In 1976 the British band Throbbing Gristle emerged from the radical arts collective COUM Transmissions through core members Genesis P-Orridge and Cosey Fanni Tutti, joined by Hipgnosis photographer Peter Christopherson and electronics specialist Chris Carter. Though having performed previously in more low-key arts environments, their major launch coincided with the COUM retrospective exhibition Prostitution at London’s ICA gallery, showcasing and contextualising an array of challenging objects from COUM’s various actions in performance art and pornography. In a deliberately curated strategy inviting press, civic and arts dignitaries, extravagant followers of the nascent punk scene and music journalists, the band created an instant controversy and media panic that tapped into the restrictive climate and encroaching conservatism of late 1970s Britain. Any opportunities that were being explored by a formative punk ethos and movement around sex, censorship and transgression were amplified and exposed by Throbbing Gristle and Prostitution. An outraged Member of Parliament Nicholas Fairbairn took the bait and called the ensemble the ‘wreckers of civilisation’, providing the suitable newspaper headline that would be followed a month later by ‘the filth and the fury’ as the Sex Pistols uttered strong profanities on live television. The switch from COUM to Throbbing Gristle encompassed a primary mode of expression in making music as opposed to art, to further coincide with the energy of the nascent punk scene. The band quickly developed a radically deviant and challenging reputation through pushing the punk format past its strictures in terms of lyrical themes, amateurism, and considerations of what constitutes music. Through a handful or record releases on their own label Industrial Records, and a sporadic string of live performances, the band nurtured a strong and devoted following including key journalists and fanzine editors of the punk and post-punk scenes such as Jon Savage and Sandy Robertson. The band’s style of exploring harsh pre-recorded sounds, samples of disconcerting narrative and conversation, and feeding all sounds through messy electronic processing devices gave rise to the title industrial music. This was further buttressed by performing a strictly timed set of one hour, and adopting a non-rockstar mode by appearing disinterested and preoccupied with electronic devices. Having given a name and impetus to the industrial music scene, many of their followers and fans formed bands in later years. Drawing on works such as Andy Bennett’s When the Lights Went Out, this book looks at late 1970s Britain, before, during and immediately after the Winter of Discontent, to situate the activism of Throbbing Gristle in this time. It explores how the band worked in and against the time, and how they worked in and against punk as punk worked in and against the time and place. Punk acts as a mediating factor and nuisance value, as Throbbing Gristle emerged with punk in late 1976, seemingly grappled with it through 1977, and then went on to create and eventually criticise a number of post-punk scenes that had flourished around 1979. Trowell narrates the story through a series of live performances, as this is a point where Throbbing Gristle interact with the various city-scenes around England during their original period of operation (1975-1981). The band reflected (and incorporated into their live music) key tropes form the time, both ‘mainstream’ and fringe (subcultural, avant-garde art, counter-culture, taboo subjects, extremes) such that Throbbing Gristle events had an impact and affect, and Trowell traces these as a series of impressions and reverberations amongst fans who went on to do their own music and projects.
In 1976 the British band Throbbing Gristle emerged from the radical arts collective COUM Transmissions through core members Genesis P-Orridge and Cosey Fanni Tutti, joined by Hipgnosis photographer Peter Christopherson and electronics specialist Chris Carter. Though having performed previously in more low-key arts environments, their major launch coincided with the COUM retrospective exhibition Prostitution at London’s ICA gallery, showcasing and contextualising an array of challenging objects from COUM’s various actions in performance art and pornography. In a deliberately curated strategy inviting press, civic and arts dignitaries, extravagant followers of the nascent punk scene and music journalists, the band created an instant controversy and media panic that tapped into the restrictive climate and encroaching conservatism of late 1970s Britain. Any opportunities that were being explored by a formative punk ethos and movement around sex, censorship and transgression were amplified and exposed by Throbbing Gristle and Prostitution. An outraged Member of Parliament Nicholas Fairbairn took the bait and called the ensemble the ‘wreckers of civilisation’, providing the suitable newspaper headline that would be followed a month later by ‘the filth and the fury’ as the Sex Pistols uttered strong profanities on live television. The switch from COUM to Throbbing Gristle encompassed a primary mode of expression in making music as opposed to art, to further coincide with the energy of the nascent punk scene. The band quickly developed a radically deviant and challenging reputation through pushing the punk format past its strictures in terms of lyrical themes, amateurism, and considerations of what constitutes music. Through a handful or record releases on their own label Industrial Records, and a sporadic string of live performances, the band nurtured a strong and devoted following including key journalists and fanzine editors of the punk and post-punk scenes such as Jon Savage and Sandy Robertson. The band’s style of exploring harsh pre-recorded sounds, samples of disconcerting narrative and conversation, and feeding all sounds through messy electronic processing devices gave rise to the title industrial music. This was further buttressed by performing a strictly timed set of one hour, and adopting a non-rockstar mode by appearing disinterested and preoccupied with electronic devices. Having given a name and impetus to the industrial music scene, many of their followers and fans formed bands in later years. Drawing on works such as Andy Bennett’s When the Lights Went Out, this book looks at late 1970s Britain, before, during and immediately after the Winter of Discontent, to situate the activism of Throbbing Gristle in this time. It explores how the band worked in and against the time, and how they worked in and against punk as punk worked in and against the time and place. Punk acts as a mediating factor and nuisance value, as Throbbing Gristle emerged with punk in late 1976, seemingly grappled with it through 1977, and then went on to create and eventually criticise a number of post-punk scenes that had flourished around 1979. Trowell narrates the story through a series of live performances, as this is a point where Throbbing Gristle interact with the various city-scenes around England during their original period of operation (1975-1981). The band reflected (and incorporated into their live music) key tropes form the time, both ‘mainstream’ and fringe (subcultural, avant-garde art, counter-culture, taboo subjects, extremes) such that Throbbing Gristle events had an impact and affect, and Trowell traces these as a series of impressions and reverberations amongst fans who went on to do their own music and projects.
Heart of England Fairs' is a unique collection of nearly 200 photographs taken by Midlands engineer and fairground enthusiast Jack Leeson. Jack photographed his first images at Rugby Fair in June 1949 and continued taking pictures that covered all aspects of the fairground - arrival in town, building up, rides, food, leaving town - for the next forty years. During this time he took almost 8,000 photographs, many of which have never been seen before, all of which show his love not only for the fair but of the fairground people and way of life.
Nutrition, Toxicity, and Cancer provides practical guidance on methodology for formulating diets and designing nutritional studies in animals and humans, in addition to valuable information on how nutrition influences specific biological processes such as biotransformation of foreign and endogenously produced compounds. The book also presents sample diets and advice on the layout of metabolic suites. Other topics discussed include the complex interactions between nutrition and carcinogenic processes, teratogenesis and mutagenesis. Toxicologists, cancer researchers, nutritionists, and biochemists should consider Nutrition, Toxicity, and Cancer to be an invaluable reference resource that provides up-to-date reviews on the effect of diet on mammalian and microbial metabolic processes in the body.
This monograph is the definitive survey of iron tools and other fittings in use during the period c1066 to 1540AD. Exceptional in a north-western European context for its range and coverage of artefacts from both rural and urban excavations, much of the material described here was recovered during 'rescue' projects in the 1960s and 1970s funded by the State through the Ministry of Public Works and Buildings and their successors. The text contains almost everything necessary to identify, date and understand medieval iron objects. In scope and detail there is still no published parallel and, as such, it will be essential for almost any archaeologist working in later medieval archaeology, particularly in the fields of excavation, finds study, museums and research.
Producing an energy efficient and environmentally friendly building can be a daunting task for the every day architect, who may only be commissioned infrequently to produce such a building. This book aims to remove the mystery and complexity from this process by helping the architect understand and put into practice the many issues involved in generating an energy efficient and environmentally friendly design.
Generation after generation has come up with new forms of punishment to inflict on those guilty (and sometimes innocent) of crimes against property and person. From the stocks and pillory, to flogging, ducking and transportation to foreign lands, this volume brings to life those turbulent times of long ago. Even after suffering the ultimate in punishments — death — the bodies of the convicted could still be punished. Stories of dissection, when the body of the deceased criminal was publicly carved up, or gibbeting, when the corpse would be coated in tar and canvass and displayed in an iron frame on a pole 30ft high, are gruesome in the extreme. Pity poor John Spencer, whose rotting remains were gibbeted for over sixty years until the cage was finally blown down in a storm. Richly illustrated, this book provides a fascinating glimpse into the dark world of punishments through the centuries and will appeal to all those wishing to discover more about Nottinghamshire’s intriguing past.
This is the first exploration of the relationship between the abdomen and British society between 1800 and 1950. Miller demonstrates how the framework of ideas established in medicine related to gastric illness often reflected wider social issues including industrialization and the impact of wartime anxiety upon the inner body.
This text presents the findings of a set of original research studies and reports on the way that care services for children are delivered, the cost of providing services and the extent to which they improve outcomes for children. It also looks at services provided by the statutory, and examines how resources are distributed.
At the beginning of 1916, as the world entered the second full year of global conflict, the cities, towns and villages of Britain continued to lay vulnerable to aerial bombardment. Throughout that period German Zeppelin airships and seaplanes had come and gone at will, their most testing opposition provided by the British weather as the country’s embryonic defences struggled to come to terms with this first ever assault from the air. Britain’s civilians were now standing on the frontline — the Home Front — like the soldiers who had marched off to war. But early in 1916 responsibility for Britain’s aerial defence passed from the Admiralty to the War Office and, as German air attacks intensified, new ideas and plans made dramatic improvements to Britain’s aerial defence capability. While this new system could give early warning of approaching raiders, there was a lack of effective weaponry with which to engage them when they arrived. Behind the scenes, however, three individuals, each working independently, were striving for a solution. The results of their work were spectacular; it lifted the mood of the nation and dramatically changed the way this campaign was fought over Britain. The German air campaign against Britain in the First World War was the first sustained strategic aerial bombing campaign in history. Despite this, it has become forgotten against the enormity of the Blitz of the Second World War, although for those caught up in the tragedy of these raids, the impact was every bit as devastating. In Zeppelin Inferno Ian Castle tells the full story of the 1916 raids in unprecedented detail in what is the second book in a trilogy that will reveal the complete story of Britain’s ‘Forgotten Blitz’.
FRESHNEY’S CULTURE OF ANIMAL CELLS THE NEW EDITION OF THE LEADING TEXT ON THE BASIC METHODOLOGY OF CELL CULTURE, FULLY UPDATED TO REFLECT NEW APPLICATIONS INCLUDING IPSCS, CRISPR, AND ORGAN-ON-CHIP TECHNOLOGIES Freshney’s Culture of Animal Cells is the most comprehensive and up-to-date resource on the principles, techniques, equipment, and applications in the field of cell and tissue culture. Explaining both how to do tissue culture and why a technique is done in a particular way, this classic text covers the biology of cultured cells, how to select media and substrates, regulatory requirements, laboratory protocols, aseptic technique, experimental manipulation of animal cells, and much more. The eighth edition contains extensively revised material that reflects the latest techniques and emerging applications in cell culture, such as the use of CRISPR/Cas9 for gene editing and the adoption of chemically defined conditions for stem cell culture. A brand-new chapter examines the origin and evolution of cell lines, joined by a dedicated chapter on irreproducible research, its causes, and the importance of reproducibility and good cell culture practice. Throughout the book, updated chapters and protocols cover topics including live-cell imaging, 3D culture, scale-up and automation, microfluidics, high-throughput screening, and toxicity testing. This landmark text: Provides comprehensive single-volume coverage of basic skills and protocols, specialized techniques and applications, and new and emerging developments in the field Covers every essential area of animal cell culture, including lab design, disaster and contingency planning, safety, bioethics, media preparation, primary culture, mycoplasma and authentication testing, cell line characterization and cryopreservation, training, and troubleshooting Features a wealth of new content including protocols for gene delivery, iPSC generation and culture, and tumor spheroid formation Includes an updated and expanded companion website containing figures, artwork, and supplementary protocols to download and print The eighth edition of Freshney’s Culture of Animal Cells is an indispensable volume for anyone involved in the field, including undergraduate and graduate students, clinical and biopharmaceutical researchers, bioengineers, academic research scientists, and managers, technicians, and trainees working in cell biology, molecular biology, and genetics laboratories.
Around 563AD a monk called Columba set off in a small boat with a few companions from the shores of his native Donegal, in the north-west tip of Ireland. Some time later they landed on the tiny island of Iona off the west coast of Scotland. Their journey is rightly perceived as one of the most significant events in the early Christian history of the British Isles. lan Bradley examines the life, character and achievements of St Columba and attempts to strip away the layers of myth and historical distortion that have grown up around him.
Since the publication of the sixth edition of this benchmark text, numerous advances in the field have been made – particularly in stem cells, 3D culture, scale-up, STR profiling, and culture of specialized cells. Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications, Seventh Edition is the updated version of this benchmark text, addressing these recent developments in the field as well as the basic skills and protocols. This eagerly awaited edition reviews the increasing diversity of the applications of cell culture and the proliferation of specialized techniques, and provides an introduction to new subtopics in mini-reviews. New features also include a new chapter on cell line authentication with a review of the major issues and appropriate protocols including DNA profiling and barcoding, as well as some new specialized protocols. Because of the continuing expansion of cell culture, and to keep the bulk of the book to a reasonable size, some specialized protocols are presented as supplementary material online. Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications, Seventh Edition provides the most accessible and comprehensive introduction available to the culture and experimental manipulation of animal cells. This text is an indispensable resource for those in or entering the field, including academic research scientists, clinical and biopharmaceutical researchers, undergraduate and graduate students, cell and molecular biology and genetics lab managers, trainees and technicians.
The new edition of this book provides a comprehensive review of the basic tests available in gastroenterology. Chapters examine widely-used modern techniques such as ultrasonography for Crohn’s disease, capsule endoscopy, elastography and video proctosigmoidoscopy among others. Fully updated to reflect the recent advances in the field in the last 20 years, this volume evaluates investigations for their current clinical usefulness in the management of patients. The reader will benefit from a critical analysis describing those older tests which have proved their worth alongside the newer procedures which have been introduced. Emphasis is placed on those techniques of which the authors have personal experience. The book is designed for trainees and clinicians without special expertise in gastroenterology, as well as being a shelf manual for the gastroenterologist and the staff of gastroenterology investigation units.
The real life story of the Plantagenet ruler, by “the most remarkable medieval historian of our time” (The Times, London). The talented, confident, and intelligent son of John of Gaunt, Henry IV started his reign as a popular and charismatic king after he dethroned the tyrannical and wildly unpopular Richard II. But six years into his reign, Henry had survived eight assassination and overthrow attempts. Having broken God’s law of primogeniture by overthrowing the man many people saw as the chosen king, Henry IV left himself vulnerable to challenges from powerful enemies about the validity of his reign. Even so, Henry managed to establish the new Lancastrian dynasty and a new rule of law—in highly turbulent times. In this book, noted historian Ian Mortimer, bestselling author of The Time Traveler’s Guide to Medieval England and The Time Traveler’s Guide to Elizabethan England, goes beyond the legend portrayed in Shakespeare’s history play, and explores the political and social forces that transformed Henry IV from his nation’s savior to its scourge.
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