How can we understand the complexity of genes, RNAs, and proteins and the associated regulatory networks? One approach is to look for recurring types of dynamical behavior. Mathematical models prove to be useful, especially models coming from theories of biochemical reactions such as ordinary differential equation models. Clever, careful experiments test these models and their basis in specific theories. This textbook aims to provide advanced students with the tools and insights needed to carry out studies of signal transduction drawing on modeling, theory, and experimentation. Early chapters summarize the basic building blocks of signaling systems: binding/dissociation, synthesis/destruction, and activation/inactivation. Subsequent chapters introduce various basic circuit devices: amplifiers, stabilizers, pulse generators, switches, stochastic spike generators, and oscillators. All chapters consistently use approaches and concepts from chemical kinetics and nonlinear dynamics, including rate-balance analysis, phase plane analysis, nullclines, linear stability analysis, stable nodes, saddles, unstable nodes, stable and unstable spirals, and bifurcations. This textbook seeks to provide quantitatively inclined biologists and biologically inclined physicists with the tools and insights needed to apply modeling and theory to interesting biological processes. Key Features: Full-color illustration program with diagrams to help illuminate the concepts Enables the reader to apply modeling and theory to the biological processes Further Reading for each chapter High-quality figures available for instructors to download
Anarchy & Amnesia in Small Town America In 1930, three joy-riding black youths robbed a young white couple parked on Lover’s Lane. One of the youths shot the white man five times while his girl friend claimed that one of the three raped her. Local law enforcement quickly located the three, interrogated them and locked them up in the county jail. The next day, the white man succumbed to his wounds. That night a mob of angry white-folks stormed the jail and removed all three suspects. They lynched two of the teens and inexplicably returned the third suspect to the jail. County and state prosecutors began a crusade to locate, prosecute and convict the mob members who hung the two. However, they discovered the whole town had difficulty remembering details. This story also tracks the trial and subsequent life of the surviving sixteen-year old. The author used dozens of articles from over twenty local, state and national newspapers along with several confidential depositions to reconstruct these events. After reading this book, one needs to consider what if anything has really changed in America during the past 90 years?
When romance was met with murder... Arthur Jordan and Elvira Corder were young and unafraid, but their love was doomed. He was black, she was white, and this was Virginia in 1880. When Elvira became pregnant, the couple fled Fauquier County to live in Maryland. But her father found them and recruited neighbors to help kidnap them. Four nights later, a mob dragged Arthur from the county jail in Warrenton and lynched him. Elvira, taken to a hotel in Williamsport, Maryland, was never heard from again. Stories of lynching are all too common in the postbellum South, but this one tells a unique tale of a couple who were willing to sacrifice everything to be together--and did. Author Jim Hall tells a classic tale of forbidden love, one of hope crushed by hate.
Born and raised as a slave, seventeen-year-old Tanner Jones has never known freedom. But on the cold night of February 27, 1848, he aims to be free, if only for a little while. Somehow he manages to escape the clinches of the Alabama Sanders Plantation, but being free after living the life of a slave poses one distinct disadvantage he has no idea what to do next. Life as a runner requires him to adapt quickly or die. The war between good and evil becomes real to him as he sees firsthand the way hate manifests itself in some, while good appears in others. The southern white men he has hated in his young life are soon facing him in the Civil War. Jones must learn to accept help from others to survive in a world turned upside down by the war. Dr. Daniel Black is one of those he must learn to trust. A medical doctor in the Confederate Army, Black understands his life before the war had been one of luxury and pride; after losing everything in the Civil War, he's determined to make his life count for God and help bring order back to the South. Cross-Pull reveals the struggle all men and women face throughout life. It shows that choices, whether made carelessly or thoughtfully, can have long-term consequences and change the direction and outcomes of one's life for eternity.
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