During the last few years there has been a rapidly increasing interest in neural modeling of brain and cognitive disorders. This multidisciplinary book presents a variety of such models in neurology, neuropsychology and psychiatry. A review of work in this area is given first. Computational models are then presented of memory impairment in Alzheimer's disease, functional brain reorganization following a stroke, patterns of neural activity in epilepsy, disruption of language processes in aphasia and acquired dyslexia, altered cognitive processes in schizophrenia and depression, and related disorders. This is the first book on this topic, with contributions from many of the leading researchers in this field.
Making a diagnosis when something goes wrong with a natural or m- made system can be difficult. In many fields, such as medicine or electr- ics, a long training period and apprenticeship are required to become a skilled diagnostician. During this time a novice diagnostician is asked to assimilate a large amount of knowledge about the class of systems to be diagnosed. In contrast, the novice is not really taught how to reason with this knowledge in arriving at a conclusion or a diagnosis, except perhaps implicitly through ease examples. This would seem to indicate that many of the essential aspects of diagnostic reasoning are a type of intuiti- based, common sense reasoning. More precisely, diagnostic reasoning can be classified as a type of inf- ence known as abductive reasoning or abduction. Abduction is defined to be a process of generating a plausible explanation for a given set of obs- vations or facts. Although mentioned in Aristotle's work, the study of f- mal aspects of abduction did not really start until about a century ago.
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