Written for students, Mind, Matter, and Nature presumes no prior philosophical training on the part of the reader. The book nevertheless holds the arguments discussed to rigorous standards and is conversant with recent literature, thus making it useful as well to more advanced students and professionals interested in a resource on Thomistic hylomorphism in the philosophy of mind.
Thinking About Thinking: Mind and Meaning in the Era of Techno-Nihilism addresses our existential crisis by reminding us of the conditions for meaning that have been obscured by the modern technological mentality. Madden weaves together disparate insights from Wittgenstein, Hegel, Aristotle, Heidegger, Merleau-Ponty, Nietzsche, Sophocles, and others in an attempt to account for our mindedness in terms of its inextricable connection to a world capable of inspiring our care. The mind is not a discrete entity locked behind the skull or withdrawn into a ghostly realm, but a participation in an inheritance (biological and cultural) held in common with other participants, and taking responsibility for that world is crucial for the meaning. The ever-increasing technological mediation of our lives undermines this worldliness. We are subsequently “losing our minds,” and as our mindedness fades, so goes our sense of dignity and value. Madden makes this case deploying insights from phenomenology, analytic philosophy, Aristotelianism, neuroscience, and cognitive science, and along the way confronts the mind-body problem, freedom, artificial intelligence, transhumanism, and nihilism. More importantly, he invites the reader into an accessible dialogue concerning issues of grave importance to the meaning of our lives.
The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.
An introduction to action research in Catholic schools through the specific lens of community and spirituality, including original research from Catholic school leaders"--Provided by publisher.
The skin is the largest human organ system. Loss of skin integrity due to injury or illness results in a substantial physiologic imbalance and ultimately in severe disability or death. From burn victims to surgical scars and plastic surgery, the therapies resulting from skin tissue engineering and regenerative medicine are important to a broad spectrum of patients. Skin Tissue Engineering and Regenerative Medicine provides a translational link for biomedical researchers across fields to understand the inter-disciplinary approaches which expanded available therapies for patients and additional research collaboration. This work expands on the primary literature on the state of the art of cell therapies and biomaterials to review the most widely used surgical therapies for the specific clinical scenarios. - Explores cellular and molecular processes of wound healing, scar formation, and dermal repair - Includes examples of animal models for wound healing and translation to the clinical world - Presents the current state of, and clinical opportunities for, extracellular matrices, natural biomaterials, synthetic biomaterials, biologic skin substitutes, and adult and fetal stem and skin cells for skin regenerative therapies and wound management - Discusses new innovative approaches for wound healing including skin bioprinting and directed cellular therapies
This book is organized as a handbook, a "beginning", to elucidate general principles on how the psychoanalyst or psychoanalytically informed psychotherapist may optimally provide and maintain the setting for the psychoanalysis, and ultimately intervene with interpretations.
Christian tradition has largely held three theological affirmations on the resurrection of the physical body. Firstly, that bodily resurrection is not a superfluous hope of afterlife. Secondly, there is immediate post-mortem existence in Paradise. Finally, there is numerical identity between pre-mortem and post-resurrection human beings. The same tradition also largely adheres to a robust doctrine of The Intermediate State, a paradisiacal disembodied state of existence following the biological death of a human being. This book argues that these positions are in fact internally inconsistent, and so a new theological model for life after death is required. The opening arguments of the book aim to show that The Intermediate State actually undermines the necessity of bodily resurrection. Additionally, substance dualism, a principle The Intermediate State requires, is shown to be equally untenable in this context. In response to this, the metaphysics of the afterlife in Christian theology is re-evaluated, and after investigating physicalist and constitutionist replacements for substance dualist metaphysics, a new theory called "Eschatological Presentism" is put forward. This model combines a broadly Thomistic hylemorphic metaphysics with a novel theory of Time. This is an innovative examination of the doctrine of life after death. It will, therefore, be of great interest to scholars of analytic theology and philosophy of religion.
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