This new illustrated paperback edition examines the Scottish country house in all its guises - from great classical houses like Hopetoun, to familiar castles such as Glamis and Craigievar - as well as giving insights into the architects who designed them, including William and Robert Adam, Sir John James Burnet and Sir William Bruce.
A unique collaboration between Ian Mackay, one of the prominent founders of clinical immunology, and Warwick Anderson, a leading historian of twentieth-century biomedical science. Connection laboratory research, clinical medicine, social theory, and lived experience, the authors reveal how doctors and patients have come to terms with this new concept of pathogenesis, one that was accepted only in the 1950s." --
First published in 1981, Critic as Scientist provides a detailed and scholarly account both of the scientific background and of contemporary artistic issues in its analysis of Ezra Pound’s poetics. During the crucial period of his years in London, Ezra Pound was striving to formulate not only a new system of poetics but also a new language through which he could both define the critic’s procedure and announce his modernity. It was in science that Pound discovered the vocabulary that became his most characteristic gesture during the literary crises of the time. The use of scientific terminology in his ‘propaganda’ for a new ‘renaissance’ belonged, initially, to specifically American modes of aesthetic tradition, as typified by Whistler and aspects of New England transcendentalism. A consideration of popular versions of physics and biology, and of the ‘scientific attitude’ displayed by such contemporaries as Fenollosa, Hulme, Ford and Eliot, reveals that the major terms and practices of Pound’s critical vocabulary were located in the issues of nineteenth and early twentieth-century science. The author has sought to demystify key words in the Poundian vocabulary and has suggested a wider literary and cultural context for the study of Pound’s aesthetic theory. This book will be of interest to students of literature.
The definitive account of the superior fighting force that powered the English Revolution The New Model Army was one of the most formidable fighting forces ever assembled. Formed in 1645, it was crucial in overthrowing the monarchy and propelling one of its most brilliant generals, Oliver Cromwell, to power during the English Revolution. Paradoxically, it was also instrumental in restoring the king in 1660. But the true nature of this army has long been debated. In this authoritative history, Ian Gentles examines the full scope of the New Model Army. As a fighting force it engineered regicide, pioneered innovative military tactics, and helped to keep Cromwell in power as Lord Protector until his death. All the while, those within its ranks promoted radical political ideas inspired by the Levellers and held dissenting religious beliefs. Gentles explores how brilliant battlefield maneuvering and logistical prowess contributed to its victories--and demonstrates the vital role religion played in building morale and military effectiveness.
Ian Grey's Peter the Great reads like a novel . . ." - Louis Fischer The first modern Russian was Peter the Great. In this enthralling biography of that remarkable ruler, award-winning historian Ian Grey paints an illuminating portrait - clear, objective, and without malice or sentimentality. Here we have, life-size, not only the great czar, but the man who fell in love with a peasant girl and made her his empress; the father who was betrayed by his son; the giant who carried all his life the scars of a childhood terror; the soldier, sailor, laborer, innovator, and architect of a nation.
The Human Thymus presents the immunological aspect of the thymus. It discusses the lymphopoietic and immunological functions of the human thymus. It addresses the physiological function of thymus that regulates neuromuscular transmission by the secretion of thymin. Some of the topics covered in the book are the origin of thymic lymphocytes; development of Hassall's corpuscles; humoral immune responses; neonatal thymectomy and wasting disease; mode of action of thymin at the neuromyal synapse; experimental autoimmune thymitis; and neuromuscular block associated with experimental autoimmune thymitis. The diseases induced with Freund's complete adjuvant are covered. The spontaneously occurring autoimmune diseases are discussed. The text describes the size of the human thymus. A study of the experimental effect of hormones on thymic size is presented. A chapter is devoted to the thymic hypoplasia and immunological deficiencies. Another section focuses on the histopathology of thymus in myasthenia gravis. The book can provide useful information to scientists, doctors, students, and researchers.
**Selected for Doody's Core Titles® 2024 in Veterinary Medicine** With nearly 100 different autoimmune diseases reported to occur in domestic animal species, this evidence-based clinical reference is a must-have for every veterinary practice! Autoimmune Diseases in Domestic Animals, from noted veterinary author Ian R. Tizard, sheds light on both common and rare conditions, including skin diseases, diabetes mellitus, thyroiditis, and hemolytic anemia. Convenient and portable, this single-source review addresses autoimmune diseases in dogs, cats, horses, and livestock species with comprehensive coverage of treatment protocols, diagnostic procedures, and the latest pathogenesis studies. - All-in-one guide covers the basic science, clinical presentation, and treatment of this set of increasingly prevalent animal diseases. - Comprehensive information for each disease prepares students to communicate effectively with clients. - Reviews of the most recent relevant literature provide a clearer understanding of complex autoimmune diseases. - Detailed coverage facilitates the accurate diagnosis and rational treatment of immunologic diseases. - Information on autoimmune mouse strains and other animal models meets the needs of comparative immunology and research students. - Expert author Ian R. Tizard is a well-established veterinary writer who is world-renowned on the topic of immunology in veterinary medicine.
Big History is a seemingly novel approach that seeks to situate human history within a grand cosmic story of life. It claims to do so by uniting the historical sciences in order to construct a linear and accurate timeline of 'threshold moments' beginning with the Big Bang and ending with the present and future development of humanity itself. As well as examining the theory and practice of Big History, this Element considers Big History alongside previous largescale attempts to unite human and natural history, and includes comparative discussions of the practices of chronology, universal history, and the evolutionary epic.
Nutrition, Toxicity, and Cancer provides practical guidance on methodology for formulating diets and designing nutritional studies in animals and humans, in addition to valuable information on how nutrition influences specific biological processes such as biotransformation of foreign and endogenously produced compounds. The book also presents sample diets and advice on the layout of metabolic suites. Other topics discussed include the complex interactions between nutrition and carcinogenic processes, teratogenesis and mutagenesis. Toxicologists, cancer researchers, nutritionists, and biochemists should consider Nutrition, Toxicity, and Cancer to be an invaluable reference resource that provides up-to-date reviews on the effect of diet on mammalian and microbial metabolic processes in the body.
John Locke (1632-1704) is a central figure in the history of thought, and in liberal doctrine especially. This major study brings a range of his wider views to bear upon his political theory. Every political theorist has a vision, a view about the basic features of life and society, as well as technique which mediates this into propositions about politics. Locke's vision spanned questions concerning Christian worship, ethics, political economy, medicine, the human understanding, revealed theology and education. This study shows how the character of these wider concerns informed Two Treatises of Government, especially in respect of a view of divine teleology, and situated a distinctive view of politics which treated the state and the church in parallel terms.
The only complete resource on immunology for veterinary students and practitioners, Veterinary Immunology: An Introduction features a straightforward presentation of basic immunologic principles with comprehensive information on the most significant immunological diseases and responses seen in domestic animals. This meticulously updated new edition explores the latest advances in the field and provides a wealth of clinical examples that illustrate and clarify important concepts. Comprehensive coverage of vaccines and vaccine usage, allergies and allergic diseases, and autoimmunity and immunodeficiencies, prepare you for the multiple immunologic issues you will encounter in practice. A wealth of clinical examples clearly illustrate key concepts and offer practical strategies for diagnosing and treating immunologic disorders in the clinical setting. More than 500 full-color diagrams and illustrations visually demonstrate and clarify complex issues. Completely updated section on innate immunity includes new chapters on natural killer (NK) cells and systemic responses to infection to ensure you have the most up-to-date information. New information on genomics and molecular diagnostic techniques explores how the emerging field of genomics impacts disease resistance and immunology in general, as well as the diagnosis and treatment of immunological and infectious diseases. Updated content provides new information on well-recognized older diseases such as rheumatoid arthritis, systemic lupus, and inflammatory bowel disease, as well as current information on new diseases such as devil facial tumor disease and bovine neonatal pancytopenia. Expanded coverage brings you the latest knowledge on resistance to infection, such as vaccine usage, especially with respect to duration of immunity, the effects of key vitamins and lipids on immune responses, the effects of old age on immunity, and both antiviral and parasitic immunity. Diagnostic tests described throughout the text include a new section on the analysis of ELISA test data, as well as a brief summary of molecular diagnostic techniques. Coverage reflecting a significant change in the overall view of immunology provides you with the foundational knowledge needed to grasp the broad pattern of immunologic reactions and understand how the immune system functions as an interconnected network, rather than a series of independent pathways. New discussions of the critical importance of commensal bacteria and intestinal flora explain help you understand the importance of this normal flora with respect to antibacterial immunity, allergies, and autoimmunity, while at the same time providing a broader view of the animal body and its microflora as a "superorganism." A discussion of the importance of adipose tissue in immunity and inflammation addresses the epidemic of obesity in domestic pets and the extraordinary growth rates expected of domestic livestock. The section on inflammatory mechanisms has been divided into separate chapters focusing on the detection of invaders and the mediators of inflammation to incorporate the vast amount of new information on pattern recognition receptors and the ways in which they warn the body of microbial invasion.
This comprehensive and authoritative reference covers all aspects of the group of disorders collectively known as the lymphoid neoplasms. The reader is taken through a description of its normal cellular origins and the molecular genetic abnormalities that can lead to this group of conditions, a section of the book that has been considerably strengt
“The Scottish concrete poet, visual artist, short story writer, aphorist, editor, and ‘avant-gardener’ Ian Hamilton Finlay is one of the great polymaths of our time. His writings alone would put him in the pantheon of twentieth century poets. Finlay’s son Alec, himself a poet, has now given us a selection of his father’s writings, beautifully edited and annotated, lavishly illustrated, and with a superb new introduction to the work. I consider this book, long overdue, to be a milestone in publishing. —Marjorie Perloff, author of The Futurist Moment and Unoriginal Genius: Poetry by other means in the 21st Century "Ian Hamilton Finlay was an entirely original, and continuously challenging, voice in the poetry of the English-speaking world over the second half of the twentieth century. This promises to be the first book in which his early verse, his concrete poetry and his distinctive compilations of aphorisms and ‘sentences’ are all substantially represented." —Stephen Bann, author of Ways Around Modernism “When I was young and trying to figure out how to think about landscapes and gardens and their cultural histories, no one opened the garden gates wider than Ian Hamilton Finlay in his poetic and sometimes provocative print projects, garden sculptures, concrete poems (sometimes in actual concrete or stone), aphorisms, and other works. Finlay was a loner, a visionary looking backward to think on revolution and paradise, Arcadia and insurrection, and this book put together by his artist son Alec makes that work available for the first time in a long while, and as gorgeously as possible. Alec's long biographical essay is itself a hugely valuable resource for anyone interested in the elder Finlay's works, and then there are the poems, and the pictures...” —Rebecca Solnit, author of Infinite City: A San Francisco Atlas “Only a handful of poets working in the visual tradition in the twentieth century have a profile that shows up in the broader scenes of fine art and modern culture. Among them, Ian Hamilton Finlay is probably the most frequently cited. But the work and thinking of this complex, enigmatic, and sometimes controversial figure is not necessarily well understood. This new volume documenting the many facets of Finlay's work as a poet, sculptor, and thinker across many media and a lifetime of creative activity will make it possible to study and appreciate his work anew. This collection makes a welcome addition to studies in book arts, visual poetry, and conceptual art through the presentation of an artist whose contributions have registered across these fields.” —Johanna Drucker, Breslauer Professor of Bibliographical Studies at the University of California, Los Angeles “While Ian Hamilton Finlay’s career is one of complexity, as a creator he was a champion of the simple. Engaging regional melodies, quotidian objects, and native terrain, he took poetry back to its Greek root, ‘to make.’ This half-century journey—from folk poem to concrete poem to poem-in-the-world—is at all points filled with a vital restlessness.” —Lisa Jarnot, author of Night Scenes “One must never forget that poets are makers, most vividly so in Scotland, where William Dunbar’s ‘Lament for the Makaris’ must still echo with uncanny poignance. Poetry is ‘a made thing’, as Robert Duncan put it. No poet will ever manage a word, much less a line, without all the resources of that art in timeless history sounding there, as each word finds its place in turn. There is no way to learn simply the intimacy of voice that Finlay has always, bringing one in to his physical person. It is a constant of his art in all its forms.” —Robert Creeley, from the foreword to the 1996 edition of Ian Hamilton Finlay’s The Dancers Inherit the Party and Glasgow Beasts, an a Burd
The Romanov dynasty has dazzled, intrigued, and confused the world for more than three centuries. These extraordinary monarchs wielded absolute power over the vast, violent lands of Russia. Savagery and kindness, asceticism and opulence, piousness and cruelty existed side by side in the royal courts. New York Times bestselling historian Ian Grey threads his way through these turbulent centuries, his focus on the private lives of the tsars themselves, the rulers whose personal histories are entwined with the history of the empire. He brings to life the passions, rages, intrigues, and greatness of the remarkable men and women who guided the destiny of Russia and changed the world.
The only complete resource on immunology for veterinary students and practitioners, Veterinary Immunology: An Introduction features a straightforward presentation of basic immunologic principles with comprehensive information on the most significant immunological diseases and responses seen in domestic animals. This meticulously updated new edition explores the latest advances in the field and provides a wealth of clinical examples that illustrate and clarify important concepts. - Comprehensive coverage of vaccines and vaccine usage, allergies and allergic diseases, and autoimmunity and immunodeficiencies, prepare you for the multiple immunologic issues you will encounter in practice. - A wealth of clinical examples clearly illustrate key concepts and offer practical strategies for diagnosing and treating immunologic disorders in the clinical setting. - More than 500 full-color diagrams and illustrations visually demonstrate and clarify complex issues. - Completely updated section on innate immunity includes new chapters on natural killer (NK) cells and systemic responses to infection to ensure you have the most up-to-date information. - New information on genomics and molecular diagnostic techniques explores how the emerging field of genomics impacts disease resistance and immunology in general, as well as the diagnosis and treatment of immunological and infectious diseases. - Updated content provides new information on well-recognized older diseases such as rheumatoid arthritis, systemic lupus, and inflammatory bowel disease, as well as current information on new diseases such as devil facial tumor disease and bovine neonatal pancytopenia. - Expanded coverage brings you the latest knowledge on resistance to infection, such as vaccine usage, especially with respect to duration of immunity, the effects of key vitamins and lipids on immune responses, the effects of old age on immunity, and both antiviral and parasitic immunity. - Diagnostic tests described throughout the text include a new section on the analysis of ELISA test data, as well as a brief summary of molecular diagnostic techniques. - Coverage reflecting a significant change in the overall view of immunology provides you with the foundational knowledge needed to grasp the broad pattern of immunologic reactions and understand how the immune system functions as an interconnected network, rather than a series of independent pathways. - New discussions of the critical importance of commensal bacteria and intestinal flora explain help you understand the importance of this normal flora with respect to antibacterial immunity, allergies, and autoimmunity, while at the same time providing a broader view of the animal body and its microflora as a "superorganism." - A discussion of the importance of adipose tissue in immunity and inflammation addresses the epidemic of obesity in domestic pets and the extraordinary growth rates expected of domestic livestock. - The section on inflammatory mechanisms has been divided into separate chapters focusing on the detection of invaders and the mediators of inflammation to incorporate the vast amount of new information on pattern recognition receptors and the ways in which they warn the body of microbial invasion.
In this highly innovative study, Ian Green examines the complete array of Protestant titles published in England from the 1530s to the 1720s. These range from the large specialist volumes at the top to cheap tracts at the bottom, from radical on one wing to conservative on the other, and from instructive and devotional manuals to edifying-cum-entertaining works such as religious verse and cautionary tales. Wherever possible the author adopts a statistical approach to permit a focus on those works which sold most copies over a number of years, and in an annotated Appendix provides a brief description of over seven hundred best selling or steady selling religious titles of the period. A close study of these texts and the forms in which they were offered to the public suggests a rapid diversification of both the types of work published and of the readerships at which they were targeted. It also demonstrates shrewd publishers' frequent attempts to plug gaps in a rapidly expanding market. Where previous studies of print have tended to focus on the polemical and the sensational, this one highlights the didactic, devotional, and consensual elements found in most steady selling works. It is also suggested that in these works there were at least three Protestantisms on offer an orthodox, clerical version, a moralistic, rational version favoured by the educated laity, and a popular version that was barely Protestant at all and that the impact of these probably varied both within and between different readerships. These conclusions shed much light not only on the means by which English Protestantism was disseminated, but also on the doctrinally and culturally diffused nature of English Protestantism by the end of the Stuart period. Both the text and the appendix should prove invaluable to anyone interested in the history of the Reformation or in printing as a medium of education and communication in early modern England.
Is it Time for a Regime Change? Protecting International Energy Investments against Political Risk. The 2013 seventh annual Juris investment arbitration conference put in issue the special role of international energy projects in the development of investor-state arbitration. It is currently one of the most active sectors of investor-state arbitration. The “facts” of the energy sector therefore are particularly well-developed in international jurisprudence. The similarities in the applicable law of investment protection between the energy sector and other sectors tend to hide from view what our panelists repeatedly uncovered: it is the facts of energy disputes that significantly set them apart. The concerns of sovereign dominion over national energy production and the protection of foreign investors in the energy sector against stranding large investments served as a key point of departure for discussions. The four questions that the Conference addressed include: The Energy Sector, Investment Arbitration and the ECT: Carving out a Special Regime? Energy Contracts and BITS – Is it Fair and Equitable to be Under the Umbrella? Mulitparty Investor Disputes in the Energy Sector – Preclusion, Consolidation or Free-For-All? Measure by Measure? Calculating Damages in Energy Disputes The discussion and debate that followed is provided in this book and sure to be of tremendous value to the international business lawyer, litigation specialist or trade and investment law policy expert.
The Digital Humanities have arrived at a moment when digital Big Data is becoming more readily available, opening exciting new avenues of inquiry but also new challenges. This pioneering book describes and demonstrates the ways these data can be explored to construct cultural heritage knowledge, for research and in teaching and learning. It helps humanities scholars to grasp Big Data in order to do their work, whether that means understanding the underlying algorithms at work in search engines, or designing and using their own tools to process large amounts of information.Demonstrating what digital tools have to offer and also what 'digital' does to how we understand the past, the authors introduce the many different tools and developing approaches in Big Data for historical and humanistic scholarship, show how to use them, what to be wary of, and discuss the kinds of questions and new perspectives this new macroscopic perspective opens up. Authored 'live' online with ongoing feedback from the wider digital history community, Exploring Big Historical Data breaks new ground and sets the direction for the conversation into the future. It represents the current state-of-the-art thinking in the field and exemplifies the way that digital work can enhance public engagement in the humanities.Exploring Big Historical Data should be the go-to resource for undergraduate and graduate students confronted by a vast corpus of data, and researchers encountering these methods for the first time. It will also offer a helping hand to the interested individual seeking to make sense of genealogical data or digitized newspapers, and even the local historical society who are trying to see the value in digitizing their holdings.The companion website to Exploring Big Historical Data can be found at www.themacroscope.org/. On this site you will find code, a discussion forum, essays, and datafiles that accompany this book.
Derived from the parent Guide to Literature in English, this volume offers in concise form over 4,000 entries on literature in English from cultures throughout the world. Writers and major works from the UK and the USA are represented, as are those from Canada, the Caribbean, Australia, India, and Africa. The coverage is broad - from the classics of English literature to the best of modern writing. Additionally, the Guide has a wealth of entries on literary movements, groups or schools in literature and criticism, literary magazines, genres and sub-genres, critical concepts, and rhetorical terms.
A Kirkus Reviews Best Middle Grade Book of 2019 An Orbis Picture Recommended Title “An outstanding case study in how science is actually done: funny, nuanced, and perceptive.” —Kirkus Reviews (starred review) Join early scientists as they piece together one of humanity’s greatest puzzles—the fossilized bones of the first dinosaur! Dinosaurs existed. That’s a fact we accept today. But not so long ago, the concept that these giant creatures could have roamed Earth millions of years before humans was unfathomable. People thought what we know as dinosaur bones were the bones of giant humans. Of large elephants. Of angels, even. So, how did we get from angel wings to the T-Rex? The First Dinosaur tells the story of the idea of dinosaurs, and the chain of fossil discoveries and advances in science that led to that idea. Be prepared to meet eccentric men and overlooked women who uncovered the pieces to a puzzle so much bigger than themselves, a puzzle far stranger and more spectacular than they could have ever imagined.
Mapping the locations and describing the natural history of some of the best wildlife habitats of the British Isles, this book also provides tips on field-craft and special photographic techniques. An introduction to the best photographic equipment, clothing, and other kit for wildlife photography, is followed by practical skills for exploring the countryside safely, and a chapter on showing and selling nature photographs.
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