Let each know that for each the body, the mind and the soul have been freed to fulfill themselves." These powerful words, spoken by Nelson Mandela in his inaugural address as the new president of South Africa, are taken from just one of the forty important and thought-provoking speeches in this collection. Ranging from 1945 to the present day, they provide an important insight into the modern world. Inspirational speeches by Winston Churchill, Mikhail Gorbachev, Martin Luther King, Barack Obama and many others are supplemented with biographies of each speaker, as well an exploration of their words' significance and an historical account of the consequences of their oratory. This is a history of the recent and contemporary world told through the speeches that shaped it.
The five hundred years that separate the mid-tenth century from the mid-15th century constitute a critical and formative period in the history of Europe. This was the age of the system of legal and military obligation known as 'feudalism', and of the birth and consolidation of powerful kingdoms in England, France and Spain; it was an era of urbanization and the expansion of trade, of the building of the great Romanesque and Gothic cathedrals, of courtly romance and the art of the troubadour, and of the founding of celebrated seats of learning in Paris, Oxford and Bologna. But it was also an epoch characterised by brutal military adventure in the launching of armed pilgrimages to liberate Jerusalem from Muslim control, of the brutal dynastic conflict of the Hundred Years' War and of the devastating pandemic of the Black Death. In a sequence of scholarly but accessible articles - accompanied by an array of beautiful and authentic images of the era, plus timelines, maps, boxed features and display quotes - distinguished historian Hywel Williams sheds revelatory light on every aspect of a rich and complex period of European history.
The five hundred years that separate the mid-tenth century from the mid-15th century constitute a critical and formative period in the history of Europe. This was the age of the system of legal and military obligation known as "feudalism," and of the birth and consolidation of powerful kingdoms in England, France and Spain; it was an era of urbanization and the expansion of trade, of the building of the great Romanesque and Gothic cathedrals, of courtly romance and the art of the troubadour, and of the founding of celebrated seats of learning in Paris, Oxford and Bologna. But it was also an epoch characterized by brutal military adventure in the launching of armed pilgrimages to liberate Jerusalem from Muslim control, of the brutal dynastic conflict of the Hundred Years' War and of the devastating pandemic of the Black Death. In a sequence of scholarly but accessible articles--accompanied by an array of beautiful and authentic images of the era, plus timelines, maps, boxed features and display quotes--distinguished historian Hywel Williams sheds revelatory light on every aspect of a rich and complex period of European history.
Raymond Williams came from Wales, and was brought up in a working-class family. These facts of place and class are the start of a thread which runs throughout his life and work. In Raymond Williams: From Wales to the World his writing, whether theoretical, historical, critical or as fiction has been treated as a single whole, recognising that his ideas were interwoven as a literary and intellectual engagement with Wales and the world over several decades. This collection of essays, edited by Stephen Woodhams, serves to further engage and extend his ideas of class and society.
The currents of History run deep and often unseen beneath the everyday ripple of events. But now and again the current rises to the surface, and the events of a single day shed an exceptional light on the meaning of the past. Such events are the subject of Days that Changed the World. Some of the 50 days described here mark the end of an era; others the start of something new. Many are the dates of bloody battles or murders; others of momentous decisions or breathtaking discoveries. All are remembered as powerful symbols of their time. Our story begins almost 2500 years ago on 28 September 480 before the Christian Era, when the Athenian navy destroyed the Persian invasion fleet in the Bay of Salamis. Had the Persians won we might never have heard the names of Plato, Aristotle or Alexander, nor recognize the word democracy. Charting 50 such defining moments, concluding with 11 September 2001 and the destruction of New York's Twin Towers, Days that Changed the World is a unique and fascinating way to portray the story of world history. These 50 history-making days include: The Battle of the Salamis; The Assassination of Julius Caesar; The Crucifixion of Jesus Christ; The Dedication of Constantinople; The Death of Muhammad; The Coronation of Charlemagne; The Death of Genghis Khan; The Fall of Constantinople; The Defeat of the Spanish Armada; The Defenestration of Prague; The Fall of the Bastille; The Battle of Waterloo; Parliament Passing the Emancipation Act; The Battle of Sedan; The Boxer Rebellion; The First Day of the Somme; The Japanese Attack on Pearl Harbor; The Bombing of Hiroshima; Martin Luther King's "I have a Dream'; The Breaching of the Berlin Wall; Nelson Mandela's Release from Prison; Nine Eleven.
After Raymond Williams: Cultural Materialism and the Break-Up of Britain has two broad aims. The first is to re-examine the concept of cultural materialism, the term used by Raymond Williams to describe his theory of how writing and other cultural forms relate to general social and historical processes. Using this theory, the second objective is to explore the material ways in which contemporary British writing participates in one particular political process - that of the break-up of Britain. The general trajectory of the book is a matter of superseding Williams: the early chapters are devoted to extrapolating Williams's materialist theory of cultural forms, while later chapters are concerned with applying this theoretical material to a series of readings of books and films produced in the years since his death in 1988. This volume provides a detailed account of some of the writing produced in Scotland and Wales in the years surrounding political devolution, and also considers the ways in which different subcultural communities use fiction to renegotiate their relationships with the British whole.
The currents of History run deep and often unseen beneath the everyday ripple of events. But now and again the current rises to the surface, and the events of a single day shed an exceptional light on the meaning of the past. Such events are the subject of Days that Changed the World. Some of the 50 days described here mark the end of an era; others the start of something new. Many are the dates of bloody battles or murders; others of momentous decisions or breathtaking discoveries. All are remembered as powerful symbols of their time. Our story begins almost 2500 years ago on 28 September 480 before the Christian Era, when the Athenian navy destroyed the Persian invasion fleet in the Bay of Salamis. Had the Persians won we might never have heard the names of Plato, Aristotle or Alexander, nor recognize the word democracy. Charting 50 such defining moments, concluding with 11 September 2001 and the destruction of New York's Twin Towers, Days that Changed the World is a unique and fascinating way to portray the story of world history. These 50 history-making days include: The Battle of the Salamis; The Assassination of Julius Caesar; The Crucifixion of Jesus Christ; The Dedication of Constantinople; The Death of Muhammad; The Coronation of Charlemagne; The Death of Genghis Khan; The Fall of Constantinople; The Defeat of the Spanish Armada; The Defenestration of Prague; The Fall of the Bastille; The Battle of Waterloo; Parliament Passing the Emancipation Act; The Battle of Sedan; The Boxer Rebellion; The First Day of the Somme; The Japanese Attack on Pearl Harbour; The Bombing of Hiroshima; Martin Luther King's 'I have a Dream'; The Breaching of the Berlin Wall; Nelson Mandela's Release from Prison; Nine Eleven.
Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest informatio
Over the last 3000 years, the great 'sun kings' of history have dazzled the world with their ability to build empires and rule them absolutely, but equally with their shows of excess and opulence. Experts in the public display of power, they have identified their own authority as the basis of their country's grandeur. From Ramses II raising the temples and statues of 13th-century BC Egypt, and Charlemagne reviving Roman imperial glory for 9th-century Europe, to Peter the Great's transformation of Russia into a western power, and Napoleon's parcelling of Europe for his family, The Sun Kings examines the lives and achievements of 50 magnificent rulers, whilst also providing a fascinating study of the changing role of kingship. The sun kings' lifestyles, palaces, art, dress and other totems of their success are brought to life with lavish colour illustrations. The following rulers are included: Ramses II Roger II Louis XIV Solomon Suryavarman II Kangxi Nebuchadnezzar II The Knights Templar Peter the Great Darius I Eleanor of Aquitaine Frederick II Croesus, King of Lydia Kublai Khan Maria-Theresa Alexander the Great Baybars I Catherine the Great Shi Huangdi Pope Alexander VI Napoleon Augustus Lorenzo de Medici Leopold II Constantine I Montezuma II Ludwig II Al-Mansur Henry VIII Mohammad Reza Shah Kammu Charles V Pahlavi Charlemagne Suleyman I Bokassa I Abd-ar-rahman III Akbar Fahd ibn 'Abd al-'Aziz Basil II ('the Bulgar-Slayer') Gustavus Adolphus al-Sa'ud Otto III Charles I William the Conqueror
The third edition of this popular textbook builds on the excellent foundations laid down by the earlier editions. It provides a thorough introduction to the principles of rational drug design, adopting a 'from the bench to the market place' approach. As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states, and in this textbook both novel and established approaches are incorporated. The introductory text explains the principles of drug design using real examples. These illustrate the discovery of 'lead' compounds and their manipulation to produce non-toxic drug candidates that will be successfully metabolized to interact with target receptors in a predicted fashion. In addition to fully updating the contents of the previous edition, the Editor has included important new sections on the pharmacological consequences of drug chirality, agonists and antagonists of neurotransmitters, and the process involved in proceeding from program sanction to clinical trials
Through his foreign conquests & internal reforms, Charlemagne is a defining figure of both Western Europe & the Middle Ages. Crowned king of the Franks in 768, he expanded their kingdoms into an empire that incorporated much of western & central Europe. In this study, Hywel Williams explores every facet of Charlemagne's rule.
This volume is not only a detailed look at some of the writing produced in Scotland and Wales in the years surrounding political devolution, it also include a look at the ways in which difference sub-cultural commuities use fiction to renegotiate their relationships with the British whole.
Raymond Williams came from Wales, and was brought up in a working-class family. These facts of place and class are the start of a thread which runs throughout his life and work. In Raymond Williams: From Wales to the World his writing, whether theoretical, historical, critical or as fiction has been treated as a single whole, recognising that his ideas were interwoven as a literary and intellectual engagement with Wales and the world over several decades. This collection of essays, edited by Stephen Woodhams, serves to further engage and extend his ideas of class and society.
The third edition of this popular textbook builds on the excellent foundations laid down by the earlier editions. It provides a thorough introduction to the principles of rational drug design, adopting a 'from the bench to the market place' approach. As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states, and in this textbook both novel and established approaches are incorporated. The introductory text explains the principles of drug design using real examples. These illustrate the discovery of 'lead' compounds and their manipulation to produce non-toxic drug candidates that will be successfully metabolized to interact with target receptors in a predicted fashion. In addition to fully updating the contents of the previous edition, the Editor has included important new sections on the pharmacological consequences of drug chirality, agonists and antagonists of neurotransmitters, and the process involved in proceeding from program sanction to clinical trials
Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest informatio
Introduction to the Principles of Drug Design provides a framework of fundamental drug design and principles into which drugs following on developments may be fitted. This book presents the rationales behind the design of drugs. Organized into nine chapters, this book begins with an overview of how the body handles a drug in terms of absorption, metabolism, distribution, and excretion. This text then examines the critical drug activity at the receptor site, which is usually related to blood and other distribution fluid levels. Other chapters consider the factors involved in binding a drug, metabolite, or substrate to a receptor. The final chapter deals with the design of chemotherapeutic agent for clinical use in the treatment of human infections. This book is intended for use in undergraduate pharmacy courses in medicinal chemistry and as an aid in similar courses in biochemistry and pharmacology. Graduates in chemistry just entering the pharmaceutical industry will also find this book useful.
The third edition of this popular textbook builds on the excellent foundations laid down by the earlier editions. It provides a thorough introduction to the principles of rational drug design, adopting a 'from the bench to the market place' approach. As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states, and in this textbook both novel and established approaches are incorporated. The introductory text explains the principles of drug design using real examples. These illustrate the discovery of 'lead' compounds and their manipulation to produce non-toxic drug candidates that will be successfully metabolized to interact with target receptors in a predicted fashion. In addition to fully updating the contents of the previous edition, the Editor has included important new sections on the pharmacological consequences of drug chirality, agonists and antagonists of neurotransmitters, and the process involved in proceeding from program sanction to clinical trials
Provides information about the lives and reigns of over 50 rulers, from ancient Egypt to the 20th century, including each ruler's achievements in the context of the history of her or his time and key biographical facts.
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