At no time in U.S. history has there been a more effective challenge to medical expertise and authority than that mounted by the contemporary Laetrile movement. The efficacy of Laetrile has been debated for over twenty-five years, but despite vigorous opposition from the medical community, support for the purported cancer treatment continues to gro
This volume is based in part upon the proceedings of the Calcium Theme held during the 67th Annual Meeting of the Federation of American Societies for Experimental Biology, which took place in Chicago, AprillO-lS, 1983. The American Society for Pharmacology and Experimental Therapeutics had the primary responsibility for organizing the scientific program with the assistance of other member societies, including the American Physiology Society, American Association of Pathologists, and American Institute of Nutrition. The purpose of the Calcium Theme was to review progress in the diverse areas of investigation bearing on the ubiquitous role of calcium in biological systems. In addition to contributions from those participating in the Theme, this volume also includes a number of invited papers that were added to fill certain voids in topics covered. The authors were selected because they are investigators active in the mainstream of their particular research area, possessing the acumen to analyze cogently not only their own recent findings but also to relate these findings to their respective area. New information as well as reviews of current concepts generally highlight the individual contributions. Undoubtedly, some readers may argue with the emphasis made and/or the conclusions reached on individual topics. In such cases, other volumes will hopefully provide a forum for alternative points of view. Due to the broad scope of subjects covered and the large number of contributions, the papers have been arranged in three sections.
Biomedical optical imaging is a rapidly emerging research area with widespread fundamental research and clinical applications. This book gives an overview of biomedical optical imaging with contributions from leading international research groups who have pioneered many of these techniques and applications. A unique research field spanning the microscopic to the macroscopic, biomedical optical imaging allows both structural and functional imaging. Techniques such as confocal and multiphoton microscopy provide cellular level resolution imaging in biological systems. The integration of this technology with exogenous chromophores can selectively enhance contrast for molecular targets as well as supply functional information on processes such as nerve transduction. Novel techniques integrate microscopy with state-of-the-art optics technology, and these include spectral imaging, two photon fluorescence correlation, nonlinear nanoscopy; optical coherence tomography techniques allow functional, dynamic, nanoscale, and cross-sectional visualization. Moving to the macroscopic scale, spectroscopic assessment and imaging methods such as fluorescence and light scattering can provide diagnostics of tissue pathology including neoplastic changes. Techniques using light diffusion and photon migration are a means to explore processes which occur deep inside biological tissues and organs. The integration of these techniques with exogenous probes enables molecular specific sensitivity.
James Harvey Young, the foremost expert on the history of medical frauds, finds quackery in the 1990s to be more extensive and insidious than in earlier and allegedly more naive eras. The modern quack isn't an outrageous-looking hawker of magic remedies operating from the back of a carnival wagon, but he knows how to use antiregulatory sentiment and ingenious promotional approaches to succeed in a "trade" that is both bizarre and deceitful. In The Toadstool Millionaires and The Medical Messiahs, Young traced the history of health quackery in America from its colonial roots to the late 1960s. This collection of essays discusses more recent health scams and reconsiders earlier ones. Liberally illustrated with examples of advertising for patent medicines and other "alternative therapies," the book links evolving quackery to changing currents in the scientific, cultural, and governmental environment. Young describes varieties of quackery, like frauds related to the teeth, nostrums aimed at children, and cure-all gadgets with such names as Electreat Mechanical Heart. The case of Laetrile illustrates how an alleged vitamin for controlling cancer could be ballyhooed and lobbied into a national mania, half the states passing laws giving the cyanide-containing drug some special status. And AIDS is the most recent example of an illness that, tragically, has panicked some of its victims and members of the general public into putting their hopes in fake cures and preventives. Young discusses the complex question of vulnerability--why people fall victim to health fraud--and considers the difficulties confronting governmental regulators. From the late 1960s to the early 1990s, the annual quackery toll has escalated from two billion to over twenty-five billion dollars. Young helps us discover why. Originally published in 1992. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Fungi research and knowledge grew rapidly following recent advances in genetics and genomics. This book synthesizes new knowledge with existing information to stimulate new scientific questions and propel fungal scientists on to the next stages of research. This book is a comprehensive guide on fungi, environmental sensing, genetics, genomics, interactions with microbes, plants, insects, and humans, technological applications, and natural product development.
**Selected for Doody's Core Titles® 2024 in Veterinary Medicine** Use the veterinarian's #1 reference on general pathology and the pathology of organ systems! Pathologic Basis of Veterinary Disease, 7th Edition helps you understand and diagnose diseases of domestic animals by using the latest scientific and medical research. Focusing on dogs, cats horses, cattle, sheep, goats, and pigs, this reference describes and vividly illustrates and explores the pathogeneses of animal diseases, how cells and tissues respond to injury, and the morphology (lesions) of this injury. New to this edition is basic coverage of tumor, inflammatory, and microbial cytology. Edited by veterinary pathologist James F. Zachary and a team of expert veterinary pathologists, this book includes access to an enhanced eBook with every new print purchase, featuring a fully searchable version of the entire text, an image collection, and much more – and available on a variety of devices. - Clear, up-to-date illustrations and explanations of the macroscopic (gross) and microscopic lesions resulting from diseases occurring in domestic animals - Complete coverage of both general pathology and the pathology of organ systems that includes the latest research, practice, and diagnostic information on disease mechanisms, pathogenesis, and lesions. - Clear explanations of disease mechanisms that describe cell, tissue, and organ system responses to injury and infection. - Easy-to-follow organization for each systemic disease chapter including a brief review of the study of diseases that occur in specific tissues, organs, and organ systems, with basic principles related to anatomy, structure, and function, followed by congenital and functional abnormalities and discussions of infectious disease responses, helping students apply principles to veterinary practice. - More than 2,100 full-color illustrations featuring color photographs, schematics, flow charts, and diagrammatic representations of disease processes as well as summary tables and boxes, making it easier to understand difficult concepts. - Content on cellular and organ system pathology updated throughout the book, with expanded coverage of genetics and disease. - Key Readings Index in each chapter with page numbers for key topics. - Essential Concept boxes in each General Pathology chapter break down complicated topics that are critical to understanding lesions and pathogeneses. - More than 20 recognized experts deliver the most relevant information for the practitioner, student, or individual preparing for the American College of Veterinary Pathologists' board examination. - An enhanced eBook is included with new print purchase, featuring the complete, fully searchable text plus an image collection; the text, tables, and boxes linked to the website that are cited throughout the book; ten new appendices that focus on veterinary diagnostic pathology, postmortem examination, interpretation of lesions, and more; plus an established appendix of photographic techniques used in veterinary diagnostic pathology.
Multiple Imputation and its Application The most up-to-date edition of a bestselling guide to analyzing partially observed data In this comprehensively revised Second Edition of Multiple Imputation and its Application, a team of distinguished statisticians delivers an overview of the issues raised by missing data, the rationale for multiple imputation as a solution, and the practicalities of applying it in a multitude of settings. With an accessible and carefully structured presentation aimed at quantitative researchers, Multiple Imputation and its Application is illustrated with a range of examples and offers key mathematical details. The book includes a wide range of theoretical and computer-based exercises, tested in the classroom, which are especially useful for users of R or Stata. Readers will find: A comprehensive overview of one of the most effective and popular methodologies for dealing with incomplete data sets Careful discussion of key concepts A range of examples illustrating the key ideas Practical advice on using multiple imputation Exercises and examples designed for use in the classroom and/or private study Written for applied researchers looking to use multiple imputation with confidence, and for methods researchers seeking an accessible overview of the topic, Multiple Imputation and its Application will also earn a place in the libraries of graduate students undertaking quantitative analyses.
A practical guide to analysing partially observed data. Collecting, analysing and drawing inferences from data is central to research in the medical and social sciences. Unfortunately, it is rarely possible to collect all the intended data. The literature on inference from the resulting incomplete data is now huge, and continues to grow both as methods are developed for large and complex data structures, and as increasing computer power and suitable software enable researchers to apply these methods. This book focuses on a particular statistical method for analysing and drawing inferences from incomplete data, called Multiple Imputation (MI). MI is attractive because it is both practical and widely applicable. The authors aim is to clarify the issues raised by missing data, describing the rationale for MI, the relationship between the various imputation models and associated algorithms and its application to increasingly complex data structures. Multiple Imputation and its Application: Discusses the issues raised by the analysis of partially observed data, and the assumptions on which analyses rest. Presents a practical guide to the issues to consider when analysing incomplete data from both observational studies and randomized trials. Provides a detailed discussion of the practical use of MI with real-world examples drawn from medical and social statistics. Explores handling non-linear relationships and interactions with multiple imputation, survival analysis, multilevel multiple imputation, sensitivity analysis via multiple imputation, using non-response weights with multiple imputation and doubly robust multiple imputation. Multiple Imputation and its Application is aimed at quantitative researchers and students in the medical and social sciences with the aim of clarifying the issues raised by the analysis of incomplete data data, outlining the rationale for MI and describing how to consider and address the issues that arise in its application.
At last, a book about a group that's been sorely neglected, those who have come of age in an advanced industrial society in the late 20th century. Looks at facets such as education, youth unemployment and crime, family structure, and personal aspirations, using a multidisciplinary approach. Discusses the prolongation of youth resulting from industrialization and legislation, economic disenfranchisement and the new service worker, and youth targeted as consumers of the media, music, fashion, and education industries. Offers a model of coming of age in Sweden. Annotation copyright by Book News, Inc., Portland, OR
Pioneering study of the anglophone 'settler boom' in North America, Canada, South Africa, Australia, and New Zealand between the early 19th and early 20th centuries, looking at what made it the most successful of all such settler revolutions, and how this laid the basis of British and American power in the 19th and 20th centuries.
James Vincent Forrestal (1892-1949) was the last Cabinet-level United States Secretary of the Navy and the first United States Secretary of Defense. These fascinating diaries begin in 1944 shortly after James Forrestal became Secretary of the Navy, and end with his resignation in March 1949 as America’s first Secretary of Defense. Blunt and forceful, Forrestal reveals the American strategy that he helped shape with verve. Expertly edited by seasoned historian Walter Millis, the American high command as is seen in a rare light as the Second World War finishes and the Cold War begins and gathers pace.
The new edition reorganizes its treatment of Greek science and significantly expands its coverage of industrial civilization and contemporary science and technology with new and revised chapters devoted to applied science, the sociology and economics of science, globalization, and the technological systems that underpin everyday life.
This book reexamines the U.S. trade policy, discussing challenges that prompted the Committee for Economic Development to construct a modern framework and reaffirm its support of the multilateral trade system. It presents recommendations essential to bolstering U.S. competitiveness in the future.
Radiation Oncology: Rationale, Technique, Results, by James D. Cox, MD and K. Kian Ang, MD, PhD, provides you with authoritative guidance on the latest methods for using radiotherapy to treat patients with cancer. Progressing from fundamental principles through specific treatment strategies for the cancers of each organ system, it also addresses the effects of radiation on normal structures and the avoidance of complications. This 9th edition covers the most recent indications and techniques in the field, including new developments in proton therapy and intensity-modulated radiotherapy (IMRT). It also features, for the first time, full-color images throughout the text to match those that you see in practice, and uses new color-coded treatment plans to make targets, structures, and doses easier to read at a glance. Evidence from randomized clinical trials is included whenever possible to validate clinical recommendations. The state-of-the-art coverage inside this trusted resource equips you to target cancer as effectively as possible while minimizing harm to healthy tissue. Stands apart as the only book in the field to cover the conceptual framework for the use of radiotherapy by describing the most effective techniques for treatment planning and delivery and presenting the results of each type of therapy. Emphasizes clinical uses of radiation therapy, providing pertinent, easy-to-understand information on state-of-the-art treatments. Includes information useful for non-radiotherapists, making it "recommended reading" for other oncology specialists. Offers a practical, uniform chapter structure to expedite reference. Guides you through the use of the newest radiation oncology techniques, including principles of proton therapy and new developments in intensity-modulated radiotherapy (IMRT). Incorporates evidence from randomized clinical trials whenever possible to validate clinical recommendations. Presents full-color images throughout to match the images that you see in practice. Extensive use of "combination" imaging presents a complete picture of how to more precisely locate and target the radiotherapy field.
We've Got You Covered for your Organizational Behavior course. Wiley provides the most current content, comprehensive resources and flexible format options to help teachers teach and students learn. Our commitment to Currency, Global Issues, Sustainability and Learning Outcomes translates into a suite of teaching and learning options that seamlessly integrate into your management courses. Organizational Behavior 12e connects OB concepts with applications and is the clearest, most current and applicable OB text today - helping students understand how they can thrive in the world of work. Through experiential exercises and activities that ask students to evaluate themselves as leaders and colleagues, students are encouraged to reflect, grow and understand how they can contribute their professional and social environments. Known for sound pedagogy, research, and a rich framework of personal and organizational skills, OB 12e presents students with a full portfolio of concepts and applications. In addition, the 12th Edition continues to emphasize global business issues important for future generations, including ethics, leadership, and sustainability.
James Harvey Young describes the development of patent medicines in America from the enactment in 1906 of the Pure Food and Drugs Act through the mid-1960s. Many predicted that the Pure Food and Drugs Act would be the end of harmful nostrums, but Young describes in colorful detail post-Act cases involving manufacturers and promoters of such products as Cuforhedake Brane-Fude, B. & M. "tuberculosis-curing" liniment, and the dangerous reducing pill Marmola. We meet, among others, the brothers Charles Frederick and Peter Kaadt, who treated diabetic patients with a mixture of vinegar and saltpeter; Louisiana state senator Dudley J. LeBlanc, who put on fabulous medicine shows as late as the 1950s promoting Hadacol and his own political career, and Adolphus Hohensee, whose lectures on nutrition provide a classic example of the continuing appeal of food faddism. Review: "The Medical Messiahs is an example of historical writing at its best—scholarly, perceptive, and exceedingly readable. Despite his objectivity, Young's dry humor shines through and illuminates his entire book."—John Duffy, Journal of Southern History "This book is written in tight, graceful prose that reflects thought rather than substitutes for it. Done with a sure feel for the larger political, social, and economic background, it demonstrates that historians who would make socially relevant contributions need only adhere to the best canons of their art."—Oscar E. Anderson, Jr., The American Historical Review "[This] material is so interestingly presented that the readers may not immediately appreciate what a major historic study [the book] is, and how carefully documented and critically analyzed."—Lester S. King, Journal of the American Medical Association "Dr. Young's well-written social history of health quackery in twentieth-century America will not only increase the understanding of our times by future historians but will also be of great value to all those interested in improving the health of the population by reminding them of the past."—F. M. Berger, The American Scientist Originally published in 1967. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Solve your toughest neurodiagnostic challenges with Neuropathology, 3rd Edition - the most information-packed, extensively illustrated neuropathology reference available! An expert author team presents more than 3,000 high-quality images - nearly all in full color - to provide unmatched visual guidance on the microscopic and gross pathologic presentation of a full range of neurologic diseases. Diagnose with confidence by consulting the most extensive published image collection in neuropathology, which includes an exceptional number of gross pathology images, a feature poorly represented in other texts. Access the complete contents online and download all the images at www.expertconsult.com. Understand the most recent developments in neurologic diseases and quickly identify important variants and outliers. Meet the needs of an aging population with expanded coverage of Alzheimer's and Parkinson's disease, motor neuron disorders, and prion diseases, as well as conditions such as multiple sclerosis. Apply the latest knowledge on molecular genetics and the growing role of genetic testing. Make optimal use of today’s functional imaging techniques with new information on PET, fMRI, and SPECT. Stay current with the newest diagnostic protocols and guidelines as endorsed by professional societies and national bodies, the most recent WHO classification of central nervous system diseases, and checklists for the handling and diagnosis of CNS tumors and tumor-like lesions. Get outstanding visual guidance with new full-color images, and new and updated drawings that clarify complex entities and concepts.
Hunter’s Tropical Medicine and Emerging Infectious Disease is your comprehensive, go-to resource on the health conditions that arise in the tropics! From infectious diseases through environmental issues, poisoning and toxicology, animal injuries, and nutritional and micronutrient deficiencies, this medical reference book provides you with all the guidance you need to diagnose and manage even the most exotic health concerns. Stay at the forefront of this ever-changing field with Hunter’s Tropical Medicine and Emerging Infectious Disease! Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Understand the common characteristics and methods of transmission for each disease, and learn all the applicable diagnosis, treatment, control, and prevention techniques. Get the information you need in the most organized way with infectious agents arranged by syndromes, as they typically present. Stay abreast of the latest maladies seen in returning travelers through useful chapters on delusional parasitosis, international adoptions, transplant patients, medical tourism, and more. Access the most up-to-date information on emerging and re-emerging diseases (such as H1N1), and see how progression occurs through all-new illustrative life cycles. Hone your techniques with a new skills-based section which includes dentistry, neonatal pediatrics and ICMI, and surgery in the tropics, and a service-based section covering transfusion in resource-poor settings, microbiology, and imaging. Learn everything you need to know about infrequently encountered tropical drugs and their practical application in the clinical setting.
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