Over 25 million people in the U.S. alone have benefited from statins--such drugs as Lipitor, Zocor, Crestor, Pravachol, and other cholesterol-lowering medicines--in preventing stroke, heart attack, and other forms of coronary heart disease. But how did these remarkable, life-saving drugs come into being? In Triumph of the Heart, Dr. Jie Jack Li, a medicinal chemist and expert on drug discovery, tells for the first time the fascinating story of statins. Drawn from discussions with many scientists involved in the discovery and development of these drugs, the book illuminates the human side of science by revealing the role played by persistence, luck, and sudden insight that characterize major discoveries. For scientists in the drug industry, health care professionals, students of medicine, and all those intrigued by the basic human drive to explore and discover, Triumph of the Heart offers a compelling view of one of the most important drug discoveries of our time.
COVID-19 reminds us how acutely the virus can impact humanity. In fact, viruses existed long before the emergence of homo sapiens. In this book on the history of antiviral drug discovery, the human aspects are highlighted. In Chapter 1, the author regales us with several episodes where history was shaped by viruses causing smallpox, yellow fever, etc. The fascinating history of the first discovery of virus, tobacco mosaic virus, was also recounted. Chapters 2-5 covered four classes of viruses such as HIV, hepatitis viruses, influenza viruses and coronaviruses. Each chapter begins how the virus was discovered, followed by vaccine development, and then focuses on the discovery of small molecule antiviral drugs. For chemistry aficionados, the end of the book is replete with abundant of bibliography for further understanding of the minutia of the stories, followed by molecular structures of the antiviral drugs. This book is of interest to anyone who wants to know the science behind virus, vaccines and antiviral drugs. It is especially useful for healthcare professionals who are interested in knowing how viruses, vaccines and antiviral drugs are discovered"--
This book uses the cases of several landmark drugs to discuss the history of the pharmaceutical industry, and discusses what could be next"--Provided by publisher.
This book is a comprehensive introduction to the fundamentals of Chinese Fingernail Image Diagnosis (FID), a non-invasive clinical examination which can assess an individual's state of health. FID can be used as an auxiliary diagnostic method to provide diagnostic clues and proper guidance for treatment. One great strength of this method is its non-invasive nature. Formed by blood and Qi between the nail bed and nail plate, the fingernail image can be used to observe pathological changes within the body. This book equips readers with the knowledge needed to analyse fingernail images and assess them for diagnostic purposes. Covering the origins of Fingernail Image Diagnosis, methods of examination and the practical application of FID for assisting diagnosis in a wide range of common disorders, the authors provide a complete guide to FID, with illustrations, visuals and detailed case examples. This practical quick reference guide and introduction to FID will be useful for anyone interested in diagnostic techniques, especially those working in the fields of Chinese Medicine, integrative medicine and alternative healthcare.
Jie Jack Li is a medicinal chemist and is intimately involved with drug discovery. Through extensive research and interviews with the inventors of drugs, including those of Viagra and Lipitor, he has assembled an astounding number of facts and anecdotes, as well as much useful information about important drugs we know and use in our lives today. Figures, diagrams, and illustrations highlight the text throughout."--BOOK JACKET.
In this fifth edition of Jack Jie Li's seminal "Name Reactions", the author has added twenty-seven new name reactions to reflect the recent advances in organic chemistry. As in previous editions, each reaction is delineated by its detailed step-by-step, electron-pushing mechanism and supplemented with the original and the latest references, especially from review articles. Now with addition of many synthetic applications, this book is not only an indispensable resource for advanced undergraduate and graduate students, but is also a good reference book for all organic chemists in both industry and academia. Unlike other books on name reactions in organic chemistry, Name Reactions, A Collection of Detailed Reaction Mechanisms and Synthetic Applications focuses on the reaction mechanisms. It covers over 320 classical as well as contemporary name reactions.
In this sixth edition of Jack Jie Li's seminal "Name Reactions", the author has added three or more synthetic applications of name reactions to reflect the recent advances in organic chemistry. As in previous editions, each reaction is delineated by its detailed step-by-step, electron-pushing mechanism and supplemented with the original and the latest references, especially from review articles. This book is not only an indispensable resource for advanced undergraduate and graduate students for learning and preparing exams, but is also a good reference book for all organic chemists in both industry and academia. Unlike other books on name reactions in organic chemistry, Name Reactions, A Collection of Detailed Reaction Mechanisms and Synthetic Applications focuses on the reaction mechanisms. It covers over 300 classical as well as contemporary name reactions.
Presenting both a panoramic introduction to the essential disciplines of drug discovery for novice medicinal chemists as well as a useful reference for veteran drug hunters, this book summarizes the state-of-the-art of medicinal chemistry. It covers key drug targets including enzymes, receptors, and ion channels, and hit and lead discovery. The book hen surveys a drug's pharmacokinetics and toxicity, with a solid chapter covering fundamental bioisosteres as a guide to structure-activity relationship investigations.
Drug Discovery with Privileged Building Blocks traces back PharmaBlock’s founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and a regular analysis of new building block structures in the latest researches have proven to be a fruitful strategy to generate novel building blocks. Using this strategy, PharmaBlock has supplied the drug industry with a great number of building blocks, which are increasingly being adopted by drug hunters, and these are identified in this book. Each chapter may be read and studied without learning the previous chapters. This book will be a good starting point for novice medicinal chemists, and veteran medicinal chemists will find it useful as well. Key Feature The book covers privileged building blocks appearing most frequently on patents for novel drugs. The latest relevant tactics are explained in the context of drug design and medicinal chemistry. Key synthesis, especially large-scale synthesis, is described. The most recent literature references are cited.
This practical, well-organized reference delves deeply into functional group transformations, to provide all the detailed information that researchers need. Topics are organized into the following sections: oxidation, reduction, asymmetric synthesis, and functional group manipulations Each section includes a description of the functional group transformation, the historical perspective, mechanisms, variations and improvements on the reaction, synthetic utilities and applications for the reaction, experimental details, and references to the primary literature Contributors are well-known and respected for their work on the specific name reactions.
A fundamental challenge for medical informatics is to develop and apply better ways of understanding how information technologies and methods can help support the best care for every patient every day given available medical knowledge and resources. In order to provide the most effective healthcare possible, the activities of teams of health professionals have to be coordinated through well-designed processes centered on the needs of patients. For information systems to be accepted and used in such an environment, they must balance standardization based on shared medical knowledge with the flexibility required for customization to the individual patient. Developing innovative approaches to design and build evidence-based careflow management systems is essential for providing the knowledge management infrastructure of health care organizations that seeks to increase performance in delivering high quality care services by efficiently exploiting available resources. Parallel challenges arise in the organization of research at the biological and clinical levels, where the focus on systematically organizing and supporting processes of scientific inquiry by novel informatics methods and databases are in their very early stages. These Proceedings of Medinfo 2004 demonstrate the base of knowledge medical informatics professionals will collectively draw upon in the years ahead to meet these challenges and realize opportunities.
In Jack London's short story "Li Wan, The Fair," a woman called Li Wan is journeying a long trail with her husband, a commanding Native American named Canim. When they come across a settlement of gold diggers and two wealthy American women, Li Wan wants to establish a connection. Instead, she is faced with a clash of cultures and the strong will of her husband. The short story is one of London's stories inspired by the period the writer spent at the Klondike Gold Rush in the late 19th century and was published in the early 20th century. Jack London (1876–1916) was an American writer and social activist. He grew up in the working class, but became a worldwide celebrity and one of the highest paid authors of his time. He wrote several novels, which are considered classics today, among these 'Call of the Wild', 'Sea Wolf' and 'White Fang'.
The fourth edition is revolutionary in comparison to the previous three editions. The format change has doubled the space to accommodate at least two to three real case applications in synthesis for each name reaction. The references are updated to 2009. Several new name reactions and reagents are included to reflect the state-of-the-art of organic chemistry. Unlike other books on name reactions in organic chemistry, Name Reactions, A Collection of Detailed Reaction Mechanisms and Synthetic Applications focuses on their mechanisms. It covers over 300 classical as well as contemporary name reactions. Each reaction is delineated by its detailed step-by-step, electron-pushing mechanism, supplemented with the original and the latest references, especially review articles. Now with addition of many synthetic applications, it is not only an indispensable resource for senior undergraduate and graduate students for learning and exams, but also a good reference book for all organic chemists interested in name reactions.
This book discusses effective and alternative uses for natural gas (NG) and highlights the utilization of NG in the field of methane activation and chemical production. It details the techniques used during the reforming process of petrochemical and bio-derived fuels and it presents cutting-edge research that describes the utilization of NG that enables it to be more cost-effective and eliminate the expensive greenhouse gas emitting process of hydrogen production. The book addresses three major topics: NG use in upstream heavy oil and bitumen upgrading, NG and its use in downstream oil refining through co-aromatization of various feeds in the petrochemical industry, and NG use in the upgrading of bio-derived fuels and discusses alternative uses of NG. In-depth chapters demonstrate uses for NG beyond heating homes, through catalysis and in-situ hydrogen donation, and its potential applications for the petrochemical and biofuel industries.
A book that examines how structural inequalities directly influence undergraduate life. Universities love to talk about diversity. They spend millions of dollars advertising just how diverse they, offering diversity statistics that are personalized with pictures. But Anthony Jack argues that this is a superficial approach. He calls it a "gift shop" approach that displays groups like trinkets and fails to truly serve students from underrepresented groups. Moreover, social class is almost entirely absent from the conversation. Never before have the platitudes of diversity left universities ill-prepared to support their students--especially those who are lower-income and/or first generation--than during the COVID-19 pandemic. Blinded by Diversity sheds lights on how entrenched inequalities in students homes and communities shape undergraduate life through the lens of how students coped with COVID-19, navigated social unrest, and experienced problems of race. Jack draws on 160 in-depth interviews with a representative sample of Asian, Black, Latino, Native and White undergraduate at Harvard and 20 interviews with students from other universities. He first examines students home lives prior to college and campus closures and explores how the pandemic shaped their lives away from campus. He looks at those who have jobs and explores how the divergent work experiences that students have shape their broader college experience. He looks at students' strategies for navigating campus, including peer group formation and acclimation to college. The final empirical chapter explores how students understand and navigate racial unrest both on campus and in America and how their experiences vary by race. The conclusion will outline sensible and practical solutions to aid colleges in their quest to help all students"--
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