Set in a small town in Austria in the 1960's, it involves the efforts of Detective Ltnt. Marco Finnand his whodunit-fan wife, Frances, to solve a complicated plot of murder, espionage and intrigue during the Cold War, the central elements of which is a group of ex-Nazis who are striving to re-establish the glory of Third Reich.
This comprehensive reference work provides immediate, fingertip access to state-of-the-art technology in nearly 700 self-contained articles written by over 900 international authorities. Each article in the Encyclopedia features current developments and trends in computers, software, vendors, and applications...extensive bibliographies of leading figures in the field, such as Samuel Alexander, John von Neumann, and Norbert Wiener...and in-depth analysis of future directions.
The stories behind drug discovery are fascinating, full of human and scientific interest. This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated them. History is replete with examples of breakthrough medicines that have saved millions of lives. Ether as an anesthetic by Morton; penicillin as an antibiotic by Fleming; and insulin as an anti-diabetic by Banting are just a few examples. The discoverers of these medicines are doubtlessly benefactors to mankind--for instance, without penicillin, 75% of us probably would not be alive because some of our parents or grandparents would have succumbed to infections. Dr. Jack Li, a medicinal chemist who is intimately involved with drug discovery, has assembled an astounding amount of facts and information behind important drugs through extensive literature research and interviews with many inventors of the drugs including Viagra and Lipitor. There have been many myths and inaccuracies associated with those legendary drugs. The inventors perspectives afforded this book an invaluable accuracy and insight because history is not history unless it is true. The text is supplemented by many anecdotes, pictures and postage stamps. Both specialist and layman will find Laughing Gas, Viagra, and Lipitor informative and entertaining. Students in chemistry, pharmacy, and medicine, workers in healthcare and high school science teachers will find this book most useful.
`This is an important book that deserves to be read by everyone concerned with presenting major environmental issues.' Geography ` ... an essential text for policy makers and aid professionals, as well as for students of environmental studies and international development ... It is indeed, a book appropriate to the urgent and critical issues which it addresses.' - Journal of Environmental Management
This book constitutes the refereed proceedings of the 7th International Conference on Applied Parallel Computing, PARA 2004, held in June 2004. The 118 revised full papers presented together with five invited lectures and 15 contributed talks were carefully reviewed and selected for inclusion in the proceedings. The papers are organized in topical sections.
Ninety years after the Battle of the Somme was fought, visitors continue to flock in very large numbers to the massive Memorial to the Missing at Thiepval, site of a bitter three-month struggle during the summer of 1916. This book explains in detail how, from the autumn of 1914 onwards, the German defenders turned this key feature into a virtually impregnable position, from which they were able for weeks on end to repulse every attempt to capture it. Drawing on original maps, photographs and personal accounts of the German defenders, the reader is taken stage by stage through the battles for the German front line between Ovillers and Saint Pierre Divion, during the two years from September 1914 to September 1916. It explains why the British attacks of 1st July 1916 failed so catastrophically, and culminates with an account of its eventual loss at the end of September 1916.
Drug Discovery with Privileged Building Blocks traces back PharmaBlock’s founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and a regular analysis of new building block structures in the latest researches have proven to be a fruitful strategy to generate novel building blocks. Using this strategy, PharmaBlock has supplied the drug industry with a great number of building blocks, which are increasingly being adopted by drug hunters, and these are identified in this book. Each chapter may be read and studied without learning the previous chapters. This book will be a good starting point for novice medicinal chemists, and veteran medicinal chemists will find it useful as well. Key Feature The book covers privileged building blocks appearing most frequently on patents for novel drugs. The latest relevant tactics are explained in the context of drug design and medicinal chemistry. Key synthesis, especially large-scale synthesis, is described. The most recent literature references are cited.
Drugs like Lipitor, Plavix, Taxol, and Zoloft are integral in today's medicinal world. These widely used products save lives and improve the quality of lives, playing a crucial role in everything from cholesterol management to cancer treatment. These advances in medicine were brought into existence after nuanced process of creation, featuring a wide range of chemical and pharmacological experimentation and discovery. Top Drugs: Their History, Pharmacology, and Synthesis provides an in-depth study on ten prominent drugs, outlining the chemistry behind each one's creation. Jie Jack Li, a medicinal chemist and an expert on drug discovery, offers a thorough analysis of the landscape of current drug development. The comprehensive text is divided by health issues, including cardiovascular, cancer, metabolic diseases, and infectious diseases. Each section features individual chapters on significant drugs, outlining the chemistry and history of the drug's discovery. Li begins each chapter with the product's history, providing necessary context. Li then proceeds to describe the mechanism of action, structure-activity relationship (SAR), bioavailability, metabolism, toxicology, the discovery route, and the process route. Top Drugs: Their History, Pharmacology, and Synthesis will acclimate students, scientists, and interested laypersons to the world of chemistry and drug discovery.
This work explores the attitudes and ideologies of the late nineteenth and early twentieth century Marxist and social democratic intellectuals toward Zionism, anti-Semitism, Jewish socialist movements, and the nature and future of Jewry."-- publisher description.
Analyzing new research relating to the Himalayan region, this text challenges the widely-held view from the 1970s and 1980s that the area faced environmental disaster, and examines recent social and economic developments relating to the topic.
In The Lost History of 1914, Jack Beatty examines the First World War and its causes, testing against fresh evidence the long-dominant assumption that it was inevitable. 'Most books set in 1914 map the path leading to war,' Beatty writes, 'this one maps the multiple paths that led away from it.' Radically challenging the standard account of the war's outbreak, Beatty presents the assassination of Archduke Franz Ferdinand not as the catalyst of a war that would have broken out in any event over some other crisis, but rather as 'its all-but unique precipitant'. Chronicling largely forgotten events faced by each of the belligerent countries in the months before the war started in August, Beatty shows how any one of them - a possible military coup in Germany; the threat to Britain of civil war in Ireland; the murder trial of the wife of the likely next premier of France, who sought détente with Germany - might have derailed the arrival of war. Europe's ruling classes, Beatty shows, were so haunted by fear of those below that they mistook democratisation for revolution, and were tempted to 'escape forward' into war to head it off. Beatty's deeply insightful book - as elegantly written as it is thought-provoking and probing - lights a lost world about to blow itself up in what George Kennan called 'the seminal catastrophe of the twentieth century'. The Lost History of 1914 is a highly original and challenging work of history.
The second edition of Structure in Protein Chemistry showcases the latest developments and innovations in the field of protein structure analysis and prediction. The book begins by explaining how proteins are purified and describes methods for elucidating their sequences of amino acids and defining their posttranslational modifications. Comprehensive explanations of crystallography and of noncovalent forces-ionic interactions, hydrogen bonding, and the hydrophobic effect-act as a prelude to an exhaustive description of the atomic details of the structures of proteins. The resulting understanding of protein molecular structure forms the basis for discussions of the evolution of proteins, the symmetry of the oligomeric associations that produce them, and the chemical, mathematical, and physical basis of the techniques used to study their structures. The latter include image reconstruction, nuclear magnetic resonance spectroscopy, proton exchange, optical spectroscopy, electrophoresis, covalent cross-linking, chemical modification, immunochemistry, hydrodynamics, and the scattering of light, X-radiation, and neutrons. These procedures are applied to study the folding of polypeptides and the assembly of oligomers. Biological membranes and their proteins are also discussed. Structure in Protein Chemistry, Second Edition, bridges the gap between introductory biophysical chemistry courses and research literature. It serves as a comprehensive textbook for advanced undergraduates and graduate students in biochemistry, biophysics, and structural and molecular biology. Professionals engaged in chemical, biochemical, and molecular biological research will find it a useful reference.
The second edition of this bestselling title provides the most up-to-date comprehensive review of all aspects of biomaterials science by providing a balanced, insightful approach to learning biomaterials. This reference integrates a historical perspective of materials engineering principles with biological interactions of biomaterials. Also provided within are regulatory and ethical issues in addition to future directions of the field, and a state-of-the-art update of medical and biotechnological applications. All aspects of biomaterials science are thoroughly addressed, from tissue engineering to cochlear prostheses and drug delivery systems. Over 80 contributors from academia, government and industry detail the principles of cell biology, immunology, and pathology. Focus within pertains to the clinical uses of biomaterials as components in implants, devices, and artificial organs. This reference also touches upon their uses in biotechnology as well as the characterization of the physical, chemical, biochemical and surface properties of these materials. - Provides comprehensive coverage of principles and applications of all classes of biomaterials - Integrates concepts of biomaterials science and biological interactions with clinical science and societal issues including law, regulation, and ethics - Discusses successes and failures of biomaterials applications in clinical medicine and the future directions of the field - Cover the broad spectrum of biomaterial compositions including polymers, metals, ceramics, glasses, carbons, natural materials, and composites - Endorsed by the Society for Biomaterials
A presentation of the most fundamental features of the biology of the mammary gland, a unique model of an organ capable of an abundant synthesis of proteins: endocrinology of lactation, role of prolactin, genetics and protein synthesis, immunology and the mammary gland, nutrition and dairy products. Readership: students, teachers, researchers, health and agriculture professionals. Lactation Biology was first published in French in 1993. The English version is not merely a translation: it has been updated by the author.
Since the launch of the infamous Silk Road the use of cryptomarkets - illicit markets for drugs on the dark web - has expanded rapidly around the world. Cryptomarkets: A Research Companion is a detailed guidebook which offers the tools necessary to begin researching cryptomarket phenomena and the dark web trade in illicit drugs.
When structuring mergers and acquisitions, there's only one way to besure that you've thought of all the tax and legal consequences: rely onMartin D. Ginsburg,Jack S. Levin andDonald E. Rocap as you plan, develop, and execute your M&Astrategy. In this five volume print set, these expert practitioners offer you:Solutions to real-life M&A problems as they arise in negotiationsStep-by-step analysis of typical and non-typical mergers transactionalpermutationsChecklists, flow charts, and other at-a-glance mergers practice materialsWhether you represent the buyer, the seller, or another interested party, youcan go straight to a model M&A agreement that gives you:A complete document structured to embody your client's M&A interestsClauses addressing a wide variety of specific mergers situationsSpecific language for even the smallest mergers and acquisitions variationsyou're likely to encounterIncludes CD-ROM containing Mergers, Acquisitions, and Buyouts: SampleAcquisition AgreementsMergers, Acquisitions, and Buyouts is recently updated with:New step-by-step methods for structuring transactions, with tax, SEC,corporate, HSR, accounting and other mergers considerationsNew table summarizing and contrasting terms of pro-buyer, pro-seller, andneutral stock & asset purchase agreementsNew mergers legislation, M&A regulations, rulings, and courtdecisions impacting M&A transactions
Emerging from the shores of the Raritan Bay, Keyport's roots trace back to the Kearney family's plantation and its vital role during Revolutionary times. Although just 1.4 square miles in size, it encompasses shipbuilding, oyster farming, a trolley network, and an Aeromarine industry within a rich and influential history. Beyond these are the abundant and captivating tales of catastrophic fires and the vaunted Prohibition days providing a colorful framework of life in this coastline community.
This groundbreaking WWI history presents a detailed narrative of German Army operations from the start of the war to the 1st Battle of the Somme. A renowned expert on the German Army during the First World War, historian Jack Sheldon draws on his extensive research into German sources to shed new light on the famous battleground. In an account filled with graphic descriptions of life and death in the trenches, Sheldon demonstrates that the dreadful losses of July 1st, 1916, were a direct consequence of meticulous German planning and preparation. Although the Battle of the Somme was a close-run affair, poor Allied co-ordination played into the hands of the German commanders. The German Army was able to maintain the overall integrity of its defenses and continue its delaying of battle until winter ultimately neutralized the considerable Allied superiority in men and material.
Where did the notion of 'moral duty' come from? In The Invention of Duty: Stoicism as Deontology, Jack Visnjic argues that it was the Stoics who first developed a robust notion of duty as well as a deontological ethics.
Rutherford's Vascular Surgery - the most acclaimed comprehensive reference in its field - presents definitive, state-of-the-art guidance on every aspect of vascular health care, equipping you to make the best clinical decisions and optimize outcomes. Extensively revised by many new, international authors - led by Drs. Jack Cronenwett and K. Wayne Johnston - and now published in association with the Society for Vascular Surgery, this 7th Edition provides the authoritative answers that surgeons, interventionalists, and vascular medicine specialists need to provide effective care for vascular surgery patients. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you’re using or where you’re located. Get answers you can depend on. Now published in association with the Society for Vascular Surgery, Rutherford's delivers the world’s most trusted information on all major areas of vascular health care, written by international experts, with up-to-date bibliographies and annotated recommended references. Overcome any clinical challenge with in-depth sections on Fundamental Considerations, Patient Evaluation, Atherosclerotic Risk Factors, Perioperative Care, Bleeding and Clotting, Complications, Venous Disease, Lymphedema, Arteriovenous Anomalies, Hemodialysis Access, Miscellaneous Technique, Grafts and Devices, Cerebrovascular Disease, Lower Extremity Arterial Disease, Upper Extremity Arterial Disease, Arterial Aneurysms, Renal and Mesenteric Disease, and Trauma and Acute Limb Ischemia. Choose the best management option for each patient with discussions of operative, endovascular, and non-operative approaches for vascular conditions. Access the complete contents of Rutherford's Vascular Surgery online at www.expertconsult.com - with monthly updates from the Journal of Vascular Surgery and the European Journal of Vascular and Endovascular Surgery, plus videos of procedures, an image library, review questions, and more. Master the latest developments, techniques, and approaches with thorough updates on endovascular applications, vascular access, imaging, non-operative management, and much more. View clinical and physical findings and operative techniques more vividly with a new full-color layout and more full-color images.
This second edition of “Sustainable Mountain Development” is a history of the development of mountain environmental awareness from its origins during the Stockholm Conference on the Environment in 1973. This provided intellectual input into UNESCO’s MAB Programme, especially MAB-6 (Impact of Human Activities on Mountain Environments), The International Geographical Union’s commission on mountains, and The United Nations University’s (UNU) mountain project, the latter initiated in 1978. All this research and intellectual activity saw its maturation during the 1992 Earth Summit held in Rio de Janeiro. The major document universally agreed upon was AGENDA 21, with Chapter 13 concentrating on mountain environmental problems which led to 2002 being dedicated as The International Year of Mountains, and December 17th as International Mountain Day. The research that inspired this book, accompanied by intensive environmental and political activity, was initially propagated by a small group of colleagues that ultimately expanded to a world-wide endeavour. The work was recognised by three awards of the King Albert Gold Medal, two RGS Gold Medals, approved by Her Majesty Queen Elizabeth II, and countless other awards. It led to the founding of the International Mountain Society in 1980 and its quarterly journal “Mountain Research and Development” (1981). The work expanded into subsequent research efforts, including specific assessments of projected major catastrophes such as the status of the potential outbreak of glacier lakes (GLOFs), the impacts of climate warming, and incorporation of the mountain subsistence men and women whose environmental knowledge was enthusiastically recognized. This edition provides a new epilogue, which outlines the considerable changes to world environmental assessment since the establishment of 2002 as the International Year of Mountains, and notes that 2022 has been designated as the International Year of Sustainable Mountain Development.
A new take on therapeutic mindfulness with specific applications to troubled and delinquent youth is the focus of this innovative text. It introduces Family Mode Deactivation Therapy (FMDT) and its core concepts and methodologies, differentiating it from other cognitive and mindfulness therapies for adolescents with problem behaviors and comorbid conditions. Step by step applications of FMDT from case conceptualization to assessment and treatment are featured, with detailed case studies demonstrating its effectiveness in treating mood disorders, aggressive behavior and trauma and guidelines for its use with abusive families and other complex cases. The book's depth of clinical detail and appendix of therapist tools make it especially practical. Included in the coverage: A comparison of MDT with other cognitive approaches. The empirical status of MDT. Mindfulness in MDT process, and in the treatment room. FMDT and sexual offender youth. MDT and mindfulness in the context of trauma. Treating the "untreatable": FMDT and challenging populations. While Treating Adolescents with Family-Based Mindfulness is immediately useful to practicing psychotherapists, it should also be of interest to other professionals with a role in adolescent health care, such as policymakers, social workers, supervisors, juvenile corrections and youth center personnel and students and researchers.
The factual, concise and first-choice guide for the real fan. Now in its 64th year, PLAYFAIR FOOTBALL ANNUAL includes all the Champions League and Europa League details; a compact directory for English and Scottish clubs; English and Scottish league and cup match results; and stats on how English league clubs have fared over the last 25 years. A pocket-size treat - this is the ideal book to take to matches and settle arguments before, during and after!
Presenting both a panoramic introduction to the essential disciplines of drug discovery for novice medicinal chemists as well as a useful reference for veteran drug hunters, this book summarizes the state-of-the-art of medicinal chemistry. It covers key drug targets including enzymes, receptors, and ion channels, and hit and lead discovery. The book hen surveys a drug's pharmacokinetics and toxicity, with a solid chapter covering fundamental bioisosteres as a guide to structure-activity relationship investigations.
Chicken Soup for the Soul: The Wisdom of Dads is a special way to pay tribute to Dad, and also a great read for all fathers and children. Stories remind readers of the special bond between fathers and children and the unique reverence children hold for their wise old dads. Children view their fathers with awe from the day they are born. Fathers are big and strong and seem to know everything, except when their kids are teenagers -- then they know nothing. This book contains 101 great stories selected from Chicken Soup for the Soul’s library, all focusing on the wisdom of fathers. These heartwarming and often humorous stories are written by sons and daughters about their fathers, and by fathers about their children.
Continuous media streaming systems will shape the future of information infrastructure. The challenge is to design systems and networks capable of supporting millions of concurrent users. Key to this is the integration of fault-tolerant mechanisms to prevent individual component failures from disrupting systems operations. These are just some of the hurdles that need to be overcome before large-scale continuous media services such as video-on-demand can be deployed with maximum efficiency. The author places the subject in context, drawing together findings from the past decade of research whilst examining the technology’s present status and its future potential. The approach adopted is comprehensive, covering topics – notably the scalability and fault-tolerance issues - that previously have not been treated in depth. Provides an accessible introduction to the technology, presenting the basic principles for media streaming system design, focusing on the need for the correct and timely delivery of data. Explores the use of parallel server architectures to tackle the two key challenges of scalability and fault-tolerance. Investigates the use of network multicast streaming algorithms to further increase the scalability of very-large-scale media streaming systems. Illustrates all findings using real-world examples and case studies gleaned from cutting-edge worldwide research. Combining theory and practice, this book will appeal to industry specialists working in content distribution in general and continuous media streaming in particular. The introductory materials and basic building blocks complemented by amply illustrated, more advanced coverage provide essential reading for senior undergraduates, postgraduates and researchers in these fields.
When East European Jews migrated westward in ever larger numbers between 1870 and 1914, both German government officials and the leaders of German Jewry were confronted by a series of new challenges. What policies did government leaders devise to cope with the seemingly unending tide of Jews flooding across Germany's borders? What was the actual, as opposed to the perceived, character of these Jewish migrants? How did native Jews respond to the arrival of coreligionists from the East? Drawing on archival research conducted in East and West Germany, Israel, and the United States, Unwelcome Strangers probes into these questions, touching on some of the most troubling issues in modern German and Jewish history--the behavior of Germans toward strangers in their midst, the status and self-perception of emancipated Jews in pre-Nazi Germany, and the responses of "privileged" Jews to needy, but alien, coreligionists.
In the aftermath of the Cold War, Jack Nelson-Pallmeyer offers his most challenging book to date: a probing assessment of the meaning and implications of what U.S. leaders have called a "new world order." While the end of the Cold War and the mobilization of sanctions against Iraq opened the possibility of a truly new world order, Nelson-Pallmeyer argues that the Gulf War was used to serve a very different purpose. United States elites in the national security establishment instead sought to make the world safe for future wars, to derail the post-Cold War "peace dividend," and to foreclose the possibility of a world order based on international justice and commitment to human rights. From the perspective of the Third World, where ever-greater debt leads to ever-greater death, Nelson-Pallmeyer shows how the "new world order" is only a new way of managing the old world order: the misery of the poor will continue to sustain the appetites of the rich. Parallel to the increased pauperization of the Third World, the 1980s saw the massive transfer of wealth within the United States, from the poor to the very wealthy. The consequences: the decay of our cities and dramatic increases in racial violence, drug abuse, and crime. At the same time, the impending ecological crisis has escalated rapidly. Finally, Nelson-Pallmeyer turns his attention to the role of Christians in blessing the "new world order." Appalled by the abuse of religious rhetoric in justification of the Gulf War he examines how Jesus confronted the "world order" of his day, and calls for a radical discipleship that worships the God of life rather than the idols of power and wealth.
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