The Handbook of Cosmetic Science & Technology has been produced as a comprehensive foundation covering all aspects of this important discipline. It is unique in that it includes sections on quality assurance, total quality management and the ISO 9001 regulations. Also, the Handbook will be of benefit to technical and non–technical people alike – as a standard reference tool or an introduction to the science and technology involved.
This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments.
Friends and Enemies presents a collection of essays on Canadian foreign policy written by J.L. Granatstein, one of the leading political and military historians in the country. The essays cover a period primarily from the Second World War through to the early 2000s and examine policy under prime ministers Mackenzie King, Louis St. Laurent, John Diefenbaker, Lester Pearson, and Pierre Trudeau. Based on interviews and extensive archival research, the essays reveal how Granatstein’s views shifted as he reacted to altered conditions in Canada, Canadian alliances, and the world situation.
This study is an outgrowth of our interest in the history of modern chemistry. The paucity of reliable, quantitative knowledge about past science was brought home forcibly to us when we undertook a research seminar in the comparative history of modern chemistry in Britain, Germany, and the United States. That seminar, which took place at the University of Pennsylvania in the spring of 1975, was paralleled by one devoted to the work of the "Annales School". The two seminars together catalyzed the attempt to construct historical measures of change in aspects of one science, or "chem ical indicators". The present volume displays our results. Perhaps our labors may be most usefully compared with the work of those students of medieval science who devote their best efforts to the establish ment of texts. Only when acceptable texts have been constructed from fragmentary and corrupt sources can scholars move on to the more satisfying business of making history. So too in the modern period, a necessary pre liminary to the full history of any scientific profession is the establishing of reliable quantitative information in the form of statistical series. This volume does not offer history. Instead it provides certain element- indicators -- that may be useful to individuals interested in the history of American chemistry and chemical industry, and suggestive for policy.
Pierre Trudeau and most of his contemporaries at home and abroad are now dead. This book offers reflections on Canadian foreign, trade, and defence policies from interviews conducted more than three decades ago with key policy makers, diplomats, and military officers in the Trudeau government and of that era. The interviews are informative and revealingly frank. There is much on the enormous difficulties in dealing with the United States, Europe, NATO, the Soviet Union, and Communist China in an era dominated by the Cold War. There are also personal insights into Trudeau himself – a man of great “esprit,” who initially seemed destined to change Canadian policy in a dramatic fashion. Over time, however, this was not to be, and his government policies reverted towards the norm. A unique resource, Trudeau’s World adds immeasurably to our understanding of the Trudeau era. It also has much to tell us about Canada and the world from 1968 to 1984.
An overview of the extensive and frequently controversial literature on communally breeding birds developed since the early 1960s, when students of evolution began to examine sociality as a product of natural selection. Jerram Brown provides original data from his own theoretical and empirical studies and summarizes the wide array of results and interpretations made by others. Originally published in 1987. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
One of the most starkly vivid and detailed accounts of survival in Georgia's notorious Andersonville prison during the American Civil War. John Ransom was only 20 years old at the time of his capture. He kept a nearly daily diary during his year of misery at the Confederate prison. He and his fellow Union prisoners endured lice, starvation, freezing cold, killing heat, theft from other inmates...and Captain Wirtz. "Capt. Wirtz very domineering and abusive. Is afraid to come into camp any more. There are a thousand men in here who would willingly die if they could kill him first." Death was a daily occurrence. Yet Ransom knew if he gave up hope, he would die. He somehow kept his humor and kept on writing. Through two escapes, time in a Rebel hospital, and eventual freedom, you'll read a POW account like none you've ever read before.
Electron Impact Phenomena and the Properties of Gaseous Ions, Revised Edition deals with data pertaining to electron impact and to molecular gaseous ionic phenomena. This book discusses electron impact phenomena in gases at low pressure that involve low-energy electrons, which result in ion formation. The text also describes the use of mass spectrometers in electron impact studies and the degree of accuracy obtained when measuring electron impact energies. This book also reviews relatively low speed electrons and the transitions that result in the ionization of the atomic system. This text then discusses diatomic molecules whose mass spectra can be interpreted using the Franck-Condon principle. This selection also presents some examples of ions in solution that resemble the gaseous ions formed by electron impacts. The energies of these gaseous ions can be the key to understanding the mechanisms of ionic reactions. These examples include the olefin addition reactions and catalytic cracking. This text will prove invaluable for research chemists, students, and professors in chemistry and related fields such as organic chemistry and electrochemistry.
The Handbook of Cosmetic Science & Technology has been produced as a comprehensive foundation covering all aspects of this important discipline. It is unique in that it includes sections on quality assurance, total quality management and the ISO 9001 regulations. Also, the Handbook will be of benefit to technical and non–technical people alike – as a standard reference tool or an introduction to the science and technology involved.
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