Inge Brouns's Books

Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors

By: Inge Brouns,Isabel Pintelon,Jean-Pierre Timmermans,Dirk Adriaensen

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Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors

By: Inge Brouns,Isabel Pintelon,Jean-Pierre Timmermans,Dirk Adriaensen

With the advances of immunohistochemistry in combination with confocal microscopy, airway sensory receptor end-organs can now be examined and evaluated objectively. Based on their ‘neurochemical coding’, morphology, location and origin, three sensory receptor end organs are currently morphologically well-characterised: smooth muscle-associated airway receptors (SMARs), neuroepithelial bodies (NEBs) and visceral pleura receptors (VPRs). The present information on the functional morphological and neurochemical characteristics of these sensory receptors, leads to important conclusions about their (possible) function.

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125

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3642227724

ISBN 13

9783642227721

The Pulmonary Neuroepithelial Body Microenvironment

A Multifunctional Unit in the Airway Epithelium

By: Inge Brouns,Line Verckist,Isabel Pintelon,Jean-Pierre Timmermans,Dirk Adriaensen

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The Pulmonary Neuroepithelial Body Microenvironment

A Multifunctional Unit in the Airway Epithelium

By: Inge Brouns,Line Verckist,Isabel Pintelon,Jean-Pierre Timmermans,Dirk Adriaensen

This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors

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Page Count

112

Publisher

Springer Nature

Published Date

ISBN 10

3030658171

ISBN 13

9783030658175

The Pulmonary Neuroepithelial Body Microenvironment

A Multifunctional Unit in the Airway Epithelium

By: Inge Brouns,Line Verckist,Isabel Pintelon,Jean-Pierre Timmermans,Dirk Adriaensen

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The Pulmonary Neuroepithelial Body Microenvironment

A Multifunctional Unit in the Airway Epithelium

By: Inge Brouns,Line Verckist,Isabel Pintelon,Jean-Pierre Timmermans,Dirk Adriaensen

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Solve jigsaw puzzle

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Page Count

112

Publisher

Springer Nature

Published Date

ISBN 10

3030658171

ISBN 13

9783030658175

Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors

By: Inge Brouns,Isabel Pintelon,Jean-Pierre Timmermans,Dirk Adriaensen

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Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors

By: Inge Brouns,Isabel Pintelon,Jean-Pierre Timmermans,Dirk Adriaensen

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

125

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3642227724

ISBN 13

9783642227721

Book's by Inge Brouns

Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors

Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors

The Pulmonary Neuroepithelial Body Microenvironment

The Pulmonary Neuroepithelial Body Microenvironment

The Pulmonary Neuroepithelial Body Microenvironment

The Pulmonary Neuroepithelial Body Microenvironment

Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors

Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors

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