A phenomenological investigation into new media artwork and its relationship to history What does it mean to live in an era of emerging digital technologies? Are computers really as antihistorical as they often seem? Drawing on phenomenology’s investigation of time and history, Sensations of History uses encounters with new media art to inject more life into these questions, making profound contributions to our understanding of the digital age in the larger scope of history. Sensations of History combines close textual analysis of experimental new media artworks with in-depth discussions of key texts from the philosophical tradition of phenomenology. Through this inquiry, author James J. Hodge argues for the immense significance of new media art in examining just what historical experience means in a digital age. His beautiful, aphoristic style demystifies complex theories and ideas, making perplexing issues feel both graspable and intimate. Highlighting underappreciated, vibrant work in the fields of digital art and video, Sensations of History explores artists like Paul Chan, Phil Solomon, John F. Simon, and Barbara Lattanzi. Hodge’s provocative interpretations, which bring these artists into dialogue with well-known works, are perfect for scholars of cinema, media studies, art history, and literary studies. Ultimately, Sensations of History presents the compelling case that we are not witnessing the end of history—we are instead seeing its rejuvenation in a surprising variety of new media art.
Widely seen as evolution's founding figure, Charles Darwin is taken by many evolutionists to be the first to propose a truly modern theory of evolution. Darwin's greatness, however, has obscured the man and his work, at times even to the point of distortion. Accessibly written, this book presents a more nuanced picture and invites us to discover some neglected ambiguities and contradictions in Darwin's masterwork. Delisle and Tierney show Darwin to be a man who struggled to reconcile the received wisdom of an unchanging natural world with his new ideas about evolution. Arguing that Darwin was unable to break free entirely from his contemporaries' more traditional outlook, they show his theory to be a fascinating compromise between old and new. Rediscovering this other Darwin – and this other side of On the Origin of Species – helps shed new light on the immensity of the task that lay before 19th century scholars, as well as their ultimate achievements.
The iconic image by Alfred Leete of Lord Kitchener with outstretched hand and finger, exhorting you to ‘do your bit’, is a design classic and has been repeatedly imitated worldwide. In the run-up to the World War I anniversary, Your Country Needs YOU celebrates the magnificent artwork of Leete and his fellow designers, and explores their legacy. Featuring colour reproductions of propaganda posters and drawing on fresh analysis of the archives, this book challenges received historical wisdom about these hugely popular and enduring images, and reveals a surprising new history that is no less than groundbreaking.
What does it mean to live in the modern world? How different is that world from those that preceded it, and when did we become modern? In Distant Strangers, James Vernon argues that the world was made modern not by revolution, industrialization, or the Enlightenment. Instead, he shows how in Britain, a place long held to be the crucible of modernity, a new and distinctly modern social condition emerged by the middle of the nineteenth century. Rapid and sustained population growth, combined with increasing mobility of people over greater distances and concentrations of people in cities, created a society of strangers. Vernon explores how individuals in modern societies adapted to live among strangers by forging more abstract and anonymous economic, social, and political relations, as well as by reanimating the local and the personal.
This article reviews progress made in the design and development of recombinant poxviral-based vaccines that express transgenes for tumor-associated antigens (TAAs) and human T-cell co-stimulatory molecules (designated TRICOM). The TRICOM vaccine platform consists of priming with a recombinant vaccinia (rV-) vector and multiple boosts with a replication defective fowlpox (rF-) vector. The rV, rF-PSA-TRICOM (PROSTVAC) has demonstrated survival benefit in randomized trials. rV, rF-CEA-MUC1-TRICOM (PANVAC) has demonstrated evidence of benefit in patients with colorectal, breast and ovarian cancers. Preclinical studies with TRICOM-based vaccines have demonstrated their ability to be used in combination with anti-CTLA4 monoclonal antibody, radiation, chemotherapeutics, and small molecule targeted therapies to enhance vaccine-mediated immune responses and antitumor activity. Randomized clinical studies have been completed, are ongoing, and are planned employing several of these TRICOM vaccine combination therapies. The importance of trial design in terms of patient population and clinical trial endpoint has been demonstrated in these studies.
A Doody's Core Title 2012 Emerging Cancer Therapeutics is a trinary, hard cover, periodical that is designed to provide an up-to-date evidence-based review of a dedicated emerging cancer therapy topic of interest to clinicians and scientists who are involved in the care of patients receiving cancer treatment. It will serve as both a reference and instructional tool for students, housestaff, fellows, practicing clinical oncologists, radiation oncologists, surgical oncologists, cancer biologists, and interdisciplinary colleagues throughout the oncology spectrum. With contributions from experts across the United States and Canada, Prostate Cancer details the current management of prostate cancer and reviews new therapies in development for prostate cancer, with an emphasis on castration-resistant prostate cancer (CRPC). Coverage includes discussion of multiple new agents that have been shown to impact overall survival or improve skeletal-related events in metastatic CRPC as well as articles covering new data on screening and prevention, integration of surgery and radiation with newly emerging medical therapies, and coverage of the newest developments in immunotherapy. This book is a valuable tool for clinicians, nurses, researchers, medical students, residents, and fellows. Included in Prostate Cancer: Updates in Prostate Cancer Prevention Prostate Cancer Screening, 2011 Current Surgical Approaches to Primary Prostate Cancer Treatment Updates in Radiation Therapy for Prostate Cancer: Dose Matters An Update on Androgen-Deprivation Therapy for Advanced Prostate Cancer Novel Androgen Receptor Therapeutic Targets for Advanced Prostate Cancer New Understanding of Metabolic Complications of Androgen-Deprivation Therapy Current State of Docetaxel-Based Therapy in Castration-Resistant Prostate Cancer Second-Line Chemotherapy for Castration-Resistant Prostate Cancer Emerging Role of Immunotherapy in the Treatment of Prostate Cancer Novel Bone-Targeted Therapy in Metastatic Prostate Cancer Emerging Treatment Strategies for Metastatic Prostate Cancer: The Next Step Forward
Feigin and Cherry's Textbook of Pediatric Infectious Diseases helps you put the very latest knowledge to work for your young patients with unparalleled coverage of everything from epidemiology, public health, and preventive medicine through clinical manifestations, diagnosis, treatment, and much more. Ideal for all physicians, whether in an office or hospital setting, Feigin and Cherry’s equips you with trusted answers to your most challenging clinical infectious disease questions. Meet your most difficult clinical challenges in pediatric infectious disease, including today’s more aggressive infectious and resistant strains as well as emerging and re-emerging diseases, with unmatched, comprehensive coverage of immunology, epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. Find the answers you need quickly thanks to an organization both by organ system and by etiologic microorganism, allowing you to easily approach any topic from either direction.
Cancer Vaccines and Tumor Immunity offers a review of the basic scientific discoveries that have moved forward into clinical trials. Presented in the context of real-world human research and experimentation, these major scientific advances demonstrate how our understanding of immune activation, T-regulatory cells, and autoimmunity will impact cancer vaccine design. The authors also explain how vaccination in the context of bone marrow transplantation will open new avenues for clinical study in the future.
Cover -- Contents -- Acknowledgments -- 1. Intersectional Inequality and Women's Imprisonment -- 2. Pathways and Intersecting Inequality -- 3. Prison Community, Prison Conditions, and Gendered Harm -- 4. Searching for Safety through Prison Capital -- 5. Inequalities and Contextual Conflict -- 6. Intersections of Inequality with Correctional Staff -- 7. Gendered Human Rights and the Search for Safety -- Appendix 1: Methodology -- Appendix 2: Tables of Findings -- Glossary -- B -- C -- D -- F -- G -- I -- J -- H -- J -- K -- L -- N -- O -- P -- R -- S -- T -- U -- W -- Bibliography -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- R -- S -- T -- U -- V -- W -- Y -- Z
Drs. Paul L. Kaufman, Albert Alm, Leonard A Levin, Siv F. E. Nilsson, James Ver Hoeve, and Samuel Wu present the 11th Edition of the classic text Adler's Physiology of the Eye, updated to enhance your understanding of ocular function. This full-color, user-friendly edition captures the latest molecular, genetic, and biochemical discoveries and offers you unparalleled knowledge and insight into the physiology of the eye and its structures. A new organization by function, rather than anatomy, helps you make a stronger connection between physiological principles and clinical practice; and more than 1,000 great new full-color illustrations help clarify complex concepts. You can also access the complete contents online at www.expertconsult.com. Deepen your grasp of the physiological principles that underlie visual acuity, color vision, ocular circulation, the extraocular muscle, and much more. Improve your understanding of physiology by referring to this totally updated volume--organized by function, rather than anatomy--and make a stronger connection between physiological principles and clinical practice. Better visualize information with a new, revamped format that includes 1,000 illustrations presented in full-color to better clarify complex concepts and functions. Access the most recent molecular, genetic, and biochemical discoveries affecting eye function, and gain fresh perspectives from a new, international editorial team. Search the entire contents online and download all the illustrations at www.expertconsult.com.
This is an exceptional book that comprehensively covers the interface between psychology and criminology regarding an empirical understanding of crime. It is written in an engaging and accessible manner, nicely linking key themes in order to situate the contribution of psychology to theories of criminal behaviour, strategies for informed practice, and contemporary challenges. It should prove to be an incredible resource for students, but also be of interest to researchers and clinicians. I cannot recommend this text more heartily." Dr Ralph Serin, Carleton University, Canada "James McGuire is one of the leading international experts on what works in reducing reoffending, and he has written an extremely valuable and accessible textbook on psychology and crime. The book is a clearly written, well-researched and up-to-date survey of important contributions of psychology to key criminological issues. It is especially noteworthy for its illuminating reviews of cognitive-social learning theories, risk factors and longitudinal studies, risk assessment, cognitive-behavioural programmes and meta-analyses of treatment effectiveness." Professor David Farrington, Institute of Criminology, University of Cambridge What contributions can psychology make to our understanding of crime? How can psychological models and research help to prevent crime and reduce repeat offending? This highly readable book discusses the complex relationships between psychology, criminology and criminal justice. Challenging the assumptions of those who object to the use of psychology within criminology, this book shows how a methodical approach to the study of criminal behaviour can generate both systematic findings and practical solutions to problems. McGuire argues for a broader understanding of crime, based on factors such as the individual’s cognitive and emotional development, in addition to the influences of socialization, peer groups, and the social and economic environment. He highlights the value of understanding ‘pathways’ to offending behaviour, and the critical points at which choices are made. Topics include: Theoretical and empirical research foundations of ‘criminogenic risk factors’ Theory turned into practice – the development of offending behaviour programmes A psychological perspective on some core concepts in criminology: retribution, deterrence and incapacitation Major practical applications of psychology in policing, prosecution and sentencing This authoritative and stimulating text is essential reading for students in criminology and psychology and for criminal justice practitioners and policy makers.
Holland Frei Cancer Medicine serves as a quick reference to current information on an extensive list of cancers, including breast, lung, thyroid, colorectal, ovarian, prostate, and gastric cancer, to name but a few. Presented as an accessible pocket-sized handbook, the chapters are organized in an outline format, offering only the most essential information on the etiology, staging (including TNM staging) and treatment for each cancer type. Individual chapters are devoted to the molecular biology of cancer, cancer prevention, cancer screening, the mechanisms of chemotherapy, and diagnostic imaging in cancer. Additionally, each chapter lists all the major phase III clinical trials, and therefore, serves as an excellent reference of the major randomized controlled trials for each cancer reported to date. Specific chapters are also dedicated to the discussion of oncologic emergencies, pain and palliation, and prescription complications. At the conclusion of the book, a glossary of oncologic terms and chemotherapeutic drug programs, a table of common cancer incidences, and an overview of the mechanisms, common uses, and related toxicities of various anti-cancer agents are featured. In addition, performance status tables, mathematical formulas and a listing of common biomedical / cancer web sites are highlighted.
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