Chemical warfare watchers, from scientists to policy advocates, often wonder what went on at the Army Chemical Center during the 1960s. It was a decade in which thousands of Army enlisted men served as volunteers for the secret testing of chemical agents. The actual historical record, however, has until now remained disturbingly incomplete. What chemicals was the Army studying? Why was the program never fully documented in books available to the public? Who planned and carried out the tests, and what was their purpose? How, and by whom, were the volunteers recruited? How adequately were they instructed before giving their informed consent? What long range effects, if any, have been found in follow-up studies? Written by the physician who played a pivotal role in psychoactive drug testing of hundreds of volunteers, the story breaks an official silence that has lasted almost fifty years. Dr. James Ketchum may be the only scientist still equal to the task. His book goes a long way toward revealing the contents of once classified documents that still reside in restricted archives. The author spent most of a decade testing over a dozen potential incapacitating agents including LSD, BZ and marijuana derivatives. His 380-page narrative, loaded with both old and recent photographs, derives from technical reports, memoranda, films, notes and memories. Written primarily for the general reader, but supplemented by a voluminous appendix of graphs and tables for the technically inclined, Dr. Ketchum's book combines a subjective diary with an objective report of the external events that shaped and eventually terminated the program. Informal and autobiographical in style, it includes numerous amusing anecdotes and personality portraits that make it simultaneously intriguing and informative.
A genealogical dictionary of our early colonists. Every volume shows three generations of those who came before 1692. Although more than a century has elapsed since the publication of this monumental work, it remains the standard to our day. We do not mean that new information has not been unearthed or that the work is free from errors, but Savage had just the peculiar qualifications necessary. He was so persistent in gathering data and so conservative in his use of them, that a statement made on his authority bears great weight. This work has the whole of New England for its field. This is volume 3, covering the surnames K - R.
A genealogical dictionary of our early colonists. Every volume shows three generations of those who came before 1692. Although more than a century has elapsed since the publication of this monumental work, it remains the standard to our day. We do not mean that new information has not been unearthed or that the work is free from errors, but Savage had just the peculiar qualifications necessary. He was so persistent in gathering data and so conservative in his use of them, that a statement made on his authority bears great weight. This work has the whole of New England for its field. This is volume 4, covering the surnames S - Z.
A genealogical dictionary of our early colonists. Every volume shows three generations of those who came before 1692. Although more than a century has elapsed since the publication of this monumental work, it remains the standard to our day. We do not mean that new information has not been unearthed or that the work is free from errors, but Savage had just the peculiar qualifications necessary. He was so persistent in gathering data and so conservative in his use of them, that a statement made on his authority bears great weight. This work has the whole of New England for its field. This is volume 1, covering the surnames A - C.
Employing the clear, student-friendly style that made previous editions so popular, Insect Physiology and Biochemistry, Fourth Edition presents an engaging and authoritative guide to the latest findings in the dynamic field of insect physiology. The book supplies a comprehensive picture of the current state of the function, development, and reproduction of insects. Expanded and updated, now in full colour, this fourth edition adds three new chapters on the role of the nervous system in behavior; the ‘Genomics Revolution’ in entomology; and global climate changes which have a major effect on insects, including warming and weather. It continues to challenge conventional entomological wisdom with the latest research and analytical interpretations. The text will appeal to upper undergraduate and graduate students and to practicing biologists who need to possess a firm knowledge of the broad principles of insect physiology. With detailed full colour illustrations to help explain physiological concepts and important anatomical details, it remains the most easily accessible guide to key concepts in the field.
Myosins are a diverse superfamily of molecular motor proteins, which share the ability to reversibly bind actin and hydrolyse MgATP. They are capable of either translocating actin filaments or translocating vesicles or other cargo on fixed actin filaments. There are currently 15 distinct classes in the myosins superfamily, based on sequence homology. Myosin II and myosin I proteins are familiar and well studied; while Classes III-XV are less well characterized. All myosins examined to date are multimeric and appear to possess at least three functional domains, a head, neck, and tail. Myosins (second edition) explores the structure and functional properties of myosins, their regulation, and mutational analysis. It has been thoroughly updated since the first edition was published in 1995 including sections on the three additional classes defined by new sequences, information provided by the crystal structure of seven new Dicytostelium motor domains, and data from new techniques such as molecular imaging and tagging proteins with GFP 20. The three human diseases that are now known to be linked to mutations in different myosin heavy or light chains are also covered, including more than 50 mutations associated with hyperotrophic cardiomyopathy.
Developing Performance Support for Computer Systems: A Strategy for Maximizing Usability and Learnability provides detailed planning, design, and development guidance for generating performance support for new or upgraded computer systems. Performance support includes documentation, online help, coaches and wizards, training, and other materials necessary to enable users to perform their jobs more efficiently and effectively. This volume offers a strategy for maximizing ease-of-use and ease-of-learning through an integrated performance support systems approach. The text provides how-to guidance throughout that developers can apply directly to the design of their performance support tools and products. Rather than cover a few specific topic areas, it examines the entire spectrum of performance support. The book explains how to match performance support methods to task requirements, gives an overview of important user characteristics, and provides general guidance for presentation, layout, formatting, media selection, the use of color and icons, and accessibility. Evaluation checklists are included in the appendices and are also available online. Although this book primarily addresses the development of performance support for large software systems, the principles and approaches are valuable for any systems development environment.
A genealogical dictionary of our early colonists. Every volume shows three generations of those who came before 1692. Although more than a century has elapsed since the publication of this monumental work, it remains the standard to our day. We do not mean that new information has not been unearthed or that the work is free from errors, but Savage had just the peculiar qualifications necessary. He was so persistent in gathering data and so conservative in his use of them, that a statement made on his authority bears great weight. This work has the whole of New England for its field. This is volume 2, covering the surnames D - J.
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