Now in its 10th edition, Sleisenger and Fordtran?s Gastrointestinal and Liver Disease remains your indispensable source for definitive, state-of-the-art answers on every aspect of gastroenterology and hepatology. Overcome your most complex clinical challenges and make optimal use of the newest techniques, technologies, and treatments?with superb guidance from hundreds of world-renowned authorities. Meticulous updates throughout include the latest approaches and improvements in gastrointestinal and liver disease diagnosis and therapy as well as hundreds of images and 35 new procedural videos. "..one of the most valuable clinical resources in the dynamic field of gastroenterology and hepatology." Reviewed by Brindusa Diaconu on behalf of the Journal of Gastrointestinal and Liver Diseases, July 2015 "..an engaging, educational yet clinically orientated textbook which is relevant to modern clinical practice." Reviewed by Dr Harry Brown on behalf of glycosmedia.com, April 2015 "I can personally attest to the remarkable advances that have been made, as I was author of the chapter on eosinophilic gastroenteritis in the second edition of the textbook, and reading the same chapter in the tenth edition underscores the important advances that have been made in our understanding of the molecular basis as well as the pathophysiology of this and related disorders." Foreword by Norton J. Greenberger, MD Boston, Massachusetts, June 2015 Consult this title on your favorite e-reader. Get the essential gastroenterology information you need from one authoritative source with an outstanding global reputation for excellence. Zero in on the key information you need to know with a consistent, full-color chapter design. Stay up to date with emerging and challenging topics: enteric microbiota and probiotics; fecal microbiota transplantation; Clostridium difficile colitis; and factitious gastrointestinal diseases. Incorporate the latest findings and improvements in care for liver disease patients—from diagnosis and treatment through post-treatment strategies and management of complications. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.
Many modern computer systems, including homogeneous and heterogeneous architectures, support shared memory in hardware. In a shared memory system, each of the processor cores may read and write to a single shared address space. For a shared memory machine, the memory consistency model defines the architecturally visible behavior of its memory system. Consistency definitions provide rules about loads and stores (or memory reads and writes) and how they act upon memory. As part of supporting a memory consistency model, many machines also provide cache coherence protocols that ensure that multiple cached copies of data are kept up-to-date. The goal of this primer is to provide readers with a basic understanding of consistency and coherence. This understanding includes both the issues that must be solved as well as a variety of solutions. We present both high-level concepts as well as specific, concrete examples from real-world systems. This second edition reflects a decade of advancements since the first edition and includes, among other more modest changes, two new chapters: one on consistency and coherence for non-CPU accelerators (with a focus on GPUs) and one that points to formal work and tools on consistency and coherence.
Since The Formulation Of Indo-European Theory In The 19Th C., Sanskrit Has Been Considered The Language Brought Over By The Aryas. This Raised The Question After The Discovery Of The Harappan Culture: What Was The Language Of The Harappans? This Book Tries To Answer This Question. Since The 19Th C. Sanskrit Has Been Considered The Language Of The Aryas. This Book Questions This Formulation And After Critically Reviewing The Evidence Of The Indo-Europeanists Offers An Alternative, Viz. That Akkadian, As The Language Of The Asuras, The Original Inhabitants Of The Land, Is The Parent Of Vedic And Classical Sanskrit.
A thoroughly revised and updated edition of a textbook for graduate students in finance, with new coverage of global financial institutions. This thoroughly revised and updated edition of a widely used textbook for graduate students in finance now provides expanded coverage of global financial institutions, with detailed comparisons of U.S. systems with non-U.S. systems. A focus on the actual practices of financial institutions prepares students for real-world problems. After an introduction to financial markets and market participants, including asset management firms, credit rating agencies, and investment banking firms, the book covers risks and asset pricing, with a new overview of risk; the structure of interest rates and interest rate and credit risks; the fundamentals of primary and secondary markets; government debt markets, with new material on non-U.S. sovereign debt markets; corporate funding markets, with new coverage of small and medium enterprises and entrepreneurial ventures; residential and commercial real estate markets; collective investment vehicles, in a chapter new to this edition; and financial derivatives, including financial futures and options, interest rate derivatives, foreign exchange derivatives, and credit risk transfer vehicles such as credit default swaps. Each chapter begins with learning objectives and ends with bullet point takeaways and questions.
Volume One: This volume catalogues the distinguished and comprehensive collection of approximately 400 works of American sculpture by artists born before 1865. This publication includes an introduction on the history of the collection's formation, particularly in the context of the Museum's early years of acquisitions, and discusses the outstanding personalities involved. --Metropolitan Museum of Art website.
This issue, edited by Drs. Robert Callan and Meredyth Jones, focuses on Digestive Disorders in Ruminants. Article topics include: Rumen (Forestomach) Development and Function; Diagnostic Approach to Forestomach Diseases; Clinical Rumen Acidosis; Diagnosis and Herd Management of Subclinical Rumen Acidosis; Disorders of Rumen Distension and Dysmotility; Diagnosis and Treatment of Hardware Disease; Temporary Rumen Fistula for the Treatment of Forestomach Diseases and Enteral Nutrition; Rumen Microbiome, probiotics, and Fermentation Additives.
The author considers how the Dido and Aeneas episode in Vergil's Aeneid was imitated and transformed in various Renaissance works, culminating in Shakespeare's Antony and Cleopatra.
A compendium of current information on arid soils. Provides a comprehensive background of the various soils and biota of arid regions, as well as a detailed account of the current understanding of degradation processes, and includes methodologies for arid land maintenance and rehabilitation and for
pH Deregulation as the Eleventh Hallmark of Cancer presents key concepts about pH deregulation in a concise and straight-forward manner. The book discusses topics such as pH regulation and metabolism, sodium hydrogen exchanger, monocarboxylate transporter, V-ATPase proton pump, carbonic anhydrases, and voltage gated sodium channels. In addition, it covers clinical and therapeutic implications and future perspectives. This is a valuable resource for researchers, oncologists, students and members of the biomedical and medical fields who want to learn more about the role of pH deregulation in cancer treatment. pH deregulation can improve the outcome of classical treatments without adding toxicity to them, and the book shows that treating the pH peculiarities of cancer is simple and can be performed with existing drugs. Based on the classification of tumor malignancy in ten hallmarks, the authors put pH deregulation at the spotlight and separated from metabolic reprogramming due to its impact on all other hallmarks, proposing it as an additional characteristic to evaluate and fight cancer. Proposes that pH deregulation should be considered as an independent hallmark of cancer from metabolic reprogramming due to its impact on all other hallmarks (based on seminal work of Hanahan and Weinberg) Explains basic issues of cancer pH deregulation and its consequences in a simple and concise manner Discusses the subject from the start with very elementary concepts on pH and pH regulation to help readers understand key concepts without proper background Presents key concepts through original illustrations and table for easy comprehension
Pathology of the Human Placenta remains the most comprehensive and authoritative text in the field. It provides extensive information on the normal placenta, encompassing physiology, metabolism, and endocrinology, and covers the full range of placental diseases in great detail. Further chapters are devoted to abortions, molar pregnancies, multiple pregnancies, and legal considerations. This sixth edition of the book has been extensively revised and expanded to reflect the most recent progress in the field, and a brand new chapter has been added on artificial reproductive technology. Some 800 illustrations are included, many of them in color. The detailed index has been further improved and tables updated. Pathology of the Human Placenta will be of enormous value to pathologists and obstetrician-gynecologists alike.
Few criminologists have drawn attention to the fact that widespread and significant forms of harm such as green or environmental crimes are neglected by criminology. Others have suggested that green crimes present the most important challenge to criminology as a discipline. This book argues that criminology needs to take green harms more seriously and to be revolutionized so that it forms part of the solution to the large environmental problems currently faced across the world. It asks how criminology should be redesigned to consider green/environmental harm as a key area of study in an era where destruction of the earth and the world’s ecosystem is a major concern and examines why this has remained unaccomplished so far. The chapters in this book apply an environmental frame of reference underlying a green approach to issues which can be addressed from within criminology and which can encourage criminologists and environmentalists to respond and react differently to environmental crime.
This book explores the prospects of rivaling ontological and epistemic interpretations of quantum mechanics (QM). It concludes with a suggestion for how to interpret QM from an epistemological point of view and with a Kantian touch. It thus refines, extends, and combines existing approaches in a similar direction. The author first looks at current, hotly debated ontological interpretations. These include hidden variables-approaches, Bohmian mechanics, collapse interpretations, and the many worlds interpretation. He demonstrates why none of these ontological interpretations can claim to be the clear winner amongst its rivals. Next, coverage explores the possibility of interpreting QM in terms of knowledge but without the assumption of hidden variables. It examines QBism as well as Healey’s pragmatist view. The author finds both interpretations or programs appealing, but still wanting in certain respects. As a result, he then goes on to advance a genuine proposal as to how to interpret QM from the perspective of an internal realism in the sense of Putnam and Kant. The book also includes two philosophical interludes. One details the notions of probability and realism. The other highlights the connections between the notions of locality, causality, and reality in the context of violations of Bell-type inequalities.
Ubiquitin-proteasome-dependent proteolysis is central to an incredible multitude of processes in all eukaryotes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, endocytosis, stress responses, antigen presentation and other aspects of the immune response, the functions of the nervous system including circadian rhythms, axon guidance and acquisition of memory.This book tells the story of the ubiquitin system as we currently know it: from the regulation of basic cellular processes to quality control and the pathogenetic mechanisms of disease, from X-ray crystallography of the 26S proteasome to the interaction between substrates and their ligases, to the development of mechanism-based drugs, and to target-specific aberrant processes.
Advances in scientific computing have made modelling and simulation an important part of the decision-making process in engineering, science, and public policy. This book provides a comprehensive and systematic development of the basic concepts, principles, and procedures for verification and validation of models and simulations. The emphasis is placed on models that are described by partial differential and integral equations and the simulations that result from their numerical solution. The methods described can be applied to a wide range of technical fields, from the physical sciences, engineering and technology and industry, through to environmental regulations and safety, product and plant safety, financial investing, and governmental regulations. This book will be genuinely welcomed by researchers, practitioners, and decision makers in a broad range of fields, who seek to improve the credibility and reliability of simulation results. It will also be appropriate either for university courses or for independent study.
An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm, mechanisms to decrease extra cellular pH and increase intracellular pH, NHE-1 activity in cancer, carbonic anhydrases, vacuolar ATPase proton pump, and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions, cellular acidification and extracellular alkalinization as a new and integral approach to cancer treatment. Analyzes the mechanisms that lead to the inversion of pH gradient in cancer tissues Summarizes almost 100 years of research on pH inversion in cancer in one single source, discussing the most relevant and updated researches in the field Proposes new efficient treatments against cancer using pH inversion mechanisms, either with new drugs like proton transport inhibitors and proton pump inhibitors (PTIs and PPIs) or with repurposed drugs
This book comprises 41 s dealing various issues, prospects and importance of conservation agriculture practices followed across different regions with special emphasis on rainfed regions. We hope this book on conservation agriculture will be highly useful to researchers, scientists, students, farmers and land managers for efficient and sustainable management of natural resources.
The current book emphasizes on basic knowledge of chemistry and biology concepts, covering multidisciplinary applications which comprises functional aspects of chemical and biological disciplines and they are resource material for young innovative minds to enhance their knowledge and research thoughts as a creative element to apply it in their research in the field of chemical biology. The main motto of this book highlights on research objectives, new developments of synthesis, a wide range of applications, and as per the industrial requirements for a useful product to launch or discover for science and society. Various innovations are the major source and new perspectives to troubleshoot the newer problems with the help of allied science applications by understanding the basic concepts, theories, protocols, needful technologies, and applied products, by knowing similar problems and their impact in current-day problems in the science field. Hence, it’s interdisciplinary research to develop highly significant pharmacology products in the areas of life science to make sure safer, cheaper, and ecological as a novel future drug/medicine. The applications aimed mainly to health of humans, health of agro-horticulture, health of environment and animalsas well as wealth of entrepreneurs. This comprehensive edited volume summarises the features of An Approach to Future Perspectives for academic, research and industrial purposes as an advanced reference material for all the learners in the area of chemistry and biology.
Soils contribute to the achievement of the UN Sustainable Development Goals through carbon sequestration. By enhancing soil health and fertility, soils can play a crucial role in climate action, land degradation neutrality, and alleviating hunger. The present study provides a spatially explicit report on the state of grassland soils and can be used as a baseline for future work to explore the impacts of livestock management on soil carbon at regional, country and farm levels. Assessing the current state of grassland systems and their potential to sequester carbon in the soil is of key importance to understand the trade-offs between grassland services on food security, biodiversity conservation and climate mitigation.
This is the first advanced, systematic and comprehensive look at weak decays in the framework of gauge theories. Included is a large spectrum of topics, both theoretical and experimental. In addition to explicit advanced calculations of Feynman diagrams and the study of renormalization group strong interaction effects in weak decays, the book is devoted to the Standard Model Effective Theory, dominating present phenomenology in this field, and to new physics models with the goal of searching for new particles and interactions through quantum fluctuations. This book will benefit theorists, experimental researchers, and Ph.D. students working on flavour physics and weak decays as well as physicists interested in physics beyond the Standard Model. In its concern for the search for new phenomena at short distance scales through the interplay between theory and experiment, this book constitutes a travel guide to physics far beyond the scales explored by the Large Hadron Collider at CERN.
This field guide covers the major resource groups likely to be encountered in the fisheries of the Cambodian Mekong. These groups include sharks, batoid fishes and bony fishes. The introduction outlines the geographical, environmental and ecological factors influencing fisheries, and the basic components of the fisheries of the Cambodian Mekong. As an aid to identification to higher taxonomic levels, a pictorial index to families and an illustrated guide to orders and families are included. Each species account provides scientific nomenclature, FAO names in English, local names, sizes, notes on fisheries, habitat and biology, and one or more illustrations. The guide is fully indexed and a list of related literature is appended. Finally, 27 colour plates are presented.
Published information and database on regional climate trend is far few in tropical regions especially in South East Asia.Present book “Climate Change Impact on ecosystem” consists twenty research topics on climate driving forces from South East Asia.These studies are from different geographical locations and ecosystems extended all over Indian continent and beyond.Subject covered in this book are of multi-characteristics and interdisciplinary viz.impact of climate change in - Jhuming the traditional agriculture among the tribal regions of Manipur, Botanical garden network ,coastal stability, water resources of islands, remote sensed data and extreme weather conditions, global temperature variation and monsoon, mitigation , policy aspects and so an.Basic information and data on the impact of climate change on physical, biological and geological systems are an important characteristics of this book.It suggest mitigation and adaptation from basic units of society viz.family / household level. This book is a significant contribution to regional climatic trend and responses from climatic data sparse Indian subcontinent.
Recognized as the most prestigious, comprehensive text on Global Health for GRADUATE programs in public and global health. Global Health, Third Edition (formerly titled International Public Health) brings together contributions from the world's leading authorities into a single comprehensive text. It thoroughly examines the wide range of global health challenges facing low and middle income countries today and the various approaches nations adopt to deal with them. These challenges include measurement of health status, infectious and chronic diseases, injuries, nutrition, reproductive health, global environmental health and complex emergencies. Important Notice: The digital edition of this book is missing some of the images or content found in the physical edition.
Down Cathedral is one of the two oldest ecclesiastical foundations in Ulster still in use. Although the present structure dates from the early 13th century it is known that there had been a monastery and place of workship on the Hill of Down for many centuries before then. This book describes and illustrates the history of the Hill of Down from those earliest times to the present day. The relationship of St Patrick with the Hill is narrated and takes careful account of the latest research, some of it controversial, on the association of the island's patron saint with the Hill on which he is thought to be buried. The intriguing early and middle history of the Cathedral, including the building of the Benedictine monastery, the bishops and priors who ruled over it and its destruction at the dissolution of the monasteries in the middle of the 16th century, is told in clear and absorbing detail. Its subsequent restoration to full glory from the 1790s, largely due to the influence of the Downshire family, marks the beginning of the modern period for this much loved building. The story is brought right up to date with the recent appointment of a New Bishop and a new Dean. Important new sources in the State Papers and in archiepiscopal registers that have only recently become accessible have been used in the telling of this fascinating study. Many of the images in this work are published for the first time and include photographs of irreplaceable artifacts uncovered during the significant archaelogical excavations of the last few years. The outcome is a comprehensive, pioneering and beautifully illustrated account of one of Ireland's most treasured historical locations, written with authority and affection by one of the country's most accomplished and respected ecclesiastical historians.
Addictions have increased markedly in contemporary societies over the past decades. As well as widely acknowledged issues surrounding illegal substance addictions, there are increasing numbers of problems related to behavioural addictions such as the use of legal substances such as antidepressants and amphetamines. These addictions are concerning for a range of public policy fields, not least, public health and social cohesion. As a result, cohesive governance of addictive substances and behaviours is paramount to future public policy. This book is based on the findings of a five year, multidisciplinary project (Addictions and Lifestyles in Contemporary Europe - Reframing Addictions Project) studying the pace and impact of addictions in Europe, and is the concluding volume in the Governance of Addictive Substances and Behaviours series. Authored by 11 leading figures in the fields of public health, psychology, sociology, psychiatry, addiction studies, epidemiology, and social and public policy, the book takes a truly comprehensive approach to the study of the current state of addiction governance in Europe and proposals for a future governance framework. No one country has yet got governance polices right. The project's outcome is a plan for the redesign of addictions governance, which includes amendments to key metrics used in research, promoting individual-level to society-level scope of understanding in policy approaches, and bringing the impact of dependency on societal well-being to the fore. New Governance of Addictive Substances and Behaviours is an unprecedented study, both in terms of international reach and scope of issues addressed. It will be a key resource for anyone with an interest in research-driven European policy change in public health and the field of addictive substances and behaviours.
Although blasphemy is as old as religion itself, its history has begun a new chapter in recent years. Slanders of the sacred are everywhere, as in the highly visible Charlie Hebdo case, with "religion" sometimes appearing as little more than a membrane for giving and receiving offense. Where some explain the contemporary preoccupation with blasphemy by pointing to the interconnectedness of twenty-first-century media, J. Barton Scott argues that we need to look deeper into the past at the colonial-era infrastructures that continue to shape our globalized world. Slandering the Sacred examines one such powerful and widely influential legal infrastructure: Section 295A of the Indian Penal Code. What would it look like to take Section 295A as a text in, of, and for religion-a connective tissue interlinking multiple religious worlds? To answer this question, Scott explores the cultural, intellectual, and legal pre-history of this law, moving between colonial India and imperial Britain as well as between secular law and modern religion. Section 295A reveals a set of problems with no easy solution. It places a chill on free speech, extends the power of the state over civil society, and exacerbates the culture of religious controversy that it was designed to fix. The legislators who enacted the law foresaw the damage it could do and they enacted it anyway, as a half-despairing measure to curb injurious speech. Their problems are still our problems. The twenty-first century has compounded modernity's free-speech headache. Section 295A opens a useful window onto these problems precisely because it is a problem, too. Its history is a tale about the afterlives of the holy dead, the legal definition of the anglophone category "religion," and the transmissibility of outrage as bureaucratized affect"--
This book outlines a selection of exciting advances currently being made worldwide in the field of modern engineering at the nanometer scale. Leading scientists and engineers give a general overview of research advances in their specialized subject areas. They also describe some of their own cutting-edge research and give their visions of the future.Written in a popular and well-illustrated style, the articles are written by young scientists many of whom hold, or have held, prestigious Royal Society or EPSRC Fellowships. Carefully selected by Professor A G Davies and Professor J M T Thompson FRS, topics include: the fabrication and measurement of nanoelectronic devices, organic conductors, and bioelectronic materials; the assembly of such structures into appropriate configurations, including the use of biological processes to drive the assembly; the development of new materials including both organic and inorganic wires, carbon nanotubes, and magnetic materials; and finally, the analysis and characterization of these structures.The book conveys the excitement and enthusiasm of the authors for their work at the frontiers of modern engineering nanotechnology. All are definitive reviews for readers with a general interest in the future directions of science and engineering at the nanometer scale./a
Completely revised and expanded new edition covering the recent and significant progress in multi-domain spectral methods at both the fundamental and application level. Including new material on discontinuous Galerkin methods, non-tensorial nodal spectral element methods in simplex domains, and stabilisation and filtering techniques; this text, written by leading experts, is a must-have for students, academics and practitioners in computational fluid mechanics, applied and numerical mathematics, computational mechanics, aerospace and mechanical engineering and climate/ocean modelling.
Here is the most comprehensive and up-to-date treatment of one of the hottest areas of chemical research. The treatment of fundamental kinetics and photochemistry will be highly useful to chemistry students and their instructors at the graduate level, as well as postdoctoral fellows entering this new, exciting, and well-funded field with a Ph.D. in a related discipline (e.g., analytical, organic, or physical chemistry, chemical physics, etc.). Chemistry of the Upper and Lower Atmosphere provides postgraduate researchers and teachers with a uniquely detailed, comprehensive, and authoritative resource. The text bridges the "gap" between the fundamental chemistry of the earth's atmosphere and "real world" examples of its application to the development of sound scientific risk assessments and associated risk management control strategies for both tropospheric and stratospheric pollutants. Serves as a graduate textbook and "must have" reference for all atmospheric scientists Provides more than 5000 references to the literature through the end of 1998 Presents tables of new actinic flux data for the troposphere and stratospher (0-40km) Summarizes kinetic and photochemical date for the troposphere and stratosphere Features problems at the end of most chapters to enhance the book's use in teaching Includes applications of the OZIPR box model with comprehensive chemistry for student use
This must-have clinical reference, by Drs. Amy S. Paller and Anthony J. Mancini, provides practical, authoritative guidance for identification and management of all types of skin disorders seen in children and adolescents. Hurwitz Clinical Pediatric Dermatology, 5th Edition, is ideal for pediatricians, dermatologists, family practitioners and anyone who sees children with skin disorders - no matter what level of experience you may have. Benefit from the knowledge and expertise of two leaders in the field, who provide a clearly written, consistent approach throughout the text. Stay on the cutting edge of what's new in pediatric dermatology - from the neonate to the adolescent - with the latest drug developments and disease classifications. Recognize virtually any skin condition you're likely to see thanks to more than 1,000 high-quality color images, including over 300 brand new to this edition. Find the most appropriate therapy options with updated evidence based guidance. Easily locate the information you need with more quick-reference boxes and summary tables throughout the text. Hurwitz provides the easiest access to the information you need to diagnose/treat the dermatologic ailments of your pediatric patients.
This book is an essential reference for anyone interested in the use of spectral/hp element methods in fluid dynamics. It provides a comprehensive introduction to the field together with detailed examples of the methods to the incompressible and compressible Navier-Stokes equations.
`This is a really useful and comprehensive textbook that will provide readers with all their needs as a primer in the field of occupational and organisational psychology′ - Cary L Cooper, Times Higher Educational Supplement `Provides excellent coverage of the main areas of Industrial, Work and Organisational Psychology. All main topics at the individual an group levels are covered... a highly competent, research based introductory text′ - Professor Neil Anderson, University of Amsterdam Understanding Occupational and Organizational Psychology is an invaluable resource for students doing a course in occupational and organizational psychology, either at third year undergraduate or Masters level. The text provides comprehensive coverage of the British Psychological Society′s training requirements for becoming a chartered occupational psychologist, yet it is also compliant with European training guidelines for industrial, work and organizational psychology too. This book will prompt and inspire further reading and research as well as ideas for dissertations, problem formulation and the creative application of knowledge to various situations. Ideal if you want to get ahead with your undergraduate study or get your foot on the ladder to becoming a fully-fledged scientist-practitioner.
The authors develop a systematic applied mathematics perspective on the problems associated with filtering complex turbulent systems. The book contains background material from filtering, turbulence theory and numerical analysis, making it suitable for graduate courses as well as for researchers in a range of disciplines where applied mathematics is required.
Tobacco, alcohol and gambling corporations have been highly effective in stalling, diverting and blocking public health measures. This book provides an original and engaging exposé of the ethical issues faced by people and organizations when they accept industry money in ways that facilitate corporate influence with the public and with policy makers. It starts with a detailed examination of the risks of accepting such profits and what might be done to reduce them, then moves on to introduce the concept of a continuum of 'moral jeopardy' which shifts the emphasis from accept/not accept binaries to a focus on the extent to which people are willing to accept funding. This shift encourages people to think and speak more about the risks and to develop clearer positions for themselves. The content will be helpful to those working in government agencies, addiction services, community organizations or anyone interested in reducing the harms of addictive consumption.
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