FROM THE BACK COVER: Are you--or is someone you care about--taking tranquilizers or sleeping pills? You could be at risk of addiction without even knowing it. Benzos are the most commonly prescribed tranquilizers and sleeping pills, in use by millions of people. Doctors prescribe these drugs routinely without ever warning patients that regular use may cause a dangerous dependency. For many people, Benzos are much harder to quit than heroin, cocaine, crack and other illegal substances, even when taken under a physician's supervision. Benzo Withdrawal may last for months, even years. Get the facts about the drugs in your medicine cabinet--facts the pharmaceutical companies, and even the FDA, don't want you to know. The Benzo Book recounts the author's experience as an unwitting addict, with full details about minimizing withdrawal symptoms, and exposes the sociological, medical and economic factors which cause this widespread--yet largely unknown--problem.
Jie Jack Li is a medicinal chemist and is intimately involved with drug discovery. Through extensive research and interviews with the inventors of drugs, including those of Viagra and Lipitor, he has assembled an astounding number of facts and anecdotes, as well as much useful information about important drugs we know and use in our lives today. Figures, diagrams, and illustrations highlight the text throughout."--BOOK JACKET.
This synthesis will be of interest to administrators, contract officers, and others interested in using consulting firms to manage a transportation agency's work activities -- ranging from a single project to a complete spectrum of work. Information is provided on various aspects of contract management systems, including examples of use of each aspect in several agencies. An increasing workload coupled with reduced staff size have caused state highway agencies to turn to private enterprise to accomplish work that has traditionally been done in-house. This report of the Transportation Research Board describes various aspects of the use of consultants to manage a highway agency's work and gives specific examples of use of each aspect in several agencies.
Bestselling novelist Jack Engelhard (Indecent Proposal) has produced a heroic work of literature. This is a superb, gutsy novel. The Bathsheba Deadline is a newsroom thriller ripped from the headlines. The present day action takes place in a Manhattan newsroom where three leading journalists find themselves caught in a sizzling three-way love triangle that may lead to murder in the Middle East (Israel). You will never forget Jay Garfield and you absolutely will never forget Lyla. Politics and sex mixed in with the war on terror provoke life-and-death rifts within the editorial staff. Journalists with the power to influence public opinion have lost their neutrality and have taken sides. Readers are taken behind the scenes and into the newsrooms where they are shown how headlines are made and often manipulated to favor one side over another. Media bias usually against Israel? Read all about it in Engelhard’s stirring pages. The war for survival in a New York City newsroom mirrors the clash of civilizations here, in the Middle East, and around the world.
Over 25 million people in the U.S. alone have benefited from statins--such drugs as Lipitor, Zocor, Crestor, Pravachol, and other cholesterol-lowering medicines--in preventing stroke, heart attack, and other forms of coronary heart disease. But how did these remarkable, life-saving drugs come into being? In Triumph of the Heart, Dr. Jie Jack Li, a medicinal chemist and expert on drug discovery, tells for the first time the fascinating story of statins. Drawn from discussions with many scientists involved in the discovery and development of these drugs, the book illuminates the human side of science by revealing the role played by persistence, luck, and sudden insight that characterize major discoveries. For scientists in the drug industry, health care professionals, students of medicine, and all those intrigued by the basic human drive to explore and discover, Triumph of the Heart offers a compelling view of one of the most important drug discoveries of our time.
This book differs from others on name reactions in organic chemistry by focusing on their mechanisms. It covers over 300 classical as well as contemporary name reactions. Biographical sketches for the chemists who discovered or developed those name reactions have been included. Each reaction is delineated by its detailed step-by-step, electron-pushing mechanism, supplemented with the original and the latest references, especially review articles. This book contains major improvements over the previous edition and the subject index is significantly expanded.
Regardless of culture, most adult humans report experiencing similar feelings such as anger, fear, humor, and joy. Such subjective emotional states, however, are not universal. Members of some cultures deny experiencing specific emo tions such as fear or grief. Moreover, within any culture, individuals differ widely in their self-reports of both the variety and intensity of their emotions. Some people report a vivid tapestry of positive and negative emotional experi ences. Other people report that a single emotion such as depression or fear totally dominates their existences. Still others report flat and barren emotional lives. Over the past 100 years, scientists have proposed numerous rival explana tions of why such large individual differences in emotions occur. Various authors have offered anthropological, biochemical, ethological, neurological, psycholog ical, and sociological models of human emotions. Indeed, the sheer number of competing theories precludes a comprehensive review in a single volume. Ac cordingly, only a representative sample of models are discussed in this book, and many equally important theories have been omitted. These omissions were not intended to prejudice the reader in favor of any particular conceptual frame work. Rather, this selective coverage was intended to focus attention upon the empirical findings that contemporary theories attempt to explain.
The topic of panic has been dominated by biological studies in many areas of anxiety research. This collection of papers, resulting from the National Institute of Mental Health Conferences, presents the viewpoints of clinical researchers assessing the state of the anxiety field. Contributors to this volume argue that biological data can be encompassed in psychological theory.
Rutherford's Vascular Surgery - the most acclaimed comprehensive reference in its field - presents definitive, state-of-the-art guidance on every aspect of vascular health care, equipping you to make the best clinical decisions and optimize outcomes. Extensively revised by many new, international authors - led by Drs. Jack Cronenwett and K. Wayne Johnston - and now published in association with the Society for Vascular Surgery, this 7th Edition provides the authoritative answers that surgeons, interventionalists, and vascular medicine specialists need to provide effective care for vascular surgery patients. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you’re using or where you’re located. Get answers you can depend on. Now published in association with the Society for Vascular Surgery, Rutherford's delivers the world’s most trusted information on all major areas of vascular health care, written by international experts, with up-to-date bibliographies and annotated recommended references. Overcome any clinical challenge with in-depth sections on Fundamental Considerations, Patient Evaluation, Atherosclerotic Risk Factors, Perioperative Care, Bleeding and Clotting, Complications, Venous Disease, Lymphedema, Arteriovenous Anomalies, Hemodialysis Access, Miscellaneous Technique, Grafts and Devices, Cerebrovascular Disease, Lower Extremity Arterial Disease, Upper Extremity Arterial Disease, Arterial Aneurysms, Renal and Mesenteric Disease, and Trauma and Acute Limb Ischemia. Choose the best management option for each patient with discussions of operative, endovascular, and non-operative approaches for vascular conditions. Access the complete contents of Rutherford's Vascular Surgery online at www.expertconsult.com - with monthly updates from the Journal of Vascular Surgery and the European Journal of Vascular and Endovascular Surgery, plus videos of procedures, an image library, review questions, and more. Master the latest developments, techniques, and approaches with thorough updates on endovascular applications, vascular access, imaging, non-operative management, and much more. View clinical and physical findings and operative techniques more vividly with a new full-color layout and more full-color images.
The use of molecular biology and biochemistry to study the regulation of gene expression has become a major feature of research in the biological sciences. Many excellent books and reviews exist that examine the experimental methodology employed in specific areas of molecular biology and regulation of gene expression. However, we have noticed a lack of books, especially textbooks, that provide an overview of the rationale and general experimental approaches used to examine chemically or disease-mediated alterations in gene expression in mammalian systems. For example, it has been difficult to find appropriate texts that examine specific experimental goals, such as proving that an increased level of mRNA for a given gene is attributable to an increase in transcription rates. Regulation of Gene Expression: Molecular Mechanisms is intended to serve as either a textbook for graduate students or as a basic reference for laboratory personnel. Indeed, we are using this book to teach a graduate-level class at The Pennsylvania State University. For more details about this class, please visit http://moltox. cas. psu. edu and select “Courses. ” The goal for our work is to provide an overview of the various methods and approaches to characterize possible mechanisms of gene regulation. Further, we have attempted to provide a framework for students to develop an understanding of how to determine the various mechanisms that lead to altered activity of a specific protein within a cell.
Drugs like Lipitor, Plavix, Taxol, and Zoloft are integral in today's medicinal world. These widely used products save lives and improve the quality of lives, playing a crucial role in everything from cholesterol management to cancer treatment. These advances in medicine were brought into existence after nuanced process of creation, featuring a wide range of chemical and pharmacological experimentation and discovery. Top Drugs: Their History, Pharmacology, and Synthesis provides an in-depth study on ten prominent drugs, outlining the chemistry behind each one's creation. Jie Jack Li, a medicinal chemist and an expert on drug discovery, offers a thorough analysis of the landscape of current drug development. The comprehensive text is divided by health issues, including cardiovascular, cancer, metabolic diseases, and infectious diseases. Each section features individual chapters on significant drugs, outlining the chemistry and history of the drug's discovery. Li begins each chapter with the product's history, providing necessary context. Li then proceeds to describe the mechanism of action, structure-activity relationship (SAR), bioavailability, metabolism, toxicology, the discovery route, and the process route. Top Drugs: Their History, Pharmacology, and Synthesis will acclimate students, scientists, and interested laypersons to the world of chemistry and drug discovery.
This book uses the cases of several landmark drugs to discuss the history of the pharmaceutical industry, and discusses what could be next"--Provided by publisher.
Published in association with the Society for Vascular Surgery, Rutherford’s Vascular Surgery presents state-of-the-art updates on all aspects of vascular health care. Extensively revised by many new authors to meet the needs of surgeons, interventionalists, and vascular medicine specialists, this medical reference book incorporates medical, endovascular and surgical treatment, as well as diagnostic techniques, decision making and fundamental vascular biology. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Master the latest developments, techniques, and approaches with thorough updates on endovascular applications, vascular access, imaging, non-operative management, and much more. View clinical and physical findings and operative techniques more vividly with a full-color layout and images. Get answers you can depend on. Rutherford's delivers the world’s most trusted information on all major areas of vascular health care, is written by international experts, and includes up-to-date bibliographies and annotated recommended references. Discover emerging techniques in rapidly advancing topics, with special emphasis on endovascular coverage, vascular imaging, angiography, CT and MRI. Explore brand new chapters on dialysis catheters, renovascular disease, and management of branches during endovascular aneurysm. Stay up-to-date with the latest coverage of endovascular procedures that reflects the changing practices and techniques in vascular surgery. Access videos at Expert Consult.
This practical, well-organized reference delves deeply into functional group transformations, to provide all the detailed information that researchers need. Topics are organized into the following sections: oxidation, reduction, asymmetric synthesis, and functional group manipulations Each section includes a description of the functional group transformation, the historical perspective, mechanisms, variations and improvements on the reaction, synthetic utilities and applications for the reaction, experimental details, and references to the primary literature Contributors are well-known and respected for their work on the specific name reactions.
This synthesis will be of interest to administrators, contract officers, and others interested in using consulting firms to manage a transportation agency's work activities -- ranging from a single project to a complete spectrum of work. Information is provided on various aspects of contract management systems, including examples of use of each aspect in several agencies. An increasing workload coupled with reduced staff size have caused state highway agencies to turn to private enterprise to accomplish work that has traditionally been done in-house. This report of the Transportation Research Board describes various aspects of the use of consultants to manage a highway agency's work and gives specific examples of use of each aspect in several agencies.
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