Using the published work of Nobel Laureate Niels Kaj Jerne, this book shows how he developd his ideas. The book is a compilation of his published work, but in fact it is much more than that. Whether the reader wants to read the book systematically, or only browse, it opens a fascinating world of hypotheses, theories, facts and vistas. His selection theory, his view of how immunological diversity is created, and his concept of lymphocytes interacting as a network, reveals Jerne's revolutionary spirit. The book ought to be a rich source of inspiration for everyone interested in science and how science is made.
BMA Book of the Year 2012 First prize in Basic and Clinical Sciences, BMA Book Awards 2012 Roitt's Essential Immunology - the textbook of choice for students and instructors of immunology worldwide Bringing you fully up-to-date with the latest knowledge and concepts about the workings of the immune system, the hallmark easy-reading style of Roitt's Essential Immunology clearly explains the key principles needed by medical and health sciences students, from the basis of immunity to clinical applications. Beautifully presented, with brand new illustrations, the pedagogy has been strengthened throughout, and includes “just to recap...” sections at the beginning of each chapter, reminding the reader of key findings and principles, and summary sections at the end of each chapter that are ideal for quick study and revision. Also available as a FREE enhanced Wiley Desktop Edition (upon purchase of the book), Roitt's Essential Immunology is supported by a suite of online resources at www.roitt.com including: Interactive MCQs and SBA questions for each chapter, with feedback on all answers selected Animations and videos showing key concepts Fully downloadable figures and illustrations, further reading and useful links Extracts from the Encyclopaedia of Life Science Podcasts to reinforce the key principles explained in the text: ideal for revision 'on the go' This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.
Immunological Methods a compendium of basic research techniques being used in one of the largest immunology research institutes, the Basel Institute for Immunology, with particular emphasis given to new methodology. The procedures have been described by individuals judged to be highly expert in their specialties. In many instances the methods developed or adapted to unique uses by the contributors have not previously been described in detail. The book contains 34 chapters covering techniques for detection, isolation, and purification of antibodies (including dansylation, two-dimensional chromatography, isoelectric focusing, polyacrylamide gel electrophoresis, and isotachophoresis); measurement of equilibrium constants (equilibrium dialysis, filtration, and sedimentation); and isotope and fluorescent labeling and detection of cell-surface components. Techniques such as isotope laboratory maintenance; chemical modification of proteins, haptens, and solid supports, and haptenation of viable biological carriers; production of antisera against allotypes and histocompatibility antigens and production of antibody with clonai dominance; histocompatibility and MLR testing; and cell separation by haptenated gels and by velocity sedimentation of rosette-forming cells are also discussed. Other chapters cover detection of antibody-secreting and alloantigen-binding cells; immune responses in vitro and their analysis by limiting dilution; production of T-cell factors; hybridoma production by cell fusion; maintenance of cell lines and cloning in semisolid media; and the mathematical analysis of immunological data.
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