Easily accessible and clinically focused, Abeloff's Clinical Oncology, 6th Edition, covers recent advances in our understanding of the pathophysiology of cancer, cellular and molecular causes of cancer initiation and progression, new and emerging therapies, current trials, and much more. Masterfully authored by an international team of leading cancer experts, it offers clear, practical coverage of everything from basic science to multidisciplinary collaboration on diagnosis, staging, treatment and follow up. - Includes new chapters on Cancer Metabolism and Clinical Trial Designs in Oncology and a standalone chapter on lifestyles and cancer prevention. - Features extensive updates including the latest clinical practice guidelines, decision-making algorithms, and clinical trial implications, as well as new content on precision medicine, genetics, and PET/CT imaging. - Includes revised diagnostic and treatment protocols for medical management, surgical considerations, and radiation oncology therapies, stressing a multispecialty, integrated approach to care. - Helps you find information quickly with updated indexing related to management recommendations, focused fact summaries, updated key points at the beginning of each chapter ideal for quick reference and board review, and algorithms for patient evaluation, diagnosis, and treatment options. - Offers more patient care coverage in disease chapters, plus new information on cancer as a chronic illness and cancer survivorship. - Discusses today's key topics such as immuno-oncology, functional imaging, precision medicine, the application of genetics in pathologic diagnosis and sub-categorization of tumors as well as the association of chronic infectious diseases such as HIV and cancer. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Viruses are the causes of approximately 25% of human cancers. Due to their importance in carcinogenesis, there is a desperate need for a book that discusses these viruses. This book is therefore timely, providing a comprehensive review of the molecular biology of oncogenic viruses and the cancers they cause. Viruses that are discussed in the individual chapters include hepatitis B virus, hepatitis C virus, human papilloma viruses, EpsteinOCoBarr virus, Kaposi's sarcoma virus and human T-cell leukemia virus type 1. This book provides up-to-date information for graduate students, postdoctoral fellows, medical students, physicians and non-experts who are interested in learning more about the oncogenic viruses and how they cause human cancers. Sample Chapter(s). Foreword (38 KB). Chapter 1: Oncogenic Viruses, Cellular Transformation and Human Cancers (211 KB). Contents: Oncogenic Viruses, Cellular Transformation and Human Cancers (Y-Y Zheng & J-H J Ou); Hepatitis B Virus and Hepatocellular Carcinogenesis (T S B Yen); Molecular Mechanism of Hepatitis C Virus Carcinogenesis (K Machida et al.); Human Papillomaviruses and Associated Malignancies (C L Nguyen et al.); Epstein-Barr Virus and Its Oncogenesis (H-P Li et al.); Human Kaposi's Sarcoma-associated Herpesvirus: Molecular Biology and Oncogenesis (P J Dillon & B Damania); Human T-Cell Leukemia Virus 1 and Cellular Transformation (Y-H Chi & K-T Jeang). Readership: Graduate students and postdoctoral fellows in infectious diseases, microbiology/virology, oncology/cancer research, and cell/molecular/structural biology; medical students, physicians and non-experts who are interested in understanding the relationship between oncogenic viruses and the cancers they cause
This clearly written, class-tested manual has long given students hands-on experience covering all the essential topics in general chemistry. Stand alone experiments provide all the background introduction necessary to work with any general chemistry text. This revised edition offers new experiments and expanded information on applications to real world situations.
Separation of chemical species is a gate to final success of synthesis and preparation of compounds in pure and defined state. Variability of natural and artificial mixtures to be treated is enormous. Task of chemistry is to separate components of homogeneous mixtures (the gaseous and liquid solutions). The book concentrates on understanding the basic philosophies of both equilibrium and nonequilibrium chemical thermodynamics and engineering performance that lay in principle of separation technique such as distillation, crystallization, centrifugation, sorption, membrane separations, chromatography, and liquid-liquid extraction. Specific phenomena connected with photochemical separation, isotope composition, and radioactivity are discussed as well. The book is written for advanced students of chemistry having the knowledge of physical chemistry. Calculation examples are based on the international system of units. Unique list of over 1,300 full references covers scientific literature of the eighteenth to the twenty-first centuries.
World-renowned coverage of today's pharmacology at your fingertips - Keeps you up-to-date with new information in this fast-changing field, including significantly revised coverage of CNS drugs, cognitive enhancers, anti-infectives, biologicals/biopharmaceuticals, lifestyle drugs, and more. - Includes access to unique features, including more than 100 brand new chapter-specific multiple-choice questions and 6 new cases for immediate self-assessment. - Features a color-coded layout for faster navigation and cross-referencing. - Clarifies complex concepts with Key Points boxes, Clinical Uses boxes and full-color illustrations throughout.
Vicksburg is the key. . . . Let us get Vicksburg, and all that country is ours.--President Abraham Lincoln, 1862 In a brilliantly constructed and powerfully rendered new account, James R. Arnold offers a penetrating analysis of Grant's strategies and actions leading to the Union victory at Vicksburg. Approaching these epic events from a unique and well-rounded perspective, and based on careful research, Grant Wins the War is fascinating reading for all Civil War and military history buffs. Acclaim for Grant Wins the War Nicely details the coordination of Union military and naval operations and the boldness and genius of General U. S. Grant that brought Union victory, and he offers an excellent discussion of the technology and tactics of siege warfare. . . . a good drums-and-bugle account of an important event.--Library Journal A particular strength of this work is its demonstration that modern weapons left no shortcuts to victory, and little room for command virtuosity.--Publishers Weekly Throughout, Arnold backs up his assessments with solid facts and sound reasoning, engagingly presented. He has produced a useful and enjoyable brief history of the Vicksburg campaign, helpful to scholars and general readers alike.--Journal of Military History Powerfully and persuasively argues that the Union victory at Vicksburg in 1863 was in fact the actual turning point of the Civil War.--Helena (Mont.) Independent Record
Offering perspectives on the history, prevalence and genetics of obesity, this book examines the origins and etiology of obesity. It considers the relationship between behavioural neuroscience and obesity.
This innovative textbook provides a concise and accessible guide for undergraduate students specializing in children and young people's nursing in the UK and further afield. Each chapter has been fully updated to reflect current knowledge and practice. The wide range of topics covered includes all the essentials, such as contemporary child health policy and legal issues; knowledge and skills for practice; and caring for children with special needs. Students will learn how to recognize the deteriorating child, use procedural play and distraction, and consider the mental health of children and young people. A Textbook of Children's and Young People's Nursing is written by multidisciplinary experts, rooted in child-centred healthcare within a family context, and draws upon best contemporary practice. It is an invaluable resource that will help nursing students provide effective, evidence-based care. - Key points, summary boxes and clearly defined aims, objectives and learning outcomes to support learning - Conversation boxes to enliven the text - Patient scenarios to relate theory to practice - New chapters on skin health and the use of therapeutic play - Suggestions for seminar discussion topics to help teachers - Resource lists and online resources for further study or research - Online slides to complement chapters within book
At a time when greater transparency is needed, this book advances a novel explanation of America's efforts to advance greater transparency in international relations. Marquardt argues that American statesmen have long sought to secure an American-dominated international system to encourage states to be more open and forthcoming about their internal affairs. Yet the United States routinely uses its calls for military transparency in particular as a policy instrument to discipline its rivals and therefore paradoxically contributes to greater tension in international relations. In contrast to conventional thinking about transparency in relation to overcoming power politics and promoting international cooperation, this book explores the relationship between America's power and international security competition. Though analytically distinct, openness and transparency have served the same strategic goal; ensuring America's position of preponderance in the international system.
Radiation Oncology: Rationale, Technique, Results, by James D. Cox, MD and K. Kian Ang, MD, PhD, provides you with authoritative guidance on the latest methods for using radiotherapy to treat patients with cancer. Progressing from fundamental principles through specific treatment strategies for the cancers of each organ system, it also addresses the effects of radiation on normal structures and the avoidance of complications. This 9th edition covers the most recent indications and techniques in the field, including new developments in proton therapy and intensity-modulated radiotherapy (IMRT). It also features, for the first time, full-color images throughout the text to match those that you see in practice, and uses new color-coded treatment plans to make targets, structures, and doses easier to read at a glance. Evidence from randomized clinical trials is included whenever possible to validate clinical recommendations. The state-of-the-art coverage inside this trusted resource equips you to target cancer as effectively as possible while minimizing harm to healthy tissue. Stands apart as the only book in the field to cover the conceptual framework for the use of radiotherapy by describing the most effective techniques for treatment planning and delivery and presenting the results of each type of therapy. Emphasizes clinical uses of radiation therapy, providing pertinent, easy-to-understand information on state-of-the-art treatments. Includes information useful for non-radiotherapists, making it "recommended reading" for other oncology specialists. Offers a practical, uniform chapter structure to expedite reference. Guides you through the use of the newest radiation oncology techniques, including principles of proton therapy and new developments in intensity-modulated radiotherapy (IMRT). Incorporates evidence from randomized clinical trials whenever possible to validate clinical recommendations. Presents full-color images throughout to match the images that you see in practice. Extensive use of "combination" imaging presents a complete picture of how to more precisely locate and target the radiotherapy field.
So you think you've got a handle on therapeutic management? How drugs work and interact with each other, how the body handles them and how drug treatments are assessed? This self-assessment volume allows you to learn, revise and test yourself on all aspects of clinical pharmacology and therapeutics. Four different question types are provided to tes
Scroungers, spongers, parasites ... These are just are some of the terms that are typically used, with increasing frequency, to describe the most vulnerable in our society, whether they be the sick, the disabled, or the unemployed. Long a popular scapegoat for all manner of social ills, under austerity we’ve seen hostility towards benefit claimants reach new levels of hysteria, with the ‘undeserving poor’ blamed for everything from crime to even rising levels of child abuse. While the tabloid press has played its role in fuelling this hysteria, the proliferation of social media has added a disturbing new dimension to this process, spreading and reinforcing scare stories, while normalising the perception of poverty as a form of ‘deviancy’ that runs contrary to the neoliberal agenda. Provocative and illuminating, Scroungers explores and analyses the ways in which the poor are portrayed both in print and online, placing these attitudes in a wider breakdown of social trust and community cohesion.
In The American South, William J. Cooper, Jr. and Thomas E. Terrill demonstrate their belief that it is impossible to divorce the history of the south from the history of the United States. Each volume includes a substantial biographical essay--completely updated for this edition--which provides the reader with a guide to literature on the history of the South. Coverage now includes the devastation of Hurricane Katrina in 2005, up-to-date analysis of the persistent racial divisions in the region, and the South's unanticipated role in the 2008 presidential primaries.
Since the general recognition of the Archaebacteria, research into the evolution, metabolism, molecular biology and ecological roles of these fastidious anaerobes has proceeded at an ever-increasing pace. All possess a very novel biochemistry and many exploit unique ecological niches. Methanogens, which convert one-and-two carbon compounds into the important atmospheric gas methane, are the largest group among the Archaebacteria. Of all microbial groups, methanogens provide perhaps the best opportunity to study evolution because of their phyologenetic diversity and unique biochemistry. Today, the analysis of methanogens is at a threshold. Molecular-biological studies of these microorganisms are revealing more and more processes unique to this group, and in turn, studies of methanogens are providing new perspectives to the broader fields of biochemistry and molecular biology. This volume is the first book to be published on methanogenesis, and it will provide the reader with a comprehensive view of the field and point to future trends.
Rang and Dale's Pharmacology is internationally acknowledged as the core textbook for students of pharmacology, and has provided accessible, up-to-date information on drugs and their mechanism of action for more than 30 years. Now in its tenth edition, it has been updated to include important new drugs such as gene therapies, personalised medicines and the new wave of RNA drugs. However it has not lost any of the elements that have contributed to its popularity, such as color coding and illustrations, making it reader-friendly while comprehensively covering the depth of detail required. This essential book is recommended as the first-choice undergraduate text for science and medical students and junior doctors and will also be useful for students in other professional disciplines such as pharmacy, veterinary medicine and nursing. - Comprehensive information on drug mechanisms, basic physiology and biochemistry, and underlying pathophysiology of disease – suitable for students from many disciplines - Clear figures to aid understanding, including data figures as well as mechanistic diagrams, - Key points box summaries, clinical boxes and colour-coded chapters help to master difficult concepts - Emphasis on therapeutic drugs to help apply theory to practice - Over 150 questions and 12 clinical cases to test your knowledge - New chapters on drugs and the eye and the pharmacological management of headache - Revised information on biopharmaceuticals (including RNA drugs), antivirals (including Covid-19 therapies) as well as general principles of antimicrobial therapy. - A completely revised and updated chapter on lifestyle drugs - Recent advances in oxygen sensing and response to reduced oxygen tension - Expanded chapters on dementia and analgesic drugs
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