The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.
Showcases thirty-five oil paintings created for an audio-visual presentation celebrating the Battle of San Jacinto, in which Texas patriots routed the Mexican army that had conquered the Alamo.
This eBook features the unabridged text of ‘The Essays, Letters and Articles’ from the bestselling edition of ‘The Complete Works of James Joyce’. Having established their name as the leading publisher of classic literature and art, Delphi Classics produce publications that are individually crafted with superior formatting, while introducing many rare texts for the first time in digital print. The Delphi Classics edition of Joyce includes original annotations and illustrations relating to the life and works of the author, as well as individual tables of contents, allowing you to navigate eBooks quickly and easily. eBook features: * The complete unabridged text of ‘The Essays, Letters and Articles’ * Beautifully illustrated with images related to Joyce’s works * Individual contents table, allowing easy navigation around the eBook * Excellent formatting of the textPlease visit www.delphiclassics.com to learn more about our wide range of titles
A comprehensive, accessible introduction to Joyce's work and provides the reader glimpses into some of the lesser read corners of his bibliography." — The Lexicon Devil Influential and innovative, James Joyce (1882–1941) led the vanguard of 20th-century fiction. Sooner or later, most undergraduates encounter him, and many scholars devote their entire careers to his exuberantly eloquent prose. Joyce's experimental use of language and stream-of-consciousness techniques continues to captivate modern readers and writers, and this anthology offers a first-rate introduction to the Irish author's fiction and poetry. A Portrait of the Artist as a Young Man, Joyce's coming-of-age novel, appears here in its entirety. Readers will also find the complete texts of the short story collection Dubliners, and the play Exiles. Additional contents include highlights from Ulysses, universally acknowledged as among the English language's most challenging and rewarding novels, and Chamber Music, an early book of poems.
This collection, marking the author's seventy-fifth birthday, contains Ask Me Tomorrow, selections from six of his major novels, three short stories, and several essays
Thirty years ago, the bestselling "letter to the government" Work in America published to national acclaim, including front-page coverage in The New York Times, Wall Street Journal, and Washington Post. It sounded an alarm about worker dissatisfaction and the effects on the nation as a whole. Now, based on thirty years of research, this new book sheds light on what has changed - and what hasn't. This groundbreaking work will illuminate the new critical issues - from worker demands to the new ethical rules to the revolution in culture at work.
Understanding the effects of radical change on public personnel systems is critically important both now and in the future to all those interested in the quality of American democracy. Civil service reform is occurring at all levels of government both in the United States and abroad. American Public Service: Radical Reform and the Merit System is a collection of papers that examine the innovations, strategies, and issues found in the contemporary civil service reform debate. Offering diverse perspectives from expert contributors, this book presents matters concerning radical reform and the merit system at the federal, state, and local levels of government. This volume offers fresh insight into the effects of merit system changes on employees. Divided into four sections, this book... · Examines a portrait of contemporary reforms from across the country and concepts to interpret those data · Addresses whether the relaxation of civil service protections against partisan intrusion will result in corruption · Provides examples of ongoing changes and analyzes survey data from state managers · Discusses a variety of key issues, such as the impact on racial inequality of moving from a protected class employment status to an unprotected at-will relationship The book provides a baseline of data on reforms as well as an account of their current promises and pitfalls. Covering topics ripped from the headlines, this text also identifies pressing issues and makes suggestions for the future. Offering a variety of methodological approaches, it is ideal for all those interested in effective governance.
Unlike Europe, where most public sector workers have long been included in collective bargaining agreements, the United States excluded public employees from such legislation until the 1960s and 70s. Since then, union membership in the U. S. has grown more rapidly among public workers than among workers in the private sector. This book provides up-to-date information on public sector collective bargaining in the United States today. The editors' seek to understand the real nature of PSB by examining eight states where the action is taking place -- California, Hawaii, Illinois, Michigan, New Jersey, New York, Pennsylvania, and Wisconsin. The chapters offer unique case studies of legal origins, developments, and challenges to collective bargaining; negotiations experience and outcomes; discussion of legislation; and emphasis of histoical development as well as current practice.
A study of the long-term decline of the labour movement in America, exploring the outlook for labour and unions in the 21st century. There are insights from contributors from a range of backgrounds - academic and non-academic, domestic and foreign, pro- and anti-union.
This fine blend of Harvard scholarship and seasoned judgment is really two books in one. The first develops a sophisticated approach to negotiation for executives, attorneys, diplomats -- indeed, for anyone who bargains or studies its challenges. The second offers a new and compelling vision of the successful manager: as a strong, often subtle negotiator, constantly shaping agreements and informal understandings throughout the complex web of relationships in an organization. Effective managers must be able to reach good formal accords such as contracts, out-of-court settlements, and joint venture agreements. Yet they also have to negotiate with others on whom they depend for results, resources, and authority. Whether getting fuller support from the marketing department, hammering out next year's budget, or winning the approval for a new line of business, managers must be adept at advantageously working out and modifying understandings, resolving disputes, and finding mutual gains where interests and perceptions conflict. In such situations, The Manager as Negotiator shows how to creatively further the totality of one's interests, including important relationships -- in a way that Richard Walton, Harvard Business School Professor of Organizational Behavior, describes as "sensitive to the nuances of negotiating in organizations" and "relentless and skillful in making systematic sense of the process." This book differs fundamentally from the recent spate of negotiation handbooks that tend to espouse one of two approaches: the competitive ("Get yours and most of theirs, too") or the cooperative ("Everyone can always win"). Transcending such cynical and naive views, the authors develop a comprehensive approach, based on strategies and tactics for productively managing the tension between the cooperation and competition that are both inherent in bargaining. Based on the authors' extensive experience with hundreds of cases, and peppered with a number of wide-ranging examples, The Manager as Negotiator will be invaluable to novice and experienced negotiators, public and private managers, academics, and anyone who needs to know the state of the art in this important field.
Examines the life and writings of James Joyce, including a biographical sketch, detailed synopses of his works, social and historical influences, and more.
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