Data Mining: A Tutorial-Based Primer, Second Edition provides a comprehensive introduction to data mining with a focus on model building and testing, as well as on interpreting and validating results. The text guides students to understand how data mining can be employed to solve real problems and recognize whether a data mining solution is a feasible alternative for a specific problem. Fundamental data mining strategies, techniques, and evaluation methods are presented and implemented with the help of two well-known software tools. Several new topics have been added to the second edition including an introduction to Big Data and data analytics, ROC curves, Pareto lift charts, methods for handling large-sized, streaming and imbalanced data, support vector machines, and extended coverage of textual data mining. The second edition contains tutorials for attribute selection, dealing with imbalanced data, outlier analysis, time series analysis, mining textual data, and more. The text provides in-depth coverage of RapidMiner Studio and Weka’s Explorer interface. Both software tools are used for stepping students through the tutorials depicting the knowledge discovery process. This allows the reader maximum flexibility for their hands-on data mining experience.
This book presents a state-of-the-art summary of the applications of low temperature to clinical situations, together with details of the underlying principles of biology. It provides specific information for the clinicians and research workers in a number of areas of current interest and attempts to provide a unifying theme of cryobiology of interest and value to those researching a clinical problem. Specific topics discussed include the effects of low temperatures on mammalian systems in the absence of ice and how the changes can be modulated to achieve desired results; low temperature storage of tissues and organs for transplantation in the liquid state; the effects of whole body hypothermia in man and how it relates to mammal hibernation; problems associated with ice formation and the subsequent freezing of cells and tissues; cryopreservation of blood cells, reproductive cells, and tissues, such as the skin and cornea. Other interesting issues featured include the developments in cryopreservation of large, highly-organized structures and the destructive powers of ice formation in cryosurgery of diseased tissues.
Cybersecurity Analytics is for the cybersecurity student and professional who wants to learn data science techniques critical for tackling cybersecurity challenges, and for the data science student and professional who wants to learn about cybersecurity adaptations. Trying to build a malware detector, a phishing email detector, or just interested in finding patterns in your datasets? This book can let you do it on your own. Numerous examples and datasets links are included so that the reader can "learn by doing." Anyone with a basic college-level calculus course and some probability knowledge can easily understand most of the material. The book includes chapters containing: unsupervised learning, semi-supervised learning, supervised learning, text mining, natural language processing, and more. It also includes background on security, statistics, and linear algebra. The website for the book contains a listing of datasets, updates, and other resources for serious practitioners.
This practical high-level guidebook offers an in-depth understanding of the newly emerging clinical trial designs in adaptive trial designs and master protocols. Both concise and readable without shying away from technical discussion, the book introduces the most innovative approaches in clinical trial research such as adaptive trial designs, master protocols, platform trial, basket trial, and umbrella trial designs. Featuring a revisionist history of clinical research before moving on to case-study based discussion and practical considerations from collective experience. The book enables readers to understand the strengths and limitations of these novel designs as well as their application to individual areas of research and clinical practice. Supplemented by real-world examples from the recent developments in medical research efficiency instigated by both personalized medicine and high-profile diseases like COVID-19 and cancer. The first book of its kind, it is the go-to resource for medical students and researchers working in clinical trial research.
This book constitutes the refereed proceedings of an international workshop on Pattern Detection and Discovery organized by the European Science Foundation in London, UK in September 2002. The 17 revised full papers presented were carefully selected and reviewed for inclusion in this state-of-the-art book. Six papers present an introduction and general issues in the emerging field. Four papers are devoted to association rules. Four papers deal with various aspects of text mining and Web mining, and three papers explore advanced applications.
The 6th Edition of the indispensable Textbook of Interventional Cardiology, by Drs. Eric Topol and Paul S. Teirstein, offers you comprehensive, seasoned clinical advice on all aspects of this rapidly evolving subspecialty. You’ll find balanced, expert perspectives on the scientific and clinical advances established over the last few decades so you can better decide which procedures deliver optimal results in any given situation. You’ll also get an updated look at promising new techniques like transcatheter aortic valve implantation; new interventional approaches for left mainstem disease and thrombus-containing lesions; transradial intervention; and optical coherence tomography (OCT). At www.expertconsult.com you can access the complete contents of the book, plus additional case discussions and procedural videos to enhance your knowledge and skills. Rely on Dr. Topol’s premier text to provide unmatched leadership in the ever-evolving practice of interventional cardiology. Achieve the best outcomes for your patients with dependable, objective advice on both proven and emerging procedures and devices. Perform effective interventions for heart disorders with the expert guidance of leading authorities who offer a fresh and balanced perspective on all aspects of interventional cardiology. Keep up with emerging procedures including transcatheter aortic valve implantation (TAVI), transradial intervention, and optical coherence tomography (OCT), as well as new interventional approaches for left mainstem disease and thrombus-containing lesions. Stay current with the latest genetic information and clinical trials. Search the complete text plus additional case discussions, download all the images, and watch procedural videos online at www.expertconsult.com.
Annotation The three volume set LNAI 5177, LNAI 5178, and LNAI 5179, constitutes the refereed proceedings of the 12th International Conference on Knowledge-Based Intelligent Information and Engineering Systems, KES 2008, held in Zagreb, Croatia, in September 2008. The 316 revised papers presented were carefully reviewed and selected. The papers present a wealth of original research results from the field of intelligent information processing in the broadest sense; topics covered in the first volume are artificial neural networks and connectionists systems; fuzzy and neuro-fuzzy systems; evolutionary computation; machine learning and classical AI; agent systems; knowledge based and expert systems; intelligent vision and image processing; knowledge management, ontologies, and data mining; Web intelligence, text and multimedia mining and retrieval; and intelligent robotics and control.
This book constitutes the refereed proceedings of the Sixth International Conference on Protocols for Multimedia Systems (PROMS 2001), held in Enschede, The Netherlands, in October 2001. The 18 papers presented were carefully reviewed and selected from a total of 43 papers. The papers are organized in sections on quality of service in the Internet, multimedia streaming, multimedia multicast, wireless networks and host mobility, tcp/ip optimization, and service development and deployment.
Brand relationships are critical because they can enhance company profitability by lowering customer acquisition and retention costs. This is the first serious academic book to offer a psychological perspective on the meaning of and basis for brand relationships, as well as their effects. "The Handbook of Brand Relationships" includes chapters by well-known marketing and psychology scholars on topics related to the meaning, significance, and measurement of brand relationships; the critical connections between consumers and the brand; how brand relationships are formed through both thoughtful and non-thoughtful processes; and how they are built, repaired, and leveraged through brand extensions. An integrative framework introduces the book and summarizes the chapters' key ideas. The handbook also identifies several novel metrics for measuring various aspects of brand relationships, and it includes recommendations for further research.
The 5-Minute Clinical Consult provides rapid-access information on the diagnosis, treatment, medications, follow-up, and associated conditions of more than 700 medical conditions. Organized alphabetically by diagnosis, this best-selling clinical reference continues to present brief, bulleted points on disease topics in a consistent templated format.
Offering unparalleled coverage of infectious diseases in children and adolescents, Feigin & Cherry's Textbook of Pediatric Infectious Diseases 8th Edition, continues to provide the information you need on epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. This extensively revised edition by Drs. James Cherry, Gail J. Demmler-Harrison, Sheldon L. Kaplan, William J. Steinbach, and Peter J. Hotez, offers a brand-new full-color design, new color images, new guidelines, and new content, reflecting today's more aggressive infectious and resistant strains as well as emerging and re-emerging diseases - Discusses infectious diseases according to organ system, as well as individually by microorganisms, placing emphasis on the clinical manifestations that may be related to the organism causing the disease. - Provides detailed information regarding the best means to establish a diagnosis, explicit recommendations for therapy, and the most appropriate uses of diagnostic imaging. - Features expanded information on infections in the compromised host; immunomodulating agents and their potential use in the treatment of infectious diseases; and Ebola virus. - Contains hundreds of new color images throughout, as well as new guidelines, new resistance epidemiology, and new Global Health Milestones. - Includes new chapters on Zika virus and Guillain-Barré syndrome. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Thoroughly revised and expanded throughout, the new edition is a graduate-level text and reference book on gaseous nebulae, nova and supernova remnants. Much of the new data and new images are from the Hubble Space Telescope with two wholly new chapters being added along with other new features. The previous edition which was tried and tested for thirty years has now been succeeded by a revised, updated, larger edition, which will be valuable to anyone seriously interested in astrophysics.
For nearly 50 years, Sleisenger & Fordtran's Gastrointestinal and Liver Disease has been the go-to reference for gastroenterology and hepatology residents, fellows, physicians, and the entire GI caregiving team. Now in a fully revised 11th Edition, this two-volume masterwork brings together the knowledge and expertise of hundreds of global experts who keep you up to date with the newest techniques, technologies, and treatments for every clinical challenge you face in gastroenterology and hepatology. A logical organization, more than 1,100 full-color illustrations, and easy-to-use algorithms ensure that you'll quickly and easily find the information you need. - Features new and expanded discussions of chronic hepatitis B and C, Helicobacter pylori infection, colorectal cancer prevention through screening and surveillance, biologic agents and novel small molecules to treat and prevent recurrences of inflammatory bowel disease (IBD), gastrointestinal immune and autoimmune diseases, and more. - Offers reliable coverage of key topics such as Barrett's esophagus, gut microbiome, enteric microbiota and probiotics, fecal microbiota transplantation, and hepatic, pancreatic, and small bowel transplantation. - Provides more quick-reference algorithms that summarize clinical decision making and practical approaches to patient management. - Employs a consistent, templated, format throughout for quick retrieval of information. - Includes monthly updates online, as well as more than 20 procedural videos. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
From traditional topics that form the core of industrial electronics, to new and emerging concepts and technologies, The Industrial Electronics Handbook, in a single volume, has the field covered. Nowhere else will you find so much information on so many major topics in the field. For facts you need every day, and for discussions on topics you have only dreamed of, The Industrial Electronics Handbook is an ideal reference.
A major task of our time is to ensure adequate food supplies for the world's current population (now nearing 7 billion) in a sustainable way while protecting the vital functions and biological diversity of the global environment. The task of providing for a growing population is likely to be even more difficult in view of actual and potential changes in climatic conditions due to global warming, and as the population continues to grow. Current projections suggest that the world's temperatures will rise 1.8-4.0 by 2100 and population may reach 8 billion by the year 2025 and some 9 billion by mid-century, after which it may stabilize. This book addresses these critical issues by presenting the science needed not only to understand climate change effects on crops but also to adapt current agricultural systems, particularly in regard to genetics, to the changing conditions. Crop Adaptation to Climate Change covers a spectrum of issues related to both crops and climatic conditions. The first two sections provide a foundation on the factors involved in climate stress, assessing current climate change by region and covering crop physiological responses to these changes. The third and final section contains chapters focused on specific crops and the current research to improve their genetic adaptation to climate change. Written by an international team of authors, Crop Adaptation to Climate Change is a timely look at the potentially serious consequences of climate change for our global food supply, and is an essential resource for academics, researchers and professionals in the fields of crop science, agronomy, plant physiology and molecular biology; crop consultants and breeders; as well as climate and food scientists.
Written by world-renowned and best-selling experts, Nobel Laureate E. J. Corey and Laszlo Kurti, Enantioselective Chemical Synthesis offers an authoritative and comprehensive overview of the field's progress; the processes and tools for key formations; future development for complex, stereocontrolled (enantiomeric or diastereoisomeric) molecules; and valuable examples of multi-step syntheses. Utilizing a color-coded scheme to illustrate chemical transformations, Enantioselective Chemical Synthesis provides clear explanation and guidance through vital asymmetrical syntheses and insight into the next steps for the field. Researchers, professionals, and academics will benefit from this valuable, thorough, and unique resource. - In Part I, the authors present clearly, comprehensively and concisely the most useful enantioselective processes available to synthetic chemists. - Part II provides an extensive discussion of the most logical ways to apply these new enantioselective methods to the planning of syntheses of stereochemically complex molecules. This hitherto neglected area is essential for the advancement of enantioselective synthesis to a more rational and powerful level. - Part III describes in detail many reaction sequences which have been used successfully for the construction of a wide variety of complex target molecules - Clearly explains stereochemical synthesis in theory and practice - Provides a handy tool box for scientists wishing to understand and apply chiral chemical synthesis - Describes almost 50 real life examples of asymmetric synthesis in practice and examines how the chiral centers were introduced at key synthetic stages
Integrating core management concepts with evidence-based research and strategies, Management Today, Second Edition provides students of all backgrounds with the foundations they need to start and enhance their careers. Authors Terri A. Scandura and Frankie J. Weinberg share their experiences as active researchers and award-winning teachers throughout the book to engage and inspire the next generation of managers. Students can apply what they have learned through self-assessments, reflection exercises, and experiential activities. Real-world case studies explore business scenarios students may encounter throughout their own careers. Practical, concise, and founded upon cutting edge research, this text equips students with the necessary skills to become impactful members of today′s business world. This title is accompanied by a complete teaching and learning package. Contact your Sage representative to request a demo. Learning Platform / Courseware Sage Vantage is an intuitive learning platform that integrates quality Sage textbook content with assignable multimedia activities and auto-graded assessments to drive student engagement and ensure accountability. Unparalleled in its ease of use and built for dynamic teaching and learning, Vantage offers customizable LMS integration and best-in-class support. It′s a learning platform you, and your students, will actually love. Assignable Video with Assessment Assignable video (available in Sage Vantage) is tied to learning objectives and curated exclusively for this text to bring concepts to life. Watch a sample video now. LMS Cartridge: Import this title′s instructor resources into your school’s learning management system (LMS) and save time. Don’t use an LMS? You can still access all of the same online resources for this title via the password-protected Instructor Resource Site. Learn more.
An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
The scientific world and modern society today is experiencing the dawning of an era of herbal medicine. Extensive research has shown that aromatic plants are important anti-inflammatory, antioxidant, anti aging and immune boosting delectable foods, with the magic and miracle to boost our immune system providing us with extended and an improved quality of life. Apart from making bland recipes into welcoming or interesting victories, herbs and spices have stirred the minds of the research community to look deeper into its active components from a functional perspective. It is essential to present the scientific and medicinal aspect of herbs and spices together with the analysis of constituents, its medicinal application, toxicology and its physiological effects. Herbs and spices with high levels of antioxidants are in great demand as they tend to promote health and prevent diseases naturally assuring increased safety and reliability for consumers. Herbs and spices are not only known for taste and flavor, but today research has opened up a new realm in which the antioxidant properties of these aromatic plants provide preservation for foods and health benefits for consumers who look forward to concrete scientific research to guide them further and explore herbal medicine. The aim of this book is to create awareness in society about the reliability of medicinal properties of certain herbs and spices through scientific and scholarly research.
Starting from fundamentals and moving through a thorough discussion of equipment, methods, and techniques, the Handbook of Laser-Induced Breakdown Spectroscopy provides a unique reference source that will be of value for many years to come for this important new analysis method. The authors, with a total of over 60 years of experience in the LIBS method, use a combination of tutorial discussions ranging from basic principles up to more advanced descriptions along with extensive figures and photographs to clearly explain topics addressed in the text. In this second edition, chapters on the use of statistical analysis and advances in detection of weapons of mass destruction have been added. Tables of data related to analysis with LIBS have been updated. The Handbook of Laser-Induced Breakdown Spectroscopy, Second Edition: provides a thorough but understandable discussion of the basic principles of the method based on atomic emission spectroscopy, including recently available data leading to better characterization of the LIBS plasma; presents a discussion of the many advantages of the method along with limitations, to provide the reader a balanced overview of capabilities of the method; describes LIBS instrumentation ranging from basic set-ups to more advanced configurations; presents a comprehensive discussion of the different types of components (laser, spectrometers, detectors) that can be used for LIBS apparatuses along with suggestions for their use, as well as an up-to-date treatment of the newest advances and capabilities of LIBS instruments; presents the analytical capabilities of the method in terms of detection limits, accuracy, and precision of measurements for a variety of different sample types; discusses methods of sampling different media such as gases, liquids, and solids; presents an overview of some real-world applications of the method, with new emphasis on sampling of biologically and physically dangerous materials; provides an up-to-date list of references to LIBS literature along with the latest detection limits and a unique list of element detection limits using a uniform analysis method; provides annotated examples of LIBS spectra which can serve as references for the general reader and will be especially useful for those starting out in the field.
Positive Psychology: The Scientific and Practical Explorations of Human Strengths comprehensively covers the science and application of positive psychology. Authors Shane J. Lopez, Jennifer Teramoto Pedrotti, and C. R. Snyder bring positive psychology to life by illustrating issues such as how psychological strength can help increase positive outcomes in school and the workplace and promote cooperative relationships among people. Furthermore, the book encourages readers to engage with concepts in order to understand positive emotions and strengths, such as empathy, altruism, gratitude, attachment, and love. Over 50 case studies grounded in practice, research, and the authors’ teaching experience reveal how positive psychological phenomena operate in the lives of real people.
This is a new edition of the first comprehensive text to show how the advances in molecular and cellular biology and in the basic neurosciences have brought the revolution in molecular medicine to the field of psychiatry. The book begins with a review of basic neuroscience and methods for studying neurobiology in human patients then proceeds to discussions of all major psychiatric syndromes with respect to knowledge of their etiology, pathophysiology, and treatment. Emphasis is placed on synthesizing information across numerous levels of analysis, including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, and behavior, and in translating information from the basic laboratory to the clinical laboratory and finally to clinical treatment. Editors Dennis Charney and Eric Nestle, along with their six section editors and over 150 contributors, have revised and updated all 80 chapters from the previous edition and have added new chapters on topics relating to, for example, genetics, experimental therapeutics, and late-life mood disorders. Both a textbook and a reference book, Neurobiology of Mental Illness is intended for psychiatrists, neuroscientists, and upper level students.
A guide to an evidence-based approach for teaching college-level psychology courses Teaching Psychology offers an evidence-based, student-centered approach that is filled with suggestions, ideas, and practices for teaching college-level courses in ways that contribute to student success. The authors draw on current scientific studies of learning, memory, and development, with specific emphasis on classroom studies. The authors offer practical advice for applying scholarly research to teaching in ways that maximize student learning and personal growth. The authors endorse the use of backward course design, emphasizing the importance of identifying learning goals (encompassing skills and knowledge) and how to assess them, before developing the appropriate curriculum for achieving these goals. Recognizing the diversity of today's student population, this book offers guidance for culturally responsive, ethical teaching. The text explores techniques for teaching critical thinking, qualitative and quantitative reasoning, written and oral communication, information and technology literacy, and collaboration and teamwork. The authors explain how to envision the learning objectives teachers want their students to achieve and advise how to select assessments to evaluate if the learning objectives are being met. This important resource: Offers an evidence-based approach designed to help graduate students and new instructors embrace a student-centered approach to teaching; Contains a wealth of examples of effective student-centered teaching techniques; Surveys current findings from the Scholarship of Teaching and Learning; Draws on the American Psychological Association's five broad goals for the undergraduate Psychology major and shows how to help students build life-long skills; and, Introduces Universal Design for Learning as a framework to support diverse learners. Teaching Psychology offers an essential guide to evidence-based teaching and provides practical advice for becoming an effective teacher. This book is designed to help graduate students, new instructors, and those wanting to update their teaching methods. It is likely to be particularly useful for instructors in psychology and other social science disciplines.
Long recognized as the authoritative leader in the field, Creasy and Resnik's Maternal-Fetal Medicine, 8th Edition, continues to provide the latest evidence-based guidelines for obstetric and neonatal management, helping you minimize complications and offer patients the best possible care. Written by renowned experts in obstetrics, gynecology, and perinatology, this comprehensive resource has been thoroughly updated and reflects new information in every area, including recent tremendous advances in genetics, imaging, and more. Focuses on complicated obstetric issues, highlighting the most commonly encountered anomalies and providing clear guidelines for obstetric and neonatal management. Offers comprehensive updates on rapidly changing topics, including a completely revised section on genetics and genetic technology for prenatal diagnoses, as well as an expanded imaging section on abdominal, urogenital, and skeletal imaging. Includes four new chapters: Molecular Genetic Technology, MRI in Obstetrical Imaging, Obesity in Pregnancy, and Pregnancy as a Window to Future Health. Features numerous flow charts for quick access to diagnosis and treatment protocols and to clarify complex material. Presents the knowledge and expertise of new editors Dr. Joshua Copel, an expert in the field of fetal therapy who has pioneered new diagnostic techniques for unborn patients and their mothers, and Dr. Robert Silver, a leader in the maternal-fetal medicine community.
The two-part, fifth edition of Advanced Organic Chemistry has been substantially revised and reorganized for greater clarity. The material has been updated to reflect advances in the field since the previous edition, especially in computational chemistry. Part B describes the most general and useful synthetic reactions, organized on the basis of reaction type. It can stand-alone; together, with Part A: Structure and Mechanisms, the two volumes provide a comprehensive foundation for the study in organic chemistry. Companion websites provide digital models for students and exercise solutions for instructors.
Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. - Presents information in a clear and concise way using a large number of figures - Historical background provides insights on how the process of drug discovery in the anticancer field has evolved - Extensive references to primary literature
The science associated with the development of artificial sen sory systems is occupied primarily with determining how information about the world can be extracted from sensory data. For example, computational vision is, for the most part, concerned with the de velopment of algorithms for distilling information about the world and recognition of various objects in the environ (e. g. localization ment) from visual images (e. g. photographs or video frames). There are often a multitude of ways in which a specific piece of informa tion about the world can be obtained from sensory data. A subarea of research into sensory systems has arisen which is concerned with methods for combining these various information sources. This field is known as data fusion, or sensor fusion. The literature on data fusion is extensive, indicating the intense interest in this topic, but is quite chaotic. There are no accepted approaches, save for a few special cases, and many of the best methods are ad hoc. This book represents our attempt at providing a mathematical foundation upon which data fusion algorithms can be constructed and analyzed. The methodology that we present in this text is mo tivated by a strong belief in the importance of constraints in sensory information processing systems. In our view, data fusion is best un derstood as the embedding of multiple constraints on the solution to a sensory information processing problem into the solution pro cess.
In Situ Testing Methods in Geotechnical Engineering covers the field of applied geotechnical engineering related to the use of in situ testing of soils to determine soil properties and parameters for geotechnical design. It provides an overview of the practical aspects of the most routine and common test methods, as well as test methods that engineers may wish to include on specific projects. It is suited for a graduate-level course on field testing of soils and will also aid practicing engineers. Test procedures for determining in situ lateral stress, strength, and stiffness properties of soils are examined, as is the determination of stress history and rate of consolidation. Readers will be introduced to various approaches to geotechnical design of shallow and deep foundations using in situ tests. Importantly, the text discusses the potential advantages and disadvantages of using in situ tests.
India has had operating railways for well-over 150 years: railways that have played a central and well-documented role in the making of India in the colonial and post-colonial eras. This handbook provides a reference guide for researchers interested in almost any facet of the history, colonial and post-colonial, of these railways. The secondary literature is identified and surveyed, primary sources and their locations identified, statistical and cartographic data discussed and presented, and a massive bibliography made available. This handbook is the indispensable tool for anyone seeking to understand India's railways and the roles they played in the making of modern India.
Due to the current obesity epidemic, non-alcoholic fatty liver disease (NAFLD) is prevalent in a significant portion of the United States patient population. It is being increasingly recognized that NAFLD affects both adults and children and can progress to end stage liver disease with resultant cirrhosis, portal hypertension, and hepatocellular carcinoma. In addition, several extrahepatic conditions may be linked to NAFLD including cardiovascular disease, insulin requiring and type 2 diabetes mellitus, obstructive sleep apnea, colonic adenomas, hyperuricemia, vitamin D deficiency, hyperferritinemia, pancreatic steatosis, hypothyroidism, and polycystic ovarian syndrome. Therapies for NAFLD are evolving rapidly. This issue will analyze patient demographics, risk factors, pathophysiology, patient presentation, and treatments for NAFLD.
This SpringerBrief sheds new light on bioactive materials from marine extremophiles. It deals with all aspects of the chemical compounds produced by organisms living under extreme conditions that may have potential as drugs or lead to novel drugs for human use.
This volume continues the series' cutting-edge reviews on developments in this field. Since its invention in the 1920s, electrostatic precipitation has been extensively used in industrial hygiene to remove dust and particulate matter from gases before entering the atmosphere. This combination of electrostatic precipitation is reported upon in the first chapter. Following this, chapter two reviews recent advances in the area of chemical modification in electrothermal atomization. Chapter three consists of a review which deal with advances and uses of electrothermal atomization atomic absorption spectrometry. Flow injection atomic spectroscopy has developed rapidly in recent years and after a general introduction, various aspects of this technique are looked at in chapter four. Finally, in chapter five the use of various spectrometric techniques for the determination of mercury are described.
This "hands-on" approach to the topic of arylation consolidates the body of key research over the last ten years (and up to around 2014) on various catalytic methods which involve an arylation process. Clearly structured, the chapters in this one-stop resource are arranged according to the reaction type, and focus on novel, efficient and sustainable processes, rather than the well-known and established cross-coupling methods. The entire contents are written by two authors with academic and industrial expertise to ensure consistent coverage of the latest developments in the field, as well as industrial applications, such as C-H activation, iron and gold-catalyzed coupling reactions, cycloadditions or novel methodologies using arylboron reagents. A cross-section of relevant tried-and-tested experimental protocols is included at the end of each chapter for putting into immediate practice, along with patent literature. Due to its emphasis on efficient, "green" methods and industrial applications of the products concerned, this interdisciplinary text will be essential reading for synthetic chemists in both academia and industry, especially in medicinal and process chemistry.
With a foreword by John T. Queenan, MD, Professor and Chair Emeritus of Obstetrics and Gynecology, Georgetown University School of Medicine, Washington. Fetal medicine has emerged as a separate subspecialty over the last 30 years as a result of major advances in a number of areas, in particular ultrasound imaging, cytogenetics, molecular biology and biochemistry. The widespread use of antenatal screening and diagnostic tests has led to an increased need for obstetricians to have knowledge and skills in fetal medicine. This book provides the information that underpins training programmes in fetal medicine and integrates science and clinical disciplines in a practical and useful way. Basic science sections provide clinicians with a vital introduction to the new language of science that will help them understand new and development treatment options. Clinical sections include: the latest advances in prenatal screening; a systems-based presentation of the diagnosis and management of fetal malformations; complete coverage of common and rare fetal conditions including growth restriction, endocrine and platelet disorders, early pregnancy loss, and twins/multiple pregnancy. Highly illustrated with over 500 ultrasound scans and line drawings. International team of expert contributors. Features new self-assessment section. Written by an international team of experts. Shorter, more focused on fetal medicine Clinical sections written in an up-to-date, problem-based style Case studies and vignettes to illustrate clinical points More focus on important basic-science concepts, such as maternofetal cell trafficking, and the relevance to clinical management Expansion of information on bereavement due to fetal loss New self-assessment section
Describes a selection of important parallel algorithms for matrix computations. Reviews the current status and provides an overall perspective of parallel algorithms for solving problems arising in the major areas of numerical linear algebra, including (1) direct solution of dense, structured, or sparse linear systems, (2) dense or structured least squares computations, (3) dense or structured eigenvaluen and singular value computations, and (4) rapid elliptic solvers. The book emphasizes computational primitives whose efficient execution on parallel and vector computers is essential to obtain high performance algorithms. Consists of two comprehensive survey papers on important parallel algorithms for solving problems arising in the major areas of numerical linear algebra--direct solution of linear systems, least squares computations, eigenvalue and singular value computations, and rapid elliptic solvers, plus an extensive up-to-date bibliography (2,000 items) on related research.
This book covers pathophysiology of fever, the general approach to the febrile patient, and offers a systematic, in-depth discussion regarding the differential diagnosis of unexplained fever. The authors define an unexplained fever as a fever which lasts a minimum of 14 days and whose etiology is not known. This one-of-a-kind publication highlights the main causes of fever, specifically infectious diseases, cancer, connective tissue diseases, various rare disorders, plus etiologies which are often ignored. Also, laboratory and medical imaging techniques for diagnosing fevers are included. Written in a comprehensive, unrepetitious style, this "must-have" resource includes such aspects as the history of the fever, a review of published cases, the approach to the patient, and an analytical review. This up-to-date volume is an indispensable guide that should be read by physicians, surgeons, internists, microbiologists and other medical professionals.
The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99% ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Analytical Methods" provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the 'tried-and-true' format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram's rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented. Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations. These shortcomings provide a challenge for future mechanistic investigations.
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