Your research has generated gigabytes of data and now you need to analyse it. You hate using spreadsheets but it is all you know, so what else can you do? This book will transform how you work with large and complex data sets, teaching you powerful programming tools for slicing and dicing data to suit your needs. Written in a fun and accessible style, this step-by-step guide will inspire and inform non-programmers about the essential aspects of Unix and Perl. It shows how, with just a little programming knowledge, you can write programs that could save you hours, or even days. No prior experience is required and new concepts are introduced using numerous code examples that you can try out for yourself. Going beyond the basics, the authors touch upon many broader topics that will help those new to programming, including debugging and how to write in a good programming style.
This is the only book completely devoted to the popular BLAST (Basic Local Alignment Search Tool), and one that every biologist with an interest in sequence analysis should learn from.
This is the only book completely devoted to the popular BLAST (Basic Local Alignment Search Tool), and one that every biologist with an interest in sequence analysis should learn from.
This book updates the thesis I produced for my PhD at the Department of Artificial Intelligence of the University of Edinburgh, correcting errors, and improving some of the formatting and readability. Since the original work was completed (early 1996), research has progressed. Most notably, the public profile of AI and game-playing has reached new heights with the feats of the chess computer DEEPER BLUE (which surely uses AI, no matter what IBM would have us believe). Although less heralded, the ability of computers to play Bridge (the main example domain in this book) has also increased. In July of 1997 a world championship for computer Bridge programs was hosted by the American Contract Bridge League in Albuquerque, New Mex ico. This contest was won by a program called Bridge Baron, produced by Great Game Products. Bridge Baron incorporates knowledge-based planning techniques developed by Stephen Smith and Dana Nau [1, 2]. Progress has also been made on the contrasting, more brute-force, approach of sampling the possible card distributions. In particular, Matt Ginsberg has developed a fast double-dummy solver based on partition search [3]. Ginsberg's program fared poorly in the 1997 Bridge championships, but Ginsberg himself reports very promising results [4] on a hard set of complete Bridge deals taken from the Bridge tutoring program Bridge Master.
Heroin is a drug that myths are made of. Whether smuggled in the stomach of a camel or used as the ultimate symbol of lifestyle chic, no drug has been more argued over and legislated against, no drug has been more subject to misinformation and moral panic. Heroin Century sets the record straight. It contains a wealth of historical and medical information about this drug which made its first appearance as a miracle medicine over a hundred years ago and makes recommendations for its future in the twenty-first century. Evidence shows that heroin is dangerous principally because it is illegal. The authors argue that a more relaxed relationship between society and the drug would benefit both the economy and public health and safely. Individual chapters describe the history of heroin production; the makeup of heroin and evolving methods of use; the spread of heroin and international efforts at control; typical "career" patterns of users, ranging from occasional recreational use to destructive dependence; the subjective experience of taking heroin; the association between heroin and crime; the use of heroin in medicine and its effects on physical health; the history of the treatment of heroin dependence; and likely changes in heroin use in the future. The authors have drawn on literary and artistic sources as well as the large pool of scientific literature to compile a comprehensive and fascinating account of this world-changing drug. Heroin Century makes available a wealth of information about the history, chemistry, pharmacology and medical aspects of heroin in a form accessible to anyone who wishes to participate in the contemporary debate bout society's attitude to drugs.
“This is the most important book on illicit drug use and social work to be published for a long time … Whilst it may inspire some to become “drug specialists” it’s most important purpose is in dealing with drug issues which are apparent in all social work settings. Just as importantly this book should be read by those responsible for redesigning social work and social work education in order that substance use forms part of the curriculum.” Ken Barrie, Alcohol and Drug Studies, University of West Scotland, UK “This comprehensive, well written book will be essential reading for social work students and practitioners who need a clear, useful and relevant overview of the issues involved in working constructively with drug using service users. Its emphasis on working in partnership, while also attending to issues of risk and vulnerability, is realistic and practical, and being resolutely ‘social’ in its outlook, the book will appeal to and inspire novice and experienced practitioners alike.” Dr Mark Hardy, Department of Social Policy and Social Work, University of York, UK Alcohol and drug use are cross-cutting issues in all areas of social work practice and social workers need to know how to identify, assess, engage and support their substance-using clients effectively. This book provides a comprehensive and practical account of this important area of health and social care and provides a basis for social workers to develop a rounded approach to their practice with drug and alcohol users. The book unravels the relevant theory and research and provides insights and practical pointers for those working with drug users. Key topics covered include: Prevalence, patterns and policy and defining drug users Stigma, HCV and HIV; care and control The service user’s perspective; involving service users in services and interventions Recovery; networking, advocacy and empowerment The authors argue that in contrast to widely held concerns about the ‘threat’ represented by drug users, the aim of social work should be to restate the importance of listening to them, taking their concerns seriously, and challenging the discrimination they encounter. Social Work and Drug Use is key reading for social work students and those training in related areas such as youth justice, criminology, education welfare and youth work. Practitioners, academics and those undertaking post-qualifying training will also find it a valuable reference.
Since the publication of the sixth edition of this benchmark text, numerous advances in the field have been made – particularly in stem cells, 3D culture, scale-up, STR profiling, and culture of specialized cells. Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications, Seventh Edition is the updated version of this benchmark text, addressing these recent developments in the field as well as the basic skills and protocols. This eagerly awaited edition reviews the increasing diversity of the applications of cell culture and the proliferation of specialized techniques, and provides an introduction to new subtopics in mini-reviews. New features also include a new chapter on cell line authentication with a review of the major issues and appropriate protocols including DNA profiling and barcoding, as well as some new specialized protocols. Because of the continuing expansion of cell culture, and to keep the bulk of the book to a reasonable size, some specialized protocols are presented as supplementary material online. Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications, Seventh Edition provides the most accessible and comprehensive introduction available to the culture and experimental manipulation of animal cells. This text is an indispensable resource for those in or entering the field, including academic research scientists, clinical and biopharmaceutical researchers, undergraduate and graduate students, cell and molecular biology and genetics lab managers, trainees and technicians.
Medical Genetics provides medical and biomedical students with an understanding of the basic principles of human genetics as they relate to clinical practice, showing how our genome lies at the heart of our health and well-being.
AI is an integral part of every video game. This book helps professionals keep up with the constantly evolving technological advances in the fast growing game industry and equips students with up-to-date information they need to jumpstart their careers. This revised and updated Third Edition includes new techniques, algorithms, data structures and representations needed to create powerful AI in games. Key Features A comprehensive professional tutorial and reference to implement true AI in games Includes new exercises so readers can test their comprehension and understanding of the concepts and practices presented Revised and updated to cover new techniques and advances in AI Walks the reader through the entire game AI development process
FRESHNEY’S CULTURE OF ANIMAL CELLS THE NEW EDITION OF THE LEADING TEXT ON THE BASIC METHODOLOGY OF CELL CULTURE, FULLY UPDATED TO REFLECT NEW APPLICATIONS INCLUDING IPSCS, CRISPR, AND ORGAN-ON-CHIP TECHNOLOGIES Freshney’s Culture of Animal Cells is the most comprehensive and up-to-date resource on the principles, techniques, equipment, and applications in the field of cell and tissue culture. Explaining both how to do tissue culture and why a technique is done in a particular way, this classic text covers the biology of cultured cells, how to select media and substrates, regulatory requirements, laboratory protocols, aseptic technique, experimental manipulation of animal cells, and much more. The eighth edition contains extensively revised material that reflects the latest techniques and emerging applications in cell culture, such as the use of CRISPR/Cas9 for gene editing and the adoption of chemically defined conditions for stem cell culture. A brand-new chapter examines the origin and evolution of cell lines, joined by a dedicated chapter on irreproducible research, its causes, and the importance of reproducibility and good cell culture practice. Throughout the book, updated chapters and protocols cover topics including live-cell imaging, 3D culture, scale-up and automation, microfluidics, high-throughput screening, and toxicity testing. This landmark text: Provides comprehensive single-volume coverage of basic skills and protocols, specialized techniques and applications, and new and emerging developments in the field Covers every essential area of animal cell culture, including lab design, disaster and contingency planning, safety, bioethics, media preparation, primary culture, mycoplasma and authentication testing, cell line characterization and cryopreservation, training, and troubleshooting Features a wealth of new content including protocols for gene delivery, iPSC generation and culture, and tumor spheroid formation Includes an updated and expanded companion website containing figures, artwork, and supplementary protocols to download and print The eighth edition of Freshney’s Culture of Animal Cells is an indispensable volume for anyone involved in the field, including undergraduate and graduate students, clinical and biopharmaceutical researchers, bioengineers, academic research scientists, and managers, technicians, and trainees working in cell biology, molecular biology, and genetics laboratories.
Catherine II of Russia was the most remarkable monarch of the eighteenth century. New York Times bestselling historian Ian Grey paints an illuminating portrait of an enigmatic woman of compelling charm and elegance. She had a prodigious appetite for work, great curiosity, and boundless ambition and vanity, and she was notorious for the number of her lovers. Her prodigal expenditures and patronage of the arts made her reign an era of splendor while her foreign policy and conquests carried Russian power and prestige to new heights. She cast a spell over most of her contemporaries in Russia and in Western Europe, and the spell has lingered. Here, in this book, is the dramatic story of an obscure German princess, without beauty or special advantage, but with courage, charisma, and determination, who became one of the arbiters of the affairs of Europe and renowned in history.
Treatment of Skin Disease is your definitive source for managing the complete range of dermatologic conditions you’re likely to encounter in practice. This medical reference book boasts an intuitive and easy to use format that covers the full spectrum of options, equipping you with not only standard treatment strategies, but second- and third-line therapies for instances when other alternatives fail. You’ll be thoroughly prepared to offer your patients the expertly informed medical care they deserve when facing common or complex dermatologic diseases. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Address your most difficult clinical challenges by having every possible therapy option at your disposal, including third- and fourth-line therapies, as well as standard treatments for dermatologic disorders. Apply the in-depth knowledge of leading dermatologists through a summary of each treatment strategy along with detailed discussions of treatment choices. Gain insight to the essential features which define each dermatologic disease with chapters presented in a tabular format, using checklists of diagnostic and investigative pearls and color-coded boxed text, for quick at-a-glance summaries of key details. Make the most informed decisions possible with the inclusion of up-to-date evidence levels throughout the text. Stay abreast of emerging drug treatments and research with the very latest options for the 251 most common dermatologic conditions, and take advantage of today’s expert knowledge on hot topics in dermatology such as bed bugs, erosive pustular dermatosis, polycystic ovary syndrome, and more. Achieve effective visual diagnoses by viewing over 250 full-color clinical images of skin diseases, most of which are brand new in this edition.
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