This reference evaluates and describes the latest strategies for hormone suppression and blockade in the management of early and advanced stage breast cancer and explores the effects of tamoxifen, selective estrogen receptor modulators (SERMs), aromatase inhibitors, and their combination on both breast cancers and normal tissues. Endocrine T
The Macedonian Empire lasted only 36 years, beginning with Philip II's assumption of the throne in 359 B.C. and ending with the death of his son Alexander the Great in 323 B.C. In that span, the two leaders changed the map in the known world. Philip established new tactics that forever ended the highly stylized mode that had characterized Classic Greek warfare, and Alexander's superb leadership made the army an unstoppable force. This work first examines the 11 great armies and three great navies of the era, along with their operations and logistics. The primary focus is then on each campaign and significant battle fought by Philip or Alexander, detailing how the battles were fought, the tactics of the opposing armies, and how the Macedonians were able to triumph.
Critical Practices in International Theory brings together for the first time the essays of the leading IR theorist, James Der Derian. The essays cover a variety of issues central to Der Derian's work including diplomacy, alienation, terrorism, intelligence, national security, new forms of warfare, the role of information technology in international relations, poststructuralist theory, and the military-entertainment-media matrix. The book includes a framing introduction written for this volume in which Der Derian provides historical and theoretical context for a diverse body of work. Discussing his own influences and reflecting upon the development of international theory, he advocates a critical pluralist approach to the most pressing problems of world politics. Written in the eloquent style that marks out Der Derian as one of the most provocative and innovative thinkers in international relations, this collection is essential reading for scholars and students interested in the past, present and future of international relations. James Der Derian is a Watson Institute research professor of international studies at Brown University, where he directs the Global Security Program and the Global Media Project. He is the author of many articles and books, including the highly acclaimed Virtuous War (2001, 2009).
Easily accessible and clinically focused, Abeloff's Clinical Oncology, 6th Edition, covers recent advances in our understanding of the pathophysiology of cancer, cellular and molecular causes of cancer initiation and progression, new and emerging therapies, current trials, and much more. Masterfully authored by an international team of leading cancer experts, it offers clear, practical coverage of everything from basic science to multidisciplinary collaboration on diagnosis, staging, treatment and follow up. - Includes new chapters on Cancer Metabolism and Clinical Trial Designs in Oncology and a standalone chapter on lifestyles and cancer prevention. - Features extensive updates including the latest clinical practice guidelines, decision-making algorithms, and clinical trial implications, as well as new content on precision medicine, genetics, and PET/CT imaging. - Includes revised diagnostic and treatment protocols for medical management, surgical considerations, and radiation oncology therapies, stressing a multispecialty, integrated approach to care. - Helps you find information quickly with updated indexing related to management recommendations, focused fact summaries, updated key points at the beginning of each chapter ideal for quick reference and board review, and algorithms for patient evaluation, diagnosis, and treatment options. - Offers more patient care coverage in disease chapters, plus new information on cancer as a chronic illness and cancer survivorship. - Discusses today's key topics such as immuno-oncology, functional imaging, precision medicine, the application of genetics in pathologic diagnosis and sub-categorization of tumors as well as the association of chronic infectious diseases such as HIV and cancer. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
The Philosophy of Science Fiction: Henri Bergson and the Fabulations of Philip K. Dick explores the deep affinity between two seemingly quite different thinkers, in their attempts to address the need for salvation in (and from) an era of accelerated mechanization, in which humans' capacity for destroying or subjugating the living has attained a planetary scale. The philosopher and the science fiction writer come together to meet the contradictory imperatives of a realist outlook-a task which, arguably, philosophy and science fiction could only ever adequately undertake in collaboration. Their respective approaches meet in a focus on the ambiguous status of fictionalizing, or fabulation, as simultaneously one of mechanization's most devastating tools, and the possibility of its undoing. When they are read together, the complexities and paradoxes thrown up by this ambiguity, with which both Bergson and Dick struggle on their own, open up new ways to navigate ideas of mechanism and mysticism, immanence and transcendence, and the possibility and meaning of salvation. The result is at once an original reading of both thinkers, a new critical theory of the socio–cultural, political and ethical function of fictionalizing, and a case study in the strange affinity, at times the uncanny similarity, between philosophy and science fiction.
As humans, we all express our grief differently. Acknowledging this truth, Dr. James Harrichand examines Old Testament accounts of grief and mourning alongside the experiences of marginalized Guyanese and Vietnamese immigrant communities in Canada. He explores both biblical and pastoral theology through an anthropological lens, bridging the horizons of Scripture and culture in a hermeneutically and pastorally sensitive manner. Dr. Harrichand’s focus on prosaic prayers in the Old Testament fills a significant gap in the scholarship, but this book is also significant for its immense practicality, sensitizing readers to grief’s varied expressions and equipping culturally intelligent pastoral caregivers. He presents five compassionate intercultural care practices for coping with grief, grounding each in the living hope of the redemptive work of Jesus Christ, the one who bore our griefs and carries our sorrows.
An inviting, fascinating compendium of twenty-one of history's most famous lost places, from the Tower of Babel to the Twin Towers Buildings are more like us than we realize. They can be born into wealth or poverty, enjoying every privilege or struggling to make ends meet. They have parents—gods, kings and emperors, governments, visionaries and madmen—as well as friends and enemies. They have duties and responsibilities. They can endure crises of faith and purpose. They can succeed or fail. They can live. And, sooner or later, they die. In Fallen Glory, James Crawford uncovers the biographies of some of the world’s most fascinating lost and ruined buildings, from the dawn of civilization to the cyber era. The lives of these iconic structures are packed with drama and intrigue. Soap operas on the grandest scale, they feature war and religion, politics and art, love and betrayal, catastrophe and hope. Frequently their afterlives have been no less dramatic—their memories used and abused down the millennia for purposes both sacred and profane. They provide the stage for a startling array of characters, including Gilgamesh, the Cretan Minotaur, Agamemnon, Nefertiti, Genghis Khan, Henry VIII, Catherine the Great, Adolf Hitler, and even Bruce Springsteen. The twenty-one structures Crawford focuses on include The Tower of Babel, The Temple of Jerusalem, The Library of Alexandria, The Bastille, Kowloon Walled City, the Berlin Wall, and the Twin Towers of the World Trade Center. Ranging from the deserts of Iraq, the banks of the Nile and the cloud forests of Peru, to the great cities of Jerusalem, Istanbul, Paris, Rome, London and New York, Fallen Glory is a unique guide to a world of vanished architecture. And, by picking through the fragments of our past, it asks what history’s scattered ruins can tell us about our own future.
Nevada has changed dramatically over the past quarter century, and in this third edition of The Silver State, renowned historian James W. Hulse recounts the major events—historical, political, and social—that have shaped our state. Hulse’s cohesive approach offers students and general readers an accessible account of Nevada’s colorful history. The new edition highlights the social and political changes that have occurred since the original publication of The Silver State in 1991. Hulse discusses the impact of a growing population; changes in the economy and education system; expanding roles of women; recent developments in state politics, including the 2003 legislative session; the influence of Nevada’s growing ethnic population and increasingly divergent demographic groups; and the impact of federal policies, including President George W. Bush’s 2002 decision to authorize the opening of a nuclear-waste depository at Yucca Mountain. In addition, all the recommended reading lists have been updated. The Silver State explores many dimensions of the Nevada experience and its peoples. This book will inspire readers to take another look at the rich cultural heritage and eventful history of Nevada, the Silver State.
A journey from Burning Man to the Akashic Field that suggest how 5-MeO-DMT triggers the human capacity for higher knowledge through direct contact with the zero-point field • Examines Bufo alvarius toad venom, which contains the potent natural psychedelic 5-MeO-DMT, and explores its entheogenic use • Proposes a new connection between the findings of modern physics and the knowledge held by shamans and religious sages for millennia The venom from Bufo alvarius, an unusual toad found in the Sonoran desert, contains 5-MeO-DMT, a potent natural chemical similar in effect to the more common entheogen DMT. The venom can be dried into a powder, which some researchers speculate was used ceremonially by Amerindian shamans. When smoked it prompts an instantaneous break with the physical world that causes out-of-body experiences completely removed from the conventional dimensions of reality. In Tryptamine Palace, James Oroc shares his personal experiences with 5-MeODMT, which led to a complete transformation of his understanding of himself and of the very fabric of reality. Driven to comprehend the transformational properties of this substance, Oroc combined extensive studies of physics and philosophy with the epiphanies he gained from his time at Burning Man. He discovered that ingesting tryptamines unlocked a fundamental human capacity for higher knowledge through direct contact with the zero-point field of modern physics, known to the ancients as the Akashic Field. In the quantum world of nonlocal interactions, the line between the physical and the mental dissolves. 5-MeO-DMT, Oroc argues, can act as a means to awaken the remarkable capacities of the human soul as well as restore experiential mystical spirituality to Western civilization.
The reign of Henry VIII saw a renascent militarism encapture England. Memories of great victories over the French remained fresh and resplendent in the psyche and pageantry of early-Tudor England, and the pursuit of glory on the battlefield and of due recognition of England as a major player in European power politics were the identifying features of Henry's reign. In an exciting new work, James Raymond traces the development of Henry's military establishment within the context of the wider European military revolution. Making use of extensive new research into the military literature of the mid-Tudor period, 'Henry VIII's Military Revolution' is able to root firmly the military theories of the time within the solid realities of Henry's army. Raymond pays particular attention to the rise of professionalism in the English military, and its adaptation to new technologies and ideas. In this vein, the career of Sir Christopher Morris, Henry's first professional artilleryman, is explored for the first time, casting light on the experience of day-to-day life in the English army of mid-Tudor England, and challenging the established view on the development of artillery both in England and in Europe. "Henry VIII's Military Revolution" develops and expands the argument that the English Army was up-to-date with its European contemporaries, and moves the English experience away from the periphery towards the centre of the debate on the European military revolution. The militarism of Henry VIII's England is seen through new eyes in this fascinating new work.
A SHARPE VIEW BRINGS TO LIFE Newark's longest serving (1986-2006) modern day Mayor Sharpe James whose extroverted personality, leadership style that bordered on civic and religious frenzy, emotional speeches defending Newark and his intemperate letters to his critics and detractors, part historian, part street fighter and always entertaining, made Newark a destination city and placed its future on a very high moral plane. Dr. Clement Price, Professor of history at Rutgers University, Newark Campus, Director of the Institute on Ethnicity, Culture, and the Modern Experience, Star Ledger, April 2, 2006.James' Legacy: A proud Newark. Former NJ Governor Thomas H. Kean as President of Drew University in honoring Mayor James with its Doctor of Humane Letters, called James a modern-day Nehemiah. He entered local government when Newark was still reeling from the riots of the 1960s. He has called upon the citizens of Newark to help him rebuild the City's great heritage. Sharpe James the former athlete, athletic director, college professor, Newark ward councilman, councilman-at-large, mayor and state senator, now spends time writing his memoir, mentoring youths, and caring for his wife of fifty-eight years Mary, and his 107 years old mother, Beulah, who takes no prescription medicine. God's benevolence has been our lighthouse steering us through troubled waters
Urban Ecology: An Introduction seeks to open the reader’s mind and eyes to the way in which nature permeates everyday urban living, and how it has to be understood, cared for, and managed in order to make our towns and cities healthier places to visit and in which to live and work. The authors examine how nature can improve our physical and mental health, the air we breathe and the waters we use, as well as boosting our enjoyment of parks and gardens. Urban Ecology sets out the science that underlies the changing natural scene and the tools used to ensure that cities become both capable of adapting to climate change and more beautiful and resilient. The book begins with a discussion of the nature of urban places and the role of nature in towns and cities. Part 1 looks at the context and content of urban ecology, its relationship to other foci of interest within ecology and other environmental sciences, and the character of city landscapes and ecosystems. In Part 2 the authors set out the physical and chemical components of urban ecosystems and ecological processes, including urban weather and climate, urban geomorphology and soils, urban hydrology and urban biogeochemical cycles. In Part 3 urban habitats, urban flora and fauna, and the effects of, deliberate and inadvertent human action on urban biota are examined. Part 4 contains an exploration of the identification and assessment of ecosystem services in urban areas, emphasising economic evaluation, the importance of urban nature for human health and well-being, and restoration ecology and creative conservation. Finally, in Part 5 the tasks for urban ecologists in optimising and sustaining urban ecosystems, providing for nature in cities, adapting to climate change and in developing the urban future in a more sustainable manner are set out. Within the 16 chapters of the book – in which examples from around the world are drawn upon - the authors explore current practice and future alternatives, set out procedures for ecological assessment and evaluation, suggest student activities and discussion topics, provide recommended reading and an extensive bibliography. The book contains more than 150 tables and over 150 photographs and diagrams.
I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
Now in full color, the sixth edition of this leading text features new chapters on remote sensing platforms (including the latest satellite and unmanned aerial systems), agriculture (including agricultural analysis via satellite imagery), and forestry (including fuel type mapping and fire monitoring). The book has introduced tens of thousands of students to the fundamentals of collecting, analyzing, and interpreting remotely sensed images. It presents cutting-edge tools and practical applications to land and water use analysis, natural resource management, climate change adaptation, and more. Each concise chapter is designed as an independent unit that instructors can use in any sequence. Pedagogical features include over 400 figures, chapter-opening lists of topics, case studies, end-of-chapter review questions, and links to recommended online videos and tutorials. New to This Edition *Discussions of Landsat 8 and Sentinel-2; the growth of unmanned aerial systems; mobile data collection; current directions in climate change detection, fire monitoring, and disaster response; and other timely topics. *Additional cases, such as river erosion; the impact of Hurricane Sandy on Mantoloking, New Jersey; and Miami Beach as an exemplar of challenges in coastal communities. *Revised throughout with 60% new material, including hundreds of new full-color figures. *New chapters on remote sensing platforms, agriculture, and forestry.
Thoroughly updated for its Second Edition, Non-Hodgkin Lymphomas is the definitive textbook on the biology, diagnosis, staging, and treatment of all forms of non-Hodgkin lymphomas. With backgrounds in medical and radiation oncology, molecular biology, and pathology, the editors and contributors provide an international, multidisciplinary approach to the topic. This edition is the first text using the new World Health Organization classification of non-Hodgkin lymphomas. The book offers complete coverage of the most current techniques for diagnosis, staging, and treatment, the approach to specific types of lymphoma, and special problems common to the management of patients with these disorders.
Holland Frei Cancer Medicine serves as a quick reference to current information on an extensive list of cancers, including breast, lung, thyroid, colorectal, ovarian, prostate, and gastric cancer, to name but a few. Presented as an accessible pocket-sized handbook, the chapters are organized in an outline format, offering only the most essential information on the etiology, staging (including TNM staging) and treatment for each cancer type. Individual chapters are devoted to the molecular biology of cancer, cancer prevention, cancer screening, the mechanisms of chemotherapy, and diagnostic imaging in cancer. Additionally, each chapter lists all the major phase III clinical trials, and therefore, serves as an excellent reference of the major randomized controlled trials for each cancer reported to date. Specific chapters are also dedicated to the discussion of oncologic emergencies, pain and palliation, and prescription complications. At the conclusion of the book, a glossary of oncologic terms and chemotherapeutic drug programs, a table of common cancer incidences, and an overview of the mechanisms, common uses, and related toxicities of various anti-cancer agents are featured. In addition, performance status tables, mathematical formulas and a listing of common biomedical / cancer web sites are highlighted.
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