Monte Carlo Methods in Fuzzy Optimization is a clear and didactic book about Monte Carlo methods using random fuzzy numbers to obtain approximate solutions to fuzzy optimization problems. The book includes various solved problems such as fuzzy linear programming, fuzzy regression, fuzzy inventory control, fuzzy game theory, and fuzzy queuing theory. The book will appeal to engineers, researchers, and students in Fuzziness and applied mathematics.
This issue of the Heart Failure Clinics, edited by Drs. James Fang and Michael Givertz, is entitled "Advanced Heart Failure" and covers a wide array of topics relating to the subject. The issue will delve into the prevalence, history and prognosis of advanced heart failure; cardiorenal interactions; cardiohepatic interactions; the role of temporary mechanical circulatory support; guided therapy; the role of heart transplantation; palliative care; frailty; and novel biological techniques, among other topics.
Vienna, 1909. When the celebrated actor Eugen Bischoff is found dead in his garden pavilion, suspicion falls immediately on Baron von Yosch, a well-to-do army officer who was once the lover of the dead man s wife. By all appearances the door was locked from the inside when the two shots rang out the actor took his own life, but someone, or something, drove him to it. The baron sets out to learn all he can about the actor s death in order to clear his name. Meanwhile, within a few days, similar apparent suicides are reported. What started out as a straightforward quest to establish Bischoff s last deeds and discover the truth of his death becomes a search through the ages for an invisible enemy identified only by the actor s dying breath, when he whispered: . . . the Day of Judgment. Leo Perutz combines his hallmark blend of suspense and the fantastic in this spine-tingling mystery.
This issue of Clinics in Geriatric Medicine, guest edited by Drs. Cynthia Boyd, James T. Pacala, and Michael W. Rich, is devoted to Chronic Conditions in Older Adults with Cardiovascular Disease. Articles in this issue include: Epidemiology of multimorbidity in older adults with cardiovascular disease; Impact of multimorbidity on clinical outcomes in older adults with cardiovascular disease; Assessment of goals of care in patients with multiple chronic conditions; Challenges in decision-making: balancing trade-offs; Multimorbidity in older adults with heart failure; Multimorbidity in older adults with acute coronary syndromes; Multimorbidity in older adults with aortic stenosis; Multimorbidity in older adults with atrial fibrillation;Anticoagulation in older adults with multimorbidity; Approach to evaluating the multimorbid patient with cardiovascular disease undergoing non-cardiac surgery; Integrating care across disciplines; Assessing risks and benefits of invasive cardiac procedures in patients with advanced multimorbidity; Multimorbidity and end of life care in patients with cardiovascular disease; and Future research directions for cardiovascular disease.
Metallic Powders for Additive Manufacturing Overview of successful pathways for producing metal powders for additive manufacturing of high-performance metallic parts and components with tailored properties Metallic Powders for Additive Manufacturing introduces the readers to the science and technology of atomized metal powders beyond empirical knowledge and the fundamental relationships among the chemistry, microstructure, and morphology of atomized metallic powders and their behavior during additive manufacturing. The text sets a foundation of the underlying science that controls the formation and microstructure of atomized metallic droplets, including the relations among the properties of metallic powders, their performance during the manufacturing processes, and the resulting products. Other topics covered include the influence of powder on defect formation, residual stress, mechanical behavior, and physical properties. The concluding two chapters encompass considerations of broader societal implications and overarching themes, including the exploration of alternative feedstock materials, economic analysis, and sustainability assessment. These chapters offer valuable perspectives on the prospective trajectory of the field. Written by a team of experienced and highly qualified professors and academics, Metallic Powders for Additive Manufacturing includes information on: Atomization techniques such as Vacuum Induction Gas Atomization (VIGA), Electrode Induction Melting Gas Atomization (EIMGA), and Plasma Rotating Electrode Process (PREP) Atomization science and technology, covering control of atomization parameters, powder size distribution, effect of processing variables, and theoretical models of atomization Heat transfer and solidification of droplets, covering nucleation, microstructure development, and important thermal and solidification conditions during atomization Atomization of Al, Fe, Ni, Co, Ti, and high entropy alloys, as well as composite powders for additive manufacturing, and guidelines for atomization equipment and powder handling Fundamental processing principles in a variety of metal additive manufacturing processes Powder characteristics and requirements for different additive manufacturing processes Effect of powder chemistry and physical characteristics on additive manufacturing processes, and the microstructure and properties of the built parts Evaluation of alternative feedstock sources for metal additive manufacturing, beyond gas atomized powder Economic and sustainability perspectives on powder production and additive manufacturing Metallic Powders for Additive Manufacturing is an excellent combination of rigorous fundamentals and a practice-oriented and forward-looking resource on the subject for materials scientists and practicing engineers seeking to understand, optimize, and further develop the field of powder production and additive manufacturing.
This book is intended to be a general reference for environmental decision makers who are interested in the fate of chlorinated aromatic compounds with respect to microbial activity. It includes reviews of microbial physiology, genetics, and methods of biodegradation assessment.
Offering unparalleled coverage of infectious diseases in children and adolescents, Feigin & Cherry's Textbook of Pediatric Infectious Diseases 8th Edition, continues to provide the information you need on epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. This extensively revised edition by Drs. James Cherry, Gail J. Demmler-Harrison, Sheldon L. Kaplan, William J. Steinbach, and Peter J. Hotez, offers a brand-new full-color design, new color images, new guidelines, and new content, reflecting today's more aggressive infectious and resistant strains as well as emerging and re-emerging diseases - Discusses infectious diseases according to organ system, as well as individually by microorganisms, placing emphasis on the clinical manifestations that may be related to the organism causing the disease. - Provides detailed information regarding the best means to establish a diagnosis, explicit recommendations for therapy, and the most appropriate uses of diagnostic imaging. - Features expanded information on infections in the compromised host; immunomodulating agents and their potential use in the treatment of infectious diseases; and Ebola virus. - Contains hundreds of new color images throughout, as well as new guidelines, new resistance epidemiology, and new Global Health Milestones. - Includes new chapters on Zika virus and Guillain-Barré syndrome. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Here is the most comprehensive and up-to-date treatment of one of the hottest areas of chemical research. The treatment of fundamental kinetics and photochemistry will be highly useful to chemistry students and their instructors at the graduate level, as well as postdoctoral fellows entering this new, exciting, and well-funded field with a Ph.D. in a related discipline (e.g., analytical, organic, or physical chemistry, chemical physics, etc.). Chemistry of the Upper and Lower Atmosphere provides postgraduate researchers and teachers with a uniquely detailed, comprehensive, and authoritative resource. The text bridges the "gap" between the fundamental chemistry of the earth's atmosphere and "real world" examples of its application to the development of sound scientific risk assessments and associated risk management control strategies for both tropospheric and stratospheric pollutants. - Serves as a graduate textbook and "must have" reference for all atmospheric scientists - Provides more than 5000 references to the literature through the end of 1998 - Presents tables of new actinic flux data for the troposphere and stratospher (0-40km) - Summarizes kinetic and photochemical date for the troposphere and stratosphere - Features problems at the end of most chapters to enhance the book's use in teaching - Includes applications of the OZIPR box model with comprehensive chemistry for student use
Consult the definitive resource in rheumatology for an in-depth understanding of scientific advances as they apply to clinical practice. Masterfully edited by Drs. Gary S. Firestein, Ralph C. Budd, Sherine E. Gabriel, Iain B. McInnes, and James R. O'Dell, and authored by internationally renowned scientists and clinicians in the field, Kelley and Firestein’s Textbook of Rheumatology, 10th Edition, delivers the knowledge you need for accurate diagnoses and effective patient care. From basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes, this state-of-the-art reference provides a global, authoritative perspective on the manifestations, diagnosis and treatment of rheumatic diseases. An ideal balance of the basic science you need to know and how to apply that information to clinical practice. An integrated chapter format allows you to review basic science advances and their clinical implications in one place and get dependable, evidence-based guidance for the full range of rheumatologic diseases and syndromes. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. New content on the latest diagnostic perspectives and approaches to therapy, including five brand-new chapters: Metabolic Regulation of Immunity, Principles of Signaling, Research Methods in the Rheumatic Diseases, Novel Intracellular Targeting Agents, and IgG4-Related Diseases. New and expanded chapter topics on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies. More schematic diagrams clearly summarize information and facilitate understanding.
Easily accessible and clinically focused, Abeloff's Clinical Oncology, 6th Edition, covers recent advances in our understanding of the pathophysiology of cancer, cellular and molecular causes of cancer initiation and progression, new and emerging therapies, current trials, and much more. Masterfully authored by an international team of leading cancer experts, it offers clear, practical coverage of everything from basic science to multidisciplinary collaboration on diagnosis, staging, treatment and follow up. - Includes new chapters on Cancer Metabolism and Clinical Trial Designs in Oncology and a standalone chapter on lifestyles and cancer prevention. - Features extensive updates including the latest clinical practice guidelines, decision-making algorithms, and clinical trial implications, as well as new content on precision medicine, genetics, and PET/CT imaging. - Includes revised diagnostic and treatment protocols for medical management, surgical considerations, and radiation oncology therapies, stressing a multispecialty, integrated approach to care. - Helps you find information quickly with updated indexing related to management recommendations, focused fact summaries, updated key points at the beginning of each chapter ideal for quick reference and board review, and algorithms for patient evaluation, diagnosis, and treatment options. - Offers more patient care coverage in disease chapters, plus new information on cancer as a chronic illness and cancer survivorship. - Discusses today's key topics such as immuno-oncology, functional imaging, precision medicine, the application of genetics in pathologic diagnosis and sub-categorization of tumors as well as the association of chronic infectious diseases such as HIV and cancer. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Equatorial Guinea is a small country located in west central Africa, bordered by Cameroon to the north and Gabon to the south and east. The country consists of the mainland region which is the RÃo Muni, and the island region of Bioko, which is made up of the islands of Bioko and Annobón. The country has a small population of around 1.2 million people, with roughly the same number of people living on the mainland as on the islands. Equatorial Guinea is one of the smallest countries in Africa in terms of both population and land area. It is also one of the most ethnically diverse countries in Africa, with over 50 different ethnic groups present. Equatorial Guinea gained independence in 1968 after Spanish colonization. Since then, the country has been ruled by one political party, the Democratic Party of Equatorial Guinea (PDGE). The country is one of the wealthiest in Africa, with a per capita GDP that ranks among the highest on the continent. This is largely due to oil reserves discovered in the 1990s, which make up the majority of the country's export earnings. Despite its wealth, Equatorial Guinea is also known for its human rights abuses and corruption, with the country frequently ranking poorly on global indices measuring these factors.
Cancer Vaccines and Tumor Immunity offers a review of the basic scientific discoveries that have moved forward into clinical trials. Presented in the context of real-world human research and experimentation, these major scientific advances demonstrate how our understanding of immune activation, T-regulatory cells, and autoimmunity will impact cancer vaccine design. The authors also explain how vaccination in the context of bone marrow transplantation will open new avenues for clinical study in the future.
The first component of intelligence involves effective adaptation to an environment. In order to adapt effectively, organizations require resources, capabilities at using them, knowledge about the worlds in which they exist, good fortune, and good decisions. They typically face competition for resources and uncertainties about the future. Many, but possibly not all, of the factors determining their fates are outside their control. Populations of organizations and individual organizations survive, in part, presumably because they possess adaptive intelligence; but survival is by no means assured. The second component of intelligence involves the elegance of interpretations of the experiences of life. Such interpretations encompass both theories of history and philosophies of meaning, but they go beyond such things to comprehend the grubby details of daily existence. Interpretations decorate human existence. They make a claim to significance that is independent of their contribution to effective action. Such intelligence glories in the contemplation, comprehension, and appreciation of life, not just the control of it.—from The Ambiguities of Experience In The Ambiguities of Experience, James G. March asks a deceptively simple question: What is, or should be, the role of experience in creating intelligence, particularly in organizations? Folk wisdom both trumpets the significance of experience and warns of its inadequacies. On one hand, experience is described as the best teacher. On the other hand, experience is described as the teacher of fools, of those unable or unwilling to learn from accumulated knowledge or the teaching of experts. The disagreement between those folk aphorisms reflects profound questions about the human pursuit of intelligence through learning from experience that have long confronted philosophers and social scientists. This book considers the unexpected problems organizations (and the individuals in them) face when they rely on experience to adapt, improve, and survive. While acknowledging the power of learning from experience and the extensive use of experience as a basis for adaptation and for constructing stories and models of history, this book examines the problems with such learning. March argues that although individuals and organizations are eager to derive intelligence from experience, the inferences stemming from that eagerness are often misguided. The problems lie partly in errors in how people think, but even more so in properties of experience that confound learning from it. "Experience," March concludes, "may possibly be the best teacher, but it is not a particularly good teacher.
Fungi research and knowledge grew rapidly following recent advances in genetics and genomics. This book synthesizes new knowledge with existing information to stimulate new scientific questions and propel fungal scientists on to the next stages of research. This book is a comprehensive guide on fungi, environmental sensing, genetics, genomics, interactions with microbes, plants, insects, and humans, technological applications, and natural product development.
Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners. - Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases - Provides knowledge from internationally recognized contributors in the field - Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases - Contains access to a companion website with additional illustrations
A cardiac point-of-care guide based on the field's leading text Hurst's the Heart Manual of Cardiology, 13e provides a concise summary of the clinical content of Hurst's the Heart, 13e. Updated throughout, the book features a streamlined, quick-access presentation designed for use in urgent clinical situations. Features Increased number of tables, illustrations, and summary visuals Completely updated to reflect new cardiovascular drugs and the latest US and European guidelines Streamlined presentation
Introducing the first evidence-based casebook for hospital clinicians This book introduces illustrated, evidence-based clinical cases drawn from real-world hospital practice. Geared to the needs of hospital clinicians, Clinical Care Conundrums: Challenging Diagnoses in Hospital Medicine focuses on sharpening clinical reasoning and diagnostic skills, giving readers the tools to recognize and diagnose a wide array of diseases, while promoting diagnostic safety in hospital medicine. Written by leading experts on the topics under discussion, this volume offers a hand-picked collection of case studies from the widely popular Clinical Care Conundrum (CCC) series found in the Journal of Hospital Medicine. Each chapter presents a case to an expert clinician, who explains his or her approach to diagnosing challenging medical dilemmas. Each chapter concludes with a concise review of recent literature and, if applicable, with discussions of cognitive errors that may impact clinical diagnosis and patient care. Readers will find: An appealing presentation style that combines high-quality images and text Coverage of both common conditions and uncommon but important diseases encountered in the hospital setting A look at the state of the art of clinical reasoning, an area of critical interest to clinicians Practical "pearls" for each case study that readers can apply in their own practice Clinical Care Conundrums is an indispensable reference for hospitalists, hospital-based physicians and midlevel providers, physicians-in-training, and the many other medical practitioners who come up against difficult cases on a daily basis.
This book introduces the technical foundations and tools for estimating the power consumption of internet networks and services, including a detailed description of how these models are constructed and applied. Modeling the Power Consumption and Energy Efficiency of Telecommunications Networks can be used to gain insight into the construction of mathematical models that provide realistic estimates of the power consumption of internet networks and services. This knowledge enables forecasting the energy footprint of future networks and services to integrate sustainability and environmental considerations into network planning and design. FEATURES Provides the motivation for developing mathematical models for telecommunications network and service power consumption and energy efficiency modeling Presents factors impacting overall network and service power consumption Discusses the types of network equipment and their power consumption profiles Reviews the basics of power modeling, including network segmentation, traffic forecasting, top-down and bottom-up models, wired and wireless networks, data centers and servers Explores the application of energy efficiency metrics for equipment, networks, and services This book is aimed at students and technologists as well as technology managers and policy makers. This book will be of value to any organization that wishes to estimate the energy footprint of the use of information and communications technologies. This book can also be integrated into a course on the sustainability of information and communications technologies.
Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention – all in one convenient resource – equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most! Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries' implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format • summary boxes • a full-color design • and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient. Offers access to the book's complete contents online – fully searchable – from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts.
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