Dr. Corinne Magnolia, a young, energetic, and enthusiastic PhD-level biochemist, is beginning her career in medical research. She accepts an impossible-to-refuse job offer at a laboratory in a suburb of Duluth, Minnesota, where she is to administer and oversee the impact of an experimental cancer drug touted as a cure-all for a wide range of cancers at all stages of growth, while not obliterating the immune system in the process. The new cancer drug was unknown in any U.S. territories until its introduction within U.S. borders by a world-renown physician Dr. Aron Perez, who is Dr. Magnolia's supervisor and mentor. At first an attentive and gracious teacher, Dr. Perez's true motives unravel once the seeds of the experiment have been planted. He all but vanishes, leaving Dr. Magnolia with an exceedingly high critical illness and death toll to tackle on her own, with only the help of her trusted Psychiatrist friend Dr. Richard Weisberg. With blood on her hands, and now the target of a nationwide manhunt leading directly back to Washington, D.C., Dr. Magnolia is forcibly sent on a quest to balance preserving her own life and freedom, with the lives of her patients. Bound by the limitations of her two-year contract and by an extraordinary devotion to her patients, Dr. Magnolia is cognizant that time is of the essence. Will she ever discover the truth? Will she be able to save the victims before it's too late?
In this work, an expert on biological weapons offers a thoughtful examination of the political and technical issues that have affected the implementation of arms control agreements from the 1960s to the present. Arms Control Policy: A Guide to the Issues examines the history of the major arms control treaties since the early 1960s. It offers readers a broad understanding of the ways in which arms control agreements were negotiated and implemented during the Cold War, the international and national events that affected treaty negotiation and implementation, and how the arms control landscape has changed in the war's aftermath. Specifically, the handbook overviews the obligations contained in bilateral U.S.-Soviet/Russian and multilateral arms control agreements covering nuclear and nonnuclear weapons. It also treats such agreements as the Biological Weapons Convention, the Chemical Weapons Convention, the Treaty to Ban Land Mines, and the Treaty to Ban Cluster Munitions. The book concludes with a look at the current challenges in the implementation of arms control agreements and the future of arms control.
In recent years, disaster events spreading across national borders have increased, which requires improved collaboration between countries. By means of an agent-based simulation and an empirical study, this thesis provides valuable insights for decision-makers in order to overcome barriers in cross-border cooperation and thus, enhance borderland resilience for future events. Finally, implications for today's world in terms of globalization versus emerging nationalism are discussed.
Although Sojourner Truth was born into bondage and oppression, in liberation she emerged as a leader in the most radical causes of her era. She travelled the country as an outspoken and riveting presence, battling for the abolition of slavery and for women’s suffrage. While her role in these movements has been well-documented, biographers have frequently overlooked the influence of religion in Truth’s life. A participant in a number of the most significant religious movements of her day, including the Methodist Perfectionists, the Kingdom of Matthias, the Utopians, and the Spiritualists, Truth drew her notions of justice from religion. Sojourner Truth: Prophet of Social Justice provides a concise biography of this important figure, integrating her religious life in ways that shed light on Truth’s work and the religious movements of her day. Accompanied by primary source documents including political records, speech transcripts, and selections from her autobiography, Richman's biography provides a rich and accessible narrative of Truth's life and legacy.
An examination of environmental revitalization efforts in low-income communities in Boston, Barcelona, and Havana that help heal traumatized urban neighborhoods. Environmental justice as studied in a variety of disciplines is most often associated with redressing disproportionate exposure to pollution, contamination, and toxic sites. In Neighborhood as Refuge, Isabelle Anguelovski takes a broader view of environmental justice, examining wide-ranging comprehensive efforts at neighborhood environmental revitalization that include parks, urban agriculture, fresh food markets, playgrounds, housing, and waste management. She investigates and compares three minority, low-income neighborhoods that organized to improve environmental quality and livability: Casc Antic, in Barcelona; Dudley, in the Roxbury section of Boston; and Cayo Hueso, in Havana. Despite the differing histories and political contexts of these three communities, Anguelovski finds similar patterns of activism. She shows that behind successful revitalization efforts is what she calls “bottom to bottom” networking, powered by broad coalitions of residents, community organizations, architects, artists, funders, political leaders, and at times environmental advocacy groups. Anguelovski also describes how, over time, environmental projects provide psychological benefits, serving as a way to heal a marginalized and environmentally traumatized urban neighborhood. They encourage a sense of rootedness and of attachment to place, creating safe havens that offer residents a space for recovery. They also help to bolster residents' ability to deal with the negative dynamics of discrimination and provide spaces for broader political struggles including gentrification. Drawing on the cases of Barcelona, Boston, and Havana, Anguelovski presents a new holistic framework for understanding environmental justice action in cities, with the right to a healthy community environment at its core.
This book is the first hands-on roadmap for conducting rigorous experimental research on second language speech processing and spoken word recognition. Isabelle Darcy expertly defines key concepts and offers a detailed step-by-step guide to designing empirical psycholinguistic research in this complex, interdisciplinary area. The book covers the following: setting up an efficient workflow to enhance reproducibility of findings; determining a methodology; selecting experimental controls and designing stimuli; collecting data using an array of methodological tools; addressing common challenges; preparing and analyzing data; preregistering the study; and sharing data transparently in accordance with Open Science practices. Darcy provides everything needed to design and carry out robust behavioral studies on L2 speech processing, in a laboratory or online. This book will be an invaluable practical resource for researchers and advanced students in second language speech learning, second language acquisition, psycholinguistics, cognitive science, and language teaching, as well as those interested in applied linguistics, pronunciation, and related subjects.
To lift and keep millions out of poverty requires that smallholder agriculture be productive and profitable in the developing world. Do we know how to make this happen? Researchers and practitioners still debate how best to do so. The prevailing methodology, which claims causality from measures of statistical significance, is inductive and yields contradictory results. In this book, instead of correlations, Isabelle Tsakok looks for patterns common to cases of successful agricultural transformation and then tests them against other cases. She proposes a hypothesis that five sets of conditions are necessary to achieve success. She concludes that government investment in and delivery of public goods and services sustained over decades is essential to maintaining these conditions and thus successfully transform poverty-ridden agricultures. No amount of foreign aid can substitute for such sustained government commitment. The single most important threat to such government commitment is subservience to the rich and powerful minority.
The campus has a deep-rooted prestige as a place of teaching, learning and nurturing. Conjuring images of cloistered quadrangles, of sunny lawns, of wood-panelled libraries, it is a word viscerally charged with centuries of scholarly tradition. And yet it is also a place of cutting-edge science, vibrancy and energy. It is this dual nature, this concurrent adherence to tradition and innovation, which renders the physical environment of the university such a redolent, enduring and dynamic realm. However, it also means that the twenty-first-century campus is a highly challenging and exacting landscape to design and manage successfully. Today, the scale of the pressures and the rate of change facing higher education institutions are greater than ever. Squeezed public spending, growing societal expectations and the broadening education ambitions of developing nations are set against a backdrop of rapid technological progress and changing pedagogies. What are the repercussions for the physical realities of university planning and architecture? And how are university campuses adapting to contend with these pressures? University Trends: Contemporary Campus Design introduces the most significant, widespread and thought-provoking trends that are currently shaping the planning and architecture of higher education institutions across the world. Within this completely revised second edition, Part One identifies current patterns such as hub buildings, large-scale expansions, adaptive reuse and innovation buildings. Part Two profiles these through recent, well-illustrated, global case studies. The essential guide to current and future trends in campus design.
This book uses a unique typology of ten core drivers of injustice to explore and question common assumptions around what urban sustainability means, how it can be implemented, and how it is manifested in or driven by urban interventions that hinge on claims of sustainability. Aligned with critical environmental justice studies, the book highlights the contradictions of urban sustainability in relation to justice. It argues that urban neighbourhoods cannot be greener, more sustainable and liveable unless their communities are strengthened by the protection of the right to housing, public space, infrastructure and healthy amenities. Linked to the individual drivers, ten short empirical case studies from across Europe and North America provide a systematic analysis of research, policy and practice conducted under urban sustainability agendas in cities such as Barcelona, Glasgow, Athens, Boston and Montréal, and show how social and environmental justice is, or is not, being taken into account. By doing so, the book uncovers the risks of continuing urban sustainability agendas while ignoring, and therefore perpetuating, systemic drivers of inequity and injustice operating within and outside of the city. Accessibly written for students in urban studies, critical geography and planning, this is a useful and analytical synthesis of issues relating to urban sustainability, environmental and social justice. The Open Access version of this book, available at http://www.taylorfrancis.com/books/e/9781003221425, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license. Funded by Universitat Autònoma de Barcelona
This book examines methods for linking osteo-archaeological data with historical and environmental sources to shed light on the living conditions of past populations. Covering all time periods from prehistory to the 20th century, it aims to construct models that capture plausible demographic dynamics from highly fragmentary evidence. Starting from the known in order to explore the unknown, this book presents a historical view of methods used in the past and present as well as proposes original ones. The paleodemographic methods presented in this handbook have been tested on anthropological and archaeological data and can easily be applied. This manual represents a fruitful collaboration between historical demographers and anthropological archaeologists who, with the help of mathematicians and statisticians, detail research that opens an important historical dimension to the discipline. Written in a readily understandable manner, it serves as an ideal resource for those wishing to interpret ancient bones in demographic terms.
This book provides a thorough overview of recent methods using higher level information (object or scene level) for advanced tasks such as image understanding along with their applications to medical images. Advanced methods for fuzzy image processing and understanding are presented, including fuzzy spatial objects, geometry and topology, mathematical morphology, machine learning, verbal descriptions of image content, fusion, spatial relations, and structural representations. For each methodological aspect covered, illustrations from the medical imaging domain are provided. This is an ideal book for graduate students and researchers in the field of medical image processing.
Genomic Control Process explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. Unifying and simplifying the descriptions of development and evolution by focusing on the causality in these processes, it provides a comprehensive method of considering genomic control across diverse biological processes. This book is essential for graduate researchers in genomics, systems biology and molecular biology seeking to understand deep biological processes which regulate the structure of animals during development. - Covers a vast area of current biological research to produce a genome oriented regulatory bioscience of animal life - Places gene regulation, embryonic and postembryonic development, and evolution of the body plan in a unified conceptual framework - Provides the conceptual keys to interpret a broad developmental and evolutionary landscape with precise experimental illustrations drawn from contemporary literature - Includes a range of material, from developmental phenomenology to quantitative and logic models, from phylogenetics to the molecular biology of gene regulation, from animal models of all kinds to evidence of every relevant type - Demonstrates the causal power of system-level understanding of genomic control process - Conceptually organizes a constellation of complex and diverse biological phenomena - Investigates fundamental developmental control system logic in diverse circumstances and expresses these in conceptual models - Explores mechanistic evolutionary processes, illuminating the evolutionary consequences of developmental control systems as they are encoded in the genome
Have globalization, virulent ethnic differences, and globally operating insurgents fundamentally changed the nature of war in the last decade? Interpretations of war as driven by politics and state rationale, formulated most importantly by the 19th century practitioner Carl von Clausewitz, have received strong criticism. Political explanations have been said to fall short in explaining conflicts in the Balkans, Africa, Asia and the attacks of 11 September 2001 in the United States. This book re-evaluates these criticisms not only by scrutinising Clausewitz's arguments and their applicability, but also by a careful reading of the criticism itself. In doing so, it presents empirical evidence on the basis of several case studies, addressing various aspects of modern war, such as the actors, conduct and purposes of war.
Are there emotional reactions towards social robots? Could you love a robot? Or, put the other way round: Could you mistreat a robot, tear it apart and sell it? Media reports people honoring military robots with funerals, mourning the "death" of a robotic dog, and granting the humanoid robot Sophia citizenship. But how profound are these reactions? Three experiments take a closer look on emotional reactions towards social robots by investigating the subjective experience of people as well as the motor expressive level. Contexts of varying degrees of Human-Robot Interaction (HRI) sketch a nuanced picture of emotions towards social robots that encompass conscious as well as unconscious reactions. The findings advance the understanding of affective experiences in HRI. It also turns the initial question into: Can emotional reactions towards social robots even be avoided?
Variability in predispositions for language learning has attracted scholarly curiosity for over 100 years. Despite major changes in theoretical explanations and foreign/second language teaching paradigms, some patterns of associations between predispositions and learning outcomes seem timelessly robust. This book discusses evidence from a research project investigating individual differences in a wide variety of domains, ranging from language aptitude over general cognitive abilities to motivational and other affective and social constructs. The focus lies on young learners aged 10 to 12, a less frequently investigated age in aptitude research. The data stem from two samples of multilingual learners in German-speaking Switzerland. The target languages are French and English. The chapters of the book offer two complementary perspectives on the topic: On the one hand, cross-sectional investigations of the underlying structure of these individual differences and their association with the target languages are discussed. Drawing on factor analytical and multivariable analyses, the different components are scrutinized with respect to their mutual dependence and their relative impact on target language skills. The analyses also take into account contextual factors such as the learners’ family background and differences across the two contexts investigated. On the other hand, the potential to predict learner’s skills in the target language over time based on the many different indicators is investigated using machine learning algorithms. The results provide new insights into the stability of the individual dispositions, on the impact of contextual variables, and on empirically robust dimensions within the array of variables tested.
Why do some countries have 'Culture Wars' over morality issues such as abortion and same-sex marriage while other countries hardly experience any conflict? This book argues that morality issues only generate major conflicts in political systems with a significant conflict between religious and secular parties.
This book lays out the principles of general pathology for biomedical researchers, grad students, medical students, and physicians, with elegance and deep insight. Disease processes are explained in the light of malfunctions at the cellular level, offering a rich understanding of the clinical correlates of all aspects of fundamental cellular physiology and basic biomedicine. The book has been fully revised and updated to present a current but deep understanding of disease states at the cell and tissue levels - cellular pathology, inflammation, immunopathology vascular disturbance, and tumor biology.
This is a Ph.D. dissertation. Many fundamental processes underlying nerve and muscle excitation, hormone secretion, learning and memory, cell proliferation, sensory transduction and regulation of blood pressure and osmotic balance, are attributed to a div
In a long and varied career, Lindsay Anderson made training films, documentaries, searing family dramas and blistering satires, including This Sporting Life, O Lucky Man! and Britannia Hospital. Students of British cinema and television from the 1950s to 1990s will find this book a valuable source of information about a director whose work came to public attention with Free Cinema but who, unlike many of his peers in that movement did not take the Hollywood route to success. What emerges is a strong feeling for the character of the man as well as for a remarkable career in British cinema. The book will appeal to admirers, researchers and students alike. Making use of hitherto unseen original materials from Anderson’s extensive personal and professional records, it is most valuable as a study of how the films came about: the production problems involved, the collaborative input of others, as well as the completed films’ promotion and reception. It also offers a finely argued take on the whole issue of film authorship, and achieves the rare feat of being academically authoritative whilst also being completely accessible. It prompts renewed respect for the man and the artist and a desire to watch the films all over again.
An urgent and deeply resonant case for the power of workplace democracy to restore balance between economy and society. What happens to a society—and a planet—when capitalism outgrows democracy? The tensions between democracy and capitalism are longstanding, and they have been laid bare by the social effects of COVID-19. The narrative of “essential workers” has provided thin cover for the fact that society’s lowest paid and least empowered continue to work risky jobs that keep our capitalism humming. Democracy has been subjugated by the demands of capitalism. For many, work has become unfair. In Democratize Work, essays from a dozen social scientists—all women—articulate the perils and frustrations of our collective moment, while also framing the current crisis as an opportunity for renewal and transformation. Amid mounting inequalities tied to race, gender, and class—and with huge implications for the ecological fate of the planet—the authors detail how adjustments in how we organize work can lead to sweeping reconciliation. By treating workers as citizens, treating work as something other than an asset, and treating the planet as something to be cared for, a better way is attainable. Building on cross-disciplinary research, Democratize Work is both a rallying cry and an architecture for a sustainable economy that fits the democratic project of our societies. Contributors include Alyssa Battistoni (Barnard College of Columbia University), Adelle Blackett (McGill University), Julia Cagé (Sciences Po), Neera Chandhoke (University of Delhi), Lisa Herzog (University of Groningen), Imge Kaya Sabanci (IE Business School), Sara Lafuente (European Trade Union Institute), Hélène Landemore (Yale University), Flávia Máximo (Universidade Federal de Ouro Preto, Brazil), and Pavlina R. Tcherneva (Levy Economics Institute of Bard College).
This open access book makes a comparative overview of the demographic evolution of the Mediterranean populations. It addresses all the demographic issues since 1950 such as fertility, mortality, growth, demographic aging, and the age structure of the population. The book discusses the major demographic changes and its consequences for the Mediterranean region and describes the socio-economic and societal opportunities such as the silver economy, improvement in health of the population, and progress in education. By providing insights into the past demographic evolutions and analyzing the most recent indicators, this book constitutes an essential reference work for those who wish to better understand the major transformations that Mediterranean societies are undergoing.
Philosophers debate the death of philosophy as much as they debate the death of God. Kant claimed responsibility for both philosophy's beginning and end, while Heidegger argued it concluded with Nietzsche. In the twentieth century, figures as diverse as John Austin and Richard Rorty have proclaimed philosophy's end, with some even calling for the advent of "postphilosophy." In an effort to make sense of these conflicting positions which often say as much about the philosopher as his subject Isabelle Thomas-Fogiel undertakes the first systematic treatment of "the end of philosophy," while also recasting the history of western thought itself. Thomas-Fogiel begins with postphilosophical claims such as scientism, which she reveals to be self-refuting, for they subsume philosophy into the branches of the natural sciences. She discovers similar issues in Rorty's skepticism and strands of continental thought. Revisiting the work of late-nineteenth and early-twentieth-century philosophers, when the split between analytical and continental philosophy began, Thomas-Fogiel finds both traditions followed the same path the road of reference which ultimately led to self-contradiction. This phenomenon, whether valorized or condemned, has been understood as the death of philosophy. Tracing this pattern from Quine to Rorty, from Heidegger to Levinas and Habermas, Thomas-Fogiel reveals the self-contradiction at the core of their claims while also carving an alternative path through self-reference. Trained under the French philosopher Bernard Bourgeois, she remakes philosophy in exciting new ways for the twenty-first century.
Antiviral drug development has led to significant advances in the control of globally prevalent viral infections by the hepatitis C (HCV) and the human immunodeficiency viruses. Nonetheless, there are current gaps in the armamentarium against global viral infections due to some herpes viruses, the hepatitis B virus, and the deadly filovirus Ebola and arenavirus Tacaribe responsible of outbreaks of hemorrhagic fever in emerging countries. Arbidol (ARB) is a cost-effective antiviral with broad-spectrum activity, administered for decades in Russia and China against flu. We showed that ARB inhibits HCV infection, and has potent antiviral activity against the Ebola, Tacaribe, hepatitis B and human herpes-8 viruses. Since these viruses have divergent life cycles, we posit that ARB may exhibit varied modes of action against different viruses. Careful dissection of molecular mechanisms of action of ARB against HCV and the Ebola virus revealed that ARB blocked viral entry. ARB might, therefore, constitute a pharmacological approach against globally prevalent viruses, and an affordable molecule for emerging countries in urgent need for effective antiviral therapies.
Find out more about natural wine—made naturally from organically or biodynamically grown grapes – from leading authority Isabelle Legeron MW. Wine-making has become ever-more unnatural, from the use of blanket crop-spraying in vineyards, to the over-use of sulfites and additives in the cellar, but luckily there is another way, as Master of Wine Isabelle Legeron explains. Isabelle, who campaigns for natural wine around the world and runs the hugely successful RAW wine fairs in London, Berlin and New York, reveals why the finest, most authentic wines are those made naturally. While currently not regulated by an official definition, natural wines are made from sustainably farmed, organic (or biodynamic) grapes, with nothing removed or added during winemaking, bar at most a dash of sulfites. It is good old-fashioned grape juice fermented into wine – just as nature intended. If you care about what’s in your glass, want to explore unique flavours, or are keen to support small-scale producers, then you need to know more about natural wine, and where to find it. The second edition of this consumer guide to natural wine has been fully updated, and explains the processes involved, introduces you to some of the growers, and suggests over 140 of the best wines for you to try. “A joyous celebration of all that Legeron believes is good and pure in the world of wine and wine production.” TLS Shortlisted for the André Simon Food & Drink Awards 2015. the Fortnum and Mason Food & Drink Awards 2014, and the Louis Roederer International Wine Writers Awards 2015.
“This book is a must read for those wanting to understand, design and improve our approach to workforce knowledge in dementia care.” Paul Edwards, Director of Clinical Services, Dementia UK “Its person-centred, theory and practice-based approaches to learning make it an essential book for everyone involved in the delivery, review and commissioning of dementia education." Dr Anna Jack-Waugh, Senior Lecturer in Dementia, Senior Fellow HEA, Alzheimer Scotland Centre for Policy, and Practice, the University of the West of Scotland, UK “A relevant, innovative, and important book that can underpin better education and training in dementia care.” Jesper Bøgmose, Associate Professor, Cand. Cur., Faculty of Health, University College Copenhagen, Denmark In the last twenty years the evidence-base for how to provide person-centred care for people with dementia has grown significantly. Despite this until recently there has been little evidence as to how to provide training and education for the dementia workforce. This book provides an evidence-based practical resource for people intending to develop, deliver, review, or commission education and training for the dementia workforce. Throughout, the book: • Considers the importance of informal routes and mechanisms for workforce development • Examines the importance of context and setting conditions for successful implementation of training at individual, service and organisational level • Contains up-to-date international research evidence, case studies and vignettes Education and Training in Dementia Care: A Person-Centred Approach is an accessible text aimed at all levels of prior experience, from those studying and working in health and social care services and private and third sector organisations who are responsible for the training and development of their staff, to commissioners of training or those who wish to take advice to inform their practice. The Reconsidering Dementia Series is an interdisciplinary series published by Open University Press that covers contemporary issues to challenge and engage readers in thinking deeply about the topic. The dementia field has developed rapidly in its scope and practice over the past ten years and books in this series will unpack not only what this means for the student, academic and practitioner, but also for all those affected by dementia. Series Editors: Dr Keith Oliver and Professor Dawn Brooker MBE. Claire Surr is Professor of Dementia Studies and Director of the Centre for Dementia Research at Leeds Beckett University, UK. Isabelle Latham is Researcher-in-Residence for Hallmark Care Homes, UK and Honorary Senior Research Fellow for the Association for Dementia Studies at the University of Worcester, UK. Sarah Jane Smith is a Reader in Dementia Research at Leeds Beckett University, UK.
Modern French Grammar Workbook, second edition, is an innovative book of exercises and language tasks for all learners of French. The book is divided into two sections: * section 1 provides exercises based on essential grammatical structures * section 2 practises everyday functions (e.g. making introductions, apologizing, expressing needs). A comprehensive answer key at the back of the book enables you to check your progress. Taking into account feedback from the first edition, this second edition now features: * exercises graded on a 3-point scale according to their level of difficulty * cross-referencing to the Modern French Grammar, Second Edition, for each and every exercise * topical exercises that develop vocabulary. Modern French Grammar Workbook is ideal for all learners of French: beginners, intermediate and advanced students. It can be used both independently and alongside the Modern French Grammar (ISBN 0-415-33162-5).
This new edition of the Modern French Grammar is an innovative reference guide to French, combining traditional and function-based grammar in a single volume. Divided into two parts, Part A covers traditional grammatical categories such as word order, nouns, verbs and adjectives and Part B is organized around language functions and notions such as: giving and seeking information describing processes and results expressing likes, dislikes and preferences. With a strong emphasis on contemporary usage, all grammar points and functions are richly illustrated with examples. Implementing feedback from users of the first edition of the Grammar, this second edition includes clearer explanations and greater emphasis on areas of particular difficulty for learners of French. This is the ideal reference grammar for learners of French at all levels, from beginner to advanced. No prior knowledge of grammatical terminology is assumed and a glossary of grammatical terms is provided. This Grammar is complemented by the Modern French Grammar Workbook Second Edition which features related exercises and activities.
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