Fireguard By: James N. Ito Fireguard is a fantasy and science-fiction novel, with a heavy dose of war. It is about two-inch tall plastic toys that consist of cowboys, Indians, spacemen, knights, ninjas, and many other factions that live within an abandoned junkyard. After decades of living here, a force of Army Men known as the Legion approach the Junkyard’s doorstep ready to attack. Brad, a prehistoric mammal and humanoid known as an Amonaut created in the late 1980s, must desperately unite the Junkyard amidst their differences in order to secure their survival. The main villain, Torvus, has declared himself emperor of the Legion. His ultimate goal is to conquer the Junkyard and wipe out all who inhabit it. His brutal tactics and his prowess for victory make him a dangerous foe. Robots, tanks, machine guns, and thousands of war-hardened Army Men follow him. Brad thinks himself as inadequate with no experience in warfare, but this war and Torvus will test him to limits that he didn’t know existed.
Ionic and Organometallic-Catalyzed Organosilane Reductions provides an up-to-date, comprehensive review of reductions with organosilanes. Both ionic and catalyst-mediated reaction types are included, with appropriate reference to reaction mechanisms where they have been elucidated. The text also provides a wide variety of organic functional group reductions by organosilicon hydrides, and includes a substantial discussion of asymmetric reductions. All known examples have been compiled in thirty-four easily scanned, comprehensive tables compiled from 809 original articles. This is a must-have reference book for all synthetic organic chemists working in academic and industrial laboratories.
I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
The skin is the largest human organ system. Loss of skin integrity due to injury or illness results in a substantial physiologic imbalance and ultimately in severe disability or death. From burn victims to surgical scars and plastic surgery, the therapies resulting from skin tissue engineering and regenerative medicine are important to a broad spectrum of patients. Skin Tissue Engineering and Regenerative Medicine provides a translational link for biomedical researchers across fields to understand the inter-disciplinary approaches which expanded available therapies for patients and additional research collaboration. This work expands on the primary literature on the state of the art of cell therapies and biomaterials to review the most widely used surgical therapies for the specific clinical scenarios. - Explores cellular and molecular processes of wound healing, scar formation, and dermal repair - Includes examples of animal models for wound healing and translation to the clinical world - Presents the current state of, and clinical opportunities for, extracellular matrices, natural biomaterials, synthetic biomaterials, biologic skin substitutes, and adult and fetal stem and skin cells for skin regenerative therapies and wound management - Discusses new innovative approaches for wound healing including skin bioprinting and directed cellular therapies
The study of neuroendocrine-immune interactions has become a highly visible and fast-growing segment of mainstream immunology. This book provides an overview of the immune system and in-depth coverage of the many different areas that make up neuroendocrine-immune research. The main emphasis is on the physiology of the processes involved, stressing an integrated approach to immunology. The text is organized in seven sections, beginning with an introduction to the immune system. Section II outlines how the central nervous system (CNS) communicates with central and peripheral lymphoid organs. Section III provides information on factors from the immune system that act as messengers to the CNS. The metabolic regulation of growth and development is discussed in Section IV. Section V examines the interactions occurring between the reproductive and immune systems. The effects of other physiologic stressors on immunity are reviewed in Section VI. Section VII considers cyclic and periodic influences on the immune system. Finally, there is a consideration of a new unifying theory for immunology. Students, researchers, clinicians, and veterinary scientists can discover new areas of interest in specific diseases and immune interactions in this novel presentation.
Kelley's Textbook of Rheumatology delivers the state-of-the-art scientific and clinical know-how you need to offer your patients the most effective diagnosis and care. This rheumatology book’s sweeping updates highlight current advances and breakthroughs that impact your practice. With Kelley's Textbook of Rheumatology, you'll be ready to handle the toughest clinical challenges you face. Search the entire contents online at www.expertconsult.com, download all of images, and watch videos demonstrating the complete musculoskeletal exam, including abnormal findings and the arthroscopic presentation of diseased joints. Review basic science advances and their clinical implications in one place and get dependable, evidence-based guidance with the integrated chapter format that readers of Kelley's Textbook of Rheumatology have always appreciated. Gain a thorough understanding of the "whys" and "hows" of rheumatic disease management with detailed coverage of the very latest breakthroughs and the newest clinical algorithms. Apply the latest therapeutic advances through new chapters in bioengineering and tissue engineering, as well as up-to-date coverage of gout and disease-modifying drugs. Learn how the study of biomarkers across populations can help you detect diseases earlier and with greater accuracy with a new chapter on epigenetics. Diagnose, monitor, and manage rheumatic disease more effectively with expanded information on the use of ultrasound and other imaging modalities.
An ambitious new model of experimentation that will reorient our understanding of the key features of experimental practice. What is experimental knowledge, and how do we get it? While there is general agreement that experiment is a crucial source of scientific knowledge, how experiment generates that knowledge is far more contentious. In this book, philosopher of science James Mattingly explains how experiments function. Specifically, he discusses what it is about experimental practice that transforms observations of what may be very localized, particular, isolated systems into what may be global, general, integrated empirical knowledge. Mattingly argues that the purpose of experimentation is the same as the purpose of any other knowledge-generating enterprise—to change the state of information of the knower. This trivial-seeming point has a non-trivial consequence: to understand a knowledge-generating enterprise, we should follow the flow of information. Therefore, the account of experimental knowledge Mattingly provides is based on understanding how information flows in experiments: what facilitates that flow, what hinders it, and what characteristics allow it to flow from system to system, into the heads of researchers, and finally into our store of scientific knowledge.
The process of inflammation, which causes the swelling and redness around a wound, is a vital part of the body's system for fighting off infections. When the body is hurt, the immune system produces chemical signals telling cells to multiply without dying, allowing skin to close over a gash, for example. Other chemicals spur the growth of new blood vessels to feed the recovering tissue. Scientists have linked inflammation to cancer and recently to heart disease in several ways. Doctors suspect that long-term inflammation or infection is involved in up to 20 per cent of cancers, including those of the oesophagus, colon, skin, stomach, liver, bladder, breast and some kinds of lymphoma. C-reactive protein (CRP) is one of the acute phase proteins that increase during systemic inflammation. It's been suggested that testing CRP levels in the blood may be a new way to assess cardiovascular disease risk. A high sensitivity assay for CRP test (hs-CRP) is now widely available. This new book presents recent leading-edge research from around the world.
The unquestioned leader in dermatopathology resources, Weedon’s Skin Pathology returns with expanded and updated coverage in this specialized field of pathology. Offering an enhanced emphasis on differential diagnosis, new author Dr. James W. Patterson provides the most clinically relevant developments in molecular biology and techniques while maintaining Dr. Weedon's consistent, uniform approach to the subject. From practitioners and specialists to pathologists and dermatologists, this medical reference book is an essential addition to any dermatopathological library. Explore in-depth and updated topics covering clinically relevant developments in molecular biology and molecular techniques. Easily comprehend complex issues with improved illustrations focusing on rare conditions and unusual manifestations. Accurately interpret difficult specimens through an increased emphasis on differential diagnosis. Take advantage of expanded content in sections including Drug Reactions, Tumors, and Infections and Infestations. Consult this title on your favorite e-reader.
The chemical synthesis of isotopically labelled compounds is a pre-requisite for many chemical, biochemical and medicinal investigations. The constraints imposed by the requirements for regiospecific labelling and, in some instances, the time-scale of the synthesis often lead to quite different synthetic strategies to those that are used for the unlabelled material. Whilst there are many specialist papers, reviews and long books devoted to particular isotopes, there is no currently available short introductory book devoted to the organic chemistry of isotopic labelling. The aim of this book is to introduce research workers to a variety of methods that have been used to achieve these synthetic labelling objectives before exploring a particular method in detail. It covers a number of different isotopes and the methods that have been used to introduce them into organic compounds. Labelling methods also provide useful undergraduate teaching examples of modern synthetic reactions and their stereochemical consequences using relatively simple substrates. The book will therefore have a wider appeal than just those involved in using isotopes in research such as environmental and pharmaceutical chemists as well as organic chemists.
This is the final volume in a three-volume work that has addressed the scientific methodologies relevant to clinical neurobehavioral toxicology. Volume III attends to what is known about industrial and environmental chemicals, medicines, and substances of abuse and how these agents affect the central nervous system. How to determine that a specified substance has caused harm is emphasized by way of case examples and discussion. Illnesses and behavioral variations that compete with toxicant-induced explanations for findings in a given case, as well as the various controversies that can arise around issues of diagnosis and causal determination, are treated comprehensively in this volume.
Encyclopedic and authoritative, Weedon’s Skin Pathology has earned outstanding reviews and accolades from practicing and trainee dermatopathologists, general pathologists, and dermatologists worldwide. The 5th Edition continues the tradition of excellence, helping you accurately and efficiently sign out challenging skin cases in everyday practice, while also keeping you up to date with recent advances in the field. This single-authored text provides comprehensive coverage of the full spectrum of dermatopathological entities, both inflammatory and neoplastic, highlighted by more than 1,200 large-sized, high-quality illustrations. Helps you arrive at the most accurate diagnoses possible by demonstrating what is seen through the microscope and identifying the characteristic features of the lesion – for established disorders, unusual and rare disease entities, and incompletely defined entities. Includes updated and expanded information on molecular diagnostics, including FISH (fluorescence in situ hybridization) techniques, plus new developments in molecular biology and molecular techniques, targeted-personalized medicine, and immunohistochemistry. Brings you fully up to date with carefully reviewed and streamlined introductory and basic science information and information on new entities since the previous edition. Presents even more key information in quick-reference formats such as tables and boxes that organize diseases into groups, synthesize diagnostic criteria, and list differential diagnoses. Identifies both important articles and more rare and unusual reports with remarkably authoritative, comprehensive, current, and relevant reference lists (over 35,000) for each entity. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
This newest addition of the comprehensive Pediatric Neuroimaging combines thousands of images with detailed textual descriptions to help you diagnose a wide range of brain, spinal, and head and neck disorders in the pediatric patient. The authors have chosen a clear, concise writing style that encourages you to grasp information quickly. By dealing with a broad range of disorders, from everyday problems to less common ones, and explaining how to recognize and differentiate them, this book offers you the opportunity to provide a concise differential diagnosis on most patients you are likely to encounter in your practice.
This book is a primer focusing on systems thinking as it spans the domains of health administration, public health, and clinical practice. Currently, the accrediting commissions within public health, health administration, and nursing are including systems thinking as part of the core competencies in their respective fields and professions. Meanwhile, academic programs do not have the materials, other than journal articles, to give students the requisite understanding of systems thinking as is expected of the next generation of health professionals. This primer is designed to meet that void and serve as a supplemental reading for this important and timely topic. This is the only book of its kind that provides a broad introduction and demonstration of the application of health systems thinking.
Describes a variety of techniques for studying the cell nucleus, its membrane system, and its cytoskeleton using tools from all the sciences available to cell and development biologists. Among the 22 topics are the import and routing of nucleus-encoded chloroplast proteins, organizing spatial pattern in limb development, germ cell development, signaling by extracellular nucleotides, and nuclear fusion in the yeast. Includes several color plates. Annotation copyrighted by Book News, Inc., Portland, OR
Written in a highly accessible style, A Factor Model Approach to Derivative Pricing lays a clear and structured foundation for the pricing of derivative securities based upon simple factor model related absence of arbitrage ideas. This unique and unifying approach provides for a broad treatment of topics and models, including equity, interest-rate, and credit derivatives, as well as hedging and tree-based computational methods, but without reliance on the heavy prerequisites that often accompany such topics. Key features A single fundamental absence of arbitrage relationship based on factor models is used to motivate all the results in the book A structured three-step procedure is used to guide the derivation of absence of arbitrage equations and illuminate core underlying concepts Brownian motion and Poisson process driven models are treated together, allowing for a broad and cohesive presentation of topics The final chapter provides a new approach to risk neutral pricing that introduces the topic as a seamless and natural extension of the factor model approach Whether being used as text for an intermediate level course in derivatives, or by researchers and practitioners who are seeking a better understanding of the fundamental ideas that underlie derivative pricing, readers will appreciate the book’s ability to unify many disparate topics and models under a single conceptual theme. James A Primbs is an Associate Professor of Finance at the Mihaylo College of Business and Economics at California State University, Fullerton.
This new book is the first to make logical and important connections between trapping and foraging ecology. It develops and describes—both verbally and mathematically--the underlying principles that determine and define trap-organism interactions. More important, it goes on to explain and illustrate how these principles and relationships can be used to estimate absolute population densities in the landscape and to address an array of important problems relating to the use of trapping for detection, population estimation, and suppression in both research and applied contexts. The breakthrough nature of subject matter described has broad fundamental and applied implications for research for addressing important real-world problems in agriculture, ecology, public health and conservation biology. Monitoring traps baited with potent attractants of animals like insects have long played a critical role in revealing what pests are present and when they are active. However, pest managers have been laboring without the tools necessary for quick and inexpensive determination of absolute pest density, which is the cornerstone of pest management decisions. This book spans the gamut from highly theoretical and fundamental research to very practical applications that will be widely useful across all of agriculture.
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