An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.
In this book, you'll learn the specialized technique of carving figures in tree bark. Included is a complete guide to the various species of cottonwood bark and the best tools to use. A step-by-step wood carving project of a magical tree house is included, along with a beautiful gallery including wood spirits, animals, whimsical tree houses, and much more.
This book differs from others on name reactions in organic chemistry by focusing on their mechanisms. It covers over 300 classical as well as contemporary name reactions. Biographical sketches for the chemists who discovered or developed those name reactions have been included. Each reaction is delineated by its detailed step-by-step, electron-pushing mechanism, supplemented with the original and the latest references, especially review articles. This book contains major improvements over the previous edition and the subject index is significantly expanded.
This volume gives a thorough and global international coverage of health policy and ethics, with an in depth look at the pertinent background concepts, current issues and future needs and assessments. It includes economics, health care delivery, in depth coverage of issues of disparity, culture, and type of medicine.
Surprisingly, no book of quotations on God and religion by atheists and agnostics exists. Luckily, for the millions of American nonbelievers who have quietly stewed for years as the religious right made gains in politics and culture, the wait is over. Bestselling author Jack Huberman's zeitgeist sense has honed into the backlash building against religious fundamentalism and collected a veritable treasure trove of quotes by philosophers, scientists, poets, writers, artists, entertainers, and political figures. His colorful cast of atheists includes Karen Armstrong, Lance Armstrong, Jules Feiffer, Federico Fellini, H. L. Mencken, Ian McKellen, Isaac Singer, Jonathan Swift, Ludwig Wittgenstein, Virginia Woolf and the Marquis de Sade.
On the cover of the 1970 record THE VANISHING REGIMENTS, Colonel CH Jaeger OBE made an interesting observation: ‘Be it true or not that old soldiers never die but only fade away, it is absolutely certain that the music connected with soldiering never does in fact. Many famous Regiments in the last few years have passed off the scene, others have been amalgamated. Much of the music of former Regiments is still in use, though the names of the Regiments concerned have vanished, perhaps forever’. Regimental colours are the symbolic spirit of the regiment; their marches are the musical spirit. Their histories are sometimes older than the regiments themselves and very much guarded and cherished by them. When you hear a regimental band play a march, why that march? This book is an attempt to cover the fascinating histories of military marches, how and why regiments adopted them, even those that have faded into history. It will appeal to those interested in Regimental Marches of Canadian and United Kingdom Armed Forces. Over 500 marches are covered with many band photos from across the centuries. Also included are narratives of the composers, Victoria Cross musicians and even words to many marches. So, get out the records, crank up the volume and listen to the bands play their MUSICAL COLOURS while reading all bout them.
In Media-Made Dixie Jack Kirby shows how the American public’s perceptions of the South have been influenced, even controlled, by the mass communications media. In this newly updated edition, Kirby surveys major movies, radio and television shows, plays, popular histories, and music from the turn of the century through the 1980s. He documents a progression in the national image of the South from the cracker wasteland of Erskine Caldwell’s God’s Little Acre to the antebellum wonderland of Hollywood’s Shirley Temple-“Bojangles” Robinson musicals; from William Styron’s searching account of the Old South in Confessions of Nat Turner to the New South ingenuity of Jimmy Carter and Ted Turner; and from the regressive back-roads of television’s The Dukes of Hazzard to the complex reconciliation found in Alice Walker’s and Steven Spielberg’s The Color Purple.
Readers will get an inside look at the personal stories behind their favorite country songs as songwriters get up close and personal with exclusive stories about how and why they wrote them. Songs tell a story, and now many of country music’s most famous singers and songwriters are sharing more of the story! These artists reveal the inspiration, influence, and background, and when and why they wrote their most famous songs, in Chicken Soup for the Soul: Country Music. Book includes great photos of the songwriters and lyrics of many of the songs. A great gift for anyone who loves country music!
Peter Ellis Bean, a fairly minor but fascinating character, cast unexpected light on conflicts, famous characters, and events from the time of Mexican rule through the years of the Texas Republic.
Presents a market research guide to the business of biotech, genetics, proteomics and related services - a tool for strategic planning, competitive intelligence, employment searches, or financial research. This title provides profiles of over 400 biotech companies and in-depth chapters on trends.
Age of Betrayal is a brilliant reconsideration of America's first Gilded Age, when war-born dreams of freedom and democracy died of their impossibility. Focusing on the alliance between government and railroads forged by bribes and campaign contributions, Jack Beatty details the corruption of American political culture that, in the words of Rutherford B. Hayes, transformed “a government of the people, by the people, and for the people” into “a government by the corporations, of the corporations, and for the corporations.” A passionate, gripping, scandalous and sorrowing history of the triumph of wealth over commonwealth.
With an introductory essay on cryptography and the history of code-breaking by Simon Singh, this book reveals the workings of Colossus and the extraordinary staff at Bletchley Park through personal accounts by those who lived and worked with the computer.
Evolution has provided a new understanding of reality, with revolutionary consequences for Christianity. In an evolutionary perspective the incarnation involved God entering the evolving human species to help it imitate the trinitarian altruism in whose image it was created and counter its tendency to self-absorption. Primarily, however, the evolutionary achievement of Jesus was to confront and overcome death in an act of cosmic significance, ushering humanity into the culminating stage of its evolutionary destiny, the full sharing of God’s inner life. Previously such doctrines as original sin, the fall, sacrifice, and atonement stemmed from viewing death as the penalty for sin and are shown not only to have serious difficulties in themselves, but also to emerge from a Jewish culture preoccupied with sin and sacrifice that could not otherwise account for death. The death of Jesus on the cross is now seen as saving humanity, not from sin, but from individual extinction and meaninglessness. Death is now seen as a normal process that affect all living things and the religious doctrines connected with explaining it in humans are no longer required or justified. Similar evolutionary implications are explored affecting other subjects of Christian belief, including the Church, the Eucharist, priesthood, and moral behavior.
This book addresses the dilemma created by the discrepancy between our efforts to prevent adolescent pregnancy and our support of adolescent parenthood, which the author argues is America's greatest unrecognized public health crisis. It is the most preventable cause of crime and welfare dependency, and because we hold no expectations for parents who conceive and give birth to children, rates of child neglect and abuse in the United States far exceed those of other developed nations. Westman explores the circumstances and values that make motherhood seem to be girls' best option and that induce males to conceive without the ability to support their children. It proposes a feasible legal procedure as the basis for ensuring that adolescents' babies have competent parents with the resources and environments they need.
Brown (1906-1972) was a popular and respected author of more than 20 mysteries and science fiction novels (The Fabulous Clipjoint, won the 1948 Edgar Award for best mystery novel). This study looks closely at his work and chronicles his unusual life. Paper edition (unseen), $16.95. Annotation copyright by Book News, Inc., Portland, OR
Corporations are spying on you more than government spies ever could. Just follow the money to find out how and why. Corporations can often predict what you will do next, detect subtle changes in your mood, and essentially know what youre thinking about. Development of behavioral biometrics accelerated after 9/11. Some of the research and development was funded by the government to identify potential terrorists and protect the public. However, these technologies are now used by corporations to trample your privacy, practically read your mind, and manipulate you to enhance their profits. Verify the facts yourself. This book contains over two hundred references, including court documents, patents, official government documents, and many other sources. You can do many things to protect yourself. With your help, this book can do for Internet privacy what Ralph Naders Unsafe at Any Speed did for automobile safety.
Over the past several years, privately run, publicly funded charter schools have been sold to the American public as an education alternative promising better student achievement, greater parent satisfaction, and more vibrant school communities. But are charter schools delivering on their promise? Or are they just hype as critics contend, a costly experiment that is bleeding tax dollars from public schools? In this book, Jack Buckley and Mark Schneider tackle these questions about one of the thorniest policy reforms in the nation today. Using an exceptionally rigorous research approach, the authors investigate charter schools in Washington, D.C., carefully examining school data going back more than a decade, interpreting scores of interviews with parents, students, and teachers, and meticulously measuring how charter schools perform compared to traditional public schools. Their conclusions are sobering. Buckley and Schneider show that charter-school students are not outperforming students in traditional public schools, that the quality of charter-school education varies widely from school to school, and that parent enthusiasm for charter schools starts out strong but fades over time. And they argue that while charter schools may meet the most basic test of sound public policy--they do no harm--the evidence suggests they all too often fall short of advocates' claims. With the future of charter schools--and perhaps public education as a whole--hanging in the balance, this book supports the case for holding charter schools more accountable and brings us considerably nearer to resolving this contentious debate.
This volume supplements the acclaimed three volume set published in 1986 and consists of an annotated listing of American Studies monographs published between 1984 and 1988. There are more than 6,000 descriptive entries in a wide range of categories: anthropology and folklore, art and architecture, history, literature, music, political science, popular culture, psychology, religion, science and technology, and sociology.
Alan Turing has long proved a subject of fascination, but following the centenary of his birth in 2012, the code-breaker, computer pioneer, mathematician (and much more) has become even more celebrated with much media coverage, and several meetings, conferences and books raising public awareness of Turing's life and work. This volume will bring together contributions from some of the leading experts on Alan Turing to create a comprehensive guide to Turing that will serve as a useful resource for researchers in the area as well as the increasingly interested general reader. The book will cover aspects of Turing's life and the wide range of his intellectual activities, including mathematics, code-breaking, computer science, logic, artificial intelligence and mathematical biology, as well as his subsequent influence.
Provides information on the truck and specialty vehicles business, including: automotive industry trends and market research; mergers, acquisitions, globalization; automobile manufacturers; truck makers; makers of specialty vehicles such as RVs; automobile loans, insurance and other financial services; dealerships; and, components manufacturers.
This book will help you sort through America's giant corporate employers to determine which may be the best for corporate employers to determine which may be the best for you, or to see how your current employer compares to others. It has reference for growth and hiring plans, salaries and benefits, women and minority advancement, industries, locations and careers, and major trends affecting job seekers.
Every discipline has its canon: the set of standard texts, approaches, examples, and stories by which it is recognized and which its members repeatedly invoke and employ. Although the last twenty-five years have seen the influence of interdisciplinary approaches to legal studies expand, there has been little recent consideration of what is and what ought to be canonical in the study of law today. Legal Canons brings together fifteen essays which seek to map out the legal canon and the way in which law is taught today. In order to understand how the twin ideas of canons and canonicity operate in law, each essay focuses on a particular aspect, from contracts and constitutional law to questions of race and gender. The ascendance of law and economics, feminism, critical race theory, and gay legal studies, as well as the increasing influence of both rational-actor methodology and postmodernism, are all scrutinized by the leading scholars in the field. A timely and comprehensive volume, Legal Canons articulates the need for, and means to, opening the debate on canonicity in legal studies. Table of Contents
Willing to take a risk? These are risky tales that celebrate the fragile, stubborn human animal: no matter what shape he takes, relationships he forms--the color of his mind. He is on contradictory flights towards love (wherever he may find it), confrontations with loss, and his search for home. He must also be packed for sudden stopovers in North Africa or "Big Easy" to check out the scenes there. Don't expect consistency. These stories leap like fleas from slapstick-farce in "The Five Dancing Brothers" through horror in "Neighboring" and "The Rats," past a Saroyanesque caper ("No Sabbaticals in Tinseltown") and gay-world hustle ("Close Shave.") to end in the dream-reality of "House of Children." You will meet some unusual folks: Big Tex from Peoria, Branka the Gypsy, the Brainert Boys, the Can Man, and Azzi's Wife. Maybe they will remind you of someone--maybe you. Two volumes of Jack Beach's poetry have been published by 1 at Books Library: THE THREE MILE BRIDGE: Across Pensacola Bay on a Span of Poems, and THE GRAND TOUR: A Steamer Trunk of Travel Poems. WITHOUT A NET is his first prose work in print.
Plunketts Health Care Industry Almanac is the only complete reference to the American Health Care Industry and its leading corporations. Whatever your purpose for researching the health care field, youll find this massive reference book to be a valuable guide. No other source provides this books easy-to-understand comparisons of national health expenditures, emerging technologies, patient populations, hospitals, clinics, corporations, research, Medicare, Medicaid, managed care, and many other areas of vital importance. Included in the market research sections are dozens of statistical tables covering every aspect of the industry, from Medicare expenditures to hospital utilization, from insured and uninsured populations to revenues to health care expenditures as a percent of GDP. A special area covers vital statistics and health status of the U.S. population. The corporate analysis section features in-depth profiles of the 500 major for-profit firms (which we call The Health Care 500) within the many industry sectors that make up the health care system, from the leading companies in pharmaceuticals to the major managed care companies. Details for each corporation include executives by title, phone, fax, website, address, growth plans, divisions, subsidiaries, brand names, competitive advantage and financial results. Purchasers of either the book or PDF version can receive a free copy of the company profiles database on CD-ROM, enabling key word search and export of key information, addresses, phone numbers and executive names with titles for every company profiled.
The energy industry is boiling over with changes. Deregulation, new opportunities in foreign fields and markets and environmental challenges are rushing together head-on to shape the energy and utilities business of the future. Extremely deep offshore wells in the Gulf of Mexico and offshore of West Africa are being drilled at immense cost. Meanwhile China has become a major energy importer and Russia has become a major exporter. In the U.S., Europe and Japan, renewable and alternative energy sources are developing quickly, including big breakthroughs in wind power and fuel cells. This exciting new reference book covers everything from major oil companies to electric and gas utilities, plus pipelines, refiners, retailers, oil field services and engineering. Petroleum topics include upstream and downstream. Additional topics include coal, natural gas and LNG. More than a dozen statistical tables cover everything from energy consumption, production and reserves to imports, exports and prices. Next, our unique profiles of the Energy 500 Firms are also included, with such vital details as executive contacts by title, revenues, profits, types of business, web sites, competitive advantage, growth plans and more. Purchasers of either the book or PDF version can receive a free copy of the company profiles database on CD-ROM, enabling key word search and export of key information, addresses, phone numbers and executive names with titles for every company profiled.
From iron-clads, submarine torpedoes, and military balloons to pontoon bridges, grenades, and siege artillery, this excellent work describes what material was available to the armies and navies of both sides. Over 500 black-and-white illustrations.
Long before the Red Sox "Impossible Dream" season, Boston’s now nearly forgotten “other” team, the 1914 Boston Braves, performed a baseball “miracle” that resounds to this very day. The "Miracle Braves" were Boston's first "worst-to-first" winners of the World Series. Shortly after the turn of the previous century, the once mighty Braves had become a perennial member of the National League’s second division. Preseason pundits didn't believe the 1914 team posed a meaningful threat to John McGraw’s powerful New York Giants. During the first half of that campaign, Boston lived down to such expectations, taking up residence in the league’s basement. Refusing to throw in the towel at the midseason mark, their leader, the pugnacious George Stallings, deftly manipulated his daily lineup and pitching staff to engineer a remarkable second-half climb in the standings all the way to first place. The team’s winning momentum carried into the postseason, where the Braves swept Connie Mack's heralded Athletics and claimed the only World Championship ever won by Boston’s National League entry. And for 100 years, the management, players, and fans of underperforming ball clubs have turned to the Miracle Braves to catch a glimmer of hope that such a midseason turnaround could be repeated. Through the collaborative efforts of a band of dedicated members of the Society for American Baseball Research, this benchmark accomplishment is richly revealed to the reader in The Miracle Braves of 1914: Boston's Original Worst-to-First World Series Champions. The essence of the “miracle” is captured through a comprehensive compendium of incisive biographies of the players and other figures associated with the team, with additional relevant research pieces on the season. After a journey through the pages of this book, the die-hard baseball fan will better understand why the call to “Wait Until Next Year” should never be voiced prematurely. Includes: FOREWORD by Bob Brady THE BRAVES Ted Cather by Jack V. Morris Gene Cocreham by Thomas Ayers Wilson Collins by Charlie Weatherby Joe Connolly by Dennis Auger Ensign Cottrell by Peter Cottrell Dick Crutcher by Jerrod Cotosman George Davis by Rory Costello Charlie Deal by Charles F. Faber Josh Devore by Peter Gordon Oscar Dugey by Charlie Weatherby Johnny Evers by David Shiner The 1914 Evers-Zimmerman Incident and How the Tale Grew Taller Over the Years by Bob Brady The Evers Ejection Record by Mark Sternman Larry Gilbert by Jack V. Morris Hank Gowdy by Carol McMains and Frank Ceresi Tommy Griffith by Chip Greene Otto Hess by Gary Hess Tom Hughes by Greg Erion Bill James by David Jones Clarence Kraft by Jon Dunkle Dolf Luque by Peter Bjarkman Les Mann by Maurice Bouchard Rabbit Maranville by Dick Leyden Billy Martin by Bob Joel Jack Martin by Charles F. Faber Herbie Moran by Charles F. Faber Jim Murray by Jim Elfers Hub Perdue by John Simpson Dick Rudolph by Dick Leyden Butch Schmidt by Chip Greene Red Smith by Charles F. Faber Paul Strand by Jack V. Morris Fred Tyler by John Shannahan Lefty Tyler by Wayne McElreavy Bert Whaling by Charles F. Faber George “Possum” Whitted by Craig Hardee MANAGER George Stallings by Martin Kohout COACH Fred Mitchell by Bill Nowlin OWNER Jim Gaffney by Rory Costello The Braves’ A.B.C. by Ring Lardner 1914 Boston Braves Timeline by Mike Lynch A Stallings Anecdote 1914 World Series by Mark Sternman “I Told You So” by O.R.C. The Rest of 1914 by Mike Lynch How An Exhibition Game Contributed To A Miracle by Bob Brady The National League Pennant Race of 1914 by Frank Vaccaro The Press, The Fans, and the 1914 Boston Braves by Donna L. Halper Return of the Miracle Braves by Bob Brady Miracle Teams by A Comparison of the 1914 Miracle Braves and 1969 Miracle Mets by Tom Nahigian An Unexpected Farewell by The South End Grounds, August 1914 by Bob Ruzzo The Time(s) the Braves Played Home Games at Fenway Park by Bill Nowlin The Kisselkar Sign The Trail Blazers in Indian File by R. E. M. - poems for 1914 Braves, collected by Joanne Hulbert The Story of the 1914 Braves by George Stallings “Mr. Warmth” and “Very Superstitious” – two George Stallings anecdotes by Bob Brady By the Numbers by Dan Fields Creature Feature by Dan Fields
This comprehensive reference work provides immediate, fingertip access to state-of-the-art technology in nearly 700 self-contained articles written by over 900 international authorities. Each article in the Encyclopedia features current developments and trends in computers, software, vendors, and applications...extensive bibliographies of leading figures in the field, such as Samuel Alexander, John von Neumann, and Norbert Wiener...and in-depth analysis of future directions.
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