Institute for Laboratory Animal Research's Books

Guide for the Care and Use of Laboratory Animals

Eighth Edition

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee for the Update of the Guide for the Care and Use of Laboratory Animals

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Guide for the Care and Use of Laboratory Animals

Eighth Edition

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee for the Update of the Guide for the Care and Use of Laboratory Animals

A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

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246

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National Academies Press

Published Date

ISBN 10

0309154006

ISBN 13

9780309154000

Use of Laboratory Animals in Biomedical and Behavioral Research

By: National Research Council,Institute of Medicine,Institute for Laboratory Animal Research,Commission on Life Sciences,Committee on the Use of Laboratory Animals in Biomedical and Behavioral Research

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Use of Laboratory Animals in Biomedical and Behavioral Research

Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.

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113

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National Academies Press

Published Date

ISBN 10

0309038391

ISBN 13

9780309038393

Science, Medicine, and Animals

A Circle of Discovery: Teacher's Guide

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research

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Science, Medicine, and Animals

A Circle of Discovery: Teacher's Guide

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research

Science, Medicine, and Animals explains the role that animals play in biomedical research and the ways in which scientists, governments, and citizens have tried to balance the experimental use of animals with a concern for all living creatures. An accompanying Teacher's Guide is available to help teachers of middle and high school students use Science, Medicine, and Animals in the classroom. As students examine the issues in Science, Medicine, and Animals, they will gain a greater understanding of the goals of biomedical research and the real-world practice of the scientific method in general. Science, Medicine, and Animals and the Teacher's Guide were written by the Institute for Laboratory Animal Research and published by the National Research Council of the National Academies. The report was reviewed by a committee made up of experts and scholars with diverse perspectives, including members of the U.S. Department of Agriculture, National Institutes of Health, the Humane Society of the United States, and the American Society for the Prevention of Cruelty to Animals. The Teacher's Guide was reviewed by members of the National Academies' Teacher Associates Network. Science, Medicine, and Animals is recommended by the National Science Teacher's Association NSTA Recommends.

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National Academies Press

Published Date

ISBN 10

0309101174

ISBN 13

9780309101172

Guide for the Care and Use of Laboratory Animals

Eighth Edition

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee for the Update of the Guide for the Care and Use of Laboratory Animals

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Guide for the Care and Use of Laboratory Animals

Eighth Edition

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee for the Update of the Guide for the Care and Use of Laboratory Animals

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246

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National Academies Press

Published Date

ISBN 10

0309154006

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9780309154000

Animal Research in a Global Environment

Meeting the Challenges: Proceedings of the November 2008 International Workshop

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research

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Animal Research in a Global Environment

Meeting the Challenges: Proceedings of the November 2008 International Workshop

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research

Animal research will play an essential role in efforts to meet increasing demands for global health care. Yet the animal research community faces the challenge of overcoming negative impressions that industry and academia engage in international collaborations in order to conduct work in parts of the world where animal welfare standards are less stringent. Thus, the importance of ensuring the international harmonization of the principles and standards of animal care and use cannot be overstated. A number of national and international groups are actively working toward this goal. The Institute for Laboratory Animal Research (ILAR), a program unit of the US National Research Council, is committed to promoting both the welfare of animals used in research and the quality of the resulting science. In 2008, to follow up on the 2003 event, ILAR convened a workshop which brought together 200 participants from 17 countries. Their mission was to identify and promote better understanding of important challenges in the conduct of animal research across country boundaries. These challenges include: the sourcing of animals; the quality of veterinary care; competent staff; the provision of a suitable environment (including nutritious food and potable water) for animals; and ongoing oversight of the animal program; among others. Animal Research in a Global Environment summarizes the proceedings of the 2008 workshop. The impact of this 2008 workshop has extended beyond the oral presentations conveyed in these proceedings. It has been a vital bridge for diverse colleagues and organizations around the world to advance initiatives designed to fill gaps in standards, professional qualifications, and coordination of animal use.

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284

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National Academies Press

Published Date

ISBN 10

0309215021

ISBN 13

9780309215022

Guide for the Care and Use of Laboratory Animals -- Japanese Edition

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Commission on Life Sciences

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Guide for the Care and Use of Laboratory Animals -- Japanese Edition

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Commission on Life Sciences

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142

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National Academies Press

Published Date

ISBN 10

0309100186

ISBN 13

9780309100182

Recognition and Alleviation of Distress in Laboratory Animals

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Recognition and Alleviation of Distress in Laboratory Animals

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Recognition and Alleviation of Distress in Laboratory Animals

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Recognition and Alleviation of Distress in Laboratory Animals

Scientific advances in our understanding of animal physiology and behavior often require theories to be revised and standards of practice to be updated to improve laboratory animal welfare. This new book from the Institute for Laboratory Animal Research (ILAR) at the National Research Council, Recognition and Alleviation of Distress in Laboratory Animals, focuses on the stress and distress which is experienced by animals when used in laboratory research. This book aims to educate laboratory animal veterinarians; students, researchers, and investigators; animal care staff, as well as animal welfare officers on the current scientific and ethical issues associated with stress and distress in laboratory animals. It evaluates pertinent scientific literature to generate practical and pragmatic guidelines. Recognition and Alleviation of Distress in Laboratory Animals focuses specifically on the scientific understanding of the causes and the functions of stress and distress, the transformation of stress to distress, and the identification of principles for the recognition and alleviation of distress. This book discusses the role of humane endpoints in situations of distress and principles for the minimization of distress in laboratory animals. It also identifies areas in which further scientific investigation is needed to improve laboratory animal welfare in order to adhere to scientific and ethical principles that promote humane care and practice.

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137

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National Academies Press

Published Date

ISBN 10

0309108179

ISBN 13

9780309108171

International Animal Research Regulations

Impact on Neuroscience Research: Workshop Summary

By: National Research Council,Institute of Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Policy and Global Affairs,Committee on Science, Technology, and Law,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

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International Animal Research Regulations

Impact on Neuroscience Research: Workshop Summary

Animals are widely used in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. To ensure the humane care and use of animals, numerous laws, policies, and regulations are in place governing the use of animals in research, and certain animal regulations have implications specific to neuroscience research. To consider animal research regulations from a global perspective, the IOM Forum on Neuroscience and Nervous System Disorders, in collaboration with the National Research Council and the Institute for Laboratory Animal Research, held a workshop in Buckinghamshire, UK, July 26-27, 2011. The workshop brought together neuroscientists, legal scholars, administrators, and other key stakeholders to discuss current and emerging trends in animal regulations as they apply to the neurosciences. This document summarizes the workshop.

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102

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National Academies Press

Published Date

ISBN 10

0309252083

ISBN 13

9780309252089

The Development of Science-based Guidelines for Laboratory Animal Care

Proceedings of the November 2003 International Workshop

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,International Workshop on the Development of Science-based Guidelines for Laboratory Animal Care Program Committee

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The Development of Science-based Guidelines for Laboratory Animal Care

Proceedings of the November 2003 International Workshop

The Development of Science-based Guidelines for Laboratory Animal Care is the summary of an international workshop held in Washington, DC, in November 2003 to bring together experts from around the world to discuss the available knowledge that can positively influence current and pending guidelines for laboratory animal care, identify gaps in that knowledge in order to encourage future research endeavors, and discuss the scientific evidence that can be used to assess the benefits and costs of various regulatory approaches affecting facilities, research, and animal welfare.

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262

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National Academies Press

Published Date

ISBN 10

0309093023

ISBN 13

9780309093026

Guidance for the Description of Animal Research in Scientific Publications

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research

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Guidance for the Description of Animal Research in Scientific Publications

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research

The publication of research articles involving animal studies is central to many disciplines in science and biomedicine. Effective descriptions in such publications enable researchers to interpret the data, evaluate and replicate findings, and move the science forward. Analyses of published studies with research animals have demonstrated numerous deficiencies in the reporting of details in research methods for animal studies. Considerable variation in the amount of information required by scientific publications and reported by authors undermines this basic scientific principle and results in the unnecessary use of animals and other resources in failed efforts to reproduce study results. Guidance for the Description of Animal Research in Scientific Publications outlines the information that should be included in scientific papers regarding the animal studies to ensure that the study can be replicated. The report urges journal editors to actively promote effective and ethical research by encouraging the provision of sufficient information. Examples of this information include: conditions of housing and husbandry, genetic nomenclature, microbial status, detailed experimental manipulations, and handling and use of pharmaceuticals. Inclusion of this information will enable assessment and interpretation of research findings and advancement of knowledge based on reproducible results.

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National Academies Press

Published Date

ISBN 10

0309219515

ISBN 13

9780309219518

Laboratory Animal Management

Dogs

By: National Research Council,Institute of Laboratory Animal Resources,Institute for Laboratory Animal Research,Commission on Life Sciences,Committee on Dogs

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Laboratory Animal Management

Dogs

By: National Research Council,Institute of Laboratory Animal Resources,Institute for Laboratory Animal Research,Commission on Life Sciences,Committee on Dogs

This newly revised edition incorporates the regulatory requirements and improved practices for laboratory animal care that have developed over the past two decades. The volume covers: Selection of dogs as research models. Design, construction, and maintenance of facilities. Temperature, humidity, food, water, bedding, sanitation, animal identification, record keeping, and transportation. General veterinary care, as well as special care of breeding animals and random-source animals. Laboratory Animal Management: Dogs examines controversies over proper cage sizes and interpretation of federal requirements for exercise and offers recommendations for researchers. Guidelines are provided on how to recognize and alleviate pain and distress in research dogs and on the sensitive topic of euthanasia. Laboratory Animal Management: Dogs discusses how to assemble a proper research protocol and how to handle conflicts. Outlined are procedures for institutional animal care and use and committee review. The volume also presents guidelines for handling aging dogs, use of radiation in experiments, and a wide range of other special circumstances. Thoroughly referenced, this guide will be indispensable to researchers, research administrators, review committees, and others concerned about laboratory dogs.

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154

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National Academies Press

Published Date

ISBN 10

0309047447

ISBN 13

9780309047449

Education and Training in the Care and Use of Laboratory Animals

A Guide for Developing Institutional Programs

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Commission on Life Sciences,Committee on Educational Programs in Laboratory Animal Science

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Education and Training in the Care and Use of Laboratory Animals

A Guide for Developing Institutional Programs

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Commission on Life Sciences,Committee on Educational Programs in Laboratory Animal Science

Federal law now requires that institutions provide training for anyone caring for or using laboratory animals. This volume provides the guidelines and resources needed to coordinate a quality training program, as well as to meet all legal requirements. A core module for all personnel takes no more than four hours to present. Most staff then proceed to one or more additional skills-development modules including the species-specific module that can be customized to any species in use at the institution, the pain management module, and the surgery module. The volume provides content information for required topics-from ethics to record keeping-and lists sources of additional publications, audiovisual programs, and computerized teaching aids. Included are: Ready-to-use teaching outlines, with detailed instructions for presenting material. Practical guidelines on logistics, covering scheduling, budgeting, and more. Guidelines on how to design training for adults and how to work with investigators who may resist taking training courses. This practical guidebook will be necessary for research institutions, particularly for staff members responsible for training coordination.

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152

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National Academies Press

Published Date

ISBN 10

0309043824

ISBN 13

9780309043823

Guide for the Care and Use of Laboratory Animals -- Korean Edition

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Commission on Life Sciences

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Guide for the Care and Use of Laboratory Animals -- Korean Edition

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Commission on Life Sciences

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128

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National Academies Press

Published Date

ISBN 10

0309103657

ISBN 13

9780309103657

Guide for the Care and Use of Laboratory Animals

By: Institute for Laboratory Animal Research,Commission on Life Sciences,Division on Earth and Life Studies,National Research Council

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Guide for the Care and Use of Laboratory Animals

By: Institute for Laboratory Animal Research,Commission on Life Sciences,Division on Earth and Life Studies,National Research Council

A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been revised by a committee of experts, based on input from scientists and the public. The Guide incorporates recent research on commonly used species, including farm animals, and includes extensive references. It is organized around major components of animal use: Institutional policies and responsibilities. The committee discusses areas that require policy attention: the role and function of the Institutional Animal Care and Use Committee, protocols for animal care and use, occupational health and safety, personnel qualifications, and other areas. Animal environment, husbandry, and management. The committee offers guidelines on how to design and run a management program, addressing environment, nutrition, sanitation, behavioral and social issues, genetics, nomenclature, and more. Veterinary care. The committee discusses animal procurement and transportation, disease and preventive medicine, and surgery. The Guide addresses pain recognition and relief and issues surrounding euthanasia. Physical plant. The committee identifies design and construction issues, providing guidelines for animal-room doors, drainage, noise control, surgery, and other areas. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities--a resource of proven value, now updated and expanded. This revision will be important to researchers, animal care technicians, facilities managers, administrators at research institutions, policymakers involved in research issues, and animal welfare advocates.

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140

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National Academies Press

Published Date

ISBN 10

0309588693

ISBN 13

9780309588690

Nutrient Requirements of Laboratory Animals,

Fourth Revised Edition, 1995

By: Subcommittee on Laboratory Animal Nutrition,Committee on Animal Nutrition,Board on Agriculture,Institute for Laboratory Animal Research,National Research Council

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Nutrient Requirements of Laboratory Animals,

Fourth Revised Edition, 1995

By: Subcommittee on Laboratory Animal Nutrition,Committee on Animal Nutrition,Board on Agriculture,Institute for Laboratory Animal Research,National Research Council

In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparation--including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.

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188

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National Academies Press

Published Date

ISBN 10

0309588499

ISBN 13

9780309588492

Use of Laboratory Animals in Biomedical and Behavioral Research

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Use of Laboratory Animals in Biomedical and Behavioral Research

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113

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National Academies Press

Published Date

ISBN 10

0309038391

ISBN 13

9780309038393

Strategies That Influence Cost Containment in Animal Research Facilities

By: National Research Council,Institute for Laboratory Animal Research,Committee on Cost of and Payment for Animal Research

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Strategies That Influence Cost Containment in Animal Research Facilities

By: National Research Council,Institute for Laboratory Animal Research,Committee on Cost of and Payment for Animal Research

Care and use of animals in research are expensive, prompting efforts to contain or reduce costs. Components of those costs are personnel, regulatory compliance, veterinary medical care, and laboratory animal management, equipment, and procedures. Many efforts have been made to control and reduce personnel costs, the largest contributing factor to cost, through better facility and equipment design, more efficient use of personnel, and automation of many routine operations. However, there has been no comprehensive, recent analysis of the various cost components or examination of the strategies that have been proven or are purported to decrease the cost of animal facility operation. Strategies that Influence Cost Containment in Animal Research Facilities examines the current interpretation of governmental policy (Office of Management and Budget Circular A-21) concerning institutional reimbursement for overhead costs of an animal research facility and describes methods for economically operating an animal research facility. This report develops recommendations by which federal auditors and research institutions can establish what cost components of research animal facilities should be charged to institutions' indirect cost pool and what animal research facility cost components should be included in the per diem charges to investigators, and assesses the financial and scientific ramifications that these criteria would have among federally funded institutions. Further, the report determines the cost components of laboratory animal care and use in biomedical research and assesses and recommends methods of cost containment for institutions maintaining animals for biomedical research.

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164

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National Academies Press

Published Date

ISBN 10

0309072611

ISBN 13

9780309072618

Design, Implementation, Monitoring, and Sharing of Performance Standards for Laboratory Animal Use

Summary of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use

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Design, Implementation, Monitoring, and Sharing of Performance Standards for Laboratory Animal Use

Summary of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use

In order to better understand the critical issues pertaining to the concept of performance standards for laboratory animal use, the Institute for Laboratory Animal Research Roundtable on Science and Welfare in Laboratory Animal Use held a public workshop on April 20-21, 2015. The purpose of the workshop was to promote the appropriate and responsible care of animals in research, to provide a balanced and civil forum for discussion and collaboration, and to help build transparency and trust among stakeholders. Participants addressed the challenges of defining, developing, implementing, assessing, and validating performance standards to ensure "optimal practices, management, and operations." This report summarizes the presentations and discussions from the workshop.

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161

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National Academies Press

Published Date

ISBN 10

030937927X

ISBN 13

9780309379274

Recognition and Alleviation of Pain in Laboratory Animals

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Recognition and Alleviation of Pain in Laboratory Animals

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Recognition and Alleviation of Pain in Laboratory Animals

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Recognition and Alleviation of Pain in Laboratory Animals

The use of animals in research adheres to scientific and ethical principles that promote humane care and practice. Scientific advances in our understanding of animal physiology and behavior often require theories to be revised and standards of practice to be updated to improve laboratory animal welfare. Recognition and Alleviation of Pain in Laboratory Animals, the second of two reports revising the 1992 publication Recognition and Alleviation of Pain and Distress in Laboratory Animals from the Institute for Laboratory Animal Research (ILAR), focuses on pain experienced by animals used in research. This book aims to educate laboratory animal veterinarians; students, researchers and investigators; Institutional Animal Care and Use Committee members; and animal care staff and animal welfare officers on the current scientific and ethical issues associated with pain in laboratory animals. It evaluates pertinent scientific literature to generate practical and pragmatic guidelines for recognizing and alleviating pain in laboratory animals, focusing specifically on the following areas: physiology of pain in commonly used laboratory species; pharmacologic and non-pharmacologic principles to control pain; identification of humane endpoints; and principles for minimizing pain associated with experimental procedures. Finally, the report identifies areas in which further scientific investigation is needed to improve laboratory animal welfare.

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198

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National Academies Press

Published Date

ISBN 10

030912834X

ISBN 13

9780309128346

Recognition and Alleviation of Pain and Distress in Laboratory Animals

By: National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on Pain and Distress in Laboratory Animals

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Recognition and Alleviation of Pain and Distress in Laboratory Animals

By: National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on Pain and Distress in Laboratory Animals

Clear guidelines on the proper care and use of laboratory animals are being sought by researchers and members of the many committees formed to oversee animal care at universities as well as the general public. This book provides a comprehensive overview of what we know about behavior, pain, and distress in laboratory animals. The volume explores: Stressors in the laboratory and the animal behaviors they cause, including in-depth discussions of the physiology of pain and distress and the animal's ecological relationship to the laboratory as an environment. A review of euthanasia of lab animals-exploring the decision, the methods, and the emotional effects on technicians. Also included is a highly practical, extensive listing, by species, of dosages and side effects of anesthetics, analgesics, and tranquilizers.

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161

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National Academies Press

Published Date

ISBN 10

0309042755

ISBN 13

9780309042758

Design, Implementation, Monitoring, and Sharing of Performance Standards for Laboratory Animal Use

Summary of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use

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Design, Implementation, Monitoring, and Sharing of Performance Standards for Laboratory Animal Use

Summary of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use

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161

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National Academies Press

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ISBN 10

030937927X

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9780309379274

Necessity, Use, and Care of Laboratory Dogs at the U.S. Department of Veterans Affairs

By: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Assessment of the Use and Care of Dogs in Biomedical Research Funded by or Conducted at the U.S. Department of Veterans Affairs

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Necessity, Use, and Care of Laboratory Dogs at the U.S. Department of Veterans Affairs

For many years, laboratory dogs have served as important animal models for biomedical research that has advanced human health. Conducted at the request of the U.S. Department of Veterans Affairs (VA), this report assesses whether laboratory dogs are or will continue to be necessary for biomedical research related to the VA's mission. The report concludes that using laboratory dogs in research at the VA is scientifically necessary for only a few areas of current biomedical research. The report recommends that the VA adopt an expanded set of criteria for determining when it is scientifically necessary to use laboratory dogs in VA biomedical research; that the VA promote the development and use of alternatives to laboratory dogs; and highlights opportunities for the VA to enhance the welfare of laboratory dogs that are being used in biomedical research areas for which they have been deemed necessary.

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171

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National Academies Press

Published Date

ISBN 10

0309676444

ISBN 13

9780309676441

The Psychological Well-Being of Nonhuman Primates

By: Committee on Well-Being of Nonhuman Primates,Institute for Laboratory Animal Research,Commission on Life Sciences,National Research Council

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The Psychological Well-Being of Nonhuman Primates

By: Committee on Well-Being of Nonhuman Primates,Institute for Laboratory Animal Research,Commission on Life Sciences,National Research Council

A 1985 amendment to the Animal Welfare Act requires those who keep nonhuman primates to develop and follow appropriate plans for promoting the animals' psychological well-being. The amendment, however, provides few specifics. The Psychological Well-Being of Nonhuman Primates recommends practical approaches to meeting those requirements. It focuses on what is known about the psychological needs of primates and makes suggestions for assessing and promoting their well-being. This volume examines the elements of an effective care program--social companionship, opportunities for species-typical activity, housing and sanitation, and daily care routines--and provides a helpful checklist for designing a plan for promoting psychological well-being. The book provides a wealth of specific and useful information about the psychological attributes and needs of the most widely used and exhibited nonhuman primates. Readable and well-organized, it will be welcomed by animal care and use committees, facilities administrators, enforcement inspectors, animal advocates, researchers, veterinarians, and caretakers.

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183

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National Academies Press

Published Date

ISBN 10

030952072X

ISBN 13

9780309520720

Animal Research in a Global Environment

Meeting the Challenges: Proceedings of the November 2008 International Workshop

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research

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Animal Research in a Global Environment

Meeting the Challenges: Proceedings of the November 2008 International Workshop

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research

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284

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National Academies Press

Published Date

ISBN 10

0309215021

ISBN 13

9780309215022

Definition of Pain and Distress and Reporting Requirements for Laboratory Animals

Proceedings of the Workshop Held June 22, 2000

By: National Research Council,Institute for Laboratory Animal Research,Committee on Regulatory Issues in Animal Care and Use

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Definition of Pain and Distress and Reporting Requirements for Laboratory Animals

Proceedings of the Workshop Held June 22, 2000

By: National Research Council,Institute for Laboratory Animal Research,Committee on Regulatory Issues in Animal Care and Use

In this first in a proposed series of workshops on regulatory issues in animal care and use, the Institute for Laboratory Animal Research (ILAR) has addressed the existing and proposed requirements for reporting pain and distress in laboratory animals. The Animal Welfare Act, administered by the Animal and Plant Health Inspection Service of the United States Department of Agriculture (USDA), mandates that pain and distress in laboratory animals be minimized. USDA is considering two policy changes with regard to this specific mandate. Firstly, since there has been no functional definition of "distress," USDA has prepared such a definition and requested feedback from the scientific community on its usefulness for regulatory and reporting requirements. The second issue concerns the pain and distress categorization scheme for reporting to USDA. Various groups and individuals have questioned the efficacy of the current categories, and specific changes have been proposed by the Humane Society of the United States. USDA is considering these and other potential changes to the existing scheme. Thus, given these potential changes to animal welfare policy, the aim of the ILAR/NIH joint workshop was to provide feedback to the USDA. The speakers were asked to address these two issues as well as to comment upon whether the information contained in the 1992 ILAR report Recognition and Alleviation of Pain and Distress in Laboratory Animals is still useful to investigators in assisting them to comply with regulations. The speakers provided perspectives based on their individual expertise in the areas of science of pain and distress, animal welfare policy, protocol review, and/or as representatives of relevant organizations or institutions. The following proceedings are an edited transcript of their presentations.

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131

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National Academies Press

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ISBN 10

0309171288

ISBN 13

9780309171281

Science, Medicine, and Animals

A Circle of Discovery: Teacher's Guide

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research

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Science, Medicine, and Animals

A Circle of Discovery: Teacher's Guide

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research

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National Academies Press

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ISBN 10

0309181992

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9780309181990

Guide for the Care and Use of Laboratory Animals -- Japanese Edition

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Commission on Life Sciences

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Guide for the Care and Use of Laboratory Animals -- Japanese Edition

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Commission on Life Sciences

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142

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National Academies Press

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ISBN 10

0309100186

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9780309100182

Recognition and Alleviation of Pain in Laboratory Animals

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Recognition and Alleviation of Pain in Laboratory Animals

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Recognition and Alleviation of Pain in Laboratory Animals

By: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Recognition and Alleviation of Pain in Laboratory Animals

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199

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National Academies Press

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0309149118

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9780309149112

Transportation of Laboratory Animals

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use

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Transportation of Laboratory Animals

Proceedings of a Workshop

By: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use

The obligation to treat animals used in research ethically and humanely extends beyond their lives in the laboratory to include their transportation from place to place. Yet transporting animals is a highly regulated and complex process that raises many difficult issues. To examine these issues, the Roundtable on Science and Welfare in Laboratory Animal Use held a workshop on September 3-4, 2014, in Washington, DC. More than 200 people participated in the workshop in person and online, including representatives of academic research institutions, pharmaceutical and consumer product companies, government agencies, research advocacy groups, professional associations, and the public. The workshop was designed to draw attention to the essential thoughtful journey planning behind each transport of laboratory animals.

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107

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National Academies Press

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0309373360

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9780309373364

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