The history of particle physics, the hunt for the most elusive particle, and the fundamental questions the search has inspired How did physicists combine talent and technology to discover the Higgs boson, the last piece in our inventory of the subatomic world? How did the Higgs change our understanding of the universe? And now, nearly a decade after its detection, what comes next? Answering these questions, Ivo van Vulpen—a CERN particle physicist and member of the team behind the detection—invites us on a journey to the frontiers of our knowledge. Enjoy van Vulpen’s accessible explanation of the history of particle physics and of concepts like quantum mechanics and relativity—and ponder his inquiries regarding the search for new particles (to explain dark matter), a new force (to combine the existing fundamental forces), and new phenomena (undiscovered dimensions of space). This is a lively account of work at the world’s highest-energy particle accelerator, with inspiring personal reflections on humanity’s discoveries deeper and deeper into the world of the very small.
The history of particle physics, the hunt for the most elusive particle, and the fundamental questions the search has inspired How did physicists combine talent and technology to discover the Higgs boson, the last piece in our inventory of the subatomic world? How did the Higgs change our understanding of the universe? And now, nearly a decade after its detection, what comes next? Answering these questions, Ivo van Vulpen--a CERN particle physicist and member of the team behind the detection--invites us on a journey to the frontiers of our knowledge. Enjoy Van Vulpen's accessible explanation of the history of particle physics and of concepts like quantum mechanics and relativity, and ponder his inquiries regarding the search for new particles (to explain dark matter), a new force (to combine the existing fundamental forces), and new phenomena (undiscovered dimensions of space). This is a lively account of work at the world's highest-energy particle accelerator, with inspiring personal reflections on humanity's discoveries deeper and deeper into the world of the very small.
This book provides a comprehensive survey of the pharmacokinetic models used for the quantitative interpretation of contrast-enhanced imaging. It discusses all the available imaging technologies and the problems related to the calibration of the imaging system and accuracy of the estimated physiological parameters. Enhancing imaging modalities using contrast agents has opened up new opportunities for going beyond morphological information and enabling minimally invasive assessment of tissue and organ functionality down to the molecular level. In combination with mathematical modeling of the contrast agent kinetics, contrast- enhanced imaging has the potential to provide clinically valuable additional information by estimating quantitative physiological parameters. The book presents the broad spectrum of diagnostic possibilities provided by quantitative contrast-enhanced imaging, with a particular focus on cardiology and oncology, as well as novel developments in the area of quantitative molecular imaging along with their potential clinical applications. Given the variety of available techniques, the choice of the appropriate imaging modality and the most suitable pharmacokinetic model is often challenging. As such, the book provides a valuable technical guide for researchers, clinical scientists, and experts in the field who wish to better understand and properly apply tracer-kinetic modeling for quantitative contrast-enhanced imaging.
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