Irma H. Russo's Books

Role of the Transcriptome in Breast Cancer Prevention

By: Jose Russo,Irma H. Russo

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Role of the Transcriptome in Breast Cancer Prevention

By: Jose Russo,Irma H. Russo

This book will provide the latest advances in molecular and cellular biology for establishing the foundation of a complete understanding of the mechanisms of breast differentiation leading to cancer prevention. The authors are based on the epidemiological evidence indicating that early first full term pregnancy is a protective factor in human against breast cancer and they have used this paradigm and developed experimental systems in both in vivo and in vitro that have demonstrated mechanistically how the differentiation at the organ and cellular level takes place. This knowledge has provided the blueprint for developing better understanding of the basis of cancer prevention. The transcriptoma analysis of the breast of pre and post-menopausal women has established a genomic signature imprinted in the breast that differs according to the reproductive history of the woman showing that early first full term pregnancy reprogram the organ. This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non coding RNA sequences and posttranscriptional control driven by the splicesome. The plasticity of the genome of the human breast make possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones that mimic pregnancy without pregnancy. The author have established the basis of clinical trials for prevention and the discovery that short 15aa peptides of the chorionic gonadotropin hormone can be used in human breast cancer prevention based on preclinical and clinical data.

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Page Count

461

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1461448840

ISBN 13

9781461448846

Molecular Basis of Breast Cancer

Prevention and Treatment

By: Jose Russo,Irma H. Russo

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Molecular Basis of Breast Cancer

Prevention and Treatment

By: Jose Russo,Irma H. Russo

This richly-illustrated atlas-like book provides a foundation for the biological and molecular understanding of how the mammary gland develops and how breast cancer originates. The main goal is to comprehensively review in ten chapters fundamental knowledge in breast cancer. New paradigms are described in which induction of differentiation in the mammary gland can promote prevention and cure of breast cancer. The text is extremely helpful both for clinicians treating patients and researchers looking for new avenues of development.

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Page Count

459

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3642187366

ISBN 13

9783642187360

Techniques and Methodological Approaches in Breast Cancer Research

By: Jose Russo,Irma H. Russo

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Techniques and Methodological Approaches in Breast Cancer Research

By: Jose Russo,Irma H. Russo

This volume explores the myriad of techniques and methodological approaches that are being used in breast cancer research. The authors critically evaluate of the advantages and disadvantages of current methodologies, starting with the tools available for understanding the architecture of the human breast, including its tissue and cellular composition. The volume discusses the importance of functional studies in breast cancer research, especially with the help of laser capture microdissection, which allows the separation of small amounts of tissue, as well as specific cells, for biochemical analysis. In addition, the authors address methodologies including stem cell separation, which has helped in significantly understanding their role in normal breast development, but also further the understanding of breast cancer and its therapeutic management. The use of in vitro techniques and established cell lines for mechanistic studies in chemotherapeutic approaches have been invaluable will be discussed. Imaging techniques for evaluating in vitro and in vivo behavior of normal and cancerous breast tissue will be explored, as it provides a better understanding of the physiopathology of cancer. The volume will also discuss the molecular analysis of gene function in breast cancer through the transcriptomic and epigenomic profile. More importantly, the advancement of more refined techniques in sequencing will be covered. This monograph will be a comprehensive, authoritative and timely, as it addresses the emerging approaches used in breast cancer research.

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Page Count

301

Publisher

Springer

Published Date

ISBN 10

1493907182

ISBN 13

9781493907182

The Evolution of the Use of Mathematics in Cancer Research

By: Pedro Jose Gutiérrez Diez,Irma H. Russo,Jose Russo

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The Evolution of the Use of Mathematics in Cancer Research

By: Pedro Jose Gutiérrez Diez,Irma H. Russo,Jose Russo

The book will provide an exhaustive and clear explanation of how Statistics, Mathematics and Informatics have been used in cancer research, and seeks to help cancer researchers in achieving their objectives. To do so, state-of-the-art Biostatistics, Biomathematics and Bioinformatics methods will be described and discussed in detail through illustrative and capital examples taken from cancer research work already published. The book will provide a guide for cancer researchers in using Statistics, Mathematics and Informatics, clarifying the contribution of these logical sciences to the study of cancer, thoroughly explaining their procedures and methods, and providing criteria to their appropriate use.

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Page Count

403

Publisher

Springer Science & Business Media

Published Date

ISBN 10

146142397X

ISBN 13

9781461423973

Techniques and Methodological Approaches in Breast Cancer Research

By: Jose Russo,Irma H. Russo

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Techniques and Methodological Approaches in Breast Cancer Research

By: Jose Russo,Irma H. Russo

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Solve jigsaw puzzle

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Page Count

301

Publisher

Springer

Published Date

ISBN 10

1493907182

ISBN 13

9781493907182

Book's by Irma H. Russo

Role of the Transcriptome in Breast Cancer Prevention

Role of the Transcriptome in Breast Cancer Prevention

Molecular Basis of Breast Cancer

Molecular Basis of Breast Cancer

Techniques and Methodological Approaches in Breast Cancer Research

Techniques and Methodological Approaches in Breast Cancer Research

The Evolution of the Use of Mathematics in Cancer Research

The Evolution of the Use of Mathematics in Cancer Research

Techniques and Methodological Approaches in Breast Cancer Research

Techniques and Methodological Approaches in Breast Cancer Research

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