Reprint of the original, first published in 1872. The publishing house Anatiposi publishes historical books as reprints. Due to their age, these books may have missing pages or inferior quality. Our aim is to preserve these books and make them available to the public so that they do not get lost.
With this study the cattle guard joins the sod house, the windmill, and barbed wire as a symbol of range country on the American Great Plains. A U.S. folk innovation now in use throughout the world, the cattle guard functions as both a gate and a fence: it keeps livestock from crossing, but allows automobiles and people to cross freely. The author blends traditional history and folklore to trace the origins of the cattle guard and to describe how, in true folk fashion, the device in its simplest form—wooden poles or logs spaced in parallel fashion over a pit in the roadway—was reinvented and adapted throughout livestock country Hoy traces the origins of the cattle guard to flat stone stiles unique to Cornwall, England, then through the railroad cattle guard, in use in this country as early as 1836, and finally to the Great Plains where, probably in 1905, the first ones appeared on roads. He describes regional variations in cattle guards and details unusual types. He provides information on cattle-guard makers, who range from local blacksmiths and welders to farmers and ranchers to large manufacturers. In addition to documenting the economic and cultural significance of the cattle guard, this volume reveals much about early twentieth-century farm and ranch life. It will be of interest not only to folklorists and historians of agriculture and Western America, but also to many Plains-area farmers, ranchers, and oilmen.
Thoroughly revised and expanded, this is the definitive reference on American immigration from both historic and contemporary perspectives. It traces the scope and sweep of U.S. immigration from the earliest settlements to the present, providing a comprehensive, multidisciplinary approach to all aspects of this critically important subject. Every major immigrant group and every era in U.S. history are fully documented and examined through detailed analysis of social, legal, political, economic, and demographic factors. Hot-topic issues and controversies - from Amnesty to the U.S.-Mexican Border - are covered in-depth. Archival and contemporary photographs and illustrations further illuminate the information provided. And dozens of charts and tables provide valuable statistics and comparative data, both historic and current. A special feature of this edition is the inclusion of more than 80 full-text primary documents from 1787 to 2013 - laws and treaties, referenda, Supreme Court cases, historical articles, and letters.
The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.
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