuses on the processes, methodologies, and reactions in enzyme chemistry, as well as kinetics, nucleases, esterases, and carbohydrates. The publication first underscores the general properties of enzymes, including chemical nature, occurrence, numerical characterization of enzyme concentration, kinetics of enzyme reactions, preparation of commercial enzymes, purification and preservation of enzymes, relations of vitamins to enzymes, and zymogens and kinases. The text then takes a look at esterases and carbohydrates. Topics include pectin depolymerase, heparinase, xylanase, chitinase, dextranase, trehalase, nucleotide phosphatases, glucosulfatase, and gastric lipase. The manuscript examines nucleases, nuclein deaminases, amidases, proteolytic enzymes, and hydrases. Discussions focus on enolase, aconitase, peptidases as metalloproteins, glutaminases, aspartase, urease, adenosine deaminase, and nucleoside phosphorylase. The book also elaborates on iron and copper enzymes, dehydrogenases containing coenzymes I and II, and yellow enzymes. The text is a dependable source of data for chemists and researchers wanting to dig deeper into the chemistry and methods of enzymes.
The most widely published book in the world is the Bible. It is also the most criticized book in print. With the development of modern communication technology, critics can attack the Bible on a global scale, bypass reviews and quality-control processes, and make unchallenged claims. The information appears to be truthful and is presented with authority but ignores the real truth. The objective of this book is to compare Bible statements primarily from Genesis with modern scientific knowledge. The result is an excellent match between the Bible, written thousands of years ahead of the scientific discoveries, and science.
Since Hollywood's first motion-picture, stunt players have given blood, sweat, and tears to the business. From high falls and horse gags to fist-fights, fire, water-work and automotive mayhem, this largely unsung group of action-performers has been making movie violence believable and telling stories through exciting sequences without so much as an Oscar category to acknowledge their work. This book follows the careers of Loren Janes and Mickey Gilbert, two fabled stunt practitioners born and trained during the pre-CGI film age, and shares their secrets of the trade while walking through five decades of movie magic. The fascinating and original conversations discuss some of Hollywood's most action-packed flicks such as Spartacus, How the West Was Won, Bullitt, The Wild Bunch, Butch Cassidy and the Sundance Kid and Little Big Man.
Childhood Autism provides clinicians with a comprehensive guide for working with autistic children and their families. It offers practical assistance with early diagnosis, cutting edge treatment options and goals, interdisciplinary insights, and available resources. Empirical research findings are presented in a clear, accessible manner. Perhaps most importantly, vivid case examples bring both the therapist’s and patient’s experience to the fore as they work towards recovery. This clear and informative book should be required reading for professionals and students in the fields of medicine, social work, psychology, education, and any other clinicians who work with children on the autism spectrum.
How did Shakespeare write his plays and how were they revised during their passage to the stage? James Purkis answers these questions through a fresh examination of often overlooked evidence provided by manuscripts used in early modern playhouses. Considering collaboration and theatre practice, this book explores manuscript plays by Anthony Munday, Thomas Middleton, and Thomas Heywood to establish new accounts of theatrical revision that challenge formerly dominant ideas in Shakespearean textual studies. The volume also reappraises Shakespeare's supposed part in the Sir Thomas More manuscript by analysing the palaeographic, orthographic, and stylistic arguments for Shakespeare's authorship of three of the document's pages. Offering a new account of manuscript writing that avoids conventional narrative forms, Purkis argues for a Shakespeare fully participant in a manuscript's collaborative process, demanding a reconsideration of his dramatic canon. The book will greatly interest researchers and advanced students of Shakespeare studies, textual history, authorship studies and theatre historians.
This book examines the way that climate change and conflict have shaped human experience historically, and forecasts future trends and possible opportunities for changing the historical path we are on.
Focuses on physical, social and applied athropology, archaeology, linguistics and symbolic communication. Topics include hominid evolution, primate behaviour, genetics, ancient civilizations, cross-cultural studies and social theories.
This text explores the representation of race/ethnicity in a multiethnic school. Employing a critical case study approach, it appeals to the wider social context to explain the unequal struggle over the meaning of race and ethnicity in the school. In doing so it examines how stereotyping, curriculum, identity and language practices provide advantages for some and penalize others. The book also provides suggestions for how educators might find ways to introduce discourses that make it possible for traditionally marginalized students and members of the community to have their voices heard and to shape meanings that work in their interest.
The definitive insider's history of the genetic revolution--significantly updated to reflect the discoveries of the last decade. James D. Watson, the Nobel laureate whose pioneering work helped unlock the mystery of DNA's structure, charts the greatest scientific journey of our time, from the discovery of the double helix to today's controversies to what the future may hold. Updated to include new findings in gene editing, epigenetics, agricultural chemistry, as well as two entirely new chapters on personal genomics and cancer research. This is the most comprehensive and authoritative exploration of DNA's impact--practical, social, and ethical--on our society and our world.
This book explores the challenges that school administratorsface in ethnically diverse contexts. Based on an empirical study, itshows how principals do or do not promote inclusive practices in theirschools. The various chapters cover principal perceptions of, andresponses to, racism and antiracism, school community relationships, and difference. Also addressed are administrators' efforts to learnabout diversity and to educate others in their school communitiesabout it.This volume is the first of its kind to specifically target schooladministrators and ethnic diversity. While collections of essays andindividual articles have explored general and specific aspects ofdiversity, no book to date has targeted leadership and ethnicaldiversity specifically, is supported by empirical data, or follows aconsistent theme throughout. This book will be of interest to schooladministrators, prospective administrators, teachers, graduatestudents, academics and all others who are concerned about education, leadership, diversity and inclusion.
In an era characterized by the rapid evolution of the concept of literacy, the Handbook of Research on Teaching Literacy Through the Communicative and Visual Arts focuses on multiple ways in which learners gain access to knowledge and skills. The handbook explores the possibilities of broadening current conceptualizations of literacy to include the full array of the communicative arts (reading, writing, speaking, listening, viewing) and to focus on the visual arts of drama, dance, film, art, video, and computer technology. The communicative and visual arts encompass everything from novels and theatrical performances to movies and video games. In today's world, new methods for transmitting information have been developed that include music, graphics, sound effects, smells, and animations. While these methods have been used by television shows and multimedia products, they often represent an unexplored resource in the field of education. By broadening our uses of these media, formats, and genres, a greater number of students will be motivated to see themselves as learners. In 64 chapters, organized in seven sections, teachers and other leading authorities in the field of literacy provide direction for the future: I. Theoretical Bases for Communicative and Visual Arts Teaching Paul Messaris, Section Editor II. Methods of Inquiry in Communicative and Visual Arts Teaching Donna Alvermann, Section Editor III. Research on Language Learners in Families, Communities, and Classrooms Vicki Chou, Section Editor IV. Research on Language Teachers: Conditions and Contexts Dorothy Strickland, Section Editor V. Expanding Instructional Environments: Teaching, Learning, and Assessing the Communicative and Visual Arts Nancy Roser, Section Editor VI. Research Perspectives on the Curricular, Extracurricular, and Policy Perspectives James Squire, Section Editor VII. Voices from the Field Bernice Cullinan and Lee Galda, Section Editors The International Reading Association has compiled in the Handbook of Research on Teaching Literacy Through the Communicative and Visual Arts an indispensable set of papers for educators that will enable them to conceptualize literacy in much broader contexts than ever before. The information contained in this volume will be extremely useful in planning literacy programs for our students for today and tomorrow.
Each May, the Continuing Education Division of the T.J.Watson School of Engineering, Applied Science and Technology at the State University of New York at Binghamton sponsors an Annual Symposium in Electronics Packaging in cooperation with local professional societies (IEEE, ASME, SME, IEPS) and UnlPEG (the University-Industry Partnership for Economic Growth.) Each volume of this Electronics Packaging Forum series is based on the the preceding Symposium, with Volume Two based on the 1990 presentations. The Preface to Volume One included a brief definition of the broad scope of the electronics packaging field with some comments on why it has recently assumed such a more prominent priority for research and development. Those remarks will not be repeated here; at this point it is assumed that the reader is a professional in the packaging field, or possibly a student of one of the many academic disciplines which contribute to it. It is worthwhile repeating the series objectives, however, so the reader will be clear as to what might be expected by way of content and level of each chapter.
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