Organized to enable students and synthetic chemists to understand and expand on aromatic reactions covered in foundation courses, the book offers a thorough and accessible mechanistic explanation of aromatic reactions involving arene compounds. • Surveys methods used for preparing arene compounds and their transformations • Connects reactivity and methodology with mechanism • Helps readers apply aromatic reactions in a practical context by designing syntheses • Provides essential information about techniques used to determine reaction mechanisms
The computer-aided design of novel molecular systems has undoubtedly reached the stage of a mature discipline offering a broad range of tools available to virtually any chemist. However, there are few books coveringmost of these techniques in a single volume and using a language which may generally be understood by students or chemists with a limited knowledge of theoretical chemistry. The purpose of this book is precisely to review, in such a language, both methodological aspects and important applications of computer-aided molecular design (CAMD), with a special emphasis on drug design and protein modeling. Using numerous examples ranging from molecular models to shapes, surfaces, and volumes, Computer-Aided Molecular Design provides coverage of the role molecular graphics play in CAMD. The text also treats the very notion of the structure of molecular systems by presenting both the various experimental techniques giving access to it and the most common model builders based on force fields. Separate chapters are devoted to other important topics in CAMD, such as Monte Carlo and molecular dynamics simulations; most common quantum chemical methods; derivation and visualization of molecular properties; and molecular similarity. Finally, strategies used in protein modeling and drug design, such as receptor mapping and the pharmacophore approach, are presented and illustrated by several examples. The book is addressed to students and researchers who wish to enter this new exciting field of molecular sciences, but also practitioners in CAMD as a comprehensive source of refreshing information in their field. Key Features * Presents a comprehensive introduction to computer-aided molecular design * Describes applications of CAMD through the use of numerous examples * Emphasizes strategies used in protein modeling and drug design * Includes separate chapters devoted to other important topics in CAMD, such as: * Monte Carlo and molecular dynamics simulations * Common quantum chemical methods * Derivation and visualization of molecular properties * Molecular similarity
An inquiry into the problematic of perjury, or lying, and forgiveness from one of the most influential philosophers of the twentieth century. “One only ever asks forgiveness for what is unforgivable.” From this contradiction begins Perjury and Pardon, a two-year series of seminars given by Jacques Derrida at the École des hautes études en sciences sociales in Paris in the late 1990s. In these sessions, Derrida focuses on the philosophical, ethical, juridical, and political stakes of the concept of responsibility. His primary goal is to develop what he calls a “problematic of lying” by studying diverse forms of betrayal: infidelity, denial, false testimony, perjury, unkept promises, desecration, sacrilege, and blasphemy. Although forgiveness is a notion inherited from multiple traditions, the process of forgiveness eludes those traditions, disturbing the categories of knowledge, sense, history, and law that attempt to circumscribe it. Derrida insists on the unconditionality of forgiveness and shows how its complex temporality destabilizes all ideas of presence and even of subjecthood. For Derrida, forgiveness cannot be reduced to repentance, punishment, retribution, or salvation, and it is inseparable from, and haunted by, the notion of perjury. Through close readings of Kant, Kierkegaard, Shakespeare, Plato, Jankélévitch, Baudelaire, and Kafka, as well as biblical texts, Derrida explores diverse notions of the “evil” or malignancy of lying while developing a complex account of forgiveness across different traditions.
When it was first published in 1781, The Confessions scandalised Europe with its emotional honesty and frank treatment of the author's sexual and intellectual development. Since then, it has had a more profound impact on European thought. Rousseau left posterity a model of the reflective life - the solitary, uncompromising individual, the enemy of servitude and habit and the selfish egoist who dedicates his life to a particular ideal. The Confessions recreates the world in which he progressed from incompetent engraver to grand success; his enthusiasm for experience, his love of nature, and his uncompromising character make him an ideal guide to eighteenth-century Europe, and he was the author of some of the most profound work ever written on the relation between the individual and the state.
The dignity of Marshal of France was to be the apogee of success for any general in Napoleonic France, since the Emperor only created 26 during his years on the throne. Fame, riches and high station in the Imperial Court were the bountiful reward for hard service on the battlefield. Napoleon handed out these dignities, along with kingdoms, principalities, admiralties, dukedoms for more than purposes of recognition; they were also to bind the recipient to his empire even more tightly. Marshal Macdonald was not a man to be flattered or bought; he was of Scottish descent and held his own views. His memoirs bear this imprint of forthright opinion, which had led him into trouble with the Emperor, but such was his value on the battlefield he was courted again by Napoleon. Marshal Macdonald fought all across Europe, particularly at the battle of Jemappes in the Revolutionary armies on the Rhine. He fought well under Napoleon’s eagles in Spain, Russia, Germany and France itself. Outstanding at the battle of Wagram, his attack on the Austrian centre, for which he became the only man to be made marshal on the field of battle by Napoleon, clinched the day. Never wholly Napoleon’s man, he was a prime mover in forcing his master’s abdication in 1814 and refused to rejoin him in 1815. This second volume Marshal Macdonald recounts his experiences up to the fall of Napoleon in 1815. Title – Recollections of Marshal Macdonald, Duke of Tarentum. — Vol. II Series Name – Recollections of Marshal Macdonald, Duke of Tarentum. Series Number —2 Author – Marshal Macdonald, Etienne-Jacques-Joseph-Alexandre, Duc de Tarente, 1765-1840. Editor - Rousset, Camille, 1821-1892. Translator - Simeon, Stephen Louis, 1857-1937 Text taken, whole and complete, from the edition published in 1892, London, by Richard Bentley and Son. Original Page Count – 328 pages.
This meticulously edited Rousseau collection is formatted for your eReader with a functional and detailed table of contents: "Emile, or On Education" or "Émile, or Treatise on Education" is a treatise on the nature of education and on the nature of man. Jean-Jacques Rousseau considered it to be the "best and most important" of all his writings. Emile is scarcely a detailed parenting guide but it does contain some specific advice on raising children. It is regarded by some as the first philosophy of education in Western culture to have a serious claim to completeness, as well as being one of the first Bildungsroman novels. "The Social Contract," originally published as On the Social Contract; or, Principles of Political Rights by Rousseau, is a 1762 book in which Rousseau theorized about the best way to establish a political community in the face of the problems of commercial society, which he had already identified in his Discourse on Inequality (1754). The Social Contract helped inspire political reforms or revolutions in Europe, especially in France "Confessions" is an autobiographical book which covers the first fifty-three years of Rousseau's life, up to 1765. It was completed in 1769, but not published until 1782, four years after Rousseau's death, even though Rousseau did read excerpts of his manuscript publicly at various salons and other meeting places. He wrote of his own life mainly in terms of his worldly experiences and personal feelings.
Waardenburg’s magisterial essay traces the rise and development of the academic study of religion from the mid-nineteenth to the mid-twentieth century, outlining the establishment of the discipline, its connections with other fields, religion as a subject of research, and perspectives on a phenomenological study of religion. Futhermore a second part comprises an anthology of texts from 41 scholars whose work was programmatic in the evolution of the academic study of religion. Each chapter presents a particular approach, theory, and method relevant to the study of religion. The pieces selected for this volume were taken from the discipline of religious studies as well as from related fields, such as anthropology, sociology, and psychology, to name a few.
In "The Social Contract" Rousseau theorized about the best way to establish a political community in the face of the problems of commercial society, which he had already identified in his Discourse on Inequality (1754). The Social Contract helped inspire political reforms or revolutions in Europe, especially in France. The Social Contract argued against the idea that monarchs were divinely empowered to legislate. Rousseau asserts that only the people, who are sovereign, have that all-powerful right. "Confessions" is an autobiographical book which covers the first fifty-three years of Rousseau's life, up to 1765. It was completed in 1769, but not published until 1782, four years after Rousseau's death, even though Rousseau did read excerpts of his manuscript publicly at various salons and other meeting places. He wrote of his own life mainly in terms of his worldly experiences and personal feelings.
Confessions" is an autobiographical book which covers the first fifty-three years of Rousseau's life, up to 1765. It was completed in 1769, but not published until 1782, four years after Rousseau's death, even though Rousseau did read excerpts of his manuscript publicly at various salons and other meeting places. He wrote of his own life mainly in terms of his worldly experiences and personal feelings.
An attempt to understand coded messages and modern interactive thinking, including the Internet, through the symbol of the labyrinth. In this cultural history, Attali shows that nonlinear searching has always been a part of cultures and may well become more important in the future. Color photos & illustrations.
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