Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease offers a detailed, scholarly historical review of the critical role animal experiments have played in advancing medical knowledge. Laboratory animals have been essential to this progress, and the knowledge gained has saved countless lives—both human and animal. Unfortunately, those opposed to using animals in research have often employed doctored evidence to suggest that the practice has impeded medical progress. This volume presents the articles Jack Botting wrote for the Research Defence Society News from 1991 to 1996, papers which provided scientists with the information needed to rebut such claims. Collected, they can now reach a wider readership interested in understanding the part of animal experiments in the history of medicine—from the discovery of key vaccines to the advancement of research on a range of diseases, among them hypertension, kidney failure and cancer.This book is essential reading for anyone curious about the role of animal experimentation in the history of science from the nineteenth century to the present.
The stories behind drug discovery are fascinating, full of human and scientific interest. This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated them. History is replete with examples of breakthrough medicines that have saved millions of lives. Ether as an anesthetic by Morton; penicillin as an antibiotic by Fleming; and insulin as an anti-diabetic by Banting are just a few examples. The discoverers of these medicines are doubtlessly benefactors to mankind--for instance, without penicillin, 75% of us probably would not be alive because some of our parents or grandparents would have succumbed to infections. Dr. Jack Li, a medicinal chemist who is intimately involved with drug discovery, has assembled an astounding amount of facts and information behind important drugs through extensive literature research and interviews with many inventors of the drugs including Viagra and Lipitor. There have been many myths and inaccuracies associated with those legendary drugs. The inventors perspectives afforded this book an invaluable accuracy and insight because history is not history unless it is true. The text is supplemented by many anecdotes, pictures and postage stamps. Both specialist and layman will find Laughing Gas, Viagra, and Lipitor informative and entertaining. Students in chemistry, pharmacy, and medicine, workers in healthcare and high school science teachers will find this book most useful.
“Playful and (un)deadly serious . . . chew[s] through a near-exhaustive array of films, television, literature, culture, music and even cocktails.”—Times Literary Supplement They have stalked the horizons of our culture, wreaked havoc on moribund concepts of dead and not dead, threatened our sense of identity, and endangered our personal safety. Now zombies have emerged from the lurking shadows of society’s fringes to wander the sacred halls of the academy, feasting on tender minds and hurling rot across our intellectual landscape. It is time to unite in common cause, to shore up defenses, firm up critical and analytical resources, and fortify crumbling lines of inquiry. Responding to this call, Brain Workers from the Zombie Research Center poke and prod the rotting corpus of zombie culture trying to make sense of cult classics and the unstoppable growth of new and even more disturbing work. They exhume “zombie theory” and decaying historical documents from America, Europe, and the Caribbean in order to unearth the zombie world and arm readers with the brain tools necessary for everyday survival. Readers will see that zombie culture today “lives” in shapes as mutable as a zombie horde—and is often just as violent. “An intelligent and highly engaging collection that will appeal to legions of zombie fans, to students in the humanities, and to scholars working in fields that have already been affected by or are now preparing for the zombie apocalypse. It blends entertaining, illuminating, and accessible readings of zombies and zombie culture with unique interventions made from authoritative positions of expertise.”—Julian Murphet, author of Faulkner’s Media Romance
The election of America’s first black president has led many to believe that race is no longer a real obstacle to success and that remaining racial inequality stems largely from the failure of minority groups to take personal responsibility for seeking out opportunities. Often this argument is made in the name of the long tradition of self-reliance and American individualism. In Awakening to Race, Jack Turner upends this view, arguing that it expresses not a deep commitment to the values of individualism, but a narrow understanding of them. Drawing on the works of Ralph Waldo Emerson, Henry David Thoreau, Frederick Douglass, Ralph Ellison, and James Baldwin, Turner offers an original reconstruction of democratic individualism in American thought. All these thinkers, he shows, held that personal responsibility entails a refusal to be complicit in injustice and a duty to combat the conditions and structures that support it. At a time when individualism is invoked as a reason for inaction, Turner makes the individualist tradition the basis of a bold and impassioned case for race consciousness—consciousness of the ways that race continues to constrain opportunity in America. Turner’s “new individualism” becomes the grounds for concerted public action against racial injustice.
Between the years 1815 and 1945, Europe achieved unrivaled global dominance, only to see it shattered by two world wars. This frenetic rise and fall was attended by immense societal change. In 1815, Europe remained largely agricultural and dependent upon horsepower. By 1945, the power of the atom had been unleashed. Two industrial revolutions occurred in the interim--the first founded upon coal, iron and steam, the second upon oil, steel, electricity and internal combustion. The implications for humanity were profound. This concise yet comprehensive study is divided into three sections. In section one, the map of Europe emerges in its modern visage as unrestrained nationalist fervor gives rise to an assemblage of new nation-states. In section two, the continent attains global hegemony as massive industrialization fuels a mad scramble for colonial markets and raw materials. In section three, a cauldron of national, ethnic and class hatreds spawn the rise of totalitarianism and the overthrow of European hegemony in two calamitous world wars. By tracing the events and undercurrents of this vital period in European history, this book offers trenchant insights for the lay reader and the student of history alike.
On the cover of the 1970 record THE VANISHING REGIMENTS, Colonel CH Jaeger OBE made an interesting observation: ‘Be it true or not that old soldiers never die but only fade away, it is absolutely certain that the music connected with soldiering never does in fact. Many famous Regiments in the last few years have passed off the scene, others have been amalgamated. Much of the music of former Regiments is still in use, though the names of the Regiments concerned have vanished, perhaps forever’. Regimental colours are the symbolic spirit of the regiment; their marches are the musical spirit. Their histories are sometimes older than the regiments themselves and very much guarded and cherished by them. When you hear a regimental band play a march, why that march? This book is an attempt to cover the fascinating histories of military marches, how and why regiments adopted them, even those that have faded into history. It will appeal to those interested in Regimental Marches of Canadian and United Kingdom Armed Forces. Over 500 marches are covered with many band photos from across the centuries. Also included are narratives of the composers, Victoria Cross musicians and even words to many marches. So, get out the records, crank up the volume and listen to the bands play their MUSICAL COLOURS while reading all bout them.
At the beginning of the twentieth century, aerialist Ivy Baldwin had achieved celebrity status as a premier tightrope walker, aeronaut and aviation pioneer. He executed astonishing and perilous performances across America and internationally, including Mexico and the Far East. First by flying balloons, he went on to pilot dirigibles and, finally, aircraft. In his later years in Colorado, he became famous for crossing canyons on a tightrope. Historian Jack Stokes Ballard deftly captures Baldwin's colorful and hazardous life from childhood runaway to aviation record holder.
AARP Digital Editions offer you practical tips, proven solutions, and expert guidance. In The Inflammation Syndrome, Jack Challem provides a powerful plan to safely prevent and overcome inflammatory disorders. Inflammation is what happens when our body's own defenses turn on us-and it is a huge and growing problem. Written by the author of the groundbreaking Syndrome X, this essential updated edition of The Inflammation Syndrome draws on cutting-edge research conducted around the world to provide a revolutionary approach to healing inflammation-related problems through an easy-to-follow nutrition and supplement program. Includes new recommendations for individualized diet and supplement plans Presents fourteen steps for restoring dietary balance, plus recipes and menu plans Reveals the powerful role inflammation plays in a wide variety of common health conditions–from simple aches and pains to heart disease, obesity, diabetes, arthritis, asthma, and athletic injuries Features dramatic case histories and the latest information on dosage recommendations for anti-inflammation supplements such as fish oils, vitamins, and herbs Read The Inflammation Syndrome and learn just how easy it can be to take charge of your diet and health.
This book uses the cases of several landmark drugs to discuss the history of the pharmaceutical industry, and discusses what could be next"--Provided by publisher.
In this sixth edition of Jack Jie Li's seminal "Name Reactions", the author has added three or more synthetic applications of name reactions to reflect the recent advances in organic chemistry. As in previous editions, each reaction is delineated by its detailed step-by-step, electron-pushing mechanism and supplemented with the original and the latest references, especially from review articles. This book is not only an indispensable resource for advanced undergraduate and graduate students for learning and preparing exams, but is also a good reference book for all organic chemists in both industry and academia. Unlike other books on name reactions in organic chemistry, Name Reactions, A Collection of Detailed Reaction Mechanisms and Synthetic Applications focuses on the reaction mechanisms. It covers over 300 classical as well as contemporary name reactions.
Positions of authority in any society are limited in number, and therefore rules of selection must operate in their recruitment. There must also be limitations upon the range of authority exercised. These problems are particularly acute in the case of high office, where the questions of recruitment and succession are of central importance. This 1979 volume provides a general and theoretical analysis of succession in different traditional African societies. Jack Goody's introduction spells out the main ways in which systems of succession to office differ, and assesses the problem each system solves and the dilemmas it creates. He also analyses the tensions to which succession gives rise, and relates these to specific methods of transferring office from one generation to the next, The four case studies, all based on extensive fieldwork, consider succession among the Bausto, the Baganda, the Nyamwezi and the Gonja.
First isolated as a chemical compound by a Russian chemist in 1866, dimethyl sulfoxide (DMSO) proved to be a near-perfect solvent for decades before its remarkable biological and medical activities were discovered. DMSO is one of the most prodigious agents ever to come out of the world of drug development. Its wide range of biological actions invol
During a stellar 20-year career punctuated by the Second World War, such was Tommy Lawton's prowess in front of goal he was a magnet for spectators at a host of top-level clubs. Prior to the war, he served Burnley and Everton with distinction; enlisted to the British army for the war effort, he guested for a host of clubs. After VE Day he maintained his career average of more than one goal every other game - with Everton, Chelsea, Notts County, Brentford, as player manager, and Arsenal; before another spell as player boss at Kettering. In 46 England games either side of the war and including wartime fixtures, he plundered 46 goals. Those impressive stats would surely be even more so but for the war. Deadly in the air or with either foot, and renowned for his sportsmanship - he was never booked throughout his career - Head and Shoulders Above the Rest is an ode to a swashbuckling centre-forward and the man Stanley Matthews described as: 'Quite simply, the greatest header of the ball I ever saw.
An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.
Lecture-Tutorials for Introductory Astronomy," which was developed by the Conceptual Astronomy and Physics Education Research (CAPER) Team, is a collection of classroom-tested activities designed for the large-lecture introductory astronomy class, although it is suitable for any astronomy class. The Lecture-Tutorials are short, structured activities designed for students to complete while working in pairs. Each activity targets one or more specific learning objectives based on research on student difficulties in astronomy. Most activities can be completed in 10 to 15 minutes. The instructor's guide provides, for each activity, the recommended prerequisite knowledge, the learning goals for the activity, a pre-activity assessment question, an answer key, suggestions for implementation, and follow-up questions to be used for class discussion or homework.
Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease offers a detailed, scholarly historical review of the critical role animal experiments have played in advancing medical knowledge. Laboratory animals have been essential to this progress, and the knowledge gained has saved countless lives—both human and animal. Unfortunately, those opposed to using animals in research have often employed doctored evidence to suggest that the practice has impeded medical progress. This volume presents the articles Jack Botting wrote for the Research Defence Society News from 1991 to 1996, papers which provided scientists with the information needed to rebut such claims. Collected, they can now reach a wider readership interested in understanding the part of animal experiments in the history of medicine—from the discovery of key vaccines to the advancement of research on a range of diseases, among them hypertension, kidney failure and cancer.This book is essential reading for anyone curious about the role of animal experimentation in the history of science from the nineteenth century to the present.
Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease offers a detailed, scholarly historical review of the critical role animal experiments have played in advancing medical knowledge. Laboratory animals have been essential to this progress, and the knowledge gained has saved countless lives-both human and animal. Unfortunately, those opposed to using animals in research have often employed doctored evidence to suggest that the practice has impeded medical progress. This volume presents the articles Jack Botting wrote for the Research Defence Society News from 1991 to 1996, papers which provided scientists with the information needed to rebut such claims. Collected, they can now reach a wider readership interested in understanding the part of animal experiments in the history of medicine-from the discovery of key vaccines to the advancement of research on a range of diseases, among them hypertension, kidney failure and cancer.This book is essential reading for anyone curious about the role of animal experimentation in the history of science from the nineteenth century to the present. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease offers a detailed, scholarly historical review of the critical role animal experiments have played in advancing medical knowledge. Laboratory animals have been essential to this progress, and the knowledge gained has saved countless lives-both human and animal. Unfortunately, those opposed to using animals in research have often employed doctored evidence to suggest that the practice has impeded medical progress. This volume presents the articles Jack Botting wrote for the Research Defence Society News from 1991 to 1996, papers which provided scientists with the information needed to rebut such claims. Collected, they can now reach a wider readership interested in understanding the part of animal experiments in the history of medicine-from the discovery of key vaccines to the advancement of research on a range of diseases, among them hypertension, kidney failure and cancer. This book is essential reading for anyone curious about the role of animal experimentation in the history of science from the nineteenth century to the present.
Vine royalty, YouTube megastars, hip-pop sensations, and best friends, Jack & Jack bring their own brand of irreverent comedy, on-point style, and heartfelt life advice to You Don't Know Jacks. Jack & Jack: You Don't Know Jacks is a 240-page, full-colour behind-the-scenes look at the lives of Jack Gilinsky and Jack Johnson, two of the hottest stars performing today. The book details the rise of two best friends growing up in Nebraska, posting Nerd Vandals Vines, to becoming iTunes bestselling rap-rock stars. Full of exclusive photographs, backstage antics, and hilarious anecdotes, it's perfect for any fan who's ever dreamed of someday being famous.
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