Examines new research on the role of cholesterol in regulating ion channels and receptors and its effect on health Drawing together and analyzing all the latest research findings, this book explores the role of cholesterol in the regulation of ion channels and receptors, including its pathological effects. It is the first book to comprehensively describe the complex mechanisms by which cholesterol regulates two major classes of membrane proteins. Moreover, it sheds new light on how cholesterol affects essential cellular functions such as the contraction of the heart, propagation of nerve impulses, and regulation of blood pressure and kidney function. Written and edited by leading pioneers in the field, Cholesterol Regulation of Ion Channels and Receptors is divided into three parts: Part I, Cholesterol Regulation of Membrane Properties, introduces the heterogeneity of cholesterol distribution in biological membranes and the physical and biological implications of the formation of cholesterol-rich membrane domains. Part II, Cholesterol Regulation of Ion Channels, examines the mechanisms underlying cholesterol sensitivities of ion channels, including the regulation of ion channels by cholesterol as a boundary lipid. Part III, Cholesterol Regulation of Receptors, explores the latest discoveries concerning how cholesterol regulates distinct types of receptors, including G-protein coupled receptors, LDL and scavenger receptors, and innate immune system receptors. Increased levels of cholesterol represent a major health risk. Understanding cholesterol regulation of ion channels and receptors is essential for facilitating the development of new therapeutic strategies to alleviate the impact of pathological cholesterol conditions. With this book as their guide, readers have access to the most current knowledge in the field.
This hitherto unpublished first-hand witness account, written in 1968-9, tells the story of a privileged Polish woman whose life was torn apart by the outbreak of the Second World War and Soviet occupation. The account has been translated into English from the original Polish and interwoven with letters and depositions, and is supplemented with commentary and notes for invaluable historical context. Irena Protassewicz's vivid account begins with the Russian Revolution, followed by a rare insight into the life and mores of the landed gentry of northeastern Poland between the wars, a rural idyll which was to be shattered forever by the coming of the Second World War. Deported in a cattle truck to Siberia and sentenced to a future of forced labour, Irena's fortunes were to change dramatically after Hitler's attack on Russia. She charts the adventure and horror of life as a military nurse with the Polish Army, on a journey that would take her from the wastes of Soviet Central Asia, through the Middle East, to an unlikely ending in the highlands of Scotland. The story concludes with Irena's search to discover the wartime and post-war fate of her family and friends on both sides of the Iron Curtain, and the challenges of life as a refugee in Britain. A Polish Woman's Experience in World War II provides a compelling, personal route into understanding how the greatest conflict of the 20th century transformed the lives of the individuals who lived through it.
This book consists of five introductory contributions by leading mathematicians on the functional analytic treatment of evolutions equations. In particular the contributions deal with Markov semigroups, maximal L^p-regularity, optimal control problems for boundary and point control systems, parabolic moving boundary problems and parabolic nonautonomous evolution equations. The book is addressed to PhD students, young researchers and mathematicians doing research in one of the above topics.
Transcultural Artificial Intelligence and Robotics in Health and Social Care provides healthcare professionals with a deeper understanding of the incredible opportunities brought by the emerging field of AI robotics. In addition, it provides robotic researchers with the point-of-view of healthcare professionals to understand what the healthcare sector – as well as the market – really needs from robotics technology. By doing so, the book fills an important gap between both fields in order to leverage new developments and collaborative work in favor of global patients. The book is aimed at the non-technical reader, especially health and social care professionals, and explains in a simple way the technological principles applied in the development of socially assistive humanoid AI robots (SAHR), the values which guide such developments, the ethics related to them, and research approaches in the field, with a focus on achieving a culturally competent SAHR. - 2023 PROSE Awards - Winner: Category: Nursing and Allied Health: Association of American Publishers - Presents user-friendly and stage-by-stage information to help readers appreciate how AI robots work and how they can be integrated in their work environments - Explains why AI and socially assistive robotics need to be culturally competent - Helps reduce readers' fears and change negative prejudices they may have about robots as a relevant tool for healthcare - Written by experts in AI robotics and the creators of transcultural health/social robotics - Informed by the largest trial conducted with real patients
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.