Corrie and the Time Arch: Corrie has been enjoying a normal Saturday, playing football and taking the dog out. Then time actually seems to stand still, and this creates all sorts of problems. She encounters some interesting and dangerous people, time and space. Corries own native wit helps set her and her new friends free from a potentially earth-shattering threat. Corrie and the Chaunt of Time: Once again Corrie is plunged into an adventure that is fraught with danger and menace. This time, however, her friends and close relatives are endangered. Christmas should be a magical time of celebration and family, but when even Santa Claus becomes a threat, and pantomime figures present bewildering and hazardous perils, Corries life becomes burdened and deeply troubled. All this acute anxiety is further complicated by a young teenaged girls normal angst concerning growing up, boys, fashion, sisters, parents, and the rest. Setting out to solve a problem at school, things get a lot worse. She is catapulted into a world that is unbelievably convoluted, much more dangerous. Corries involvement with an extremely strange, if even more strangely familiar Time Lord, along with a welcome and much missed other Time Traveller, pitches her at an accelerating rapidity, further into an intricate and terrifying situation. In this nightmare land of dreams, enchanted forests, wizards, fairies, magicians, cities occupied by a ruthless desperate army all mixed with an old friend, a beloved grandpa, it takes all of Corries native wit, luck, and perseverance to win out.
This book brings together specialist authors from a variety of medical disciplines to give comprehensive coverage of the whole spectrum of women's vascular health. Covering coronary artery disease and its precursors, venous disease, thrombophilic defects, hormonal therapy and haemorrhagic problems, the content is divided into three sections. Section one reviews generic issues including the pathophysiology of arteriosclerosis, metabolic factors in vascular disease, the epidemiology and management of CHD in women. The management of cardiac syndrome X and the problem of diabetes are also discussed here. The second section looks at women's vascular health as it applies to fertility issues and during pregnancy such as polycystic ovarian disease, menstrual dysfunction, the menopause, venous thromboembolism and haemorrhagic problems. In the concluding third section, hormonal therapy in women and in particular the oral contraceptive pill and hormone replacement therapies are covered. The reader will be given a clear overview of the potential mechanisms whereby such therapy can act as a risk factor for arterial and venous disease, and will receive clear guidance regarding prescribing.
Returning for its fifth edition, the Oxford Handbook of Anaesthesia has been re-energized by new editors and a specialist contributor team, while still retaining its much-loved, clear and concise style. Written for anaesthetists at all stages of their careers, from trainees sitting exams through to experienced consultants as well as ODPs and nurses involved in theatre area work and pre-assessment, this comprehensive guide to the anaesthetic world is as indispensable as ever. This new edition has been completely revised and brings you the most up-to-date guidance and information to keep pace with fast-moving areas of anaesthesia, including a completely revised regional anaesthesia chapter. Now in full colour and packed with enhanced illustrations throughout, including new ECG rhythm strips and illustrations of specialist equipment, the Handbook also includes colour coding for easier navigation. Designed for daily use, this Handbook is your essential companion to anaesthesia, with everything you need at your fingertips whether on the go or for revision.
Through 10 outstanding editions, Kelley & Firestein's Textbook of Rheumatology has provided authoritative, in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. The 11th Edition of this classic text continues this tradition of excellence, while keeping you abreast of recent advances in genetics and the microbiome, new therapies such as biologics and biosimilars, and other rapid changes in the field. It provides comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, in a user-friendly, full color reference. - Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes—including key data on therapeutic outcomes to better inform clinical decision making. - Includes new chapters on Innate Lymphoid Cells and Natural Killer Cells, Pathogenesis of Inflammasome Mediated Diseases, Bisphosphonates, Ultrasound Evaluation of the Musculoskeletal System, and Evaluation of Monoarticular and Polyarticular Arthritis. - Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs. - Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editor Dr. Gary Koretzky, specialist in immunology and rheumatology. - Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Kelley's Textbook of Rheumatology delivers the state-of-the-art scientific and clinical know-how you need to offer your patients the most effective diagnosis and care. This rheumatology book’s sweeping updates highlight current advances and breakthroughs that impact your practice. With Kelley's Textbook of Rheumatology, you'll be ready to handle the toughest clinical challenges you face. Search the entire contents online at www.expertconsult.com, download all of images, and watch videos demonstrating the complete musculoskeletal exam, including abnormal findings and the arthroscopic presentation of diseased joints. Review basic science advances and their clinical implications in one place and get dependable, evidence-based guidance with the integrated chapter format that readers of Kelley's Textbook of Rheumatology have always appreciated. Gain a thorough understanding of the "whys" and "hows" of rheumatic disease management with detailed coverage of the very latest breakthroughs and the newest clinical algorithms. Apply the latest therapeutic advances through new chapters in bioengineering and tissue engineering, as well as up-to-date coverage of gout and disease-modifying drugs. Learn how the study of biomarkers across populations can help you detect diseases earlier and with greater accuracy with a new chapter on epigenetics. Diagnose, monitor, and manage rheumatic disease more effectively with expanded information on the use of ultrasound and other imaging modalities.
The Chapters of the Wisdom of My Lord Mani, a Coptic papyrus codex preserved at the Chester Beatty Library in Dublin, describes Mani’s mission, teachings and debates with sages in the courts of the Sasanian empire during the reign of Shapur I; with an extended account of his last days and death under Bahram I. The text offers an unprecedented new source for the history of religions in Late Antiquity, including interactions of Manichaean, Zoroastrian, Christian, Jewish, and Buddhist traditions in Iran, remarkably transmitted into the Mediterranean world as part of Manichaean missionary literature. This is the first of four fascicles constituting the editio princeps, based on enhanced digital and multispectral imaging and extended autoptic study of the manuscript.
Incidences of public disorder, and the manner in which they have been suppressed, have repeatedly ignited debate on the role of policing, the effectiveness of current legislation and the implications for human rights and civil liberties. These same issues have reverberated throughout British history, and have frequently resulted in the enactment of new legislation that reactively aimed to counter the specific concern of that era. This book offers a detailed analysis of the expansion of public order law in the context of the historical and political developments in British society. The correlation of key historical events and the enactment of consequent legislation is a key theme that resonates throughout the book, and demonstrates the expanding influence of the law on public assemblies and protest, which has continued to criminalise and prohibit certain social behaviours. Crucial movements in Britain’s social and political history who have all engaged in, or have provoked public disorder, are examined in the book. Other incidents of riot and disorder, such as the Featherstone Riot (1893), the Battle of Cable Street (1936), the Inner City Riots (1980s) and the UK riots (2011) are also covered. By positioning legal developments within their historical context, the book demonstrates the ebb and flow between the prominence of the competing demands of the liberties of free expression and assembly on the one hand and the protection of the general public and property on the other. This book is essential reading for academics and students in the fields of criminology, history and law.
This new edition continues to provide a critical introduction to the legal regulation of consumer markets, situating it within the context of broader debates about rationales for regulation, the role of the state and the growth of neo-liberalism. It draws on interdisciplinary sources, assessing, for example, the increased influence of behavioural economics on consumer law. It analyses the Europeanisation of consumer law and the tensions between neo-liberalism and the social market, consumer protection and consumer choice, in the establishment of the single market ground rules. The book also assesses national, regional and international responses to the world financial crisis as reflected in the regulation of consumer credit markets. This edition incorporates recent legislative and judicial developments of the law, blending substantial extracts from primary UK, EU and international legal materials.
Periodontology at a Glance The market‐leading at a Glance series is popular among healthcare students and newly qualified practitioners, for its concise and simple approach and excellent illustrations. Each bite‐sized chapter is covered in a double‐page spread with clear, easy‐to‐follow diagrams, supported by succinct explanatory text. Covering a wide range of topics, books in the at a Glance series are ideal as introductory texts for teaching, learning and revision, and are useful throughout university and beyond. Everything you need to know about Periodontology... at a Glance! Brief but comprehensive overview of periodontology from the At a Glance series Periodontology at a Glance, Second Edition provides readers with key information on periodontology in an easy-to-use reference. Following the At a Glance series style, this revised and expanded edition illustrates each topic with a double page spread/short chapter that encapsulates the essential knowledge. Clear diagrams and clinical pictures are included throughout and accompanied by succinct text, providing a highly visual format to facilitate ease of learning. This second edition is divided into 6 uniquely colour-coded parts, designed to guide the reader through the various topics in a visually appealing manner. The authors have distilled the salient research literature and evidence base, and made suggestions for further reading where appropriate. Sample topics covered in Periodontology at a Glance include: Anatomy of the periodontium, classification of periodontal diseases, periodontal epidemiology, role of plaque in the aetiology of periodontal diseases, and plaque biofilm microbiology. Host defenses, development and progression of periodontal diseases, systemic risk factors for periodontal diseases, periodontal diseases and general health. Diet and periodontal diseases, local risk factors for periodontal diseases, periodontal history, examination and diagnosis, and periodontal screening. Principles of periodontal diagnosis and treatment planning, plaque control, non-surgical periodontal therapy, and periodontal tissue responses, healing, and monitoring. Periodontal surgery, dental implants and peri-implant mucositis/peri-implantitis. Periodontal health; plaque biofilm-induced gingivitis, non-plaque-induced gingival conditions, gingival recession, gingival enlargement, periodontitis and its staging and grading, periodontal management of patients who smoke/have diabetes, necrotising periodontal diseases, periodontal abscesses, endodontic-periodontal lesions, periodontal diseases in younger and older patients, and the delivery of periodontal care Providing comprehensive coverage of the subject, the Second Edition of Periodontology at a Glance is an essential resource for dental undergraduates and hygiene therapy students, and also serves as a helpful refresher for qualified dentists preparing for a general examination or looking for a relatively quick update in the field.
Consult the definitive resource in rheumatology for an in-depth understanding of scientific advances as they apply to clinical practice. Masterfully edited by Drs. Gary S. Firestein, Ralph C. Budd, Sherine E. Gabriel, Iain B. McInnes, and James R. O'Dell, and authored by internationally renowned scientists and clinicians in the field, Kelley and Firestein’s Textbook of Rheumatology, 10th Edition, delivers the knowledge you need for accurate diagnoses and effective patient care. From basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes, this state-of-the-art reference provides a global, authoritative perspective on the manifestations, diagnosis and treatment of rheumatic diseases. An ideal balance of the basic science you need to know and how to apply that information to clinical practice. An integrated chapter format allows you to review basic science advances and their clinical implications in one place and get dependable, evidence-based guidance for the full range of rheumatologic diseases and syndromes. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. New content on the latest diagnostic perspectives and approaches to therapy, including five brand-new chapters: Metabolic Regulation of Immunity, Principles of Signaling, Research Methods in the Rheumatic Diseases, Novel Intracellular Targeting Agents, and IgG4-Related Diseases. New and expanded chapter topics on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies. More schematic diagrams clearly summarize information and facilitate understanding.
Are you looking for a complete course in Gaelic which takes you effortlessly from beginner to confident speaker? Whether you are starting from scratch, or are just out of practice, Complete Gaelic will guarantee success! This edition is fully updated to reflect the published spelling conventions, and has complete audio support online. The course is structured in thematic units and the emphasis is placed on communication, so that you effortlessly progress from introducing yourself and dealing with everyday situations, to using the phone and talking about work. By the end of this course, you will approach Level B2 of the Common European Framework for Languages: Can interact with a degree of fluency and spontaneity that makes regular interaction with native speakers quite possible without strain for either party. Learn effortlessly with a new easy-to-read page design and interactive features: NOT GOT MUCH TIME? One, five and ten-minute introductions to key principles to get you started. AUTHOR INSIGHTS Lots of instant help with common problems and quick tips for success, based on the author's many years of experience. GRAMMAR TIPS Easy-to-follow building blocks to give you a clear understanding. USEFUL VOCABULARY Easy to find and learn, to build a solid foundation for speaking. DIALOGUES Read and listen to everyday dialogues to help you speak and understand fast. TEST YOURSELF Tests in the book and online to keep track of your progress. TRY THIS Innovative exercises illustrate what you've learnt and how to use it. Access the audio for this course for free by downloading it to the Teach Yourself Library app or streaming it on library.teachyourself.com. Rely on Teach Yourself, trusted by language learners for over 85 years.
Body weight is determined by the balance between energy intake and energy expenditure. Obesity ensues when energy intake exceeds that of energy expenditure. To date, the majority of pharmaco-therapies to control body weight have been directed towards the appetitive limb of this energy balance equation. Very few anti-obesity agents target the manipulation of energy expenditure. The recent unequivocal demonstration that functional brown adipose tissue is present in adult humans has sparked a great deal of interest in developing means to exploit thermogenesis to control body weight. Thermogenesis is defined as the dissipation of energy through the production of heat and occurs in specialised tissues including brown adipose tissue and skeletal muscle. This chapter will highlight a number of animal models that are currently utilised in effort to understand the mechanisms that underpin thermogenesis. It will describe the control of thermogenesis in skeletal muscle and adipose tissue as well as detailing the role of thermogenesis in determining the susceptibility to obesity in a number of distinct animal models.
This textbook provides a comprehensive introduction to the interdisciplinary field of the Social Studies of Science and Technology (SSST). Over the past two decades, the biomedical sciences have transformed our understanding of the relationship between the social and natural worlds, while its ‘promissory visions’ are seen to offer extraordinary opportunities for economic and social development. But alongside these scientific innovations have emerged new, and frequently unanticipated social, political, bioethical, and legal dilemmas and challenges. This cutting-edge text explores ‘post-genomic’ developments in the field of pharmacogenomics and the prospects for a new ‘precision’ or personalised medicine; the potential of environmental epigenetics to reconfigure the boundaries of the social and natural worlds; the emergence of an array of ‘neuro-disciplines’, seeking to identify the neural basis of a whole range of social and economic behaviours; and the challenges of constructing a coherent and robust governance framework for the conduct of biomedical science research and innovation, responsive to the social and health needs of the whole population.
The Third Edition of this much celebrated textbook continues to focus on the four major and influential perspectives in contemporary social psychology - social cognition, social identity, social representations, and discursive psychology. A foundational chapter presenting an account of these perspectives is then followed by topic-based chapters from the point of view of each perspective in turn, discussing commonalities and divergences across each of them. Key Features of the Third Edition: - Now includes coverage of the social neuroscience paradigm and research on implicit social cognition - Updated pedagogical features and visual material - An extended conclusion covers the ways in which the different approaches of the field intersect as well as a general discussion of the direction in which the field is moving. Social Cognition: An Integrated Introduction is an integrative, holistic textbook that will enhance the reader′s understanding of social cognition and of each of the topical issues considered. It remains a key textbook for psychology students, particularly those on courses in social psychology and social cognition.
This title focuses on vision as an active process, rather than a passive activity and provides an integrated account of seeing and looking. The authors give a thorough description of basic details of the visual and oculomotor systems necessary to understand active vision.
This comprehensive volume describes how ecosystem services-based approaches can assist in addressing major global and regional water challenges, such as climate change, biodiversity loss, and water security in the developing world, by integrating scientific knowledge from different disciplines, such as hydrological modelling, environmental economics, psychology and international law. Empirical assessments at the national, catchment and regional levels are used to critically appraise this systemic approach, and the merits and potential limitations are presented. The practicalities of this approach with regard to water resources management, nature conservation, and sustainable business practices are discussed, and the role of society in underpinning the concept of ecosystem services is explored. Presenting new insights and perspectives on how to shape future strategies, this contributory volume is a valuable reference for researchers, academics, students and policy makers, in environmental studies, hydrology, water resource management, ecology, environmental law, policy and economics, and conservation biology." -- Provided by publisher.
The Oxford American Handbooks of Medicine, now available in PDA format, each offer a short but comprehensive overview of an entire specialty featuring instant access to guidance on the conditions that are most likely to be encountered. Precise and prescriptive, the handbooks offer up-to-date advice on examination, investigations, common procedures, and in-patient care. Written by leading American practitioners, these PDAs will be invaluable resources for students, residents, and practitioners. These PDA versions enable enhanced, multi-layered access to the entire text, illustrations, and tables. Other features include fast access available via the key word search, and a facility for book marking and annotating the text. It is suitable for Palm and Windows Mobile.
When all sorts of accusations, denials, revelations, disclosures, and leaks are swarming and spilling around the security agencies of the United Kingdom and the USA, it is worse when the Snowden effect erupts. A bruised and slightly disillusioned Commander Elaine Black, training officer and senior security advisor at GCHQ Bude Listening Facility, is plunged into a bewildering and dangerous battle to make sense of and counter a desperate threat to British Security. Headless bodies, fire bombings, threats of chemical warfare unloosed on a small West Country town, apparently straightforward murders and the killing of a policeman make Elaine Black thankful for the involvement of a pair of incorruptible and driven police detectives and the experience and expertise that they bring to the party. However, as the stakes get higher and higher, Elaine is further gratified to have two old fighting companions on side. The question is, can the team confound the multinational conspiracy that stretches to the highest echelons of British and American financial and political establishments?
Steroid Hormone Receptors in Endocrine Physiology and Diseases covers the role of steroid hormones in human physiology and receptor activity in the pathophysiology of disease. The book discusses how these receptors can be used as therapeutic targets for the treatment of conditions from cancer to aging, offering immediate applications of biochemical principles into clinical applications such as diagnosis and treatment. This book is a valuable reference for graduate and postdoctoral scientists but is also ideal for medical students interested in the functional role of various steroid hormone receptors in a wide variety of endocrine related diseases.Steroid hormone receptors (SHRs) are known to play vital roles in normal physiology through the control of development, differentiation, metabolic homeostasis and reproduction. Due to their involvement in various pathological and disease conditions, SHRs are also important therapeutic targets in several disorders including inflammation, autoimmune diseases, hormone-dependent cancers, osteoporosis and cardiovascular diseases. - Discusses the importance of steroid hormone receptors in the physiology and pathophysiology of various endocrine related diseases - Provides state-of-the-art information based on key research findings in the field, along with hypotheses and perspectives for future directions for basic and translational research and clinical applications - Offers a comprehensive description of the challenges associated with steroid hormone receptors-based therapies
Reclaiming Social Work is a thought-provoking and innovative book which examines how social work′s commitment to social justice has been deepened and enriched by its contact with wider social movements. It explores the tensions between social work values and a market-driven agenda, and locates new resources of hope for the social work profession in the developing resistance to managerialism. The book: " discusses pertinent social work issues such as inequality and risk, the voluntary sector, and service-user involvement " examines values such as democracy, solidarity, accountability, participation, justice, equality, liberty and diversity " is written in an accessible style, drawing on diverse examples to illustrate theoretical concepts. Reclaiming Social Work is an accessible yet challenging book and will be essential reading for all social work students and practitioners wanting to think outside the boundaries of their profession. The book will be particularly helpful to students taking courses in anti-oppressive practice, social work values, social work theories and concepts, and international social work. Iain Ferguson is a Senior Lecturer in Social Work at the University of Stirling. Previous publications include Rethinking Welfare: A Critical Perspective (SAGE, 2002, co-authored with Michael Lavalette and Gerry Mooney); Globalisation, Global Justice and Social Work (Routledge, 2004, co-edited with Michael Lavalette and Elizabeth Whitmore); and International Social Work and the Radical Tradition (Venture Press, 2007, co-edited with Michael Lavalette).
This guidebook describes the Cape Wrath Trail, a long-distance trek from Fort William to Cape Wrath crossing the wild northwest of the Scottish Highlands. The route is described from south to north in 14 stages, with 6 alternative stages along the way, allowing for a flexible itinerary of between two and three weeks. A long tough trek with no waymarking, this is for the tried and tested backpacker. The guidebook includes OS mapping, route profiles and detailed route descriptions and gives you all the information you need about accommodation (including hotels, bothies, B&Bs and bunkhouses), campsites and amenities en route, to help you plan and prepare for this epic challenge. The Cape Wrath Trail is regarded as the toughest long-distance route in Britain and offers unparalleled freedom and adventure to the experienced and self-sufficient backpacker prepared to walk for many days in remote wilderness. Travelling through the wild and rugged landscapes of Morar, Knoydart, Torridon and Assynt, it will test the limits of your endurance.
*Interested in purchasing The Art and Science of Mental Health Nursing as a SmartBook? Visit https://connect2.mheducation.com/join/?c=normanryrie4e to register for access today* This well-established textbook is a must-buy for all mental health nursing students and nurses in registered practice. Comprehensive and broad, it explores how mental health nursing has a positive impact on the lives of people with mental health difficulties. Several features help you get the most out of each chapter and apply theory to practice, including: • Personal Stories: Provide insight into the experience of mental health difficulties from the perspective of service users and their carers • Thinking Spaces: Help you reflect on your practice and assess your learning individually and in groups, with further guidance available online • Recommended Resources: Provide additional materials and support to help extend your learning New to this edition: With four brand new chapters plus nine chapters re-written by original authors, key developments in this edition include: • Physical health care of people with mental health problems • Care of people who experience trauma • Promoting mental health and well-being • Support needed by nurses to provide therapeutic care and to derive satisfaction from their work • Innovations in mental health practice ‘The newly revised and updated edition has continued to offer an intelligent and readable text that offers a great deal to both students and those undertaking continuous professional development … This edition continues to offer “thinking spaces” that encourage the reader to reflect upon and consider what they have learned in a most practical way. I wholeheartedly recommend this book and continue to be impressed with its high standards of presentation and scholarship’. Emeritus Professor Tony Butterworth CBE, Chair, Foundation of Nursing Studies, Vice Chair RCN Foundation, UK ‘It is a pleasure to open this book and to see the comprehensive range of information and evidence based guidance in relation to effective practice in nursing. Even If you only buy one professional book this year make it this one!’ Baroness Watkins of Tavistock; Crossbench Peer, PhD and RN (Adult and Mental Health), UK ‘The importance of the teaching within this book cannot be underestimated … The book is written by credible and respected practitioners and will support mental health nurses to practice from the best evidence available today working from and with the human condition’. Beverley Murphy, Director of Nursing, South London and Maudsley NHS Foundation Trust
A new edition of the bestselling classic—published with a special introduction to mark its 10th anniversary This pioneering account sets out to understand the structure of the human brain – the place where mind meets matter. Until recently, the left hemisphere of our brain has been seen as the ‘rational’ side, the superior partner to the right. But is this distinction true? Drawing on a vast body of experimental research, Iain McGilchrist argues while our left brain makes for a wonderful servant, it is a very poor master. As he shows, it is the right side which is the more reliable and insightful. Without it, our world would be mechanistic – stripped of depth, colour and value.
Modern western education finds its origins in the practices, systems and schools of the ancient Greeks and Romans. It is in the field of education, in fact, that classical antiquity has exerted one of its clearest influences on the modern world. Yet the story of Greek and Roman education, extending from the eighth century B.C. into the Middle Ages, is familiar in its details only to relatively few specialists. Containing nearly 300 translated texts and documents, Greek and Roman Education: A Sourcebook is the first book to provide readers with a large, diverse and representative sample of the primary evidence for ancient Greek and Roman education. A special feature of this Sourcebook is the inclusion not only of the fundamental texts for the study of the subject, but also unfamiliar sources that are of great interest but are not easily accessible, including inscriptions on stone and Greek papyri from Egypt. Introductions to each chapter and to each selection provide the guidance which readers need to set the historical periods, themes and topics into meaningful contexts. Fully illustrated and including extensive suggestions for further reading, together with an index of passages explored, students will have no further need for any other sourcebook on Greek and Roman education.
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