A good understanding of the long-term outcome of epileptic disorders that have begun in infancy or childhood allows the practitioner to choose the best medical management and to adjust it throughout the life of the patient. The identification of risk factors of poor outcome is crucial, the issue being to prevent or minimize their impacts by appropriate interventions. However, knowledge on the natural course and long-term outcome of pediatric epilepsies is fragmentary for a lot of them for reasons that the authors discuss in this chapter. After reviewing general considerations on outcome for the epilepsies persisting throughout life, the authors will discuss the present state of knowledge on specific aspects concerning some pediatric epilepsy syndromes. These disorders have been chosen because they are representative of the wide range of potential outcomes that can be observed in adults.