This book is a full-color atlas of both benign and neoplastic proliferations in the blood. It illustrates the morphologic features on peripheral blood smears of the various disorders, and the text will focus on diagnostic criteria, differential diagnosis, and modern classification terminology. The book may be used as a stand-alone resource and should be useful to trainees and clinicians that routinely review peripheral blood smears. The accompanying on-line site contains the full text and an image bank of over 340 additional full-color images of the various disorders.
This volume explores the myriad of techniques and methodological approaches that are being used in breast cancer research. The authors critically evaluate of the advantages and disadvantages of current methodologies, starting with the tools available for understanding the architecture of the human breast, including its tissue and cellular composition. The volume discusses the importance of functional studies in breast cancer research, especially with the help of laser capture microdissection, which allows the separation of small amounts of tissue, as well as specific cells, for biochemical analysis. In addition, the authors address methodologies including stem cell separation, which has helped in significantly understanding their role in normal breast development, but also further the understanding of breast cancer and its therapeutic management. The use of in vitro techniques and established cell lines for mechanistic studies in chemotherapeutic approaches have been invaluable will be discussed. Imaging techniques for evaluating in vitro and in vivo behavior of normal and cancerous breast tissue will be explored, as it provides a better understanding of the physiopathology of cancer. The volume will also discuss the molecular analysis of gene function in breast cancer through the transcriptomic and epigenomic profile. More importantly, the advancement of more refined techniques in sequencing will be covered. This monograph will be a comprehensive, authoritative and timely, as it addresses the emerging approaches used in breast cancer research.
The Index of Middle English Prose' will ultimately locate, identify and record all extant Middle English prose texts composed between c.1200 and c.1500. The initial volumes, the 'Handlists' give descriptions of each item in a particular collection, with identification, categorisation, and full bibliographical data. This volume examines libraries in Scandinavia containing Middle English prose texts: the Royal Library of Copenhagen, Denmark, the Royal Library of Stockholm, theUniversity Library of Uppsala, Sweden, and the Sch yen Collection in Oslo, Norway. An extensive collection of alchemical writings in Copenhagen is listed for the first time. Medical texts are well represented, including Lanfrank's surgery and a Canutus treatise in Copenhagen, and the famous medical miscellanies in Stockholm. Uppsala has a number of religious works. The Sch yen Collection is a private MS collection ontaining items of Middle English prose. IRMA TAAVITSAINEN is a researcher and member of the staff of the English Department at the University of Helsinki, Finland.
Heartwarming and inspiring, In Search of My Destiny tells a story about true family love. A wonderful tale that portrays the strength of the human spirit and proves that there is strength in unity, and highlights the special bond between parents and children. It is the story of a woman who lived her life in two different cultures. She lived her childhood and adolescence in a small Mayan village in Guatemala, Central America, where the customs were drastic and dramatic. When she became a single mother of three small children, she lived in California, where she faced a different culture, where she made a promise to herself that she would survive the struggle for those years ahead and achieve the triumph in the physical, emotional, and intellectual development of her and her children. Though she faced many challenges in life, she persevered in search of love, peace, happiness, and family union. Readers can witness her fascinating story unfold in In Search of My Destiny. A book by: Irma Reyes Herrera. Parents Find very similar facts and renewed inspiration. Grandparents Bring back memories of when you raised your children. Young People You'll have an understanding of the love that is felt for your children and what it takes to raise them. Children Be inspired to embrace your family history and events.
This book will provide the latest advances in molecular and cellular biology for establishing the foundation of a complete understanding of the mechanisms of breast differentiation leading to cancer prevention. The authors are based on the epidemiological evidence indicating that early first full term pregnancy is a protective factor in human against breast cancer and they have used this paradigm and developed experimental systems in both in vivo and in vitro that have demonstrated mechanistically how the differentiation at the organ and cellular level takes place. This knowledge has provided the blueprint for developing better understanding of the basis of cancer prevention. The transcriptoma analysis of the breast of pre and post-menopausal women has established a genomic signature imprinted in the breast that differs according to the reproductive history of the woman showing that early first full term pregnancy reprogram the organ. This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non coding RNA sequences and posttranscriptional control driven by the splicesome. The plasticity of the genome of the human breast make possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones that mimic pregnancy without pregnancy. The author have established the basis of clinical trials for prevention and the discovery that short 15aa peptides of the chorionic gonadotropin hormone can be used in human breast cancer prevention based on preclinical and clinical data.
Conmovedora e inspiradora. En Busca de Mi Destino cuenta una historia verdadera de amor de familia. Un relato maravilloso que muestra la resistencia del espíritu humano; prueba que hay fuerza en la unidad, y refleja el vínculo especial entre padres e hijos. Es la historia de una mujer que ha vivido su vida en dos culturas diferentes. Vivió su niñez y adolescencia en un pueblo Maya en Guatemala, donde las costumbres eran drásticas y dramáticas. Cuando se convirtió en madre soltera de tres niños pequeños, vivía en California, sin conocer las costumbres ni el idioma. Sin perder su compostura, les prometió a sus hijos que juntos sobrevivirían los obstáculos de los años venideros, y los guiaría, los cuidaría, y los amaría incondicionalmente hasta que ellos triunfaran en la vida. Aunque enfrentó muchos retos, ella perseveró en la búsqueda de amor, paz, felicidad y unión familiar. Los lectores podrán ser testigos de su fascinante historia en: En Busca de Mi Destino. Un libro por: Irma Reyes Herrera. Más que una autobiografía, En Busca de Mi Destino es el trayecto espiritual de una mujer con la determinación de adquirir control sobre su vida, encontrar su propósito, y por lo tanto, su destino. PADRES Relacionen y se darán cuenta de lo que comúnmente experimentamos. ABUELOS Les traerá recuerdos de cuando ustedes criaron a sus hijos. JOVENES Tendrán una idea de lo que es criar hijos, y el amor que se siente por ellos. NIÑOS Se inspirarán para tener una bella historia de su propia familia.
About the Book In What an Adventure That Was!, Irma Stoll tells a unique story through letters to her family as a missionary with her husband in Brazil. Through fun and challenges, sickness and health, she details the adventures of her family, providing an uncommon tale of an extraordinary experience. About the Author In high school in Illinois, Irma felt God intended for her to marry a missionary. After graduation, she pursued her desire to help others as a nurse and enrolled in a five-year college program to attain her B.S. and R.N. Then, while attending seminary to get her master’s degree, Irma met her husband. After graduation, she continued to engage her passion for teaching and educating students worldwide. Irma resides presently in Brewster, NY, with family nearby. Her passions include reading and writing. She is only a few hours away from the Kearny Baptist Church she and her husband founded in New Jersey, where she still has many Brazilian and American friends.
This richly-illustrated atlas-like book provides a foundation for the biological and molecular understanding of how the mammary gland develops and how breast cancer originates. The main goal is to comprehensively review in ten chapters fundamental knowledge in breast cancer. New paradigms are described in which induction of differentiation in the mammary gland can promote prevention and cure of breast cancer. The text is extremely helpful both for clinicians treating patients and researchers looking for new avenues of development.
This book is a full-color atlas of both benign and neoplastic proliferations in the blood. It illustrates the morphologic features on peripheral blood smears of the various disorders, and the text will focus on diagnostic criteria, differential diagnosis, and modern classification terminology. The book may be used as a stand-alone resource and should be useful to trainees and clinicians that routinely review peripheral blood smears. The accompanying on-line site contains the full text and an image bank of over 340 additional full-color images of the various disorders.
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