Most complex biological systems, such as enzyme pathways, are effec tively controlled near the beginning of the process. There is increasing evidence that the same is true for the immune system, with the initial interactions between antigen, antigen-presenting cells, and T cells hav ing a paramount influence on the ensuing events. Thus, analysis of the early stages of the immune responses has been a preoccupation of many immunologists. This has been considerably aided by the capac ity to expand these early events, and 'immortalize' them as clones of T cells, for detailed analysis. The discovery by Morgan, Ruscetti, and Gallo (Science 193, 1007, 1976) of T-cell growth factor (now termed interleukin-2 or IL-2) has had a major impact in immunology that is far from over. The greater ease of handling murine tissues experimentally, with the availability of more precisely defined reagents such as inbred strains, has meant that, to date, most of the work on long-term T-cell cultures has been per formed in the mouse, as summarized by Fathman and Fitch (eds. , Iso lation, Characterization and Utilization of T Lymphocyte Clones, Aca demic Press, NY, 1982). However, the limitations of working with human tissues are counterbalanced by the great long-term importance of understanding disorders of human immune regulation, especially since it is becoming evident that these are far from rare. Immune deficiencies such as agammaglobulinemia and T-cell deficiencies are not common, but immune hyperresponsiveness occurring in allergy and allergiC diseases (e. g.
Join Multiple Harvey Award nominee James Asmus (Thief of Thieves), New York Times best-selling writer Fred Van Lente (IVAR, TIMEWALKER), Eisner Award-winning artist Steve Lieber (Superior Foes of Spider-Man), and explosive artist Kano (Daredevil) for the next deluxe hardcover of the superhero joyride Salon calls """"one of the year's funniest comics""""! Quantum and Woody are the world?s worst superhero team. Archer & Armstrong are a mismatched pair of conspiracy-busting adventurers. When a mysterious force collides with these ill-suited and irresponsible ?heroes,? they?re in for a cross-country race through the darkest corners of American mythology?and all hell is bound to break loose. Can two busted pairs become four of a kind in time to defeat the Hobo King, save the day, and make it back home for happy hour? Let?s hope so...?cause these guys make a really, really bad team. (And you don?t even want to know about the Goat.) Collecting THE DELINQUENTS #1?4, QUANTUM AND WOODY MUST DIE! #1?4, VALIANT-SIZED QUANTUM AND WOODY #1, and UNITY #25 along with 20+ pages of rarely seen art and extras!
This volume documents this unique family of cell surface proteins. Despite masquerading as intractable and difficult to clone and characterize, ENOX proteins have and continue to offer remarkable opportunities for research, commercial development and outside confirmation of therapeutic, diagnostic and new paradigms to help explain complex biological processes.
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