A comprehensive look at empirical approaches to molecular discovery, their relationships with rational design, and the future of both Empirical methods of discovery, along with serendipitous and rational design approaches, have played an important role in human history. Searching for Molecular Solutions compares empirical discovery strategies for biologically useful molecules with serendipitous discovery and rational design, while also considering the strengths and limitations of empirical pathways to molecular discovery. Logically arranged, this text examines the different modes of molecular discovery, empha-sizing the historical and ongoing importance of empirical strategies. Along with a broad overview of the subject matter, Searching for Molecular Solutions explores: The differing modes of molecular discovery Biological precedents for evolutionary approaches Directed evolutionary methods and related areas Enzyme evolution and design Functional nucleic acid discovery Antibodies and other recognition molecules General aspects of molecular recognition Small molecule discovery approaches Rational molecular design The interplay between empirical and rational strategies and their ongoing roles in the future of molecular discovery Searching for Molecular Solutions covers several major areas of modern research, development, and practical applications of molecular sciences. This text offers empirical-rational principles of broad relevance to scientists, professionals, and students interested in general aspects of molecular discovery, as well as the thought processes behind experimental approaches.
The Patient-Centered Clinical Method (PCCM) has been a core tenet of the practice and teaching of medicine since the first edition of Patient-Centered Medicine - Transforming the Clinical Method was published in 1995. This timely fourth edition continues to define the principles underpinning the patient-centered clinical method using four major components, clarifying its evolution and consequent development, and it brings the reader fully up to date. It reinforces the relevance of the method in the current much-changed realities of health care in a world where virtual care will remain common, dependence on technology is rising, and societal changes away from compassion, equity, and relationships toward confrontation, inequity, and self-absorption. Fully revised by its highly experienced author team ensuring wide interest and written for those practising now and for the practitioners of the future, this new edition will be welcomed by a wide international audience comprising all health professionals from medicine, nursing, social work, occupational therapy, physical therapy, pharmacy, veterinary medicine, and other fields.
Introduction to Critical Legal Theory provides an accessible introduction to the study of law and legal theory. It covers all the seminal movements in classical, modern and postmodern legal thought, engaging the reader with the ideas of jurists as diverse as Aristotle, Hobbes and Kant, Marx, Foucault and Dworkin. At the same time, it impresses the interdisciplinary nature of critical legal thought, introducing the reader to the philosophy, the economics and the politics of law. This new edition focuses even more intently upon the narrative aspect of critical legal thinking and the re-emergence of a distinctive legal humanism, as well as the various related challenges posed by our 'new' world order. Introduction to Critical Theory is a comprehensive text for both students and teachers of legal theory, jurisprudence and related subjects.
Why is Eastern Europe still different from Western Europe, more than a quarter-century after the collapse of Communism? A History of Eastern Europe 1918 to the Present shows how the roots of this difference are based in Eastern Europe's tortured 20th century. Eastern Europe emerged in 1918 as the 'lands between', new states whose weakness vis-à-vis Germany and Soviet Russia soon became obvious. The region was the main killing-field of the Second World War, which visited unimaginable horrors on its inhabitants before their 'liberation' by the Soviets in 1945. The imposition of Communist dictatorships on the region, ironically, only deepened Eastern Europe's backwardness. Even in the post-Communist period, its problems continue to make it a fertile breeding-ground for nationalism and political extremism. A History of Eastern Europe 1918 to the Present explores the comparative backwardness of Eastern Europe and how this has driven strategies of modernisation; it looks at the ways in which the region has served as a giant test-tube for political experimentation and, in particular, at the enduring strength of nationalism, which since 1989 has re-emerged more virulent than ever. This book in the essential textbook for any student of 20th-century Eastern Europe.
Among the many upheavals in North America caused by the French and Indian War was a commonplace practice that affected the lives of thousands of men, women, and children: being taken captive by rival forces. Most previous studies of captivity in early America are content to generalize from a small selection of sources, often centuries apart. In Setting All the Captives Free, Ian Steele presents, from a mountain of data, the differences rather than generalities as well as how these differences show the variety of circumstances that affected captives’ experiences. The product of a herculean effort to identify and analyze the captives taken on the Allegheny frontier during the era of the French and Indian War, Setting All the Captives Free is the most complete study of this topic. Steele explores genuine, doctored, and fictitious accounts in an innovative challenge to many prevailing assumptions and arguments, revealing that Indians demonstrated humanity and compassion by continuing to take numerous captives when their opponents took none, by adopting and converting captives into kin during the war, and by returning captives even though doing so was a humiliating act that betrayed their societies' values. A fascinating and comprehensive work by an acclaimed scholar, Setting All the Captives Free takes the study of the French and Indian War in America to an exciting new level.
International Investment Law and Arbitration: History, Modern Practice, and Future Prospects explores international law on foreign investment: its creation, functioning and evolution.
Exploding the curious myth that the ocean is a barrier rather than a highway for communication, this unusual interdisciplinary study examines the English Atlantic context of early American life. From the winterless Caribbean to the ice-locked Hudson Bay, maritime communications in fact usually met the legitimate expectations for frequency, speed, and safety, while increased shipping, new postal services, and newspapers hastened the exchange of news. These changes in avenues of communications reflected--and, in turn, enhanced--the political, economic, and social integration of the English Atlantic between 1675 and 1740. As Steele deftly describes the influence of physical, technological, socioeconomic, and political aspects of seaborne communication on the community, he suggests an exciting new mode of analyzing Colonial history.
Principles and Practice of Pediatric Neurosurgery, Third Edition is a completely revised edition of the most authoritative guide to the management of pediatric neurosurgical disorders encountered in clinical practice. Written by leaders in the field, it provides pediatric neurosurgeons with a clear understanding of the current standards of practice and treatment in the subspecialty. Key Features: Now in full color, with more than 1,000 images An increased emphasis on clinical management strategies in pediatric neurosurgery Seven new chapter topics, including cellular therapy for pediatric neurosurgical disease, conjoined twins, lipomeningoceles, and skeletal syndromes Pearls and pitfalls in every chapter This book is an essential reference for all residents and practitioners in pediatric neurosurgery and pediatric neurology.
From basic science to clinical care, to epidemiological disease patters, The Neurology of AIDS is the only complete textbook available on AIDS neurology and the only one comprehensive enough to stand alone in each segment of study in brain disorders affected by the human immunodeficiency virus. It is an indispensable resource for students, resident physicians, practicing physicians, and for researchers and experts in the HIV/AIDS field. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's prestigious neuroscience texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format.
Polyphosphazenes are a unique family of inorganic polymers with an unparalleled broad spectrumof properties. Furthermore, these properties can be easily fine-tuned by organic side-group substituents to give poly(organo)phosphazenes with precisely desired characteristics making them valuable tools to prepare multifunctional, advanced materials for biomedical applications. Bioerodible poly(organo)phosphazenes are of particular interest and with suitable organic substituents their rate of degradation can be tailored to give materials ranging from highly biostable to rapidly hydrolysable, with proven biocompatibility and nontoxic products. This book provides an overview of the current state of development of poly(organo)phosphazenes designed specifically for use in medical applications. The objective is firstly to provide detailed information on the latest preparation techniques to synthesise well-defined, customised materials for the desired application. Secondly, a detailed review of the most recent data for application studies in medicine is provided, with particular focus given to their applications as macromolecular carriers innanomedicine, including drug delivery, immunology and gene therapy, as well as their use as degradable scaffolds for tissue regeneration. This book should not only provide a valuable and critical summary for researchers already working in, or looking to enter the field, but also those contemplating the use of polyphosphazenes for their desired application.
The highest incidence for clinical depressions is during adolescence. Furthermore, mental health illnesses that recur over the life-course begin in young people. 70% of all mental health emerge before thirty years of age. Almost all interventions for young people have been first developed for and targeted at adults. Here for the first time is a talking therapy (BPI), that has been developed for, and with, adolescents. After thirty years of clinical experience with mentally ill adolescents and two major randomised controlled trials of treatment, the authors reveal a brief psychosocial intervention that is as effective as CBT for adolescents with depression with and without comorbid anxiety and conduct disorder. BPI can be taught to mental health practitioners in sixteen hours and they can immediately start delivery of care. After a six-month supervision, new BPI practitioners offer an evidence based and NICE approved treatment in their usual clinical practice.
This book explores a novel methodological approach which combines analytical techniques from linguistics and geography to bring fresh insights to the study of poverty. Using Geographical Text Analysis, it maps the discursive construction of poverty in the UK and compares the results to what administrative data reveal. The analysis draws together qualitative and quantitative techniques from corpus linguistics, critical discourse analysis, Geographical Information Science, and the spatial humanities. By identifying the place-names that occur within close proximity to search terms associated with to poverty it shows how different newspapers use place to foreground different aspects of poverty (including employment, housing, money, and benefits), and how the London-centric nature of newspaper reporting dominates the discursive construction of UK poverty. This book demonstrates how interdisciplinary research methods can illuminate complex social issues and will appeal to researchers in a number of disciplines from sociology, geography and the spatial humanities, economics, linguistics, health, and public policy, in addition to policymakers and practitioners.
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